Aliases for GAB1 Gene
Aliases for GAB1 Gene
External Ids for GAB1 Gene
- HGNC: 4066
- Entrez Gene: 2549
- Ensembl: ENSG00000109458
- OMIM: 604439
- UniProtKB: Q13480
Previous GeneCards Identifiers for GAB1 Gene
- GC04P145054
- GC04P144619
- GC04P144724
- GC04P144835
- GC04P144615
- GC04P144477
- GC04P144257
- GC04P139987
Summaries for GAB1 Gene
-
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for GAB1 Gene
GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Deafness, Autosomal Recessive 26 and Leopard Syndrome. Among its related pathways are Akt Signaling and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and SH3/SH2 adaptor activity. An important paralog of this gene is GAB2.
UniProtKB/Swiss-Prot for GAB1 Gene
-
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Additional gene information for GAB1 Gene
- Monarch Initiative
- Search for GAB1 at DataMed
- Search for GAB1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAB1 Gene
Genomics for GAB1 Gene
GeneHancer (GH) Regulatory Elements for GAB1 Gene
Promoters and enhancers for GAB1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J143335 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.2 | 153 | 3.4 | ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 REST KAT8 GLIS1 | GC04M143335 GAB1 | |
| GH04J143373 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE dbSUPER | 662.1 | +42.0 | 42044 | 10.6 | PKNOX1 FOXA2 ARID4B FEZF1 ZNF48 YY1 TCF12 ZNF143 ATF7 RUNX3 | GAB1 USP38 RPS2P20 RPSAP36 | |
| GH04J143404 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 16.5 | +69.2 | 69207 | 2.7 | PKNOX1 FOXA2 SMAD1 NFIB RAD21 YY1 EGR1 ATF7 IKZF2 RUNX3 | GAB1 RPSAP36 RPS2P20 | |
| GH04J143410 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE dbSUPER | 14.5 | +75.1 | 75061 | 2 | STAT1 JUN CEBPB ZNF623 JUND PRDM6 PRDM10 ZXDB TRIM28 | GAB1 RPSAP36 RPS2P20 | |
| GH04J143416 | Enhancer | 0.7 | dbSUPER | 15.2 | +83.9 | 83894 | 8.5 | PKNOX1 BACH1 ZNF384 EBF1 BMI1 RELA ATF7 ZSCAN29 IKZF2 RUNX3 | GAB1 USP38 LOC105377623 RPSAP36 RPS2P20 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GAB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GAB1 gene promoter:
-
- STAT3
- AP-1
- ATF-2
- c-Jun
Regulatory Element Products
Genomic Locations for GAB1 Gene
Genomic Locations for GAB1 Gene
- chr4:143,336,762-143,474,568
- (GRCh38/hg38)
- Size:
- 137,807 bases
- Orientation:
- Plus strand
- chr4:144,257,915-144,395,721
- (GRCh37/hg19)
- Size:
- 137,807 bases
- Orientation:
- Plus strand
Genomic View for GAB1 Gene
Genes around GAB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.21 by Entrez Gene
- 4q31.21 by HGNC
- 4q31.21 by Ensembl
GAB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GAB1 Gene
Proteins for GAB1 Gene
-
Protein details for GAB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13480-GAB1_HUMAN
- Recommended name:
- GRB2-associated-binding protein 1
- Protein Accession:
- Q13480
- A8K152
- Q4W5G2
- Q6P1W2
Protein attributes for GAB1 Gene
- Size:
- 694 amino acids
- Molecular mass:
- 76616 Da
- Quaternary structure:
-
- Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK.
Protein Expression for GAB1 Gene
Post-translational modifications for GAB1 Gene
- Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GAB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GAB1
-
Abcam antibodies for GAB1
- Invitrogen Antibodies for GAB1 (AFLGC-GAB1)
- antibodies-online: Search results for available GAB1 related products ranked by validation data
- GeneTex GAB1 Antibody for GAB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GAB1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GAB1
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- antibodies-online: Search results for available GAB1 related products ranked by validation data
- Search GeneTex for Proteins for GAB1
-
Abcam proteins for GAB1
Assay Products
- antibodies-online: Search results for available GAB1 related products ranked by validation data
No data available for DME Specific Peptides for GAB1 Gene
Domains & Families for GAB1 Gene
Gene Families for GAB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GAB1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GAB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13480- Family:
-
- Belongs to the GAB family.
Function for GAB1 Gene
Molecular function for GAB1 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Phenotypes From GWAS Catalog for GAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | 8596638 |
| GO:0005515 | protein binding | IPI | 9658397 |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | TAS | -- |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for GAB1 Gene
- MGI mutant phenotypes for GAB1:
-
inferred from 9 alleles
- cardiovascular system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- integument phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- embryo phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for GAB1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased Dengue Infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased NF-kappaB reporter expression
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for GAB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GAB1
-
CRISPR Products
-
OriGene CRISPR knockouts for GAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GAB1
- genomics-online: gRNA clones - Search results for available GAB1 gene related products
- Applied Biological Materials CRISPR for GAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAB1
- GenScript: Design CRISPR guide RNA sequences for GAB1
miRNA for GAB1 Gene
- miRTarBase miRNAs that target GAB1
-
- hsa-mir-17-5p (MIRT031364)
- hsa-mir-181d-5p (MIRT041177)
- hsa-mir-20a-5p (MIRT164198)
- hsa-mir-93-5p (MIRT164200)
- hsa-mir-106b-5p (MIRT164203)
- hsa-mir-20b-5p (MIRT164206)
- hsa-mir-519d-3p (MIRT164212)
- hsa-mir-30a-5p (MIRT164233)
- hsa-mir-30c-5p (MIRT164234)
- hsa-mir-30d-5p (MIRT164235)
- hsa-mir-30b-5p (MIRT164236)
- hsa-mir-30e-5p (MIRT164237)
- hsa-mir-409-3p (MIRT735159)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GAB1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAB1
- genomics-online: shRNA clones - Search results for available GAB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GAB1
- genomics-online: cdna clones - Search results for available GAB1 gene related products
- orf clones - Search results for available GAB1 gene related products
- Applied Biological Materials Clones for GAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GAB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GAB1 Gene
Localization for GAB1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| nucleus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for GAB1 Gene
Pathways & Interactions for GAB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
.92
|
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | Development HGF signaling pathway | ||
| 5 | Signaling by EGFR in Cancer | ||
Pathways by source for GAB1 Gene
2 Sino Biological pathways for GAB1 Gene
1 GeneTex pathway for GAB1 Gene
23 BioSystems pathways for GAB1 Gene
10 KEGG pathways for GAB1 Gene
10 GeneGo (Thomson Reuters) pathways for GAB1 Gene
11 Qiagen pathways for GAB1 Gene
1 Cell Signaling Technology pathway for GAB1 Gene
Interacting Proteins for GAB1 Gene
Selected Interacting proteins:
Q13480-GAB1_HUMAN
ENSP00000262995
for GAB1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for GAB1
SIGNOR curated interactions for GAB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IMP | 17178724 |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0008283 | cell proliferation | TAS | 8596638 |
| GO:0008286 | insulin receptor signaling pathway | TAS | 8596638 |
Transcripts for GAB1 Gene
mRNA/cDNA for GAB1 Gene
- (10) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000262995 7981 bps (uc003ijd.4)
- ENST00000262994 2648 bps (uc003ije.4)
- ENST00000514639 728 bps (uc062zwi.1)
- ENST00000515366 582 bps (uc062zwj.1)
- ENST00000505913 2477 bps (uc011chq.3)
Unigene Clusters for GAB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GAB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GAB1
- genomics-online: gRNA clones - Search results for available GAB1 gene related products
- Applied Biological Materials CRISPR for GAB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GAB1
- GenScript: Design CRISPR guide RNA sequences for GAB1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GAB1
- Browse OriGene Inhibitory RNA Products For GAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAB1
- genomics-online: shRNA clones - Search results for available GAB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GAB1
- genomics-online: cdna clones - Search results for available GAB1 gene related products
- orf clones - Search results for available GAB1 gene related products
- Applied Biological Materials Clones for GAB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||
| SP3: |
Expression for GAB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Tongue Muscles
- Limb Muscle Progenitor Cells Hindlimb Myotome
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Hindlimb Myotome
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Tongue Muscles
This gene is overexpressed in Fetal Brain (14.1), Gallbladder (13.2), and Testis (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GAB1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GAB1 Gene:
GAB1SOURCE GeneReport for Unigene cluster for GAB1 Gene:
Hs.80720Evidence on tissue expression from TISSUES for GAB1 Gene
- Nervous system(4.8)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for GAB1
-
OriGene qPCR primer pairs and template standards for GAB1
- genomics-online: primer clones - Search results for available GAB1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAB1 Gene
Orthologs for GAB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GAB1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GAB1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GAB1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GAB1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GAB1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gab1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gab1 33 |
|
||
| chicken (Gallus gallus) |
Aves | GAB1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GAB1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gab1 33 |
|
||
| Str.956 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7533 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gab1 34 33 |
|
OneToOne | |
| Dr.17509 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | dos 34 |
|
OneToMany |
- Species where no ortholog for GAB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GAB1 Gene
- ENSEMBL:
- Gene Tree for GAB1 (if available)
- TreeFam:
- Gene Tree for GAB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GAB1: view image
Paralogs for GAB1 Gene
Variants for GAB1 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036132 | A breast cancer sample | p.Tyr83Cys | |||
| VAR_036133 | A breast cancer sample | p.Thr387Asn | |||
| rs1000075588 | -- | 143,337,548(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000083913 | -- | 143,363,200(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000093145 | -- | 143,474,764(+) | A/G | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5411n100 | CNV | gain | 25217958 |
| esv2576302 | CNV | deletion | 19546169 |
| esv2759288 | CNV | gain+loss | 17122850 |
| esv3602506 | CNV | loss | 21293372 |
| esv3602508 | CNV | loss | 21293372 |
| nsv1018566 | CNV | loss | 25217958 |
| nsv1019980 | CNV | gain | 25217958 |
| nsv1026110 | CNV | gain | 25217958 |
| nsv1033902 | CNV | gain | 25217958 |
| nsv1123852 | CNV | deletion | 24896259 |
| nsv437941 | CNV | loss | 16468122 |
| nsv830103 | CNV | loss | 17160897 |
| nsv964100 | CNV | duplication | 23825009 |
| nsv980261 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.01;
37.03% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GAB1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAB1 Gene
Disorders for GAB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 26 |
|
|
| leopard syndrome |
|
|
| noonan syndrome 1 |
|
|
Search GAB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GAB1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GAB1 Gene
Publications for GAB1 Gene
- A Grb2-associated docking protein in EGF- and insulin-receptor signalling. (PMID: 8596638) Holgado-Madruga M … Wong AJ (Nature 1996) 2 3 4 22 58
- Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. (PMID: 17211494) Goto Y … Hamajima N (International journal of medical sciences 2006) 3 22 44 58
- Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells. (PMID: 15010462) Podar K … Anderson KC (The Journal of biological chemistry 2004) 3 4 22 58
- Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. (PMID: 12475979) Palka HL … Tonks NK (The Journal of biological chemistry 2003) 3 4 22 58
- Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T … Tamari M (Nature genetics 2011) 3 44 58
Products for GAB1 Gene
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- Abcam proteins for GAB1
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GAB1 (AFLGC-GAB1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for GAB1
- antibodies-online: Search results for available GAB1 related products ranked by validation data
- antibodies-online: Search results for available GAB1 related products ranked by validation data
- antibodies-online: Search results for available GAB1 related products ranked by validation data
- GeneTex GAB1 Antibody for GAB1
- Search GeneTex for Proteins for GAB1
- Santa Cruz Biotechnology (SCBT) Antibodies for GAB1
- Search Santa Cruz Biotechnology (SCBT) for GAB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GAB1
- Horizon Cell Lines for GAB1
- genomics-online: cdna clones - Search results for available GAB1 gene related products
- orf clones - Search results for available GAB1 gene related products
- genomics-online: gRNA clones - Search results for available GAB1 gene related products
- genomics-online: primer clones - Search results for available GAB1 gene related products
- genomics-online: shRNA clones - Search results for available GAB1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GAB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GAB1
- GeneCopoeia miRNA 3'UTR Target clone products for GAB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GAB1
Sources for GAB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt