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Aliases for FUT4 Gene

Aliases for FUT4 Gene

  • Fucosyltransferase 4 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Alpha (1,3) Fucosyltransferase, Myeloid-Specific 2 3
  • ELAM-1 Ligand Fucosyltransferase 3 4
  • ELAM Ligand Fucosyltransferase 2 3
  • Fucosyltransferase IV 3 4
  • FUC-TIV 3 4
  • FucT-IV 3 4
  • FCT3A 3 4
  • ELFT 3 4
  • Stage-Specific Embryonic Antigen 1 3
  • Alpha-(1,3)-Fucosyltransferase 4 3
  • EC 2.4.1.65 56
  • EC 2.4.1.- 4
  • EC 2.4.1 56
  • Lewis X 3
  • SSEA-1 3
  • FUTIV 3
  • CD15 3
  • LeX 3

External Ids for FUT4 Gene

Previous HGNC Symbols for FUT4 Gene

  • CD15
  • FCT3A
  • ELFT

Previous GeneCards Identifiers for FUT4 Gene

  • GC11P096607
  • GC11P095784
  • GC11P094461
  • GC11P093965
  • GC11P093916
  • GC11P094277
  • GC11P090342

Summaries for FUT4 Gene

Entrez Gene Summary for FUT4 Gene

  • The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]

GeneCards Summary for FUT4 Gene

FUT4 (Fucosyltransferase 4) is a Protein Coding gene. Diseases associated with FUT4 include Colon Adenocarcinoma and Liver Lymphoma. Among its related pathways are Mannose type O-glycan biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT7.

UniProtKB/Swiss-Prot for FUT4 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Additional gene information for FUT4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT4 Gene

Genomics for FUT4 Gene

GeneHancer (GH) Regulatory Elements for FUT4 Gene

Promoters and enhancers for FUT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I094542 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 556.4 +2.4 2402 6.8 HDGF SIN3A DMAP1 ZNF2 POLR2B ZNF213 ZNF207 ZNF143 KLF13 SP3 FUT4 GC11P094548 PIR62201 GC11M094542 MED17 CEP295 MRE11 ANKRD49 SNORA1 ENSG00000255666
GH11I094544 Enhancer 0.2 dbSUPER 550.8 -1.9 -1864 0.3 PIWIL4 FUT4 MRE11 C11orf97
GH11I094601 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +59.2 59205 2.2 PKNOX1 SMAD1 RB1 BMI1 FEZF1 BATF KLF5 BRCA1 RAD21 YY1 LOC105369438 PIWIL4 FUT4 ENSG00000255893 MRE11 PANX1 ANKRD49 LOC105369436 GC11M094556
GH11I095364 Enhancer 0.8 ENCODE 10.1 +820.8 820774 0.6 ELF3 FOXA2 RAD21 YY1 FOS CREM THAP11 RXRA REST KAT8 MRE11 ANKRD49 FAM76B SESN3 MAML2 LOC101929295 FUT4 GC11M095337 LOC105369439
GH11I094237 Enhancer 0.8 ENCODE 10.1 -306.0 -306010 0.1 ZNF473 ZNF195 BRCA1 GLIS2 HSF1 ZNF416 ZNF350 MCM3 ZNF114 YY2 CEP295 MED17 MRE11 ANKRD49 SNORA1 BUD13P1 ENSG00000270578 KDM4D ENSG00000255893 FUT4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT4 gene promoter:

Genomic Locations for FUT4 Gene

Genomic Locations for FUT4 Gene
chr11:94,543,840-94,549,898
(GRCh38/hg38)
Size:
6,059 bases
Orientation:
Plus strand
chr11:94,277,017-94,283,064
(GRCh37/hg19)

Genomic View for FUT4 Gene

Genes around FUT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT4 Gene

Proteins for FUT4 Gene

  • Protein details for FUT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22083-FUT4_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 4
    Protein Accession:
    P22083
    Secondary Accessions:
    • B2RMS0

    Protein attributes for FUT4 Gene

    Size:
    530 amino acids
    Molecular mass:
    59084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB20349.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305};

neXtProt entry for FUT4 Gene

Selected DME Specific Peptides for FUT4 Gene

P22083:
  • FYLAFENS
  • RFNISGC
  • DWPPPWG
  • VLLWWEPF
  • LGPDRANYE
  • AVHITSFWDE
  • VPVVLGP
  • QLPPLPWASP
  • DYITEKLW
  • FIHVDDF

Post-translational modifications for FUT4 Gene

  • Glycosylation at isoforms=216 and isoforms=315

Other Protein References for FUT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT4 Gene

Gene Families for FUT4 Gene

Protein Domains for FUT4 Gene

Suggested Antigen Peptide Sequences for FUT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22083

UniProtKB/Swiss-Prot:

FUT4_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT4: view

Function for FUT4 Gene

Molecular function for FUT4 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),4,(FucT-IV),myeloid;same as CD15
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Enzyme Numbers (IUBMB) for FUT4 Gene

Phenotypes From GWAS Catalog for FUT4 Gene

Gene Ontology (GO) - Molecular Function for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1716630
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT4: view
genes like me logo Genes that share phenotypes with FUT4: view

Animal Models for FUT4 Gene

MGI Knock Outs for FUT4:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT4 Gene

Localization for FUT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
lysosome 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 1716630
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT4: view

Pathways & Interactions for FUT4 Gene

genes like me logo Genes that share pathways with FUT4: view

Pathways by source for FUT4 Gene

UniProtKB/Swiss-Prot P22083-FUT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1716630
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT4: view

No data available for SIGNOR curated interactions for FUT4 Gene

Drugs & Compounds for FUT4 Gene

(3) Drugs for FUT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for FUT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FUT4: view

Transcripts for FUT4 Gene

mRNA/cDNA for FUT4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT4 Gene

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT4 Gene

No ASD Table

Relevant External Links for FUT4 Gene

GeneLoc Exon Structure for
FUT4
ECgene alternative splicing isoforms for
FUT4

Expression for FUT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT4 Gene

Protein differential expression in normal tissues from HIPED for FUT4 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUT4 Gene



Protein tissue co-expression partners for FUT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT4 Gene:

FUT4

SOURCE GeneReport for Unigene cluster for FUT4 Gene:

Hs.390420

Evidence on tissue expression from TISSUES for FUT4 Gene

  • Blood(4.6)
  • Bone marrow(3.4)
  • Lymph node(2.7)
  • Spleen(2.4)
  • Nervous system(2.4)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with FUT4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT4 Gene

Orthologs for FUT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT4 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia FUT4 34
  • 89 (a)
OneToOne
LOC100682680 33
  • 85.53 (n)
cow
(Bos Taurus)
Mammalia FUT4 33 34
  • 82.74 (n)
rat
(Rattus norvegicus)
Mammalia Fut4 33
  • 78.12 (n)
mouse
(Mus musculus)
Mammalia Fut4 33 16 34
  • 77.25 (n)
oppossum
(Monodelphis domestica)
Mammalia FUT4 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT4 33 34
  • 69.6 (n)
lizard
(Anolis carolinensis)
Reptilia FUT4 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut4 33
  • 58.31 (n)
Species where no ortholog for FUT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT4 Gene

ENSEMBL:
Gene Tree for FUT4 (if available)
TreeFam:
Gene Tree for FUT4 (if available)

Paralogs for FUT4 Gene

Paralogs for FUT4 Gene

(5) SIMAP similar genes for FUT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT4: view

Variants for FUT4 Gene

Sequence variations from dbSNP and Humsavar for FUT4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000023336 -- 94,542,140(+) T/C upstream_transcript_variant
rs1000694446 -- 94,544,104(+) G/A 5_prime_UTR_variant
rs1000879031 -- 94,546,404(+) A/C 3_prime_UTR_variant
rs1000907456 -- 94,544,314(+) G/A coding_sequence_variant, missense_variant
rs1001172907 -- 94,542,803(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT4 Gene

Variant ID Type Subtype PubMed ID
nsv951059 CNV duplication 24416366
esv3580028 CNV gain 25503493
esv2671948 CNV deletion 23128226

Variation tolerance for FUT4 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT4 Gene

Disorders for FUT4 Gene

MalaCards: The human disease database

(31) MalaCards diseases for FUT4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colon adenocarcinoma
  • adenocarcinoma of colon
liver lymphoma
  • lymphoma of liver
sternum cancer
  • malignant sternal neoplasm
malignant ovarian cyst
adult xanthogranuloma
- elite association - COSMIC cancer census association via MalaCards
Search FUT4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT4

genes like me logo Genes that share disorders with FUT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT4 Gene

Publications for FUT4 Gene

  1. ELFT: a gene that directs the expression of an ELAM-1 ligand. (PMID: 1702034) Goelz SE … Lobb R (Cell 1990) 2 3 4 22 58
  2. Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis. (PMID: 17409497) Azuma Y … Matsumoto K (Biological & pharmaceutical bulletin 2007) 3 22 58
  3. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. (PMID: 15182935) Azuma Y … Matsumoto K (Biochimica et biophysica acta 2004) 3 22 58
  4. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line. (PMID: 11006292) Withers DA … Hakomori SI (The Journal of biological chemistry 2000) 3 22 58
  5. Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. (PMID: 1718983) Kumar R … Stanley P (The Journal of biological chemistry 1991) 3 4 58

Products for FUT4 Gene

Sources for FUT4 Gene

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