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Aliases for FXYD7 Gene

Aliases for FXYD7 Gene

  • FXYD Domain Containing Ion Transport Regulator 7 2 3 5
  • FXYD Domain-Containing Ion Transport Regulator 7 2

External Ids for FXYD7 Gene

Previous GeneCards Identifiers for FXYD7 Gene

  • GC19P036251
  • GC19P036083
  • GC19P040310
  • GC19P040325
  • GC19P035634
  • GC19P032142

Summaries for FXYD7 Gene

Entrez Gene Summary for FXYD7 Gene

  • This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,, Dec 2000]

GeneCards Summary for FXYD7 Gene

FXYD7 (FXYD Domain Containing Ion Transport Regulator 7) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Ion channel transport. Gene Ontology (GO) annotations related to this gene include ion channel activity and sodium channel regulator activity.

Additional gene information for FXYD7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD7 Gene

Genomics for FXYD7 Gene

GeneHancer (GH) Regulatory Elements for FXYD7 Gene

Promoters and enhancers for FXYD7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035142 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 550.8 -0.4 -402 1.3 NFIB KLF17 RAD21 ZNF335 GLIS2 EGR1 ZNF366 ZNF143 ZNF391 CREM FXYD7 LGI4 ENSG00000221857 KMT2B ZNF792 RBM42 PROSER3 LSM14A ENSG00000271032 U2AF1L4
GH19I035145 Enhancer 0.9 ENCODE 550.8 +2.0 1992 0.2 SMAD1 SIN3A ZNF2 GLIS2 KLF7 SP3 RFX3 GLIS1 KDM1A ZNF300 FXYD7 ZNF599 ZNF302 TMEM147-AS1 ZNF30 LSM14A ZNF181 HAUS5 KIAA0355 LIN37
GH19I035143 Enhancer 0.6 ENCODE 550.8 +0.3 302 0.2 SMARCA5 ZBTB10 CTCF RFX1 ZNF740 BMI1 ZEB1 GLIS2 KDM1A FXYD7 LGI4 ENSG00000221857 FXYD5
GH19I035136 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.8 -3.8 -3792 5.4 HDGF FOXA2 MLX ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 ZNF548 ENSG00000221857 FXYD1 ENSG00000279619 ZNF599 TMEM147-AS1 LSM14A HAUS5 KIAA0355 ZNF792 KMT2B
GH19I035134 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 12.5 -7.9 -7914 1.5 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF207 ZNF143 KLF13 MCM3 SP3 LGI4 KMT2B LSM14A RBM42 PROSER3 ZNF792 KIAA0355 ENSG00000221857 HAUS5 ZNF599
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FXYD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FXYD7 gene promoter:

Genomic Locations for FXYD7 Gene

Genomic Locations for FXYD7 Gene
11,053 bases
Plus strand

Genomic View for FXYD7 Gene

Genes around FXYD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD7 Gene

Proteins for FXYD7 Gene

  • Protein details for FXYD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 7
    Protein Accession:

    Protein attributes for FXYD7 Gene

    80 amino acids
    Molecular mass:
    8524 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD7 Gene

Post-translational modifications for FXYD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXYD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD7 Gene

Domains & Families for FXYD7 Gene

Gene Families for FXYD7 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FXYD7 Gene

Suggested Antigen Peptide Sequences for FXYD7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD7: view

Function for FXYD7 Gene

Gene Ontology (GO) - Molecular Function for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0017080 sodium channel regulator activity IBA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with FXYD7: view
genes like me logo Genes that share phenotypes with FXYD7: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD7 Gene

Localization for FXYD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD7 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FXYD7 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FXYD7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FXYD7 Gene

Pathways & Interactions for FXYD7 Gene

genes like me logo Genes that share pathways with FXYD7: view

Pathways by source for FXYD7 Gene

Gene Ontology (GO) - Biological Process for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport TAS,IEA --
GO:0043269 regulation of ion transport IEA --
GO:1903779 regulation of cardiac conduction TAS --
genes like me logo Genes that share ontologies with FXYD7: view

No data available for SIGNOR curated interactions for FXYD7 Gene

Drugs & Compounds for FXYD7 Gene

No Compound Related Data Available

Transcripts for FXYD7 Gene

mRNA/cDNA for FXYD7 Gene

Unigene Clusters for FXYD7 Gene

FXYD domain containing ion transport regulator 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD7 Gene

No ASD Table

Relevant External Links for FXYD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FXYD7 Gene

mRNA differential expression in normal tissues according to GTEx for FXYD7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.8), Brain - Cortex (x7.7), Brain - Anterior cingulate cortex (BA24) (x6.3), Brain - Hippocampus (x5.9), Brain - Amygdala (x5.8), and Brain - Putamen (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for FXYD7 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FXYD7 Gene

Protein tissue co-expression partners for FXYD7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FXYD7 Gene:


SOURCE GeneReport for Unigene cluster for FXYD7 Gene:


Evidence on tissue expression from TISSUES for FXYD7 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with FXYD7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FXYD7 Gene

Orthologs for FXYD7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FXYD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD7 33 34
  • 89.47 (n)
(Rattus norvegicus)
Mammalia Fxyd7 33
  • 86.25 (n)
(Mus musculus)
Mammalia Fxyd7 33 16 34
  • 85.42 (n)
(Monodelphis domestica)
Mammalia FXYD7 34
  • 66 (a)
Species where no ortholog for FXYD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD7 Gene

Gene Tree for FXYD7 (if available)
Gene Tree for FXYD7 (if available)

Paralogs for FXYD7 Gene

(5) SIMAP similar genes for FXYD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD7: view

No data available for Paralogs for FXYD7 Gene

Variants for FXYD7 Gene

Sequence variations from dbSNP and Humsavar for FXYD7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057707 -- 35,150,553(+) G/T intron_variant
rs1000139815 -- 35,144,307(+) C/G intron_variant
rs1000146135 -- 35,151,042(+) G/C intron_variant
rs1000279557 -- 35,144,570(+) C/G intron_variant
rs1000958259 -- 35,145,360(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD7 Gene

Variant ID Type Subtype PubMed ID
nsv953282 CNV deletion 24416366

Variation tolerance for FXYD7 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FXYD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD7 Gene

Disorders for FXYD7 Gene

Additional Disease Information for FXYD7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FXYD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD7 Gene

Publications for FXYD7 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells. (PMID: 22535957) Moshitzky S … Garty H (The Journal of biological chemistry 2012) 3 58
  5. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-López M … Aloy P (Genome research 2011) 3 58

Products for FXYD7 Gene

Sources for FXYD7 Gene

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