Aliases for G3BP2 Gene

Aliases for G3BP2 Gene

  • G3BP Stress Granule Assembly Factor 2 2 3 5
  • Ras-GTPase Activating Protein SH3 Domain-Binding Protein 2 2 3
  • GTPase Activating Protein (SH3 Domain) Binding Protein 2 2 3
  • Ras GTPase-Activating Protein-Binding Protein 2 3 4
  • GAP SH3 Domain-Binding Protein 2 3 4
  • G3BP-2 3 4
  • KIAA0660 4

External Ids for G3BP2 Gene

Previous GeneCards Identifiers for G3BP2 Gene

  • GC04M076463
  • GC04M076758
  • GC04M076960
  • GC04M077026
  • GC04M076925
  • GC04M076567
  • GC04M072314

Summaries for G3BP2 Gene

GeneCards Summary for G3BP2 Gene

G3BP2 (G3BP Stress Granule Assembly Factor 2) is a Protein Coding gene. Diseases associated with G3BP2 include Mouth Disease and Chikungunya. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

UniProtKB/Swiss-Prot Summary for G3BP2 Gene

  • Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.

Gene Wiki entry for G3BP2 Gene

Additional gene information for G3BP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for G3BP2 Gene

Genomics for G3BP2 Gene

GeneHancer (GH) Regulatory Elements for G3BP2 Gene

Promoters and enhancers for G3BP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J075671 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 513.2 +51.3 51331 4.8 ZBTB40 EP300 NRF1 POLR2G SP1 NCOR1 PHF8 POLR2A CLOCK ZBTB11 G3BP2 lnc-CDKL2-2 USO1 CDKL2 NAAA ENSG00000201644
GH04J075722 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.6 -566 5.8 ZBTB40 EP300 CTCF NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2 USO1 G3BP2 RF00017-4332 lnc-G3BP2-1 NUP54 THAP6 SDAD1 CDKL2 PARM1-AS1 ODAPH
GH04J075701 Enhancer 1.2 Ensembl ENCODE dbSUPER 19 +20.1 20109 5.1 POLR2G NCOR1 TEAD4 SKI TEAD1 ZKSCAN8 HDAC2 ZNF341 TBP SAP130 G3BP2 USO1 CDKL2 ODAPH CCDC158 piR-61945-387 lnc-CDKL2-2
GH04J075682 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +39.2 39224 5.4 TRIM24 TRIM28 ZNF280A CBX5 ZFP36 SETDB1 SPI1 CHAMP1 RUNX3 G3BP2 USO1 ENSG00000229717 RNU2-16P CDKL2 ODAPH RCHY1 lnc-CDKL2-2 piR-61945-387
GH04J075629 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 12 +94.2 94224 2.6 ZNF217 EP300 USF1 SP1 ZNF10 ZIC2 FOS ZBTB26 SAP30 KLF4 CDKL2 G3BP2 ODAPH USO1 lnc-G3BP2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around G3BP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for G3BP2

Top Transcription factor binding sites by QIAGEN in the G3BP2 gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • Pax-3
  • Spz1
  • Zic1

Genomic Locations for G3BP2 Gene

Genomic Locations for G3BP2 Gene
chr4:75,642,769-75,724,525
(GRCh38/hg38)
Size:
81,757 bases
Orientation:
Minus strand
chr4:76,567,953-76,649,709
(GRCh37/hg19)
Size:
81,757 bases
Orientation:
Minus strand

Genomic View for G3BP2 Gene

Genes around G3BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G3BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G3BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G3BP2 Gene

Proteins for G3BP2 Gene

  • Protein details for G3BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN86-G3BP2_HUMAN
    Recommended name:
    Ras GTPase-activating protein-binding protein 2
    Protein Accession:
    Q9UN86
    Secondary Accessions:
    • A8K6X1
    • O60606
    • O75149
    • Q9UPA1

    Protein attributes for G3BP2 Gene

    Size:
    482 amino acids
    Molecular mass:
    54121 Da
    Quaternary structure:
    • Forms homooligomers (PubMed:23279204). Forms heterodimers with G3BP1 (PubMed:23279204). Interacts with NFKBIA (via N-terminus) (PubMed:10969074). Interacts with USP10 (PubMed:23279204). Interacts with PABPC1 (PubMed:23279204).
    • (Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP2 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.
    SequenceCaution:
    • Sequence=BAA31635.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for G3BP2 Gene

    Alternative splice isoforms for G3BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for G3BP2 Gene

Post-translational modifications for G3BP2 Gene

  • Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
  • (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.
  • Ubiquitination at Lys25, Lys76, Lys107, and Lys370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for G3BP2 Gene

Domains & Families for G3BP2 Gene

Gene Families for G3BP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for G3BP2 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • Nuclear transport factor 2 (NTF2)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for G3BP2 Gene

GenScript: Design optimal peptide antigens:
  • GAP SH3 domain-binding protein 2 (G3BP2_HUMAN)
genes like me logo Genes that share domains with G3BP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for G3BP2 Gene

Function for G3BP2 Gene

Molecular function for G3BP2 Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.

Phenotypes From GWAS Catalog for G3BP2 Gene

Gene Ontology (GO) - Molecular Function for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 19615732
GO:0030159 receptor signaling complex scaffold activity NAS 10969074
genes like me logo Genes that share ontologies with G3BP2: view
genes like me logo Genes that share phenotypes with G3BP2: view

Animal Models for G3BP2 Gene

MGI Knock Outs for G3BP2:
  • G3bp2 G3bp2<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for G3BP2 Gene

miRTarBase miRNAs that target G3BP2

Clone Products

  • Addgene plasmids for G3BP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for G3BP2 Gene

Localization for G3BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G3BP2 Gene

Cytoplasm. Cytoplasm, Stress granule.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for G3BP2 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10969074
GO:0005829 cytosol IDA --
GO:0010494 cytoplasmic stress granule IMP 23279204
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with G3BP2: view

Pathways & Interactions for G3BP2 Gene

PathCards logo

SuperPathways for G3BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007253 cytoplasmic sequestering of NF-kappaB NAS 10969074
GO:0007265 Ras protein signal transduction NAS 9575347
GO:0009967 positive regulation of signal transduction IEA --
GO:0016032 viral process IEA --
GO:0034063 stress granule assembly IEA --
genes like me logo Genes that share ontologies with G3BP2: view

No data available for Pathways by source and SIGNOR curated interactions for G3BP2 Gene

Drugs & Compounds for G3BP2 Gene

No Compound Related Data Available

Transcripts for G3BP2 Gene

mRNA/cDNA for G3BP2 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for G3BP2

Alternative Splicing Database (ASD) splice patterns (SP) for G3BP2 Gene

No ASD Table

Relevant External Links for G3BP2 Gene

GeneLoc Exon Structure for
G3BP2

Expression for G3BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for G3BP2 Gene

Protein differential expression in normal tissues from HIPED for G3BP2 Gene

This gene is overexpressed in Brain (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for G3BP2 Gene



Protein tissue co-expression partners for G3BP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for G3BP2

SOURCE GeneReport for Unigene cluster for G3BP2 Gene:

Hs.303676

Evidence on tissue expression from TISSUES for G3BP2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(2.7)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with G3BP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for G3BP2 Gene

Orthologs for G3BP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for G3BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia G3BP2 31 30
  • 99.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia G3BP2 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia G3BP2 31 30
  • 96.06 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia G3BP2 31
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia G3bp2 17 31 30
  • 93.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia G3BP2 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves G3BP2 31 30
  • 81.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia G3BP2 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia g3bp2 30
  • 76.16 (n)
MGC75649 30
zebrafish
(Danio rerio)
Actinopterygii g3bp2 31
  • 69 (a)
OneToMany
G3BP2 (3 of 3) 31
  • 68 (a)
OneToMany
G3BP2 (2 of 3) 31
  • 65 (a)
OneToMany
zgc:56304 30
  • 64.16 (n)
Dr.5661 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6884 30
fruit fly
(Drosophila melanogaster)
Insecta rin 31
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69250 30
  • 52.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10329 31
  • 21 (a)
OneToOne
Cin.11520 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11520 30
Species where no ortholog for G3BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G3BP2 Gene

ENSEMBL:
Gene Tree for G3BP2 (if available)
TreeFam:
Gene Tree for G3BP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for G3BP2: view image

Paralogs for G3BP2 Gene

Paralogs for G3BP2 Gene

(3) SIMAP similar genes for G3BP2 Gene using alignment to 12 proteins:

  • G3BP2_HUMAN
  • D6R9A4_HUMAN
  • D6R9X5_HUMAN
  • D6RAC7_HUMAN
  • D6RB17_HUMAN
  • D6RBM9_HUMAN
  • D6RBR0_HUMAN
  • D6RBW8_HUMAN
  • D6RE13_HUMAN
  • D6REX8_HUMAN
  • D6RGJ4_HUMAN
  • H0YAE3_HUMAN
genes like me logo Genes that share paralogs with G3BP2: view

Variants for G3BP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for G3BP2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
VAR_036128 A breast cancer sample p.Pro434Leu

Additional dbSNP identifiers (rs#s) for G3BP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for G3BP2 Gene

Variant ID Type Subtype PubMed ID
esv2670113 CNV deletion 23128226
esv3308530 CNV mobile element insertion 20981092
esv3424694 CNV insertion 20981092
esv3601033 CNV loss 21293372
nsv1117103 CNV deletion 24896259
nsv7363 OTHER inversion 18451855

Variation tolerance for G3BP2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for G3BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
G3BP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G3BP2 Gene

Disorders for G3BP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for G3BP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mouth disease
  • mouth disorders
chikungunya
  • chikungunya fever
noonan syndrome 6
  • ns6
noonan syndrome 3
  • ns3
- elite association - COSMIC cancer census association via MalaCards
Search G3BP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for G3BP2

genes like me logo Genes that share disorders with G3BP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for G3BP2 Gene

Publications for G3BP2 Gene

  1. IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2. (PMID: 10969074) Prigent M … Dargemont C (The Journal of biological chemistry 2000) 3 4 23 54
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  3. Both G3BP1 and G3BP2 contribute to stress granule formation. (PMID: 23279204) Matsuki H … Fujii M (Genes to cells : devoted to molecular & cellular mechanisms 2013) 3 4 54
  4. PKCα binds G3BP2 and regulates stress granule formation following cellular stress. (PMID: 22536444) Kobayashi T … Larsson C (PloS one 2012) 2 3 54
  5. Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). (PMID: 17297477) Kim MM … Yuan ZM (Oncogene 2007) 3 23 54

Products for G3BP2 Gene

Sources for G3BP2 Gene