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Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
GABARAP (GABA Type A Receptor-Associated Protein) is a Protein Coding gene. Diseases associated with GABARAP include Stiff-Person Syndrome and Hyperoxaluria, Primary, Type Ii. Among its related pathways are TBC/RABGAPs and Macroautophagy. Gene Ontology (GO) annotations related to this gene include microtubule binding and GABA receptor binding. An important paralog of this gene is GABARAPL1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9892355 |
GO:0008017 | microtubule binding | IBA | -- |
GO:0031625 | ubiquitin protein ligase binding | IBA,IPI | 25127057 |
GO:0048487 | beta-tubulin binding | IDA | 9892355 |
GO:0050811 | GABA receptor binding | IBA,IPI | 9892355 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0000421 | autophagosome membrane | IBA,TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005764 | lysosome | IEA | -- |
GO:0005776 | autophagosome | IBA,IDA | 19056683 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Macroautophagy |
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2 | Vesicle-mediated transport | ||
3 | Apelin signaling pathway | ||
4 | Autophagy - animal | ||
5 | FoxO signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000045 | autophagosome assembly | IBA | 21873635 |
GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
GO:0000422 | autophagy of mitochondrion | IBA | 21873635 |
GO:0006605 | protein targeting | TAS | 9892355 |
GO:0006914 | autophagy | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
gamma-Aminobutyric acid | Approved, Investigational | Pharma | 25 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||
SP2: | - | ||||||||||||||
SP3: | - | - | - | ||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GABARAP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GABARAP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gabarap 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gabarap 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GABARAP 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | GABARAP (2 of 2) 31 |
|
OneToMany | |
gabarapa 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Atg8a 31 |
|
OneToMany | |
CG12334 32 |
|
|
|||
Atg8b 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | lgg-1 31 32 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ATG8 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422288 | CNV | deletion | 17116639 |
esv2665200 | CNV | deletion | 23128226 |
esv3639861 | CNV | loss | 21293372 |
nsv457659 | CNV | loss | 19166990 |
nsv574322 | CNV | loss | 21841781 |
nsv952118 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
stiff-person syndrome |
|
|
hyperoxaluria, primary, type ii |
|
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hereditary sensory and autonomic neuropathy type 1 |
|
|
amyotrophic lateral sclerosis 1 |
|
|