Aliases for FZD8 Gene
Aliases for FZD8 Gene
External Ids for FZD8 Gene
- HGNC: 4046
- Entrez Gene: 8325
- Ensembl: ENSG00000177283
- OMIM: 606146
- UniProtKB: Q9H461
Previous GeneCards Identifiers for FZD8 Gene
- GC10M035674
- GC10M036077
- GC10M035931
- GC10M035967
- GC10M035927
Summaries for FZD8 Gene
-
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for FZD8 Gene
FZD8 (Frizzled Class Receptor 8) is a Protein Coding gene. Diseases associated with FZD8 include Cystitis and Split-Hand/Foot Malformation 6. Among its related pathways are Presynaptic function of Kainate receptors and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is FZD5.
UniProtKB/Swiss-Prot for FZD8 Gene
-
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD8 Gene
Genomics for FZD8 Gene
GeneHancer (GH) Regulatory Elements for FZD8 Gene
Promoters and enhancers for FZD8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J035639 | Promoter/Enhancer | 1.7 | FANTOM5 Ensembl ENCODE | 652.9 | +0.0 | 48 | 5 | PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF143 SP3 NFYC REST | FZD8 MIR4683 PIR39028 LOC105376494 PRDX2P2 | |
| GH10J035683 | Enhancer | 1.1 | VISTA | 16.1 | -43.2 | -43206 | 3 | PKNOX1 FOXA2 ZFP64 RARA ZNF121 ZNF213 ZNF138 ZSCAN5C CREM MIXL1 | ENSG00000271335 FZD8 RPL7P37 LOC105376494 | |
| GH10J035668 | Enhancer | 0.5 | ENCODE | 15.8 | -27.3 | -27256 | 1.1 | OSR2 ZNF121 SUZ12 ZSCAN4 MAX MNT WT1 | FZD8 LOC105376494 RPL7P37 | |
| GH10J035887 | Enhancer | 0.3 | ENCODE | 22.1 | -245.7 | -245655 | 1.2 | ZNF680 | FZD8 LOC105376495 PCAT5 | |
| GH10J035692 | Enhancer | 0.4 | ENCODE | 11.3 | -49.9 | -49860 | 0.2 | NANOG POU5F1 | FZD8 RPL7P37 LOC105376494 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FZD8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FZD8 gene promoter:
-
- CHOP-10
- C/EBPalpha
- ER-alpha
- AREB6
- E2F
- IRF-1
- E2F-1
- GR
- GR-alpha
- TBP
Regulatory Element Products
Genomic Locations for FZD8 Gene
Genomic Locations for FZD8 Gene
- chr10:35,638,249-35,642,278
- (GRCh38/hg38)
- Size:
- 4,030 bases
- Orientation:
- Minus strand
- chr10:35,927,177-35,930,362
- (GRCh37/hg19)
- Size:
- 3,186 bases
- Orientation:
- Minus strand
Genomic View for FZD8 Gene
Genes around FZD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p11.21 by Entrez Gene
- 10p11.21 by HGNC
- 10p11.21 by Ensembl
FZD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FZD8 Gene
Proteins for FZD8 Gene
-
Protein details for FZD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H461-FZD8_HUMAN
- Recommended name:
- Frizzled-8
- Protein Accession:
- Q9H461
Protein attributes for FZD8 Gene
- Size:
- 694 amino acids
- Molecular mass:
- 73300 Da
- Quaternary structure:
-
- Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity).
Protein Expression for FZD8 Gene
Post-translational modifications for FZD8 Gene
- Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
- Glycosylation at Asn475, isoforms=152, and isoforms=49
- Modification sites at PhosphoSitePlus
Other Protein References for FZD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FZD8 (Frizzled-8)
-
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-
Abcam antibodies for FZD8
- Invitrogen Antibodies for FZD8 (AFLGC-FZD8)
- antibodies-online: Search results for 87 available FZD8 Antibodies ranked by validation data
- Compare Top FZD8 Antibodies
-
Recommended
- 40 WB Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 16 WB Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 39 WB Antibodies (anti-mouse)
- 9 IHC (p) Antibodies (anti-mouse)
- anti-Frizzled 5/8 Protein Receptor Antibodies (anti-8)
- GeneTex FZD8 Antibody for FZD8
Protein Products
- R&D Systems Proteins and Enzymes for FZD8 (Frizzled-8)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FZD8
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- Novus Biologicals proteins for FZD8
- Search GeneTex for Proteins for FZD8
-
Abcam proteins for FZD8
Assay Products
No data available for DME Specific Peptides for FZD8 Gene
Domains & Families for FZD8 Gene
Gene Families for FZD8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Plasma proteins
- Predicted membrane proteins
Protein Domains for FZD8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FZD8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H461UniProtKB/Swiss-Prot:
FZD8_HUMAN :- The PDZ-binding motif mediates interaction with GOPC.
- Belongs to the G-protein coupled receptor Fz/Smo family.
- Domain:
-
- The PDZ-binding motif mediates interaction with GOPC.
- Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
- The FZ domain is involved in binding with Wnt ligands.
- Family:
-
- Belongs to the G-protein coupled receptor Fz/Smo family.
Function for FZD8 Gene
Molecular function for FZD8 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Phenotypes From GWAS Catalog for FZD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IBA | -- |
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 22682250 |
Phenotypes for FZD8 Gene
- MGI mutant phenotypes for FZD8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FZD8:
-
- Decreased viability ratio
- Synthetic lethal with imatinib mesylate
- Decreased shRNA abundance (Z-score < -2)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- shRNA abundance <= 50%
Animal Model Products
-
Taconic Biosciences Mouse Models for FZD8
- Cyagen custom Knockout/knockin (KOKI) mouse models for FZD8
-
CRISPR Products
-
OriGene CRISPR knockouts for FZD8
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- genomics-online: gRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- Applied Biological Materials CRISPR for FZD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FZD8
- GenScript: Design CRISPR guide RNA sequences for FZD8
miRNA for FZD8 Gene
- miRTarBase miRNAs that target FZD8
-
- hsa-mir-375 (MIRT007255)
- hsa-mir-374b-5p (MIRT016029)
- hsa-mir-335-5p (MIRT018441)
- hsa-let-7c-5p (MIRT051873)
- hsa-mir-4433a-5p (MIRT668230)
- hsa-mir-6507-3p (MIRT668231)
- hsa-mir-5588-3p (MIRT668232)
- hsa-mir-548t-5p (MIRT668233)
- hsa-mir-548az-5p (MIRT668234)
- hsa-mir-188-5p (MIRT668235)
- hsa-mir-6866-3p (MIRT668236)
- hsa-mir-204-5p (MIRT668237)
- hsa-mir-211-5p (MIRT668238)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FZD8
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- genomics-online: shRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FZD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FZD8
- Applied Biological Materials Clones for FZD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FZD8 (Frizzled-8)
Cell Line Products
- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor for FZD8
-
Horizon Cell Lines for FZD8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD8 Gene
Localization for FZD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FZD8 Gene
- Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| golgi apparatus | 3 |
| extracellular | 2 |
| nucleus | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS | 11295046 |
| GO:1990851 | Wnt-Frizzled-LRP5/6 complex | IEA | -- |
Pathways & Interactions for FZD8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gastric cancer |
.62
.62
|
|
| 2 | Wnt Signaling Pathway and Pluripotency | ||
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.70
|
|
| 4 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
| 5 | Aldosterone synthesis and secretion |
.41
|
|
Pathways by source for FZD8 Gene
2 GeneTex pathways for FZD8 Gene
7 BioSystems pathways for FZD8 Gene
14 Reactome pathways for FZD8 Gene
14 KEGG pathways for FZD8 Gene
2 GeneGo (Thomson Reuters) pathways for FZD8 Gene
2 R&D Systems pathways for FZD8 Gene
11 Qiagen pathways for FZD8 Gene
Interacting Proteins for FZD8 Gene
Selected Interacting proteins:
ENSP00000363826
Q9H461-FZD8_HUMAN
for FZD8 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for FZD8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
Drugs & Compounds for FZD8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 |
Drug Products
Transcripts for FZD8 Gene
mRNA/cDNA for FZD8 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000374694 4030 bps (uc001iyz.2)
Unigene Clusters for FZD8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FZD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FZD8
- genomics-online: gRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- Applied Biological Materials CRISPR for FZD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FZD8
- GenScript: Design CRISPR guide RNA sequences for FZD8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FZD8
- Browse OriGene Inhibitory RNA Products For FZD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FZD8
- genomics-online: shRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FZD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FZD8
- Applied Biological Materials Clones for FZD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FZD8 (Frizzled-8)
Expression for FZD8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hypoblast (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Distal Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Distal Visceral Endoderm Cells Extraembryonic Visceral Endoderm
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
- Epiblast (Early Embryonic Tissues)
- Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
This gene is overexpressed in Cervix (37.2) and Lung (26.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FZD8 Gene
NURSA nuclear receptor signaling pathways regulating expression of FZD8 Gene:
FZD8SOURCE GeneReport for Unigene cluster for FZD8 Gene:
Hs.302634mRNA Expression by UniProt/SwissProt for FZD8 Gene:
Q9H461-FZD8_HUMAN
Tissue specificity:
Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
Primer Products
-
OriGene qPCR primer pairs for FZD8
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FZD8 Gene
Orthologs for FZD8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FZD8 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FZD8 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FZD8 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FZD8 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | LOC100909849 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Fzd8 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | FZD8 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FZD8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fzd8 33 |
|
||
| Str.10842 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.412 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fzd8a 34 33 33 |
|
OneToMany | |
| fzd8b 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | fz2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | cfz-2 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for FZD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FZD8 Gene
- ENSEMBL:
- Gene Tree for FZD8 (if available)
- TreeFam:
- Gene Tree for FZD8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FZD8: view image
Paralogs for FZD8 Gene
Variants for FZD8 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000117060 | -- | 35,642,727(-) | C/G | upstream_transcript_variant | |
| rs1000524802 | -- | 35,641,881(-) | G/A | upstream_transcript_variant | |
| rs1000551106 | -- | 35,642,482(-) | T/G | upstream_transcript_variant | |
| rs1001282277 | -- | 35,643,070(-) | C/G | upstream_transcript_variant | |
| rs1001514046 | -- | 35,641,853(-) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1034n54 | CNV | loss | 21841781 |
| dgv1035n54 | CNV | loss | 21841781 |
| dgv1036n54 | CNV | loss | 21841781 |
| dgv144n67 | CNV | gain | 20364138 |
| esv22469 | CNV | loss | 19812545 |
| nsv1068298 | CNV | deletion | 25765185 |
| nsv466871 | CNV | loss | 19166990 |
| nsv521143 | CNV | loss | 19592680 |
| nsv550413 | CNV | loss | 21841781 |
| nsv550415 | CNV | loss | 21841781 |
| nsv550416 | CNV | gain | 21841781 |
| nsv825337 | CNV | gain | 20364138 |
| nsv825340 | CNV | gain | 20364138 |
| nsv825341 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
6.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.13;
22.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FZD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FZD8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD8 Gene
Disorders for FZD8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cystitis |
|
|
| split-hand/foot malformation 6 |
|
|
| exudative vitreoretinopathy |
|
|
Search FZD8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FZD8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FZD8 Gene
Publications for FZD8 Gene
- Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. (PMID: 11295046) Saitoh T … Katoh M (International journal of oncology 2001) 2 3 4 22 58
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PMID: 22575959) Hao HX … Cong F (Nature 2012) 3 4 58
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 44 58
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
Products for FZD8 Gene
- R&D Systems Antibodies for FZD8 (Frizzled-8)
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- Custom Antibody ServicesOriGene Antibodies for FZD8
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- Browse OriGene miRNA Products For FZD8
- GenScript: Next-day shipping of latest version cDNA ORF clones for FZD8 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FZD8
- GenScript Custom Assay Services for FZD8
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- GenScript: Design CRISPR guide RNA sequences for FZD8
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for FZD8
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for FZD8
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- ESI BIO PureStem 7SMOO32, NCr-fac & Meso Progenitor for FZD8
- Taconic Biosciences Mouse Models for FZD8
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FZD8 (AFLGC-FZD8)
- Cyagen custom Knockout/knockin (KOKI) mouse models for FZD8
- antibodies-online: Search results for 87 available FZD8 Antibodies ranked by validation data
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- 40 WB Antibodies (anti-human)
- 17 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 16 WB Antibodies (anti-rat)
- 6 IHC (p) Antibodies (anti-rat)
- 39 WB Antibodies (anti-mouse)
- 9 IHC (p) Antibodies (anti-mouse)
- anti-Frizzled 5/8 Protein Receptor Antibodies (anti-8)
- antibodies-online: Search results for 21 available FZD8 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 5 available FZD8 Proteins ranked by validation data
- Compare Top FZD8 Proteins
- GeneTex FZD8 Antibody for FZD8
- Search GeneTex for Proteins for FZD8
- Horizon Cell Lines for FZD8
- genomics-online: cdna clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- orf clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- genomics-online: gRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- genomics-online: primer clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- genomics-online: shRNA clones - Search results for 79 available FZD8 gene related products
- Overview of 79 available FZD8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FZD8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FZD8
- GeneCopoeia miRNA 3'UTR Target clone products for FZD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FZD8
Sources for FZD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt