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Aliases for FXYD4 Gene

Aliases for FXYD4 Gene

  • FXYD Domain Containing Ion Transport Regulator 4 2 3 5
  • FXYD Domain-Containing Ion Transport Regulator 4 2 3
  • Channel-Inducing Factor 3
  • CHIF 3

External Ids for FXYD4 Gene

Previous GeneCards Identifiers for FXYD4 Gene

  • GC00U990738
  • GC10M043337
  • GC10P043642
  • GC10P043151
  • GC10P043187
  • GC10P043867
  • GC10P040393

Summaries for FXYD4 Gene

Entrez Gene Summary for FXYD4 Gene

  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]

GeneCards Summary for FXYD4 Gene

FXYD4 (FXYD Domain Containing Ion Transport Regulator 4) is a Protein Coding gene. Diseases associated with FXYD4 include Deafness, Autosomal Recessive 33. Among its related pathways are Cardiac conduction and Aldosterone-regulated sodium reabsorption. Gene Ontology (GO) annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is FXYD3.

Additional gene information for FXYD4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD4 Gene

Genomics for FXYD4 Gene

GeneHancer (GH) Regulatory Elements for FXYD4 Gene

Promoters and enhancers for FXYD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I043371 Promoter/Enhancer 1.1 EPDnew dbSUPER 550.8 0.0 -25 0.1 HDAC1 MXI1 ATF1 L3MBTL2 BHLHE40 CEBPB MAX CEBPG REST MNT FXYD4 GC10P043364 PIR61799
GH10I043373 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.8 +1.8 1803 0.1 PRDM10 FXYD4 PIR56810
GH10I043370 Enhancer 0.5 dbSUPER 554.9 -0.8 -806 1.1 ZFHX2 ATF4 ATF1 VEZF1 CEBPB CEBPG EGR2 FXYD4 LOC105378272 PIR61799 GC10P043364
GH10I043372 Enhancer 0.5 dbSUPER 550.8 +1.2 1228 0.8 SOX13 GLIS1 ZIC2 ZBTB20 FXYD4 LOC105378272 PIR56810
GH10I043348 Enhancer 1.1 ENCODE dbSUPER 13.1 -23.0 -23014 0.2 HDAC1 ELF3 PKNOX1 ATF1 RB1 SIN3A ZNF48 RAD21 RFX5 ZNF213 GC10P043350 FXYD4 GC10P043344 LOC105378271
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FXYD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FXYD4 gene promoter:

Genomic Locations for FXYD4 Gene

Genomic Locations for FXYD4 Gene
4,694 bases
Plus strand

Genomic View for FXYD4 Gene

Genes around FXYD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD4 Gene

Proteins for FXYD4 Gene

  • Protein details for FXYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 4
    Protein Accession:
    Secondary Accessions:
    • Q6UWZ1
    • Q7Z4M5

    Protein attributes for FXYD4 Gene

    89 amino acids
    Molecular mass:
    9373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD4 Gene

Post-translational modifications for FXYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD4 Gene

Domains & Families for FXYD4 Gene

Gene Families for FXYD4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FXYD4 Gene

Suggested Antigen Peptide Sequences for FXYD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD4: view

Function for FXYD4 Gene

Phenotypes From GWAS Catalog for FXYD4 Gene

Gene Ontology (GO) - Molecular Function for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity IEA --
GO:0017080 sodium channel regulator activity IBA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with FXYD4: view
genes like me logo Genes that share phenotypes with FXYD4: view

Animal Models for FXYD4 Gene

MGI Knock Outs for FXYD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for FXYD4

miRNA for FXYD4 Gene

miRTarBase miRNAs that target FXYD4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FXYD4 Gene

Localization for FXYD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FXYD4 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FXYD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FXYD4 Gene

Pathways & Interactions for FXYD4 Gene

genes like me logo Genes that share pathways with FXYD4: view

Pathways by source for FXYD4 Gene

Interacting Proteins for FXYD4 Gene

Selected Interacting proteins: P59646-FXYD4_HUMAN for FXYD4 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0071805 potassium ion transmembrane transport IEA --
GO:1903779 regulation of cardiac conduction TAS --
genes like me logo Genes that share ontologies with FXYD4: view

No data available for SIGNOR curated interactions for FXYD4 Gene

Drugs & Compounds for FXYD4 Gene

(1) Drugs for FXYD4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FXYD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FXYD4: view

Transcripts for FXYD4 Gene

mRNA/cDNA for FXYD4 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FXYD4 Gene

FXYD domain containing ion transport regulator 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: -

Relevant External Links for FXYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FXYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD4 Gene

This gene is overexpressed in Kidney - Cortex (x42.4).

NURSA nuclear receptor signaling pathways regulating expression of FXYD4 Gene:


SOURCE GeneReport for Unigene cluster for FXYD4 Gene:


Evidence on tissue expression from TISSUES for FXYD4 Gene

  • Kidney(4.7)
genes like me logo Genes that share expression patterns with FXYD4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FXYD4 Gene

Orthologs for FXYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FXYD4 33 34
  • 98.88 (n)
(Canis familiaris)
Mammalia FXYD4 33 34
  • 82.38 (n)
(Bos Taurus)
Mammalia FXYD4 33
  • 78.1 (n)
(Mus musculus)
Mammalia Fxyd4 33 16 34
  • 75.49 (n)
(Rattus norvegicus)
Mammalia Fxyd4 33
  • 74.87 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
Species where no ortholog for FXYD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD4 Gene

Gene Tree for FXYD4 (if available)
Gene Tree for FXYD4 (if available)

Paralogs for FXYD4 Gene

Paralogs for FXYD4 Gene

(1) SIMAP similar genes for FXYD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FXYD4: view

Variants for FXYD4 Gene

Sequence variations from dbSNP and Humsavar for FXYD4 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000146563 -- 43,370,236(+) A/T upstream_transcript_variant
rs1000213898 -- 43,371,609(+) A/G upstream_transcript_variant
rs1000248334 -- 43,370,545(+) G/A upstream_transcript_variant
rs1000299501 -- 43,376,317(+) C/T 3_prime_UTR_variant
rs1000642000 -- 43,375,009(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD4 Gene

Variant ID Type Subtype PubMed ID
dgv728n100 CNV gain 25217958
nsv521283 CNV loss 19592680
nsv831842 CNV loss 17160897

Variation tolerance for FXYD4 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FXYD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD4 Gene

Disorders for FXYD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FXYD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 33
  • dfnb33
- elite association - COSMIC cancer census association via MalaCards
Search FXYD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FXYD4

genes like me logo Genes that share disorders with FXYD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FXYD4 Gene

Publications for FXYD4 Gene

  1. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner KJ … Rael E (Genomics 2000) 2 3 4 22 58
  2. FXYD proteins as regulators of the Na,K-ATPase in the kidney. (PMID: 12763854) Sweadner KJ … Wetzel RK (Annals of the New York Academy of Sciences 2003) 2 3 22 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for FXYD4 Gene

Sources for FXYD4 Gene

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