Free for academic non-profit institutions. Other users need a Commercial license
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
FZD8 (Frizzled Class Receptor 8) is a Protein Coding gene. Diseases associated with FZD8 include Interstitial Cystitis and Exudative Vitreoretinopathy. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is FZD5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J035636 | Promoter/Enhancer | 2.3 | VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas | 602.8 | +1.7 | 1651 | 8.3 | PRDM10 ZNF629 ZNF512 KDM1A CTCF ZNF692 PRDM1 MTA2 ZIC2 ZSCAN4 | FZD8 ENSG00000287528 MIR4683 piR-46029 LOC105376494 ENSG00000273312 GJD4 | |
GH10J035683 | Enhancer | 1.2 | VISTA Ensembl | 16.1 | -43.2 | -43206 | 3 | GATAD2A RXRB IRF2 ZNF341 CEBPA SOX13 ZNF140 TCF7 ZXDB ZSCAN5C | ENSG00000271335 FZD8 piR-41525-062 RPL7P37 | |
GH10J035889 | Enhancer | 1 | Ensembl ENCODE | 14.5 | -248.1 | -248123 | 2 | ATF7 ZNF629 ZNF692 ZIC2 ZSCAN4 SP1 ZNF501 ZNF600 ZNF561 ZBTB44 | FZD8 LINC02630 piR-59769-055 | |
GH10J035668 | Enhancer | 0.7 | Ensembl ENCODE | 16.2 | -27.2 | -27174 | 1.3 | ZSCAN4 MNT OSR2 WT1 MAX TBP ZNF121 | FZD8 HSALNG0077287 piR-41525-062 | |
GH10J035887 | Enhancer | 0.3 | ENCODE | 22.1 | -245.7 | -245655 | 1.2 | TRIM28 ZNF680 | FZD8 LINC02630 piR-59769-055 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 22682250 |
GO:0017147 | Wnt-protein binding | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IBA,TAS | 11295046 |
GO:1990851 | Wnt-Frizzled-LRP5/6 complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Translation Non-genomic (rapid) action of Androgen Receptor |
Transcription Androgen Receptor nuclear signaling
.49
Translation Non-genomic (rapid) action of Androgen Receptor
.49
|
|
2 | Gastric cancer |
.62
.62
|
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.69
|
|
4 | Aldosterone synthesis and secretion |
.41
|
.41
|
5 | mTOR signaling pathway (KEGG) |
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FZD8 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FZD8 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fzd8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fzd8 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FZD8 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FZD8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fzd8 30 |
|
||
Str.10842 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.412 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fzd8a 30 31 |
|
OneToMany | |
fzd8b 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | fz2 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cfz-2 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1034n54 | CNV | loss | 21841781 |
dgv1035n54 | CNV | loss | 21841781 |
dgv1036n54 | CNV | loss | 21841781 |
dgv144n67 | CNV | gain | 20364138 |
esv22469 | CNV | loss | 19812545 |
nsv1068298 | CNV | deletion | 25765185 |
nsv466871 | CNV | loss | 19166990 |
nsv521143 | CNV | loss | 19592680 |
nsv550413 | CNV | loss | 21841781 |
nsv550415 | CNV | loss | 21841781 |
nsv550416 | CNV | gain | 21841781 |
nsv825337 | CNV | gain | 20364138 |
nsv825340 | CNV | gain | 20364138 |
nsv825341 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
interstitial cystitis |
|
|
exudative vitreoretinopathy |
|
|
schizophrenia 19 |
|
|
cystitis |
|
|
colorectal cancer |
|
|