Aliases for FXYD5 Gene
External Ids for FXYD5 Gene
Previous GeneCards Identifiers for FXYD5 Gene
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., email@example.com., Sep 2009]
GeneCards Summary for FXYD5 Gene
FXYD5 (FXYD Domain Containing Ion Transport Regulator 5) is a Protein Coding gene. Diseases associated with FXYD5 include Mixed Germ Cell Cancer and Epithelioid Sarcoma. Gene Ontology (GO) annotations related to this gene include actin binding and sodium channel regulator activity.
UniProtKB/Swiss-Prot Summary for FXYD5 Gene
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.