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Aliases for FZD7 Gene

Aliases for FZD7 Gene

  • Frizzled Class Receptor 7 2 3 5
  • Frizzled 7, Seven Transmembrane Spanning Receptor 2 3
  • Frizzled Family Receptor 7 2 3
  • Fz-7 3 4
  • FzE3 3 4
  • HFz7 3 4
  • Frizzled, Drosophila, Homolog Of, 7 3
  • Frizzled (Drosophila) Homolog 7 2
  • Frizzled Homolog 7 (Drosophila) 2
  • Frizzled Homolog 7 3
  • Frizzled-7 3

External Ids for FZD7 Gene

Previous GeneCards Identifiers for FZD7 Gene

  • GC02P201116
  • GC02P201623
  • GC02P202863
  • GC02P203101
  • GC02P202724
  • GC02P202607
  • GC02P194748

Summaries for FZD7 Gene

Entrez Gene Summary for FZD7 Gene

  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FZD7 Gene

FZD7 (Frizzled Class Receptor 7) is a Protein Coding gene. Diseases associated with FZD7 include Hepatocellular Carcinoma and Exudative Vitreoretinopathy. Among its related pathways are Presynaptic function of Kainate receptors and Reelin Pathway (Cajal-Retzius cells). Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD2.

UniProtKB/Swiss-Prot for FZD7 Gene

  • Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene Wiki entry for FZD7 Gene

Additional gene information for FZD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FZD7 Gene

Genomics for FZD7 Gene

GeneHancer (GH) Regulatory Elements for FZD7 Gene

Promoters and enhancers for FZD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J202030 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 672.4 +0.6 607 9.8 CLOCK ATF1 ZNF133 SIN3A ZNF2 ZNF48 YY1 ETS1 GLIS2 ZNF213 FZD7 ENSG00000273209 NOP58 CDK15 KIAA2012 CARF LOC100420110 LOC729224 RNU6-440P FAM117B
GH02J201114 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -910.4 -910371 19 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CFLAR PPIL3 CLK1 ORC2 CASP10 CFLAR-AS1 CDK15 KCTD18 FAM126B LOC105373835
GH02J202063 Enhancer 0.8 Ensembl ENCODE 18.8 +29.7 29738 2 TEAD4 ZNF10 TAL1 CBFA2T3 SIN3A TCF12 ZFHX2 POLR2A CBFA2T2 PRDM10 FZD7 LOC729224 KIAA2012
GH02J201805 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.5 -227.4 -227442 2.4 PKNOX1 MZF1 FEZF1 ZIC2 ZNF2 FOSL1 ZNF335 CTBP1 POLR2A PRDM10 ENSG00000202137 GC02P201809 CDK15 ALS2 FZD7 RNU6-440P LOC729224 NOP58 SNORD70B SNORD70
GH02J202965 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.1 +931.2 931156 1.2 PKNOX1 ATF1 ARNT SIN3A IRF4 ATF7 RUNX3 JUNB ZNF592 MEF2D NBEAL1 CARF NOP58 WDR12 FZD7 RAPH1 ICA1L GC02M202945 GC02P202987
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FZD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FZD7 gene promoter:
  • E2F-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • Chx10
  • E2F-5
  • NF-kappaB
  • NF-kappaB1
  • LCR-F1

Genomic Locations for FZD7 Gene

Genomic Locations for FZD7 Gene
chr2:202,034,587-202,038,445
(GRCh38/hg38)
Size:
3,859 bases
Orientation:
Plus strand
chr2:202,899,310-202,903,160
(GRCh37/hg19)
Size:
3,851 bases
Orientation:
Plus strand

Genomic View for FZD7 Gene

Genes around FZD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FZD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FZD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FZD7 Gene

Proteins for FZD7 Gene

  • Protein details for FZD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75084-FZD7_HUMAN
    Recommended name:
    Frizzled-7
    Protein Accession:
    O75084
    Secondary Accessions:
    • O94816
    • Q53S59
    • Q96B74

    Protein attributes for FZD7 Gene

    Size:
    574 amino acids
    Molecular mass:
    63620 Da
    Quaternary structure:
    • Interacts with MAGI3 and DVL1 (By similarity). Interacts with MYOC. Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966).

    Three dimensional structures from OCA and Proteopedia for FZD7 Gene

neXtProt entry for FZD7 Gene

Post-translational modifications for FZD7 Gene

  • Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  • Glycosylation at Asn164, isoforms=63, and isoforms=42
  • Modification sites at PhosphoSitePlus

Other Protein References for FZD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FZD7 Gene

Domains & Families for FZD7 Gene

Gene Families for FZD7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for FZD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75084

UniProtKB/Swiss-Prot:

FZD7_HUMAN :
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • Belongs to the G-protein coupled receptor Fz/Smo family.
Domain:
  • Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
  • The FZ domain is involved in binding with Wnt ligands.
Family:
  • Belongs to the G-protein coupled receptor Fz/Smo family.
genes like me logo Genes that share domains with FZD7: view

Function for FZD7 Gene

Molecular function for FZD7 Gene

UniProtKB/Swiss-Prot Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
GENATLAS Biochemistry:
Drosophila frizzled polarity gene homolog,G protein coupled receptor superfamily,exhibiting characteristics of a WNT receptor,expressed in fetal kidney and adult skeletal muscle,heart,brain and placenta

Phenotypes From GWAS Catalog for FZD7 Gene

Gene Ontology (GO) - Molecular Function for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IBA --
GO:0005109 frizzled binding IPI 19188438
GO:0005515 protein binding IPI 16189514
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA 27386966
genes like me logo Genes that share ontologies with FZD7: view
genes like me logo Genes that share phenotypes with FZD7: view

Animal Models for FZD7 Gene

MGI Knock Outs for FZD7:
  • Fzd7 Fzd7<tm1.1Nat>

Animal Model Products

  • Taconic Biosciences Mouse Models for FZD7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FZD7 Gene

Localization for FZD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FZD7 Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. {ECO:0000269 PubMed:27386966}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FZD7 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 9707618
genes like me logo Genes that share ontologies with FZD7: view

Pathways & Interactions for FZD7 Gene

genes like me logo Genes that share pathways with FZD7: view

SIGNOR curated interactions for FZD7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FZD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 18681827
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FZD7: view

Drugs & Compounds for FZD7 Gene

(2) Drugs for FZD7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with FZD7: view

Transcripts for FZD7 Gene

mRNA/cDNA for FZD7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(124) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FZD7 Gene

Frizzled family receptor 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FZD7 Gene

No ASD Table

Relevant External Links for FZD7 Gene

GeneLoc Exon Structure for
FZD7
ECgene alternative splicing isoforms for
FZD7

Expression for FZD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FZD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FZD7 Gene

This gene is overexpressed in Seminal vesicle (39.4), Placenta (17.5), and Fetal gut (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FZD7 Gene



Protein tissue co-expression partners for FZD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of FZD7 Gene:

FZD7

SOURCE GeneReport for Unigene cluster for FZD7 Gene:

Hs.173859

mRNA Expression by UniProt/SwissProt for FZD7 Gene:

O75084-FZD7_HUMAN
Tissue specificity: High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Evidence on tissue expression from TISSUES for FZD7 Gene

  • Lung(4.3)
  • Intestine(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with FZD7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FZD7 Gene

Orthologs for FZD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FZD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FZD7 34 33
  • 99.65 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FZD7 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FZD7 34 33
  • 93.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FZD7 34 33
  • 92.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fzd7 16 34 33
  • 90.15 (n)
rat
(Rattus norvegicus)
Mammalia LOC100360552 33
  • 90.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FZD7 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FZD7 34 33
  • 85.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FZD7 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fzd7 33
  • 82.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Fzd7 33
zebrafish
(Danio rerio)
Actinopterygii fzd7a 34 33
  • 82 (a)
OneToMany
fzd7b 34
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fz 34 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mom-5 35
  • 38 (a)
cfz-2 35
  • 36 (a)
Species where no ortholog for FZD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FZD7 Gene

ENSEMBL:
Gene Tree for FZD7 (if available)
TreeFam:
Gene Tree for FZD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FZD7: view image

Paralogs for FZD7 Gene

Paralogs for FZD7 Gene

(10) SIMAP similar genes for FZD7 Gene using alignment to 1 proteins:

  • FZD7_HUMAN
genes like me logo Genes that share paralogs with FZD7: view

Variants for FZD7 Gene

Sequence variations from dbSNP and Humsavar for FZD7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000137088 -- 202,034,570(+) C/G upstream_transcript_variant
rs1000635928 -- 202,038,423(+) A/C 3_prime_UTR_variant
rs1000638805 -- 202,033,673(+) G/A upstream_transcript_variant
rs1000638888 -- 202,036,030(+) C/A/T coding_sequence_variant, synonymous_variant
rs1001812619 -- 202,038,292(+) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FZD7 Gene

Variant ID Type Subtype PubMed ID
esv29879 CNV loss 19812545
nsv584172 CNV loss 21841781
nsv584173 CNV loss 21841781
nsv584174 CNV gain 21841781
nsv954821 CNV deletion 24416366

Variation tolerance for FZD7 Gene

Residual Variation Intolerance Score: 3.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FZD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FZD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FZD7 Gene

Disorders for FZD7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FZD7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
- elite association - COSMIC cancer census association via MalaCards
Search FZD7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FZD7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FZD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FZD7 Gene

Publications for FZD7 Gene

  1. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PMID: 9707618) Tanaka S … Sugimachi K (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
  2. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. (PMID: 9813155) Sagara N … Katoh M (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  3. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. (PMID: 27386966) Egea-Jimenez AL … Zimmermann P (Nature communications 2016) 3 4 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58

Products for FZD7 Gene

Sources for FZD7 Gene

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