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Aliases for G3BP2 Gene

Aliases for G3BP2 Gene

  • G3BP Stress Granule Assembly Factor 2 2 3 5
  • Ras-GTPase Activating Protein SH3 Domain-Binding Protein 2 2 3
  • GTPase Activating Protein (SH3 Domain) Binding Protein 2 2 3
  • GAP SH3 Domain-Binding Protein 2 3 4
  • G3BP-2 3 4
  • Ras GTPase-Activating Protein-Binding Protein 2 3
  • KIAA0660 4

External Ids for G3BP2 Gene

Previous GeneCards Identifiers for G3BP2 Gene

  • GC04M076463
  • GC04M076758
  • GC04M076960
  • GC04M077026
  • GC04M076925
  • GC04M076567
  • GC04M072314

Summaries for G3BP2 Gene

GeneCards Summary for G3BP2 Gene

G3BP2 (G3BP Stress Granule Assembly Factor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

UniProtKB/Swiss-Prot for G3BP2 Gene

  • Probable scaffold protein that may be involved in mRNA transport.

Gene Wiki entry for G3BP2 Gene

Additional gene information for G3BP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for G3BP2 Gene

Genomics for G3BP2 Gene

GeneHancer (GH) Regulatory Elements for G3BP2 Gene

Promoters and enhancers for G3BP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I075671 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.2 +51.1 51125 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B G3BP2 USO1 CDKL2 NUP54 NAAA ENSG00000201644 GC04M075663
GH04I075722 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -218 5.1 HDGF FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 USO1 G3BP2 CDKL2 ODAPH GC04P075797
GH04I075686 Enhancer 1 FANTOM5 ENCODE dbSUPER 19.4 +37.8 37774 1.2 ZNF280A CBX5 ZFP36 TRIM24 TRIM28 CHAMP1 SETDB1 G3BP2 USO1 LOC105377284 RNU2-16P CDKL2 RCHY1 ENSG00000201644 GC04M075663
GH04I075701 Enhancer 1 ENCODE dbSUPER 18.9 +20.1 20109 5.1 FOXA2 ARID4B DMAP1 RAD21 ZNF143 RCOR1 CREM MIXL1 RXRA MIER2 G3BP2 USO1 CDKL2 ODAPH CCDC158 GC04M075663 ENSG00000201644
GH04I075629 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 7.8 +94.0 93983 1.7 PKNOX1 SIN3A ZNF2 GLIS2 KLF7 FOS KLF13 SP3 ZNF610 GLIS1 CDKL2 ODAPH G3BP2 GC04M075630
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around G3BP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the G3BP2 gene promoter:

Genomic Locations for G3BP2 Gene

Genomic Locations for G3BP2 Gene
81,757 bases
Minus strand

Genomic View for G3BP2 Gene

Genes around G3BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
G3BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for G3BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for G3BP2 Gene

Proteins for G3BP2 Gene

  • Protein details for G3BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K6X1
    • O60606
    • O75149
    • Q9UPA1

    Protein attributes for G3BP2 Gene

    482 amino acids
    Molecular mass:
    54121 Da
    Quaternary structure:
    • Binds to the N-terminal domain of I-kappa-B-alpha.
    • Sequence=BAA31635.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for G3BP2 Gene

    Alternative splice isoforms for G3BP2 Gene


neXtProt entry for G3BP2 Gene

Post-translational modifications for G3BP2 Gene

  • Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at isoforms=225, posLast=7676, isoforms=2107, and posLast=370370

No data available for DME Specific Peptides for G3BP2 Gene

Domains & Families for G3BP2 Gene

Gene Families for G3BP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for G3BP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with G3BP2: view

No data available for UniProtKB/Swiss-Prot for G3BP2 Gene

Function for G3BP2 Gene

Molecular function for G3BP2 Gene

UniProtKB/Swiss-Prot Function:
Probable scaffold protein that may be involved in mRNA transport.

Phenotypes From GWAS Catalog for G3BP2 Gene

Gene Ontology (GO) - Molecular Function for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 19615732
GO:0030159 receptor signaling complex scaffold activity NAS 10969074
genes like me logo Genes that share ontologies with G3BP2: view
genes like me logo Genes that share phenotypes with G3BP2: view

Animal Models for G3BP2 Gene

MGI Knock Outs for G3BP2:

Animal Model Products

miRNA for G3BP2 Gene

miRTarBase miRNAs that target G3BP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for G3BP2 Gene

Localization for G3BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for G3BP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for G3BP2 gene
Compartment Confidence
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10969074
GO:0005829 cytosol IDA --
GO:0030529 intracellular ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with G3BP2: view

Pathways & Interactions for G3BP2 Gene

SuperPathways for G3BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for G3BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB NAS 10969074
GO:0007265 Ras protein signal transduction NAS 9575347
GO:0034063 stress granule assembly IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with G3BP2: view

No data available for Pathways by source and SIGNOR curated interactions for G3BP2 Gene

Drugs & Compounds for G3BP2 Gene

No Compound Related Data Available

Transcripts for G3BP2 Gene

Unigene Clusters for G3BP2 Gene

GTPase activating protein (SH3 domain) binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for G3BP2 Gene

No ASD Table

Relevant External Links for G3BP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for G3BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for G3BP2 Gene

Protein differential expression in normal tissues from HIPED for G3BP2 Gene

This gene is overexpressed in Brain (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for G3BP2 Gene

Protein tissue co-expression partners for G3BP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of G3BP2 Gene:


SOURCE GeneReport for Unigene cluster for G3BP2 Gene:


Evidence on tissue expression from TISSUES for G3BP2 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(2.7)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with G3BP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for G3BP2 Gene

Orthologs for G3BP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for G3BP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia G3BP2 33 34
  • 99.79 (n)
(Bos Taurus)
Mammalia G3BP2 34
  • 98 (a)
(Canis familiaris)
Mammalia G3BP2 33 34
  • 96.06 (n)
(Monodelphis domestica)
Mammalia G3BP2 34
  • 94 (a)
(Mus musculus)
Mammalia G3bp2 33 16 34
  • 93.22 (n)
(Ornithorhynchus anatinus)
Mammalia G3BP2 34
  • 74 (a)
(Gallus gallus)
Aves G3BP2 33 34
  • 81.33 (n)
(Anolis carolinensis)
Reptilia G3BP2 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia g3bp2 33
  • 76.16 (n)
MGC75649 33
(Danio rerio)
Actinopterygii g3bp2 34
  • 69 (a)
G3BP2 (3 of 3) 34
  • 68 (a)
G3BP2 (2 of 3) 34
  • 65 (a)
zgc:56304 33
  • 64.16 (n)
Dr.5661 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6884 33
fruit fly
(Drosophila melanogaster)
Insecta rin 34
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69250 33
  • 52.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10329 34
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11520 33
Species where no ortholog for G3BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for G3BP2 Gene

Gene Tree for G3BP2 (if available)
Gene Tree for G3BP2 (if available)

Paralogs for G3BP2 Gene

Paralogs for G3BP2 Gene

genes like me logo Genes that share paralogs with G3BP2: view

Variants for G3BP2 Gene

Sequence variations from dbSNP and Humsavar for G3BP2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_036128 A breast cancer sample p.Pro434Leu
rs1000033236 -- 75,700,245(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000059936 -- 75,664,172(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000087813 -- 75,657,484(-) T/C intron_variant
rs1000130565 -- 75,705,296(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for G3BP2 Gene

Variant ID Type Subtype PubMed ID
esv2670113 CNV deletion 23128226
esv3308530 CNV mobile element insertion 20981092
esv3424694 CNV insertion 20981092
esv3601033 CNV loss 21293372
nsv1117103 CNV deletion 24896259
nsv7363 OTHER inversion 18451855

Variation tolerance for G3BP2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for G3BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for G3BP2 Gene

Disorders for G3BP2 Gene

Additional Disease Information for G3BP2

No disorders were found for G3BP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for G3BP2 Gene

Publications for G3BP2 Gene

  1. IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2. (PMID: 10969074) Prigent M … Dargemont C (The Journal of biological chemistry 2000) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. PKCα binds G3BP2 and regulates stress granule formation following cellular stress. (PMID: 22536444) Kobayashi T … Larsson C (PloS one 2012) 2 3 58
  4. Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). (PMID: 17297477) Kim MM … Yuan ZM (Oncogene 2007) 3 22 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for G3BP2 Gene

Sources for G3BP2 Gene

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