Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase V 3 4
  • EC 2.4.1.65 4 51
  • FUC-TV 2 3
  • FucT-V 3 4
  • 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase FUT5 4
  • 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT5 4
  • Alpha-(1,3)-Fucosyltransferase 5 3
  • EC 2.4.1.152 4
  • EC 2.4.1 51
  • Fuc-TV 4
  • FUT5 5

External Ids for FUT5 Gene

Previous GeneCards Identifiers for FUT5 Gene

  • GC19M005957
  • GC19M005805
  • GC19M005816
  • GC19M005625

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5) is a Protein Coding gene. Diseases associated with FUT5 include Gastrointestinal Carcinoma and Dowling-Degos Disease. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT3.

UniProtKB/Swiss-Prot Summary for FUT5 Gene

  • Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosacccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates to the surface espression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274, PubMed:9737989). Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate (PubMed:7721776, PubMed:17604274). Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosacccharide via an alpha (1,4) linkage (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274). Preferentially catalyzes sialylated type 2 oligosacccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosacccharide acceptors (PubMed:1740457, PubMed:9737989). Lactose-based structures are also acceptor substrates (PubMed:1740457, PubMed:7721776).

Gene Wiki entry for FUT5 Gene

Additional gene information for FUT5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FUT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J005956 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 19.5 -92.7 -92712 13.9 HNRNPL GATAD2A CTCF ZBTB33 ZNF629 PRDM10 TFE3 ZNF512 IKZF1 NFKBIZ VMAC ENSG00000267571 CAPS DUS3L NDUFA11 GPR108 FUT5 ACSBG2 SAFB KDM4B
GH19J006215 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -349.6 -349616 9.1 HNRNPL CTCF TEAD4 RFX1 ZNF692 LARP7 ZNF143 ZIC2 POLR2A PATZ1 ACSBG2 RFX2 NDUFA11 VMAC FUT5 SLC25A23 lnc-MLLT1-2 ENSG00000267563 MLLT1
GH19J005945 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 15.1 -80.5 -80517 10.3 HNRNPL GATAD2A REST TFE3 NFKBIZ RCOR2 FOXA1 PRDM1 ZIC2 PKNOX1 NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 LOC100128568 RANBP3
GH19J005803 Promoter/Enhancer 1.7 ENCODE CraniofacialAtlas dbSUPER 11.5 +65.6 65565 3.2 RNF2 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 IKZF1 ZNF692 RCOR2 NRTN lnc-DUS3L-1 DUS3L KHSRP SAFB SAFB2 GTF2F1 CATSPERD LONP1 FUT6
GH19J005826 Promoter/Enhancer 1.8 ENCODE CraniofacialAtlas dbSUPER 11.2 +42.4 42408 3.7 BRCA1 ARHGAP35 HNRNPL GATAD2A PRDM10 ZNF629 TFE3 LEF1 SOX13 IKZF1 DUS3L ENSG00000267571 VMAC KHSRP SNRPEP4 NDUFA11 PTPRS RANBP3 PRR22 SAFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUT5

Top Transcription factor binding sites by QIAGEN in the FUT5 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • E2F
  • NRSF form 1
  • NRSF form 2

Genomic Locations for FUT5 Gene

Genomic Locations for FUT5 Gene
chr19:5,865,826-5,870,540
(GRCh38/hg38)
Size:
4,715 bases
Orientation:
Minus strand
chr19:5,865,837-5,903,798
(GRCh37/hg19)
Size:
37,962 bases
Orientation:
Minus strand

Genomic View for FUT5 Gene

Genes around FUT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11128-FUT5_HUMAN
    Recommended name:
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
    Protein Accession:
    Q11128
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    Size:
    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Selected DME Specific Peptides for FUT5 Gene

Q11128:
  • APNGSRCQDS
  • FYLAFENS
  • HPPLNLSAKTELVAWAVSNW
  • ALPRCSEM
  • SARVRYYQSL
  • QGQRWIWF
  • CFFSYLR
  • VIVHHWDIM
  • PYGWLEPW
  • VYPQADAVIVHH
  • GTMMETLSRYKFYLAFENS
  • VPVVLGP
  • AHLKVDVYG
  • RCSEMVPG
  • DFQSPKDLA
  • ADCNITA
  • DYITEKLW
  • FCKACWKLQ
  • WFSMESPSNC
  • FIHVDDF

Post-translational modifications for FUT5 Gene

  • Glycosylation at Asn60, Asn105, Asn167, and Asn198
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT5 Gene

Gene Families for FUT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for FUT5 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 10
ProtoNet:

Suggested Antigen Peptide Sequences for FUT5 Gene

GenScript: Design optimal peptide antigens:
  • Galactoside 3-L-fucosyltransferase (FUT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q11128

UniProtKB/Swiss-Prot:

FUT5_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes preferentially the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosacccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage and participates to the surface espression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274, PubMed:9737989). Preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate (PubMed:7721776, PubMed:17604274). Also catalyzes to a lesser extend the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosacccharide via an alpha (1,4) linkage (PubMed:14718375, PubMed:1740457, PubMed:7721776, PubMed:9737988, PubMed:17604274). Preferentially catalyzes sialylated type 2 oligosacccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosacccharide acceptors (PubMed:1740457, PubMed:9737989). Lactose-based structures are also acceptor substrates (PubMed:1740457, PubMed:7721776).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:23628, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133506, ChEBI:CHEBI:140304; EC=2.4.1.65; Evidence={ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+); Xref=Rhea:RHEA:14257, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:137941; EC=2.4.1.152; Evidence={ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48376, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90379; Evidence={ECO:0000269|PubMed:7721776, ECO:0000269|PubMed:9737988};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48364, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90357, ChEBI:CHEBI:90358; Evidence={ECO:0000269|PubMed:17604274, ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48336, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:61610, ChEBI:CHEBI:90307; Evidence={ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48332, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:77240; Evidence={ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide; Xref=Rhea:RHEA:48352, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90335, ChEBI:CHEBI:90339; Evidence={ECO:0000269|PubMed:17604274, ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+); Xref=Rhea:RHEA:62824, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:60152, ChEBI:CHEBI:62287; Evidence={ECO:0000269|PubMed:1740457, ECO:0000269|PubMed:7721776, ECO:0000269|PubMed:9737988, ECO:0000269|PubMed:9737989};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine; Xref=Rhea:RHEA:62836, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:145937, ChEBI:CHEBI:145938; Evidence={ECO:0000269|PubMed:1740457, ECO:0000269|PubMed:7721776, ECO:0000269|PubMed:9737989};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+); Xref=Rhea:RHEA:62900, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:62263, ChEBI:CHEBI:62507; Evidence={ECO:0000269|PubMed:9737989};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:62904, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:146021, ChEBI:CHEBI:146022; Evidence={ECO:0000269|PubMed:7721776};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=38 uM for GDP-fucose {ECO:0000269|PubMed:14718375}; KM=1.1 uM for alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc-sp-biotin {ECO:0000269|PubMed:14718375}; KM=18.8 uM for GDP-fucose {ECO:0000269|PubMed:9737989}; KM=60 mM for beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine {ECO:0000269|PubMed:9737988}; KM=3.4 mM for beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine {ECO:0000269|PubMed:9737988}; Vmax=1 nmol/h/mg enzyme toward GDP-fucose {ECO:0000269|PubMed:14718375}; Vmax=38 nmol/h/mg enzyme toward alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc-sp-biotin {ECO:0000269|PubMed:14718375}; Note=kcat is 1.70 min(-1) for the alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc (PubMed:9737989). kcat is 9.3 min(-1) for the beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine (PubMed:9737988). {ECO:0000269|PubMed:9737988, ECO:0000269|PubMed:9737989};
GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma

Enzyme Numbers (IUBMB) for FUT5 Gene

Phenotypes From GWAS Catalog for FUT5 Gene

Gene Ontology (GO) - Molecular Function for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 7721776
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA,IDA 1740457
GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity IDA 1740457
genes like me logo Genes that share ontologies with FUT5: view
genes like me logo Genes that share phenotypes with FUT5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
plasma membrane 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FUT5 Gene

Pathways & Interactions for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1339443
GO:0006486 protein glycosylation TAS 11698403
GO:0006672 ceramide metabolic process IDA 7721776
GO:0009311 oligosaccharide metabolic process IDA 1740457
GO:0036065 fucosylation IBA 21873635
genes like me logo Genes that share ontologies with FUT5: view

No data available for SIGNOR curated interactions for FUT5 Gene

Drugs & Compounds for FUT5 Gene

(1) Drugs for FUT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT5

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
FUT5

Expression for FUT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUT5 Gene

Protein differential expression in normal tissues from HIPED for FUT5 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUT5 Gene



Protein tissue co-expression partners for FUT5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUT5

SOURCE GeneReport for Unigene cluster for FUT5 Gene:

Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene:

Q11128-FUT5_HUMAN
Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain.

Evidence on tissue expression from TISSUES for FUT5 Gene

  • Kidney(4.3)
  • Intestine(4.3)
  • Blood(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FUT5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT5 Gene

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FUT5 30 31
  • 98.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 68 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia FUT5 31 31
  • 67 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 46 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 45 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 30
  • 52.95 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta FucTA 32
  • 35 (a)
FucTC 30 32
  • 26 (n)
Species where no ortholog for FUT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FUT5 Gene

ENSEMBL:
Gene Tree for FUT5 (if available)
TreeFam:
Gene Tree for FUT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUT5: view image

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

(5) SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

  • FUT5_HUMAN
  • K7ENC0_HUMAN
genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUT5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
768957 Benign: not provided 5,866,725(-) T/C MISSENSE_VARIANT
769446 Benign: not provided 5,866,713(-) G/A MISSENSE_VARIANT
rs4807054 - p.Thr338Met
rs778970 - p.Pro187Leu

Additional dbSNP identifiers (rs#s) for FUT5 Gene

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv482210 CNV gain 20164927

Variation tolerance for FUT5 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.97; 94.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT5 Gene

Disorders for FUT5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUT5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal carcinoma
  • gastrointestinal neoplasms
dowling-degos disease
  • ddd
- elite association - COSMIC cancer census association via MalaCards
Search FUT5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT5

genes like me logo Genes that share disorders with FUT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT5 Gene

Publications for FUT5 Gene

  1. Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain. (PMID: 17604274) Shetterly S … Holmes EH (The Journal of biological chemistry 2007) 3 4 23
  2. Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain. (PMID: 14718375) Dupuy F … Maftah A (Glycobiology 2004) 3 4 23
  3. Acceptor specificity of different length constructs of human recombinant alpha 1,3/4-fucosyltransferases. Replacement of the stem region and the transmembrane domain of fucosyltransferase V by protein A results in an enzyme with GDP-fucose hydrolyzing activity. (PMID: 7721776) de Vries T … Macher BA (The Journal of biological chemistry 1995) 3 4 23
  4. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron HS … Weston BW (The Journal of biological chemistry 1995) 3 4 23
  5. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PMID: 1740457) Weston BW … Lowe JB (The Journal of biological chemistry 1992) 2 3 4

Products for FUT5 Gene

Sources for FUT5 Gene