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Aliases for FUT8 Gene

Aliases for FUT8 Gene

  • Fucosyltransferase 8 2 3 4 5
  • GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase 3 4
  • Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) 2 3
  • GDP-Fucose--Glycoprotein Fucosyltransferase 3 4
  • Glycoprotein 6-Alpha-L-Fucosyltransferase 3 4
  • Alpha1-6FucT 3 4
  • Alpha-(1,6)-Fucosyltransferase 3
  • Alpha (1,6) Fucosyltransferase 2
  • EC 4

External Ids for FUT8 Gene

Previous GeneCards Identifiers for FUT8 Gene

  • GC14P063206
  • GC14P059672
  • GC14P063867
  • GC14P064947
  • GC14P065877
  • GC14P046046

Summaries for FUT8 Gene

Entrez Gene Summary for FUT8 Gene

  • This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

GeneCards Summary for FUT8 Gene

FUT8 (Fucosyltransferase 8) is a Protein Coding gene. Diseases associated with FUT8 include Congenital Disorder Of Glycosylation With Defective Fucosylation and Pancreatic Acinar Cell Adenocarcinoma. Among its related pathways are N-Glycan biosynthesis and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.

UniProtKB/Swiss-Prot for FUT8 Gene

  • Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Gene Wiki entry for FUT8 Gene

Additional gene information for FUT8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT8 Gene

Genomics for FUT8 Gene

GeneHancer (GH) Regulatory Elements for FUT8 Gene

Promoters and enhancers for FUT8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J065410 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 654.8 +2.3 2338 4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 FUT8 FUT8-AS1 LOC102723809 ZBTB1 ZBTB25 YBX1P1 MIR625 RPL21P8 GC14M065468
GH14J065333 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.2 -74.5 -74463 5.2 HDGF CLOCK FOXA2 SIN3A STAT5A BATF IRF4 FOS ETV6 RCOR1 GC14M065336 MIR4708 FUT8 YBX1P1 LINC02324
GH14J065296 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 654.1 -109.1 -109081 9.4 HDGF PKNOX1 FOXA2 ARNT DMAP1 IRF4 TCF12 ATF7 RUNX3 SP5 FUT8 LINC02324 ZBTB25 GC14M065292 ENSG00000258760
GH14J065351 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 654.7 -55.9 -55863 6.8 PKNOX1 BATF RAD21 GLIS2 ELK1 ZNF366 RCOR1 ATF7 FOS BCLAF1 FUT8 LINC02324 GC14M065336 LOC105370537
GH14J065287 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.1 -122.5 -122539 2.4 HDGF STAT5A BATF RAD21 ZNF207 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 FUT8 PTBP1P GC14M065292 ENSG00000258760
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT8 gene promoter:
  • Egr-2
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • POU3F1

Genomic Locations for FUT8 Gene

Genomic Locations for FUT8 Gene
333,530 bases
Plus strand
333,530 bases
Plus strand

Genomic View for FUT8 Gene

Genes around FUT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT8 Gene

Proteins for FUT8 Gene

  • Protein details for FUT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DFS7
    • G3V5N0
    • O00235
    • Q8IUA5
    • Q9BYC6
    • Q9P2U5
    • Q9P2U6

    Protein attributes for FUT8 Gene

    575 amino acids
    Molecular mass:
    66516 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FUT8 Gene

    Alternative splice isoforms for FUT8 Gene


neXtProt entry for FUT8 Gene

Post-translational modifications for FUT8 Gene

No data available for DME Specific Peptides for FUT8 Gene

Domains & Families for FUT8 Gene

Gene Families for FUT8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FUT8 Gene

Suggested Antigen Peptide Sequences for FUT8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 23 family.
  • Belongs to the glycosyltransferase 23 family.
genes like me logo Genes that share domains with FUT8: view

Function for FUT8 Gene

Molecular function for FUT8 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.
GENATLAS Biochemistry:
fucosyltransferase,alpha (1,6),8,involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides

Enzyme Numbers (IUBMB) for FUT8 Gene

Phenotypes From GWAS Catalog for FUT8 Gene

Gene Ontology (GO) - Molecular Function for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity TAS 11698403
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with FUT8: view
genes like me logo Genes that share phenotypes with FUT8: view

Animal Models for FUT8 Gene

MGI Knock Outs for FUT8:

Animal Model Products

  • Taconic Biosciences Mouse Models for FUT8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT8

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT8 Gene

Localization for FUT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT8 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT8 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 5
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus NAS 11698403
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT8: view

Pathways & Interactions for FUT8 Gene

genes like me logo Genes that share pathways with FUT8: view

UniProtKB/Swiss-Prot Q9BYC5-FUT8_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development NAS 11698403
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation TAS 9133635
GO:0006491 N-glycan processing TAS 11698403
GO:0007179 transforming growth factor beta receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FUT8: view

No data available for SIGNOR curated interactions for FUT8 Gene

Drugs & Compounds for FUT8 Gene

(2) Drugs for FUT8 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
genes like me logo Genes that share compounds with FUT8: view

Transcripts for FUT8 Gene

mRNA/cDNA for FUT8 Gene

Unigene Clusters for FUT8 Gene

Fucosyltransferase 8 (alpha (1,6) fucosyltransferase):
Representative Sequences:

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP8: - - -

Relevant External Links for FUT8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUT8 Gene

This gene is overexpressed in Nasal epithelium (36.1), Breast (12.4), and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUT8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT8 Gene:


SOURCE GeneReport for Unigene cluster for FUT8 Gene:


Evidence on tissue expression from TISSUES for FUT8 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(3.3)
  • Pancreas(3.1)
  • Eye(2.7)
  • Stomach(2.5)
  • Skin(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with FUT8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT8 Gene

Orthologs for FUT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUT8 34 33
  • 99.83 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
-- 34
  • 85 (a)
(Canis familiaris)
Mammalia FUT8 34 33
  • 93.62 (n)
(Bos Taurus)
Mammalia FUT8 34 33
  • 93.57 (n)
(Ornithorhynchus anatinus)
Mammalia FUT8 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Fut8 33
  • 92.12 (n)
(Mus musculus)
Mammalia Fut8 16 34 33
  • 91.77 (n)
(Gallus gallus)
Aves FUT8 34 33
  • 83.48 (n)
(Anolis carolinensis)
Reptilia FUT8 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut8 33
  • 78.03 (n)
Str.230 33
African clawed frog
(Xenopus laevis)
Amphibia fut8-A 33
(Danio rerio)
Actinopterygii FUT8 (2 of 2) 34
  • 76 (a)
fut8a 34 33
  • 71.77 (n)
Dr.5303 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001888 33
  • 53.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta FucT6 34 35 33
  • 52.7 (n)
(Caenorhabditis elegans)
Secernentea fut-8 34 33
  • 50.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Cin.11077 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11077 33
Species where no ortholog for FUT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUT8 Gene

Gene Tree for FUT8 (if available)
Gene Tree for FUT8 (if available)
Evolutionary constrained regions (ECRs) for FUT8: view image

Paralogs for FUT8 Gene

No data available for Paralogs for FUT8 Gene

Variants for FUT8 Gene

Sequence variations from dbSNP and Humsavar for FUT8 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs2229677 benign, not specified 65,561,728(+) A/G coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, synonymous_variant
rs35137471 benign, not specified 65,629,579(+) G/A/T coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000008276 -- 65,450,947(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000009430 -- 65,568,488(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000017467 -- 65,710,603(+) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT8 Gene

Variant ID Type Subtype PubMed ID
esv1385928 CNV deletion 17803354
esv1713819 CNV deletion 17803354
esv2413773 CNV deletion 18987734
esv2659861 CNV deletion 23128226
esv2664690 CNV deletion 23128226
esv2672840 CNV deletion 23128226
esv2677649 CNV deletion 23128226
esv2748779 CNV deletion 23290073
esv2748793 CNV deletion 23290073
esv2748794 CNV deletion 23290073
esv2748795 CNV deletion 23290073
esv2748797 CNV deletion 23290073
esv2748798 CNV deletion 23290073
esv3434438 CNV insertion 20981092
esv3551673 CNV deletion 23714750
esv3551675 CNV deletion 23714750
esv3581230 CNV loss 25503493
esv3581231 CNV loss 25503493
esv3581232 CNV loss 25503493
esv3581233 CNV loss 25503493
esv3634773 CNV loss 21293372
esv3634775 CNV loss 21293372
esv3634776 CNV loss 21293372
nsv1148956 CNV deletion 26484159
nsv456327 CNV loss 19166990
nsv473029 CNV novel sequence insertion 20440878
nsv510639 CNV deletion 20534489
nsv517316 CNV loss 19592680
nsv564951 CNV loss 21841781
nsv7255 OTHER inversion 18451855
nsv832818 CNV gain 17160897
nsv832819 CNV gain 17160897
nsv958781 CNV deletion 24416366
nsv976347 CNV duplication 23825009

Variation tolerance for FUT8 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT8 Gene

Disorders for FUT8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT8 Gene - From: HGMD, OMIM, ClinVar, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search FUT8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUT8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT8 Gene

Publications for FUT8 Gene

  1. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. (PMID: 17172260) Ihara H … Taniguchi N (Glycobiology 2007) 3 4 22 58
  2. Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8). (PMID: 10814706) Yamaguchi Y … Taniguchi N (Glycobiology 2000) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation. (PMID: 21203500) Lauc G … Rudan I (PLoS genetics 2010) 3 44 58
  5. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. (PMID: 19508951) Takahashi M … Taniguchi N (Carbohydrate research 2009) 3 22 58

Products for FUT8 Gene

Sources for FUT8 Gene

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