Aliases for FUZ Gene
External Ids for FUZ Gene
Previous GeneCards Identifiers for FUZ Gene
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for FUZ Gene
FUZ (Fuzzy Planar Cell Polarity Protein) is a Protein Coding gene. Diseases associated with FUZ include Upper Thoracic Spina Bifida Cystica and Cervicothoracic Spina Bifida Cystica. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog.
UniProtKB/Swiss-Prot Summary for FUZ Gene
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).