Aliases for FZR1 Gene
External Ids for FZR1 Gene
Previous GeneCards Identifiers for FZR1 Gene
GeneCards Summary for FZR1 Gene
FZR1 (Fizzy And Cell Division Cycle 20 Related 1) is a Protein Coding gene. Diseases associated with FZR1 include Breast Cancer and Kabuki Syndrome 1. Among its related pathways are Oocyte meiosis and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is CDC20.
UniProtKB/Swiss-Prot Summary for FZR1 Gene
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).