Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. ... See more...

Aliases for FZD7 Gene

Aliases for FZD7 Gene

  • Frizzled Class Receptor 7 2 3 5
  • Frizzled 7, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 7 2 3
  • Frizzled-7 3 4
  • Fz-7 3 4
  • FzE3 3 4
  • HFz7 3 4
  • Frizzled, Drosophila, Homolog Of, 7 3
  • Frizzled (Drosophila) Homolog 7 2
  • Frizzled Homolog 7 (Drosophila) 2
  • Frizzled Homolog 7 3

External Ids for FZD7 Gene

Previous GeneCards Identifiers for FZD7 Gene

  • GC02P201116
  • GC02P201623
  • GC02P202863
  • GC02P203101
  • GC02P202724
  • GC02P202607
  • GC02P194748

Summaries for FZD7 Gene

Entrez Gene Summary for FZD7 Gene

  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD7 Gene

FZD7 (Frizzled Class Receptor 7) is a Protein Coding gene. Diseases associated with FZD7 include Exudative Vitreoretinopathy and Gastric Cancer. Among its related pathways are ERK Signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD1.

UniProtKB/Swiss-Prot Summary for FZD7 Gene

  • Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene Wiki entry for FZD7 Gene

Additional gene information for FZD7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FZD7 Gene

Genomics for FZD7 Gene

GeneHancer (GH) Regulatory Elements for FZD7 Gene

Promoters and enhancers for FZD7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FZD7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FZD7

Top Transcription factor binding sites by QIAGEN in the FZD7 gene promoter:
  • Chx10
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for FZD7 Gene

Genomic Locations for FZD7 Gene
chr2:202,034,587-202,038,445
(GRCh38/hg38)
Size:
3,859 bases
Orientation:
Plus strand
chr2:202,899,310-202,903,160
(GRCh37/hg19)
Size:
3,851 bases
Orientation:
Plus strand

Genomic View for FZD7 Gene

Genes around FZD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FZD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FZD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD7 Gene

Proteins for FZD7 Gene

  • Protein details for FZD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75084-FZD7_HUMAN
    Recommended name:
    Frizzled-7
    Protein Accession:
    O75084
    Secondary Accessions:
    • O94816
    • Q53S59
    • Q96B74

    Protein attributes for FZD7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63620 Da
    Quaternary structure:
    • Interacts with MAGI3 (By similarity). Interacts with DVL1 (By similarity). Interacts with CCDC88C/DAPLE; the interaction displaces DVL1 from FZD7, leading to inhibition of canonical Wnt signaling and triggering of non-canonical Wnt responses (PubMed:26126266). Interacts with MYOC (PubMed:19188438). Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966). Interacts with glypican GPC3 (PubMed:24496449).

    Three dimensional structures from OCA and Proteopedia for FZD7 Gene

neXtProt entry for FZD7 Gene

Post-translational modifications for FZD7 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Ser42, Asn63, and Asn164
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FZD7 Gene

Domains & Families for FZD7 Gene

Gene Families for FZD7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for FZD7 Gene

Suggested Antigen Peptide Sequences for FZD7 Gene

GenScript: Design optimal peptide antigens:
  • FzE3 (FZD7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75084

UniProtKB/Swiss-Prot:

FZD7_HUMAN :
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD7: view

Function for FZD7 Gene

Molecular function for FZD7 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
GENATLAS Biochemistry:
Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta

Phenotypes From GWAS Catalog for FZD7 Gene

Gene Ontology (GO) - Molecular Function for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005109 frizzled binding IPI 19188438
GO:0005515 protein binding IPI,IEA 16189514
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 27386966
GO:0017147 Wnt-protein binding IEA,NAS 24431302
genes like me logo Genes that share ontologies with FZD7: view
genes like me logo Genes that share phenotypes with FZD7: view

Animal Models for FZD7 Gene

MGI Knock Outs for FZD7:
  • Fzd7 Fzd7<tm1.1Nat>

Animal Model Products

  • Taconic Biosciences Mouse Models for FZD7

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD7 Gene

Localization for FZD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD7 Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000269 PubMed:27386966}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FZD7 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IBA,TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 9707618
genes like me logo Genes that share ontologies with FZD7: view

Pathways & Interactions for FZD7 Gene

genes like me logo Genes that share pathways with FZD7: view

Pathways by source for FZD7 Gene

11 Qiagen pathways for FZD7 Gene
  • Colorectal Cancer Metastasis
  • Factors Promoting Cardiogenesis in Vertebrates
  • G12-G13 in Cellular Signaling
  • Glioblastoma Multiforme
  • GSK3 Signaling
2 GeneTex pathways for FZD7 Gene

SIGNOR curated interactions for FZD7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 18681827
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FZD7: view

Drugs & Compounds for FZD7 Gene

(2) Drugs for FZD7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with FZD7: view

Transcripts for FZD7 Gene

mRNA/cDNA for FZD7 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD7 Gene

No ASD Table

Relevant External Links for FZD7 Gene

GeneLoc Exon Structure for
FZD7

Expression for FZD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FZD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FZD7 Gene

This gene is overexpressed in Seminal vesicle (39.4), Placenta (17.5), and Fetal gut (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FZD7 Gene



Protein tissue co-expression partners for FZD7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FZD7

SOURCE GeneReport for Unigene cluster for FZD7 Gene:

Hs.173859

mRNA Expression by UniProt/SwissProt for FZD7 Gene:

O75084-FZD7_HUMAN
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Evidence on tissue expression from TISSUES for FZD7 Gene

  • Lung(4.3)
  • Intestine(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with FZD7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FZD7 Gene

Orthologs for FZD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD7 31 30
  • 99.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD7 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD7 31 30
  • 93.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FZD7 31 30
  • 92.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd7 17 31 30
  • 90.15 (n)
rat
(Rattus norvegicus)
Mammalia LOC100360552 30
  • 90.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FZD7 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD7 31 30
  • 85.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD7 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd7 30
  • 82.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Fzd7 30
zebrafish
(Danio rerio)
Actinopterygii fzd7a 31 30
  • 82 (a)
OneToMany
fzd7b 31
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fz 31 32
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mom-5 32
  • 38 (a)
cfz-2 32
  • 36 (a)
Species where no ortholog for FZD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD7 Gene

ENSEMBL:
Gene Tree for FZD7 (if available)
TreeFam:
Gene Tree for FZD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FZD7: view image

Paralogs for FZD7 Gene

Paralogs for FZD7 Gene

(10) SIMAP similar genes for FZD7 Gene using alignment to 1 proteins:

  • FZD7_HUMAN
genes like me logo Genes that share paralogs with FZD7: view

Variants for FZD7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FZD7 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
722432 Benign: not provided 202,035,874(+) G/A SYNONYMOUS_VARIANT
770695 Benign: not provided 202,035,234(+) G/A MISSENSE_VARIANT
795887 Likely Benign: not provided 202,035,436(+) G/A SYNONYMOUS_VARIANT
rs34908164 - p.Gly196Glu
rs35111363 - p.Gly24Asp

Additional dbSNP identifiers (rs#s) for FZD7 Gene

Structural Variations from Database of Genomic Variants (DGV) for FZD7 Gene

Variant ID Type Subtype PubMed ID
esv29879 CNV loss 19812545
nsv584172 CNV loss 21841781
nsv584173 CNV loss 21841781
nsv584174 CNV gain 21841781
nsv954821 CNV deletion 24416366

Variation tolerance for FZD7 Gene

Residual Variation Intolerance Score: 3.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FZD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FZD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD7 Gene

Disorders for FZD7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for FZD7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
gastric cancer
  • gastric cancer, somatic
hepatocellular carcinoma
  • hcc
colorectal cancer
  • crc
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search FZD7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FZD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FZD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD7 Gene

Publications for FZD7 Gene

  1. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PMID: 9707618) Tanaka S … Sugimachi K (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 23 54
  2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PMID: 9813155) Sagara N … Katoh M (Biochemical and biophysical research communications 1998) 2 3 4 23 54
  3. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. (PMID: 27386966) Egea-Jimenez AL … Zimmermann P (Nature communications 2016) 3 4 54
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54

Products for FZD7 Gene

Sources for FZD7 Gene