This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provide... See more...

Aliases for FYN Gene

Aliases for FYN Gene

  • FYN Proto-Oncogene, Src Family Tyrosine Kinase 2 3 5
  • FYN Oncogene Related To SRC, FGR, YES 2 3
  • Tyrosine-Protein Kinase Fyn 3 4
  • Proto-Oncogene C-Fyn 3 4
  • Proto-Oncogene Syn 3 4
  • Src-Like Kinase 3 4
  • EC 2.7.10.2 4 52
  • SLK 3 4
  • OKT3-Induced Calcium Influx Regulator 3
  • Tyrosine Kinase P59fyn(T) 3
  • Src/Yes-Related Novel 3
  • C-Syn Protooncogene 3
  • EC 2.7.10.2'); 52
  • EC 2.7.10 52
  • P59-FYN 3
  • P59-Fyn 4
  • SYN 3

External Ids for FYN Gene

Previous GeneCards Identifiers for FYN Gene

  • GC06M111817
  • GC06M112005
  • GC06M112028
  • GC06M112089
  • GC06M111981
  • GC06M109555

Summaries for FYN Gene

Entrez Gene Summary for FYN Gene

  • This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for FYN Gene

FYN (FYN Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FYN include Hepatitis E and Autoimmune Cardiomyopathy. Among its related pathways are G-protein signaling_RhoA regulation pathway and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is YES1.

UniProtKB/Swiss-Prot Summary for FYN Gene

  • Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity).

Tocris Summary for FYN Gene

  • Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins. Members of the Src kinase family have a very similar domain structure.

Gene Wiki entry for FYN Gene

Additional gene information for FYN Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FYN Gene

Genomics for FYN Gene

GeneHancer (GH) Regulatory Elements for FYN Gene

Promoters and enhancers for FYN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FYN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FYN

Top Transcription factor binding sites by QIAGEN in the FYN gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • STAT5A

Genomic Locations for FYN Gene

Genomic Locations for FYN Gene
chr6:111,660,332-111,873,452
(GRCh38/hg38)
Size:
213,121 bases
Orientation:
Minus strand
chr6:111,981,535-112,194,655
(GRCh37/hg19)
Size:
213,121 bases
Orientation:
Minus strand

Genomic View for FYN Gene

Genes around FYN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYN Gene

Proteins for FYN Gene

  • Protein details for FYN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06241-FYN_HUMAN
    Recommended name:
    Tyrosine-protein kinase Fyn
    Protein Accession:
    P06241
    Secondary Accessions:
    • B5BU57
    • E1P557
    • H0UI48
    • Q16248
    • Q5R3A6
    • Q5R3A7
    • Q8N5D7

    Protein attributes for FYN Gene

    Size:
    537 amino acids
    Molecular mass:
    60762 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501). Interacts with DSCAM (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity).
    • (Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3.

    Three dimensional structures from OCA and Proteopedia for FYN Gene

    Alternative splice isoforms for FYN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYN Gene

Selected DME Specific Peptides for FYN Gene

P06241:
  • KTLKPGTM
  • FVALYDYE
  • RAAGLCCRLVVPCHKGMPRL
  • KWTAPEA
  • KHYKIRKLD
  • NREVLEQVERGYRM
  • FLEDYFT
  • IKSDVWSFGILL
  • RGYRMPCP
  • FLIRESE
  • NYIHRDLR
  • FTIKSDVWSFG
  • CKIADFGLAR
  • VSEEPIYIV
  • EGDWWEARS
  • PIYIVTE
  • RKDAERQLL
  • GQFGEVW
  • SLSIRDWD
  • LFVALYD
  • DSIQAEEWY
  • QVAAGMAY
  • VKHYKIR
  • GYIPSNYVA
  • ADFGLARLIED
  • EAQIMKKL
  • ALYDYEARTEDDL
  • KGSLLDFLK
  • DNGGYYI
  • GGYYITTRAQF
  • DPTPQHYPSFGVT
  • KSDVWSFG
  • DLSVKTKDVWEIPRESLQL
  • KFPIKWTAPE
  • RESETTKGA
  • KLVQLYAVV
  • FGEVWMGTWN
  • KGRVPYPGM
  • GMAYIER
  • PEERPTFE
  • EPQYQPG

Post-translational modifications for FYN Gene

  • Autophosphorylated at Tyr-420 (By similarity). Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (PubMed:1699196). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation (PubMed:1533589). Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus (PubMed:15537652). Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling (PubMed:22080863). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (By similarity).
  • Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.
  • Ubiquitination at Lys405
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for FYN
  • Boster Bio Antibodies for FYN

Domains & Families for FYN Gene

Gene Families for FYN Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FYN Gene

Blocks:
  • Tyrosine protein kinase, active site
  • SH3 domain signature
  • SH2 domain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FYN Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ32137 fis, clone PEBLM2000479, highly similar to Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (B3KPS6_HUMAN)
  • p59-Fyn (FYN_HUMAN)
  • FYN protein (P78484_HUMAN)
  • FYN protein (Q14342_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P06241

UniProtKB/Swiss-Prot:

FYN_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FYN: view

Function for FYN Gene

Molecular function for FYN Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
GENATLAS Biochemistry:
SRC/YES-related oncogene homolog,involved in T cell signaling regulation,STAR (signal transduction and activator of RNA) family

Enzyme Numbers (IUBMB) for FYN Gene

Phenotypes From GWAS Catalog for FYN Gene

Gene Ontology (GO) - Molecular Function for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001664 G protein-coupled receptor binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 17526495
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,NAS 7822789
genes like me logo Genes that share ontologies with FYN: view
genes like me logo Genes that share phenotypes with FYN: view

Animal Models for FYN Gene

MGI Knock Outs for FYN:
  • Fyn Fyn<tm1Sor>
  • Fyn Fyn<tm1a(EUCOMM)Wtsi>
  • Fyn Fyn<tm1Yik>
  • Fyn Fyn<tm1Fam>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for FYN

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FYN Gene

Localization for FYN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYN Gene

Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FYN gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 4
endoplasmic reticulum 4
endosome 4
extracellular 3
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IEA 27525436
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion ISS 27525436
GO:0005768 endosome IDA 15611048
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FYN: view

Pathways & Interactions for FYN Gene

PathCards logo

SuperPathways for FYN Gene

SuperPathway Contained pathways
1 RET signaling
2 GAB1 signalosome
3 EPH-Ephrin signaling
.35
.35
4 HIV Life Cycle
.45
5 EPHA forward signaling
.30
genes like me logo Genes that share pathways with FYN: view

Pathways by source for FYN Gene

16 GeneGo (Thomson Reuters) pathways for FYN Gene
  • Cell adhesion Ephrins signaling
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Chemotaxis CXCR4 signaling pathway
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Development ACM2 and ACM4 activation of ERK
2 R&D Systems pathways for FYN Gene
26 Qiagen pathways for FYN Gene
  • Calcium Mediated T-Cell Apoptosis
  • CD28 Signaling in T-Helper Cell
  • CTLA4 Signaling
  • EphrinA-EphR Signaling
  • Ephrin-Eph Signaling
2 Cell Signaling Technology pathways for FYN Gene

Gene Ontology (GO) - Biological Process for FYN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000304 response to singlet oxygen ISS 27525436
GO:0001764 neuron migration IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with FYN: view

Drugs & Compounds for FYN Gene

(41) Drugs for FYN Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target, multitarget, Inhibition, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 319
Calcium Approved Nutra 7884
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Manganese Approved Nutra 51
Triglyme Experimental Pharma Target 0

(27) Additional Compounds for FYN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
PD 166285 dihydrochloride
212391-63-4

(4) Tocris Compounds for FYN Gene

Compound Action Cas Number
Herbimycin A Src family kinase inhibitor. Also Hsp90 inhibitor 70563-58-5
MNS Selective inhibitor of Src and Syk 1485-00-3
PD 166285 dihydrochloride Potent Src inhibitor; also inhibits FGFR1, PDGFRbeta and Wee1 212391-63-4
PP 3 Negative control for PP 2 (Cat. No. 1407) 5334-30-5

(6) ApexBio Compounds for FYN Gene

Compound Action Cas Number
1-NM-PP1 Pp60c-src inhibitor 221244-14-0
KX2-391 Src inhibitor,highly selective 897016-82-9
NVP-BHG712 EphB4 inhibitor,potent and selective 940310-85-0
PP 1 Src family tyrosine kinase inhibitor 172889-26-8
PP 2 (AG 1879) Src-family kinases inhibitor 172889-27-9
WH-4-023 Lck/Src inhibitor,potent and selective 837422-57-8
genes like me logo Genes that share compounds with FYN: view

Drug Products

Transcripts for FYN Gene

mRNA/cDNA for FYN Gene

5 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for FYN

Alternative Splicing Database (ASD) splice patterns (SP) for FYN Gene

No ASD Table

Relevant External Links for FYN Gene

GeneLoc Exon Structure for
FYN

Expression for FYN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FYN Gene

Protein differential expression in normal tissues from HIPED for FYN Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Cervix (8.1), and Breast (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FYN Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FYN

SOURCE GeneReport for Unigene cluster for FYN Gene:

Hs.390567

mRNA Expression by UniProt/SwissProt for FYN Gene:

P06241-FYN_HUMAN
Tissue specificity: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.

Evidence on tissue expression from TISSUES for FYN Gene

  • Blood(4.6)
  • Nervous system(4.2)
  • Kidney(2.6)
  • Lymph node(2.6)
  • Heart(2.5)
  • Spleen(2.5)
  • Muscle(2.4)
  • Intestine(2.3)
  • Lung(2.3)
  • Bone marrow(2.1)
  • Liver(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with FYN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FYN Gene

Orthologs for FYN Gene

This gene was present in the common ancestor of animals.

Orthologs for FYN Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia FYN 31
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYN 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FYN 31 30
  • 95.07 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fyn 17 31 30
  • 92.76 (n)
cow
(Bos Taurus)
Mammalia FYN 31 30
  • 90.01 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FYN 31 30
  • 89.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fyn 30
  • 88.26 (n)
chicken
(Gallus gallus)
Aves FYN 31 30
  • 85.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FYN 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyn 30
  • 81.34 (n)
zebrafish
(Danio rerio)
Actinopterygii fyna 31
  • 92 (a)
OneToOne
fynb 30
  • 74.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src64B 32
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea src-1 32 30
  • 55.63 (n)
F57B9.8 32
  • 34 (a)
F23C8.7 32
  • 33 (a)
C25A8.5 32
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.5221 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5221 30
Species where no ortholog for FYN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FYN Gene

ENSEMBL:
Gene Tree for FYN (if available)
TreeFam:
Gene Tree for FYN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FYN: view image

Paralogs for FYN Gene

(67) SIMAP similar genes for FYN Gene using alignment to 17 proteins:

  • FYN_HUMAN
  • E5RFM0_HUMAN
  • E5RFM4_HUMAN
  • E5RFM6_HUMAN
  • E5RFS5_HUMAN
  • E5RGM6_HUMAN
  • E5RGT0_HUMAN
  • E5RH71_HUMAN
  • E5RHF7_HUMAN
  • E5RHX7_HUMAN
  • E5RI25_HUMAN
  • E5RIX5_HUMAN
  • E5RJX7_HUMAN
  • E5RK23_HUMAN
  • P78484_HUMAN
  • Q14342_HUMAN
  • Q5R3A8_HUMAN
genes like me logo Genes that share paralogs with FYN: view

Variants for FYN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FYN Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
709055 Benign: not provided 111,719,926(-) G/A SYNONYMOUS_VARIANT
714319 Benign: not provided 111,696,350(-) G/A SYNONYMOUS_VARIANT
768108 Benign: not provided 111,694,367(-) G/A INTRON_VARIANT
770554 Benign: not provided 111,694,538(-) C/T INTRON_VARIANT
770555 Benign: not provided 111,694,620(-) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for FYN Gene

Structural Variations from Database of Genomic Variants (DGV) for FYN Gene

Variant ID Type Subtype PubMed ID
esv2662755 CNV deletion 23128226
esv2752088 CNV gain 17911159
esv3414538 CNV insertion 20981092
esv3610380 CNV gain 21293372
esv3610382 CNV loss 21293372
nsv1074007 CNV deletion 25765185
nsv1074954 CNV deletion 25765185
nsv1137554 CNV deletion 24896259
nsv1161444 CNV duplication 26073780
nsv476660 CNV novel sequence insertion 20440878
nsv5444 CNV insertion 18451855
nsv5445 CNV deletion 18451855

Variation tolerance for FYN Gene

Residual Variation Intolerance Score: 9.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FYN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FYN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYN Gene

Disorders for FYN Gene

MalaCards: The human disease database

(13) MalaCards diseases for FYN Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FYN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FYN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FYN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FYN Gene

Publications for FYN Gene

  1. The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients. (PMID: 19330793) Szczepankiewicz A … Rybakowski JK (Human psychopharmacology 2009) 3 23 41 54
  2. Fyn phosphorylates human MAP-2c on tyrosine 67. (PMID: 15536091) Zamora-Leon SP … Shafit-Zagardo B (The Journal of biological chemistry 2005) 3 4 23 54
  3. Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase. (PMID: 15537652) He Z … Dong Z (The Journal of biological chemistry 2005) 3 4 23 54
  4. Regulation of TRPC6 channel activity by tyrosine phosphorylation. (PMID: 14761972) Hisatsune C … Mikoshiba K (The Journal of biological chemistry 2004) 3 4 23 54
  5. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. (PMID: 12788081) Taniguchi S … Yamamoto T (Biochemical and biophysical research communications 2003) 3 4 23 54

Products for FYN Gene