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Aliases for FUT9 Gene

Aliases for FUT9 Gene

  • Fucosyltransferase 9 2 3 4 5
  • Fucosyltransferase 9 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Fucosyltransferase IX 3 4
  • FucT-IX 3 4
  • Fuc-TIX 3 4
  • Alpha-(1,3)-Fucosyltransferase 9 3
  • Alpha (1,3) Fucosyltransferase 2
  • EC 56
  • EC 2.4.1.- 4
  • EC 2.4.1 56

External Ids for FUT9 Gene

Previous GeneCards Identifiers for FUT9 Gene

  • GC06P096332
  • GC06P096480
  • GC06P096509
  • GC06P096570
  • GC06P096463
  • GC06P093896

Summaries for FUT9 Gene

Entrez Gene Summary for FUT9 Gene

  • The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]

GeneCards Summary for FUT9 Gene

FUT9 (Fucosyltransferase 9) is a Protein Coding gene. Diseases associated with FUT9 include Malaria. Among its related pathways are Globo Sphingolipid Metabolism and terminal O-glycans residues modification. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT4.

UniProtKB/Swiss-Prot for FUT9 Gene

  • Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.

Gene Wiki entry for FUT9 Gene

Additional gene information for FUT9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT9 Gene

Genomics for FUT9 Gene

GeneHancer (GH) Regulatory Elements for FUT9 Gene

Promoters and enhancers for FUT9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I096014 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -0.1 -127 1.8 ZNF202 GTF2F1 CTCF MXI1 E2F1 POLR2A MTA1 TARDBP PRDM10 ZNF444 FUT9 MANEA-AS1 FHL5 KRT18P50
GH06I096155 Enhancer 0.5 ENCODE 7.3 +140.6 140633 1.6 GATA3 ZNF680 ATF7 EBF1 PRDM1 FUT9 GC06P096208 LOC105377905
GH06I096185 Enhancer 0.4 dbSUPER 7.1 +170.8 170807 3.4 SP1 SRF CTBP1 FUT9 GC06P096208 LOC105377905
GH06I096162 Enhancer 0.4 ENCODE 7 +147.3 147347 1.8 SP1 POU5F1 FUT9 GC06P096208 LOC105377905
GH06I096168 Enhancer 0.2 FANTOM5 2.1 +152.8 152841 0.1 FUT9 GC06P096208 LOC105377905
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUT9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT9 gene promoter:

Genomic Locations for FUT9 Gene

Genomic Locations for FUT9 Gene
199,644 bases
Plus strand

Genomic View for FUT9 Gene

Genes around FUT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT9 Gene

Proteins for FUT9 Gene

  • Protein details for FUT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 9
    Protein Accession:
    Secondary Accessions:
    • Q5T0W4

    Protein attributes for FUT9 Gene

    359 amino acids
    Molecular mass:
    42071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT9 Gene

Selected DME Specific Peptides for FUT9 Gene


Post-translational modifications for FUT9 Gene

  • Glycosylation at posLast=6262, isoforms=101, and isoforms=153
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT9 Gene

Domains & Families for FUT9 Gene

Gene Families for FUT9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FUT9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 10 family.
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT9: view

Function for FUT9 Gene

Molecular function for FUT9 Gene

GENATLAS Biochemistry:
fucosyltransferase 9,alpha (1.3) fucosyltransferase,abundantly expressed in brain and stomach,also detected in spleen and peripheral blood leukocytes,mouse Fuc-TIX ortholog,catalyzing the last step of Lewis X synthesis
UniProtKB/Swiss-Prot Function:
Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.

Enzyme Numbers (IUBMB) for FUT9 Gene

Phenotypes From GWAS Catalog for FUT9 Gene

Gene Ontology (GO) - Molecular Function for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 10386598
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity IEA,TAS 11698403
genes like me logo Genes that share ontologies with FUT9: view
genes like me logo Genes that share phenotypes with FUT9: view

Animal Models for FUT9 Gene

MGI Knock Outs for FUT9:

Clone Products

  • Addgene plasmids for FUT9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT9 Gene

Localization for FUT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT9 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT9 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT9: view

Pathways & Interactions for FUT9 Gene

genes like me logo Genes that share pathways with FUT9: view

UniProtKB/Swiss-Prot Q9Y231-FUT9_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10386598
GO:0006486 protein glycosylation TAS 11698403
GO:0007399 nervous system development IEA --
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT9: view

No data available for SIGNOR curated interactions for FUT9 Gene

Drugs & Compounds for FUT9 Gene

(1) Drugs for FUT9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
  • Lacto-N-neo-tetraose
  • Lacto-N-neotetraose
  • Lacto-N-tetraose
  • LNnt
  • O-beta-D-Galactopyranosyl-(1->4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->3)-O-beta-D-galactopyranosyl-(1->4)- D-glucose
genes like me logo Genes that share compounds with FUT9: view

Transcripts for FUT9 Gene

mRNA/cDNA for FUT9 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT9 Gene

Fucosyltransferase 9 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Clone Products

  • Addgene plasmids for FUT9

Alternative Splicing Database (ASD) splice patterns (SP) for FUT9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: - -

Relevant External Links for FUT9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT9 Gene

This gene is overexpressed in Brain - Cerebellum (x8.0), Brain - Cerebellar Hemisphere (x6.5), Brain - Cortex (x4.5), and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for FUT9 Gene

This gene is overexpressed in Serum (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT9 Gene

Protein tissue co-expression partners for FUT9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUT9 Gene:


SOURCE GeneReport for Unigene cluster for FUT9 Gene:


mRNA Expression by UniProt/SwissProt for FUT9 Gene:

Tissue specificity: Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.

Evidence on tissue expression from TISSUES for FUT9 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with FUT9: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT9 Gene

Orthologs for FUT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUT9 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia FUT9 33 34
  • 94.71 (n)
(Bos Taurus)
Mammalia FUT9 33 34
  • 93.31 (n)
(Mus musculus)
Mammalia Fut9 33 16 34
  • 91.46 (n)
(Rattus norvegicus)
Mammalia Fut9 33
  • 91.27 (n)
(Ornithorhynchus anatinus)
Mammalia FUT9 34
  • 91 (a)
(Monodelphis domestica)
Mammalia FUT9 34
  • 90 (a)
(Gallus gallus)
Aves CFUC-TIX 34
  • 84 (a)
FUT9 33
  • 83.01 (n)
(Anolis carolinensis)
Reptilia FUT9 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut9 33
  • 75.77 (n)
(Danio rerio)
Actinopterygii fut9a 33 34
  • 62.11 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta FucTA 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea fut-4 34
  • 23 (a)
fut-5 34
  • 23 (a)
fut-6 34
  • 23 (a)
fut-3 34
  • 20 (a)
fut-1 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
-- 34
  • 31 (a)
-- 34
  • 27 (a)
Species where no ortholog for FUT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUT9 Gene

Gene Tree for FUT9 (if available)
Gene Tree for FUT9 (if available)

Paralogs for FUT9 Gene

Paralogs for FUT9 Gene

(5) SIMAP similar genes for FUT9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FUT9: view

Variants for FUT9 Gene

Sequence variations from dbSNP and Humsavar for FUT9 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000009473 -- 96,051,153(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000048345 -- 96,139,240(+) G/A intron_variant
rs1000050277 -- 96,146,557(+) A/G intron_variant
rs1000053107 -- 96,140,178(+) G/T intron_variant
rs1000078213 -- 96,098,987(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT9 Gene

Variant ID Type Subtype PubMed ID
esv1046648 CNV insertion 17803354
esv1667871 CNV insertion 17803354
esv2422431 CNV duplication 17116639
esv2669302 CNV deletion 23128226
esv2675747 CNV deletion 23128226
esv2732455 CNV deletion 23290073
esv2732456 CNV deletion 23290073
esv2732457 CNV deletion 23290073
esv2732458 CNV deletion 23290073
esv3356638 CNV insertion 20981092
esv3610064 CNV loss 21293372
esv3610068 CNV loss 21293372
esv3610070 CNV loss 21293372
nsv1027905 CNV gain 25217958
nsv1124105 CNV deletion 24896259
nsv1125883 CNV tandem duplication 24896259
nsv1132001 CNV deletion 24896259
nsv1139868 CNV duplication 24896259
nsv1153643 CNV deletion 26484159
nsv1161437 CNV deletion 26073780
nsv349387 CNV deletion 16902084
nsv349975 CNV deletion 16902084
nsv528247 CNV gain 19592680
nsv604248 CNV loss 21841781
nsv823781 CNV gain 20364138
nsv823782 CNV gain 20364138
nsv830738 CNV loss 17160897

Variation tolerance for FUT9 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT9 Gene

Disorders for FUT9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FUT9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search FUT9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUT9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT9 Gene

Publications for FUT9 Gene

  1. Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. (PMID: 10386598) Kaneko M … Narimatsu H (FEBS letters 1999) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization. (PMID: 18395013) Brito C … Costa J (Biochimie 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for FUT9 Gene

  • Addgene plasmids for FUT9

Sources for FUT9 Gene

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