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Aliases for FUT3 Gene

Aliases for FUT3 Gene

  • Fucosyltransferase 3 (Lewis Blood Group) 2 3 5
  • Blood Group Lewis Alpha-4-Fucosyltransferase 3 4
  • Galactoside 3(4)-L-Fucosyltransferase 2 3
  • Fucosyltransferase III 3 4
  • EC 2.4.1.65 4 56
  • Lewis FT 3 4
  • FucT-III 3 4
  • FT3B 3 4
  • LE 3 4
  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group Included) 2
  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group) 3
  • Alpha-(1,3/1,4)-Fucosyltransferase 3
  • Fucosyltransferase 3 4
  • EC 2.4.1 56
  • CD174 3
  • Les 3

External Ids for FUT3 Gene

Previous HGNC Symbols for FUT3 Gene

  • LE

Previous GeneCards Identifiers for FUT3 Gene

  • GC19M005935
  • GC19M005782
  • GC19M005793
  • GC19M005602

Summaries for FUT3 Gene

Entrez Gene Summary for FUT3 Gene

  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT3 Gene

FUT3 (Fucosyltransferase 3 (Lewis Blood Group)) is a Protein Coding gene. Diseases associated with FUT3 include Hypertropia and Inflammatory Breast Carcinoma. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot for FUT3 Gene

  • May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Gene Wiki entry for FUT3 Gene

Additional gene information for FUT3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT3 Gene

Genomics for FUT3 Gene

GeneHancer (GH) Regulatory Elements for FUT3 Gene

Promoters and enhancers for FUT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I005850 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.3 289 1.4 CEBPG IRF9 PATZ1 SCRT2 ATF7 ZNF362 HLF CEBPB ZEB2 ZNF398 FUT3 NRTN DUS3L PRR22 CATSPERD LOC101928844
GH19I005956 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -111.8 -111778 13.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 VMAC ENSG00000267571 CAPS DUS3L NDUFA11 GPR108 FUT5 ACSBG2 SAFB KDM4B
GH19I005913 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.1 -63.8 -63844 3.3 KLF1 MAZ RFX1 KLF17 ZIC2 RAD21 OSR2 ZFP69B GLIS2 ZNF692 CAPS ENSG00000267571 FUT3 FUT6 CATSPERD ENSG00000267314 GC19P005968 RANBP3
GH19I005803 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.7 +46.2 46163 3.4 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZNF213 E2F8 ZNF207 ZNF143 KLF13 NRTN DUS3L SAFB2 KHSRP GTF2F1 FUT6 FUT3 FUT5 VMAC NDUFA11
GH19I005945 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -99.6 -99583 10.3 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 SP5 NFYC NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 GC19P005968 RANBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT3 gene promoter:

Genomic Locations for FUT3 Gene

Genomic Locations for FUT3 Gene
chr19:5,842,888-5,851,474
(GRCh38/hg38)
Size:
8,587 bases
Orientation:
Minus strand
chr19:5,842,899-5,851,485
(GRCh37/hg19)

Genomic View for FUT3 Gene

Genes around FUT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT3 Gene

Proteins for FUT3 Gene

  • Protein details for FUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21217-FUT3_HUMAN
    Recommended name:
    Galactoside 3(4)-L-fucosyltransferase
    Protein Accession:
    P21217
    Secondary Accessions:
    • B5U7U9
    • B5U7V0
    • Q32NE7
    • Q99448
    • Q99449

    Protein attributes for FUT3 Gene

    Size:
    361 amino acids
    Molecular mass:
    42117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT3 Gene

Selected DME Specific Peptides for FUT3 Gene

P21217:
  • FYLAFENS
  • HPPLNLSAKTELVAWAVSNW
  • ITADRKVYPQAD
  • SARVRYYQSL
  • QGQRWIWF
  • CFFSYLR
  • VIVHHWDIM
  • PYGWLEPW
  • GTMMETLSRYKFYLAFENS
  • VPVVLGP
  • AHLKVDVYG
  • RCSEMVPG
  • LPPSPRP
  • DFQSPKDLA
  • DYITEKLW
  • FCKACWKLQ
  • FIHVDDF

Post-translational modifications for FUT3 Gene

  • Glycosylation at isoforms=154 and isoforms=185
  • Modification sites at PhosphoSitePlus

Domains & Families for FUT3 Gene

Gene Families for FUT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FUT3 Gene

Graphical View of Domain Structure for InterPro Entry

P21217

UniProtKB/Swiss-Prot:

FUT3_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT3: view

Function for FUT3 Gene

Molecular function for FUT3 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Enzyme Numbers (IUBMB) for FUT3 Gene

Phenotypes From GWAS Catalog for FUT3 Gene

Gene Ontology (GO) - Molecular Function for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IEA,IDA 7721776
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity TAS --
GO:0046920 alpha-(1->3)-fucosyltransferase activity IDA 1977660
genes like me logo Genes that share ontologies with FUT3: view
genes like me logo Genes that share phenotypes with FUT3: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT3 Gene

Localization for FUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 2
lysosome 2
endosome 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA,IEA 1977660
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FUT3 Gene

Pathways & Interactions for FUT3 Gene

genes like me logo Genes that share pathways with FUT3: view

UniProtKB/Swiss-Prot P21217-FUT3_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006672 ceramide metabolic process IDA 7721776
GO:0009312 oligosaccharide biosynthetic process IDA 1977660
GO:0009988 cell-cell recognition IC 12668675
GO:0036065 fucosylation IEA --
genes like me logo Genes that share ontologies with FUT3: view

No data available for SIGNOR curated interactions for FUT3 Gene

Drugs & Compounds for FUT3 Gene

(4) Drugs for FUT3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(7) Additional Compounds for FUT3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT3: view

Transcripts for FUT3 Gene

Unigene Clusters for FUT3 Gene

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT3 Gene

No ASD Table

Relevant External Links for FUT3 Gene

GeneLoc Exon Structure for
FUT3
ECgene alternative splicing isoforms for
FUT3

Expression for FUT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT3 Gene

mRNA differential expression in normal tissues according to GTEx for FUT3 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.3), Colon - Transverse (x11.2), Minor Salivary Gland (x6.9), Small Intestine - Terminal Ileum (x4.9), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for FUT3 Gene

This gene is overexpressed in Nasal epithelium (59.7) and Saliva (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT3 Gene



NURSA nuclear receptor signaling pathways regulating expression of FUT3 Gene:

FUT3

SOURCE GeneReport for Unigene cluster for FUT3 Gene:

Hs.169238

mRNA Expression by UniProt/SwissProt for FUT3 Gene:

P21217-FUT3_HUMAN
Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

Evidence on tissue expression from TISSUES for FUT3 Gene

  • Intestine(4.5)
  • Blood(4.4)
  • Liver(4.3)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with FUT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT3 Gene

Orthologs for FUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT3 33 34
  • 98.43 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 34 34
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FucTA 35
  • 35 (a)
FucTC 35
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea fut-3 33
  • 41.77 (n)
Species where no ortholog for FUT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FUT3 Gene

ENSEMBL:
Gene Tree for FUT3 (if available)
TreeFam:
Gene Tree for FUT3 (if available)

Paralogs for FUT3 Gene

Paralogs for FUT3 Gene

(5) SIMAP similar genes for FUT3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FUT3: view

Variants for FUT3 Gene

Sequence variations from dbSNP and Humsavar for FUT3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs28362459 association, Le(-) PHENOTYPE 5,844,781(-) A/C/T coding_sequence_variant, missense_variant
rs3745635 association, Le(-) PHENOTYPE 5,844,332(-) C/T coding_sequence_variant, missense_variant
rs1000273296 -- 5,845,033(-) A/G intron_variant
rs1000820395 -- 5,852,261(-) G/A upstream_transcript_variant
rs1000897292 -- 5,853,464(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT3 Gene

Variant ID Type Subtype PubMed ID
esv3643541 CNV loss 21293372
nsv1062851 CNV gain 25217958
nsv1152644 CNV duplication 26484159
nsv578459 CNV gain 21841781

Variation tolerance for FUT3 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.86; 91.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT3 Gene

Human Gene Mutation Database (HGMD)
FUT3
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT3 Gene

Disorders for FUT3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FUT3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertropia
inflammatory breast carcinoma
  • inflammatory carcinoma of breast
visceral myopathy
  • vscm
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search FUT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT3 Gene

Publications for FUT3 Gene

  1. Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians. (PMID: 19175549) Soejima M … Koda Y (Transfusion 2009) 3 22 44 58
  2. Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study. (PMID: 17383304) Djoussé L … Ellison RC (American heart journal 2007) 3 22 44 58
  3. [FUT3 gene polymorphism associated with Lewis blood group in Chinese Zhejiang population]. (PMID: 16800951) Xu XG … Yan LX (Zhongguo shi yan xue ye xue za zhi 2006) 3 22 44 58
  4. Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 14687237) Cakir B … Weston BW (Journal of internal medicine 2004) 3 22 44 58
  5. Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. (PMID: 12730721) Serpa J … David L (Journal of human genetics 2003) 3 22 44 58

Products for FUT3 Gene

Sources for FUT3 Gene

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