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This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating t... See more...
Aliases for FZD8 Gene
Aliases for FZD8 Gene
External Ids for FZD8 Gene
- HGNC: 4046
- Entrez Gene: 8325
- Ensembl: ENSG00000177283
- OMIM: 606146
- UniProtKB: Q9H461
Previous GeneCards Identifiers for FZD8 Gene
- GC10M035674
- GC10M036077
- GC10M035931
- GC10M035967
- GC10M035927
Summaries for FZD8 Gene
-
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for FZD8 Gene
FZD8 (Frizzled Class Receptor 8) is a Protein Coding gene. Diseases associated with FZD8 include Interstitial Cystitis and Exudative Vitreoretinopathy. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is FZD5.
UniProtKB/Swiss-Prot Summary for FZD8 Gene
-
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Additional gene information for FZD8 Gene
- HGNC(4046)
- Entrez Gene(8325)
- Ensembl(ENSG00000177283)
- OMIM(606146)
- UniProtKB(Q9H461)
- Open Targets Platform(ENSG00000177283)
- Search for FZD8 at DataMed
- Search for FZD8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FZD8 Gene
Genomics for FZD8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FZD8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J035636 | Promoter/Enhancer | 2.3 | VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas | 602.8 | +1.7 | 1651 | 8.3 | PRDM10 ZNF629 ZNF512 KDM1A CTCF ZNF692 PRDM1 MTA2 ZIC2 ZSCAN4 | FZD8 ENSG00000287528 MIR4683 piR-46029 LOC105376494 ENSG00000273312 GJD4 | |
| GH10J035683 | Enhancer | 1.2 | VISTA Ensembl | 16.1 | -43.2 | -43206 | 3 | GATAD2A RXRB IRF2 ZNF341 CEBPA SOX13 ZNF140 TCF7 ZXDB ZSCAN5C | ENSG00000271335 FZD8 piR-41525-062 RPL7P37 | |
| GH10J035889 | Enhancer | 1 | Ensembl ENCODE | 14.5 | -248.1 | -248123 | 2 | ATF7 ZNF629 ZNF692 ZIC2 ZSCAN4 SP1 ZNF501 ZNF600 ZNF561 ZBTB44 | FZD8 LINC02630 piR-59769-055 | |
| GH10J035668 | Enhancer | 0.7 | Ensembl ENCODE | 16.2 | -27.2 | -27174 | 1.3 | ZSCAN4 MNT OSR2 WT1 MAX TBP ZNF121 | FZD8 HSALNG0077287 piR-41525-062 | |
| GH10J035887 | Enhancer | 0.3 | ENCODE | 22.1 | -245.7 | -245655 | 1.2 | TRIM28 ZNF680 | FZD8 LINC02630 piR-59769-055 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FZD8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FZD8
- Top Transcription factor binding sites by QIAGEN in the FZD8 gene promoter:
-
- AREB6
- C/EBPalpha
- CHOP-10
- E2F
- E2F-1
- ER-alpha
- GR
- GR-alpha
- IRF-1
- TBP
Genomic Locations for FZD8 Gene
Genomic Locations for FZD8 Gene
- chr10:35,638,249-35,642,278
- (GRCh38/hg38)
- Size:
- 4,030 bases
- Orientation:
- Minus strand
- chr10:35,927,177-35,930,362
- (GRCh37/hg19)
- Size:
- 3,186 bases
- Orientation:
- Minus strand
Genomic View for FZD8 Gene
Genes around FZD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.21 by HGNC
- 10p11.21 by Entrez Gene
- 10p11.21 by Ensembl
FZD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FZD8 Gene
Proteins for FZD8 Gene
-
Protein details for FZD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H461-FZD8_HUMAN
- Recommended name:
- Frizzled-8
- Protein Accession:
- Q9H461
Protein attributes for FZD8 Gene
- Size:
- 694 amino acids
- Molecular mass:
- 73300 Da
- Quaternary structure:
-
- Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity). Interacts with glypican GPC3 (PubMed:24496449).
Protein Expression for FZD8 Gene
Post-translational modifications for FZD8 Gene
- Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
-
Glycosylation at Asn49, Asn152, and Asn475
- NX_Q9H461 (NX_Q9H461-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FZD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FZD8 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FZD8
- Novus Biologicals Antibodies for FZD8
-
Abcam antibodies for FZD8
- Invitrogen Antibodies for FZD8 (AFLGC-Fzd8)
- antibodies-online: Show 21 available FZD8 Antibodies ranked by validation data
- Compare Top FZD8 Antibodies
-
Recommended
- 48 WB Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 43 WB Antibodies (anti-mouse)
- 9 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FZD8
- Origene Custom Protein Services for FZD8
- Novus Biologicals proteins for FZD8
-
Abcam proteins for FZD8
Assay Products
- G Biosciences Immunotag™ Frizzled-8 ELISA Kit
- antibodies-online: Show 22 available FZD8 Elisa Kits ranked by validation data
- Compare Top FZD8 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FZD8 Gene
Domains & Families for FZD8 Gene
Gene Families for FZD8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Plasma proteins
- Predicted membrane proteins
Protein Domains for FZD8 Gene
- InterPro:
- Blocks:
-
- Frizzled protein signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FZD8 Gene
- GenScript: Design optimal peptide antigens:
-
- Frizzled-8 (FZD8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H461UniProtKB/Swiss-Prot:
FZD8_HUMAN :- The PDZ-binding motif mediates interaction with GOPC.
- Belongs to the G-protein coupled receptor Fz/Smo family.
- Domain:
-
- The PDZ-binding motif mediates interaction with GOPC.
- Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
- The FZ domain is involved in binding with Wnt ligands.
- Family:
-
- Belongs to the G-protein coupled receptor Fz/Smo family.
Function for FZD8 Gene
Molecular function for FZD8 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Phenotypes From GWAS Catalog for FZD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0004930 | G protein-coupled receptor activity | IEA | -- |
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 22682250 |
| GO:0017147 | Wnt-protein binding | IEA,IBA | 21873635 |
Phenotypes for FZD8 Gene
- MGI mutant phenotypes for FZD8:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FZD8:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Synthetic lethal with Ras
- Decreased shRNA abundance
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with imatinib mesylate
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), many micronuclei (grape), large nuclei, decreased viability (cell death)
Animal Model Products
-
Taconic Biosciences Mouse Models for FZD8
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FZD8 - Select products 50% OFF >
- * FZD8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FZD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FZD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for FZD8
miRNA for FZD8 Gene
- miRTarBase miRNAs that target FZD8
-
- hsa-miR-375 (MIRT007255)
- hsa-miR-374b-5p (MIRT016029)
- hsa-miR-335-5p (MIRT018441)
- hsa-let-7c-5p (MIRT051873)
- mmu-miR-499-5p (MIRT054733)
- hsa-miR-4433a-5p (MIRT668230)
- hsa-miR-6507-3p (MIRT668231)
- hsa-miR-5588-3p (MIRT668232)
- hsa-miR-548t-5p (MIRT668233)
- hsa-miR-548az-5p (MIRT668234)
- hsa-miR-188-5p (MIRT668235)
- hsa-miR-6866-3p (MIRT668236)
- hsa-miR-204-5p (MIRT668237)
- hsa-miR-211-5p (MIRT668238)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FZD8
- Browse OriGene Inhibitory RNA Products For FZD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FZD8
Clone Products
- Applied Biological Materials (abm): Clones for FZD8 - Select products 50% OFF >
- * FZD8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FZD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FZD8
Cell Line Products
- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor for FZD8
-
Horizon Cell Lines for FZD8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD8 Gene
Localization for FZD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FZD8 Gene
- Membrane. Multi-pass membrane protein. Golgi apparatus. Cell membrane. Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IBA,TAS | 11295046 |
| GO:1990851 | Wnt-Frizzled-LRP5/6 complex | IEA | -- |
Pathways & Interactions for FZD8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
| 2 | Gastric cancer |
.62
.62
|
|
| 3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.69
|
|
| 4 | Aldosterone synthesis and secretion |
.41
|
.41
|
| 5 | mTOR signaling pathway (KEGG) |
.38
|
|
Pathways by source for FZD8 Gene
7 BioSystems pathways for FZD8 Gene
14 Reactome pathways for FZD8 Gene
14 KEGG pathways for FZD8 Gene
2 GeneGo (Thomson Reuters) pathways for FZD8 Gene
- Transcription Androgen Receptor nuclear signaling
- Translation Non-genomic (rapid) action of Androgen Receptor
2 R&D Systems pathways for FZD8 Gene
11 Qiagen pathways for FZD8 Gene
- Colorectal Cancer Metastasis
- Factors Promoting Cardiogenesis in Vertebrates
- G12-G13 in Cellular Signaling
- Glioblastoma Multiforme
- GSK3 Signaling
2 GeneTex pathways for FZD8 Gene
Interacting Proteins for FZD8 Gene
Selected Interacting proteins:
Q9H461-FZD8_HUMAN
ENSP00000363826
for FZD8 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FZD8
SIGNOR curated interactions for FZD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
Drugs & Compounds for FZD8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Nutra | 6556 |
Transcripts for FZD8 Gene
mRNA/cDNA for FZD8 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374694 4030 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FZD8 - Select products 50% OFF >
- * FZD8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FZD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FZD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for FZD8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FZD8
- Browse OriGene Inhibitory RNA Products For FZD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FZD8
Clone Products
- Applied Biological Materials (abm): Clones for FZD8 - Select products 50% OFF >
- * FZD8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FZD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FZD8
Relevant External Links for FZD8 Gene
- GeneLoc Exon Structure for
- FZD8
Expression for FZD8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hypoblast (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Distal Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Distal Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Epiblast (Early Embryonic Tissues)
- Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
This gene is overexpressed in Cervix (37.2) and Lung (26.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FZD8 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FZD8
SOURCE GeneReport for Unigene cluster for FZD8 Gene:
Hs.302634mRNA Expression by UniProt/SwissProt for FZD8 Gene:
Q9H461-FZD8_HUMAN
Tissue specificity:
Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
Evidence on tissue expression from TISSUES for FZD8 Gene
- Nervous system(2.2)
- Kidney(2.2)
- Muscle(2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for FZD8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FZD8 Gene
Orthologs for FZD8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FZD8 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fzd8 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fzd8 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FZD8 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FZD8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fzd8 30 |
|
||
| Str.10842 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.412 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fzd8a 30 31 |
|
OneToMany | |
| fzd8b 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | fz2 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cfz-2 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for FZD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FZD8 Gene
- ENSEMBL:
- Gene Tree for FZD8 (if available)
- TreeFam:
- Gene Tree for FZD8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FZD8: view image
Paralogs for FZD8 Gene
Variants for FZD8 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1034n54 | CNV | loss | 21841781 |
| dgv1035n54 | CNV | loss | 21841781 |
| dgv1036n54 | CNV | loss | 21841781 |
| dgv144n67 | CNV | gain | 20364138 |
| esv22469 | CNV | loss | 19812545 |
| nsv1068298 | CNV | deletion | 25765185 |
| nsv466871 | CNV | loss | 19166990 |
| nsv521143 | CNV | loss | 19592680 |
| nsv550413 | CNV | loss | 21841781 |
| nsv550415 | CNV | loss | 21841781 |
| nsv550416 | CNV | gain | 21841781 |
| nsv825337 | CNV | gain | 20364138 |
| nsv825340 | CNV | gain | 20364138 |
| nsv825341 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
6.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.13;
22.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FZD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FZD8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FZD8 Gene
Disorders for FZD8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| interstitial cystitis |
|
|
| exudative vitreoretinopathy |
|
|
| schizophrenia 19 |
|
|
| cystitis |
|
|
| colorectal cancer |
|
|
Search FZD8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FZD8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FZD8 Gene
Publications for FZD8 Gene
- Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. (PMID: 11295046) Saitoh T … Katoh M (International journal of oncology 2001) 2 3 4 23
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PMID: 22575959) Hao HX … Cong F (Nature 2012) 3 4
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 41
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
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Products for FZD8 Gene
- View all 6 R&D Systems FZD8 (Frizzled-8) Products
- View all 2 R&D Systems FZD8 (Frizzled-8) Proteins and Enzymes
- View all 3 R&D Systems FZD8 (Frizzled-8) Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for FZD8
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- antibodies-online: Show 21 available FZD8 Antibodies ranked by validation data
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- 48 WB Antibodies (anti-human)
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- antibodies-online: Show 22 available FZD8 Elisa Kits ranked by validation data
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- antibodies-online: Show 5 available FZD8 Proteins ranked by validation data
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Sources for FZD8 Gene
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