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Aliases for FUT7 Gene

Aliases for FUT7 Gene

  • Fucosyltransferase 7 2 3 4 5
  • Fucosyltransferase 7 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Fucosyltransferase VII 3 4
  • Fuc-TVII 3 4
  • FucT-VII 3 4
  • Alpha-(1,3)-Fucosyltransferase 7 3
  • Alpha (1,3) Fucosyltransferase 2
  • Selectin-Ligand Synthase 3
  • Selectin Ligand Synthase 4
  • EC 2.4.1.- 4

External Ids for FUT7 Gene

Previous GeneCards Identifiers for FUT7 Gene

  • GC09P131057
  • GC09M131614
  • GC09M133365
  • GC09M135281
  • GC09M137200
  • GC09M139044
  • GC09M139924
  • GC09M109383

Summaries for FUT7 Gene

Entrez Gene Summary for FUT7 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT7 Gene

FUT7 (Fucosyltransferase 7) is a Protein Coding gene. Diseases associated with FUT7 include Ehrlichiosis and Human Granulocytic Anaplasmosis. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT4.

UniProtKB/Swiss-Prot for FUT7 Gene

  • Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.

Gene Wiki entry for FUT7 Gene

Additional gene information for FUT7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT7 Gene

Genomics for FUT7 Gene

GeneHancer (GH) Regulatory Elements for FUT7 Gene

Promoters and enhancers for FUT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137025 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 665.5 +2.4 2421 10.8 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B IRF4 YY1 FUT7 ABCA2 SNHG7 EHMT1 SEC16A ENTR1 DPH7 ANAPC2 NDOR1 MAN1B1-DT
GH09J136653 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 +370.6 370589 17.1 HDGF HNRNPUL1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GLIS2 GATA2 EGFL7 HSPC324 GC09M136660 DPH7 ANAPC2 EHMT1 AGPAT2 SNHG7 EXD3 MAN1B1
GH09J137042 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 6.7 -12.0 -12043 4.5 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 KLF13 DEK NPDC1 UAP1L1 MAN1B1 FUT7 ENSG00000279073
GH09J136613 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.4 +412.1 412148 14.5 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 FOS DEK NOTCH1 FUT7 EGFL7 SEC16A ABCA2 CARD9 UAP1L1 LINC01451 LOC105376325
GH09J136537 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.3 +489.7 489724 10.7 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 NOTCH1 ENSG00000227512 INPP5E ANAPC2 NALT1 SEC16A ENTR1 C9orf163 SNHG7 SNAPC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT7 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • GATA-3
  • GATA-2
  • GATA-1
  • Sp1
  • deltaCREB

Genomic Locations for FUT7 Gene

Genomic Locations for FUT7 Gene
chr9:137,030,174-137,033,010
(GRCh38/hg38)
Size:
2,837 bases
Orientation:
Minus strand
chr9:139,924,626-139,927,462
(GRCh37/hg19)
Size:
2,837 bases
Orientation:
Minus strand

Genomic View for FUT7 Gene

Genes around FUT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT7 Gene

Proteins for FUT7 Gene

  • Protein details for FUT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11130-FUT7_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 7
    Protein Accession:
    Q11130
    Secondary Accessions:
    • B2R7U7
    • Q6DK54

    Protein attributes for FUT7 Gene

    Size:
    342 amino acids
    Molecular mass:
    39239 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT7 Gene

Post-translational modifications for FUT7 Gene

  • Glycosylation at isoforms=291 and Asn81
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FUT7 Gene

Domains & Families for FUT7 Gene

Gene Families for FUT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUT7 Gene

Suggested Antigen Peptide Sequences for FUT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q11130

UniProtKB/Swiss-Prot:

FUT7_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT7: view

Function for FUT7 Gene

Molecular function for FUT7 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 uM for GDP-fucose {ECO:0000269 PubMed:11404359};
GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),7 (FucT-VII),leukocyte,catalyzing in sialyl-Lewis X synthesis

Enzyme Numbers (IUBMB) for FUT7 Gene

Phenotypes From GWAS Catalog for FUT7 Gene

Gene Ontology (GO) - Molecular Function for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 9299472
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT7: view
genes like me logo Genes that share phenotypes with FUT7: view

Animal Models for FUT7 Gene

MGI Knock Outs for FUT7:

Animal Model Products

CRISPR Products

miRNA for FUT7 Gene

miRTarBase miRNAs that target FUT7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT7

Clone Products

  • R&D Systems cDNA Clones for FUT7 (Fucosyltransferase 7/FUT7)

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT7 Gene

Localization for FUT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT7 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT7 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane HDA 19946888
GO:0016021 integral component of membrane IEA,TAS --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT7: view

Pathways & Interactions for FUT7 Gene

genes like me logo Genes that share pathways with FUT7: view

Pathways by source for FUT7 Gene

UniProtKB/Swiss-Prot Q11130-FUT7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA --
GO:0002522 leukocyte migration involved in immune response IEA --
GO:0006486 protein glycosylation TAS 11698403
GO:0006672 ceramide metabolic process IDA 9299472
GO:0036065 fucosylation IEA --
genes like me logo Genes that share ontologies with FUT7: view

No data available for SIGNOR curated interactions for FUT7 Gene

Drugs & Compounds for FUT7 Gene

(2) Drugs for FUT7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(8) Additional Compounds for FUT7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT7: view

Transcripts for FUT7 Gene

mRNA/cDNA for FUT7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT7 Gene

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT7

Clone Products

  • R&D Systems cDNA Clones for FUT7 (Fucosyltransferase 7/FUT7)

Alternative Splicing Database (ASD) splice patterns (SP) for FUT7 Gene

No ASD Table

Relevant External Links for FUT7 Gene

GeneLoc Exon Structure for
FUT7
ECgene alternative splicing isoforms for
FUT7

Expression for FUT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT7 Gene

This gene is overexpressed in Whole Blood (x45.3).

Protein differential expression in normal tissues from HIPED for FUT7 Gene

This gene is overexpressed in Spleen (45.3) and Adipocyte (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT7 Gene



Protein tissue co-expression partners for FUT7 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT7 Gene:

FUT7

SOURCE GeneReport for Unigene cluster for FUT7 Gene:

Hs.457

mRNA Expression by UniProt/SwissProt for FUT7 Gene:

Q11130-FUT7_HUMAN
Tissue specificity: Leukocytic/myeloid lineage cells.

Evidence on tissue expression from TISSUES for FUT7 Gene

  • Blood(4.4)
  • Lung(4)
genes like me logo Genes that share expression patterns with FUT7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT7 Gene

Orthologs for FUT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUT7 34 33
  • 83.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FUT7 34 33
  • 80.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut7 33
  • 79.63 (n)
mouse
(Mus musculus)
Mammalia Fut7 16 34 33
  • 78.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FUT7 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUT7 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT7 33
  • 62.26 (n)
CFTII 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut7 33
  • 60.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333727 33
  • 53.01 (n)
Species where no ortholog for FUT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT7 Gene

ENSEMBL:
Gene Tree for FUT7 (if available)
TreeFam:
Gene Tree for FUT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUT7: view image

Paralogs for FUT7 Gene

Paralogs for FUT7 Gene

(5) SIMAP similar genes for FUT7 Gene using alignment to 1 proteins:

  • FUT7_HUMAN
genes like me logo Genes that share paralogs with FUT7: view

Variants for FUT7 Gene

Sequence variations from dbSNP and Humsavar for FUT7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000227654 -- 137,032,851(-) T/C upstream_transcript_variant
rs1000324 -- 137,033,913(-) G/A upstream_transcript_variant
rs1000940518 -- 137,030,164(-) A/G downstream_transcript_variant
rs1001032959 -- 137,033,121(-) G/A upstream_transcript_variant
rs1002308186 -- 137,032,670(-) C/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT7 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616004 CNV loss 21841781
nsv951206 CNV deletion 24416366

Variation tolerance for FUT7 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT7 Gene

Human Gene Mutation Database (HGMD)
FUT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT7 Gene

Disorders for FUT7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUT7 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ehrlichiosis
  • human ehrlichiosis
human granulocytic anaplasmosis
  • hge
- elite association - COSMIC cancer census association via MalaCards
Search FUT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT7 Gene

Publications for FUT7 Gene

  1. Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. (PMID: 8182079) Sasaki K … Nishi T (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. (PMID: 8207002) Natsuka S … Lowe JB (The Journal of biological chemistry 1994) 2 3 4 22 58
  3. Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures. (PMID: 11425803) de Vries T … Macher BA (Glycobiology 2001) 3 4 22 58
  4. Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene. (PMID: 11404359) Bengtson P … Påhlsson P (The Journal of biological chemistry 2001) 3 4 22 58
  5. Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII. (PMID: 9299472) Stroud MR … Holmes EH (Biochemical and biophysical research communications 1997) 3 4 22 58

Products for FUT7 Gene

Sources for FUT7 Gene

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