Aliases for FZD2 Gene
External Ids for FZD2 Gene
Previous GeneCards Identifiers for FZD2 Gene
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
GeneCards Summary for FZD2 Gene
FZD2 (Frizzled Class Receptor 2) is a Protein Coding gene. Diseases associated with FZD2 include Omodysplasia 2 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Presenilin-Mediated Signaling and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD1.
UniProtKB/Swiss-Prot Summary for FZD2 Gene
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium (PubMed:27680706, PubMed:29748286). TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling (PubMed:29748286).