Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Alpha-(1,3)-Fucosyltransferase 5 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase V 3 4
  • EC 2.4.1.65 4 54
  • FucT-V 3 4
  • EC 2.4.1 54
  • FUC-TV 3
  • Fuc-TV 4

External Ids for FUT5 Gene

Previous GeneCards Identifiers for FUT5 Gene

  • GC19M005957
  • GC19M005805
  • GC19M005816
  • GC19M005625

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT3.

UniProtKB/Swiss-Prot Summary for FUT5 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Gene Wiki entry for FUT5 Gene

Additional gene information for FUT5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

GeneHancer (GH) Regulatory Elements for FUT5 Gene

Promoters and enhancers for FUT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J005956 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 19.5 -92.7 -92712 13.9 CTCF FOXA1 MLX RBPJ NR2F6 ATF1 MIXL1 NFYC ZNF701 RBM39 VMAC ENSG00000267571 CAPS DUS3L NDUFA11 GPR108 FUT5 ACSBG2 SAFB KDM4B
GH19J006215 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -349.6 -349616 9.1 CTCF LCORL CC2D1A RAD21 HDGF MNT NFIB SP1 ZNF148 AHR ACSBG2 RFX2 NDUFA11 VMAC FUT5 SLC25A23 lnc-MLLT1-2 ENSG00000267563 MLLT1
GH19J005945 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 15.1 -80.5 -80517 10.3 LCORL FOXA1 RBPJ TCF7L2 MIXL1 L3MBTL2 RAD21 ZNF121 MNT NFIB NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 LOC100128568 RANBP3
GH19J005803 Promoter/Enhancer 1.7 ENCODE CraniofacialAtlas dbSUPER 11.5 +65.6 65565 3.2 CTCF FOXA1 ZBTB6 RBPJ MIXL1 CC2D1A L3MBTL2 MAX RAD21 DACH1 NRTN lnc-DUS3L-1 DUS3L KHSRP SAFB SAFB2 GTF2F1 HSD11B1L RANBP3 PTPRS
GH19J005826 Promoter/Enhancer 1.8 ENCODE CraniofacialAtlas dbSUPER 11.2 +42.4 42408 3.7 SIN3A ZBTB40 CTCF LCORL FOXA1 MLX RBPJ SMARCE1 POLR2A NR2F6 KHSRP DUS3L VMAC ENSG00000267571 SAFB2 RANBP3 SAFB GTF2F1 PTPRS GPR108
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT5 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • E2F
  • NRSF form 1
  • NRSF form 2

Genomic Locations for FUT5 Gene

Genomic Locations for FUT5 Gene
chr19:5,865,826-5,870,540
(GRCh38/hg38)
Size:
4,715 bases
Orientation:
Minus strand
chr19:5,865,837-5,903,798
(GRCh37/hg19)
Size:
37,962 bases
Orientation:
Minus strand

Genomic View for FUT5 Gene

Genes around FUT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11128-FUT5_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5
    Protein Accession:
    Q11128
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    Size:
    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Selected DME Specific Peptides for FUT5 Gene

Q11128:
  • APNGSRCQDS
  • FYLAFENS
  • HPPLNLSAKTELVAWAVSNW
  • ALPRCSEM
  • SARVRYYQSL
  • QGQRWIWF
  • CFFSYLR
  • VIVHHWDIM
  • PYGWLEPW
  • VYPQADAVIVHH
  • GTMMETLSRYKFYLAFENS
  • VPVVLGP
  • AHLKVDVYG
  • RCSEMVPG
  • DFQSPKDLA
  • ADCNITA
  • DYITEKLW
  • FCKACWKLQ
  • WFSMESPSNC
  • FIHVDDF

Post-translational modifications for FUT5 Gene

  • Glycosylation at Asn60, Asn105, Asn167, and Asn198
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT5 Gene

Gene Families for FUT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for FUT5 Gene

Suggested Antigen Peptide Sequences for FUT5 Gene

GenScript: Design optimal peptide antigens:
  • Galactoside 3-L-fucosyltransferase (FUT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q11128

UniProtKB/Swiss-Prot:

FUT5_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:23628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133506, ChEBI:CHEBI:140304; EC=2.4.1.65;.
GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma

Enzyme Numbers (IUBMB) for FUT5 Gene

Phenotypes From GWAS Catalog for FUT5 Gene

Gene Ontology (GO) - Molecular Function for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 7721776
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT5: view
genes like me logo Genes that share phenotypes with FUT5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
lysosome 0

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FUT5 Gene

Pathways & Interactions for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1339443
GO:0006486 protein glycosylation TAS 11698403
GO:0006672 ceramide metabolic process IDA 7721776
GO:0036065 fucosylation IBA 21873635
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT5: view

No data available for SIGNOR curated interactions for FUT5 Gene

Drugs & Compounds for FUT5 Gene

(1) Drugs for FUT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
FUT5
ECgene alternative splicing isoforms for
FUT5

Expression for FUT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT5 Gene

Protein differential expression in normal tissues from HIPED for FUT5 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUT5 Gene



Protein tissue co-expression partners for FUT5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT5 Gene:

FUT5

SOURCE GeneReport for Unigene cluster for FUT5 Gene:

Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene:

Q11128-FUT5_HUMAN
Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain.

Evidence on tissue expression from TISSUES for FUT5 Gene

  • Kidney(4.3)
  • Blood(4.2)
  • Intestine(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with FUT5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT5 Gene

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT5 33 32
  • 98.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 33
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 33 33
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 55 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
-- 33
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 33
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 32
  • 52.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta FucTA 34
  • 35 (a)
FucTC 34 32
  • 26 (n)
Species where no ortholog for FUT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT5 Gene

ENSEMBL:
Gene Tree for FUT5 (if available)
TreeFam:
Gene Tree for FUT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUT5: view image

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

(5) SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

  • FUT5_HUMAN
  • K7ENC0_HUMAN
genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations from dbSNP and Humsavar for FUT5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000155249 -- 5,868,738(-) G/A intron_variant
rs1000561991 -- 5,870,841(-) C/T upstream_transcript_variant
rs1000579951 -- 5,870,558(-) C/A/T upstream_transcript_variant
rs1000678743 -- 5,872,006(-) A/C upstream_transcript_variant
rs1000746825 -- 5,869,657(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv482210 CNV gain 20164927

Variation tolerance for FUT5 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.97; 94.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT5 Gene

Disorders for FUT5 Gene

Additional Disease Information for FUT5

No disorders were found for FUT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT5 Gene

Publications for FUT5 Gene

  1. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron HS … Weston BW (The Journal of biological chemistry 1995) 3 4 23 56
  2. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PMID: 1740457) Weston BW … Lowe JB (The Journal of biological chemistry 1992) 2 3 4 56
  3. Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain. (PMID: 17604274) Shetterly S … Holmes EH (The Journal of biological chemistry 2007) 3 23 56
  4. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PMID: 17148576) Chiu PC … Yeung WS (Journal of cell science 2007) 3 23 56
  5. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PMID: 10622713) Nishihara S … Narimatsu H (FEBS letters 1999) 3 23 56

Products for FUT5 Gene

Sources for FUT5 Gene