Aliases for FYB1 Gene
External Ids for FYB1 Gene
Previous HGNC Symbols for FYB1 Gene
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for FYB1 Gene
FYB1 (FYN Binding Protein 1) is a Protein Coding gene. Diseases associated with FYB1 include Thrombocytopenia 3 and Thrombocytopenia. Among its related pathways are TCR signaling (REACTOME) and Cell junction organization. An important paralog of this gene is FYB2.
UniProtKB/Swiss-Prot Summary for FYB1 Gene
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.