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The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene.... See more...
Aliases for FUT2 Gene
Aliases for FUT2 Gene
- Fucosyltransferase 2 2 3 4 5
- GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3 4
- Secretor Blood Group Alpha-2-Fucosyltransferase 2 3 4
- Secretor Factor 2 3 4
- SEC2 2 3 4
- Fucosyltransferase 2 (Secretor Status Included) 2 3
- Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3
- Alpha (1,2) Fucosyltransferase 2 3
- Alpha(1,2)FT 2 3 4
- Alpha(1,2)FT2 2 3
- EC 2.4.1.69 4 51
External Ids for FUT2 Gene
- HGNC: 4013
- Entrez Gene: 2524
- Ensembl: ENSG00000176920
- OMIM: 182100
- UniProtKB: Q10981
Previous HGNC Symbols for FUT2 Gene
- SE
Previous GeneCards Identifiers for FUT2 Gene
- GC19P049896
- GC19P049551
- GC19P053859
- GC19P053875
- GC19P053869
- GC19P049199
- GC19P045578
Summaries for FUT2 Gene
-
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FUT2 Gene
FUT2 (Fucosyltransferase 2) is a Protein Coding gene. Diseases associated with FUT2 include Vitamin B12 Plasma Level Quantitative Trait Locus 1 and Bombay Phenotype. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT1.
UniProtKB/Swiss-Prot Summary for FUT2 Gene
-
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
Additional gene information for FUT2 Gene
- HGNC(4013)
- Entrez Gene(2524)
- Ensembl(ENSG00000176920)
- OMIM(182100)
- UniProtKB(Q10981)
- Open Targets Platform(ENSG00000176920)
- Monarch Initiative
- Search for FUT2 at DataMed
- Search for FUT2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT2 Gene
Genomics for FUT2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FUT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FUT2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUT2
- Top Transcription factor binding sites by QIAGEN in the FUT2 gene promoter:
-
- AhR
- ATF6
- E47
- Elk-1
- LCR-F1
- p53
- SRY
- Tal-1
Genomic Locations for FUT2 Gene
Genomic Locations for FUT2 Gene
- chr19:48,695,971-48,705,951
- (GRCh38/hg38)
- Size:
- 9,981 bases
- Orientation:
- Plus strand
- chr19:49,199,228-49,209,207
- (GRCh37/hg19)
- Size:
- 9,980 bases
- Orientation:
- Plus strand
Genomic View for FUT2 Gene
Genes around FUT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
FUT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FUT2 Gene
Proteins for FUT2 Gene
-
Protein details for FUT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q10981-FUT2_HUMAN
- Recommended name:
- Galactoside alpha-(1,2)-fucosyltransferase 2
- Protein Accession:
- Q10981
- Q0VAG5
- Q14338
- Q5D0G2
Protein attributes for FUT2 Gene
- Size:
- 343 amino acids
- Molecular mass:
- 39017 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA11638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
Protein Expression for FUT2 Gene
Selected DME Specific Peptides for FUT2 Gene
- Q10981:
-
- TGYPCSWTFYHHLR
- GMWTINA
- FVVTSNGM
- EFTLHDH
- VGVHVRRGDY
- AHFILFVFTVSTIFH
- NYHLNDWMEE
- MNGRPAFIP
- TIYLANYTLPDSPFLK
- WAAYLTGGDT
- YRHIPGEYVR
- QCNHTIMTIGTFG
- GRLGNQMGEYATL
- FRITLPVL
- LAPIFRI
- KDFALLTQCNHT
- AAFLPEW
- QQRLAKIQAMWELP
- GDVVFAG
- VWKGVVADR
- GTFGIWAAYL
- QIPVLASTSKALGPSQLRG
- WCRENID
Post-translational modifications for FUT2 Gene
Other Protein References for FUT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences FUT2 / SE Antibody
- G Biosciences Immunotag™ FUT2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FUT2
- Novus Biologicals Antibodies for FUT2
-
Abcam antibodies for FUT2
- Invitrogen Antibodies for FUT2 (AFLGC-FUT2)
-
Boster Bio Antibodies for FUT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FUT2
Protein Products
-
OriGene Purified Proteins for FUT2
- Search Origene for MassSpec and Protein Over-expression Lysates for FUT2
- Origene Custom Protein Services for FUT2
- antibodies-online: Show 9 available FUT2 Proteins ranked by validation data
- Compare Top FUT2 Proteins
-
Quality Products:
-
Abcam proteins for FUT2
Domains & Families for FUT2 Gene
Gene Families for FUT2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Blood group antigen proteins
- Enzymes
- Predicted membrane proteins
Protein Domains for FUT2 Gene
- InterPro:
- Blocks:
-
- Glycosyl transferase, family 11
- ProtoNet:
Suggested Antigen Peptide Sequences for FUT2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75308, highly similar to Human alpha(1,2)fucosyltransferase (FUT2) gene (A8K2L2_HUMAN)
- Fucosyltransferase (B3W6G7_HUMAN)
- Fucosyltransferase (B5B9L6_HUMAN)
- Secretor factor (FUT2_HUMAN)
- Alpha 1,2 fucosyltransferase (Q5XLR8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q10981- Family:
-
- Belongs to the glycosyltransferase 11 family.
Function for FUT2 Gene
Molecular function for FUT2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50664, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133506, ChEBI:CHEBI:133509; EC=2.4.1.69; Evidence={ECO:0000269|PubMed:7876235};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:133510; EC=2.4.1.344; Evidence={ECO:0000269|PubMed:7876235};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48800, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90803; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48304, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM1a + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+); Xref=Rhea:RHEA:48320, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:88069, ChEBI:CHEBI:90262; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48792, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90800, ChEBI:CHEBI:90802; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+); Xref=Rhea:RHEA:32175, ChEBI:CHEBI:15378, ChEBI:CHEBI:17292, ChEBI:CHEBI:28743, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; EC=2.4.1.69; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+); Xref=Rhea:RHEA:48324, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82939, ChEBI:CHEBI:90265; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:42040, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:77709, ChEBI:CHEBI:78607; Evidence={ECO:0000250|UniProtKB:Q10984};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+); Xref=Rhea:RHEA:42044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:62571, ChEBI:CHEBI:62649; Evidence={ECO:0000250|UniProtKB:Q10984};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+); Xref=Rhea:RHEA:62616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90811, ChEBI:CHEBI:142612; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+); Xref=Rhea:RHEA:62964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:84728, ChEBI:CHEBI:546807; Evidence={ECO:0000250|UniProtKB:Q28113};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=11.5 mM for phenyl-beta-D-galactoside {ECO:0000269|PubMed:7876235}; KM=3.6 mM for lacto-N-biose {ECO:0000269|PubMed:7876235}; KM=3.8 mM for N-acetyllactosamine {ECO:0000269|PubMed:7876235}; KM=197 uM for GDP-fucose {ECO:0000269|PubMed:7876235};
- GENATLAS Biochemistry:
- fucosyltransferase,alpha-(1,2),2,type I (secretor status)
Enzyme Numbers (IUBMB) for FUT2 Gene
Phenotypes From GWAS Catalog for FUT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity | IBA,TAS | 11698403 |
| GO:0008417 | fucosyltransferase activity | TAS | 7876235 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0031127 | alpha-(1,2)-fucosyltransferase activity | ISS | -- |
Phenotypes for FUT2 Gene
- MGI mutant phenotypes for FUT2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FUT2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Decreased viability
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased centriole number
- Increased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Models for FUT2 Gene
- MGI Knock Outs for FUT2:
-
- Fut2 Fut2<tm1Sdo>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FUT2 - Select products 50% OFF >
- * FUT2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FUT2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUT2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUT2
miRNA for FUT2 Gene
- miRTarBase miRNAs that target FUT2
-
- hsa-miR-15b-5p (MIRT437485)
- hsa-miR-6878-3p (MIRT662028)
- hsa-miR-640 (MIRT662029)
- hsa-miR-6744-3p (MIRT662030)
- hsa-miR-4757-5p (MIRT662031)
- hsa-miR-3922-3p (MIRT662032)
- hsa-miR-3176 (MIRT662033)
- hsa-miR-3620-3p (MIRT662034)
- hsa-miR-8079 (MIRT662035)
- hsa-miR-1245a (MIRT662036)
- hsa-miR-504-5p (MIRT662037)
- hsa-miR-665 (MIRT674197)
- hsa-miR-6771-5p (MIRT674198)
- hsa-miR-7160-5p (MIRT674199)
- hsa-miR-4722-5p (MIRT674200)
- hsa-miR-1827 (MIRT674201)
- hsa-miR-4649-3p (MIRT674202)
- hsa-miR-6746-5p (MIRT674203)
- hsa-miR-4768-3p (MIRT674204)
- hsa-miR-4478 (MIRT674205)
- hsa-miR-4419b (MIRT674206)
- hsa-miR-3929 (MIRT674207)
- hsa-miR-940 (MIRT674208)
- hsa-miR-6893-5p (MIRT674209)
- hsa-miR-6808-5p (MIRT674210)
- hsa-miR-500a-5p (MIRT674211)
- hsa-miR-6513-5p (MIRT690878)
- hsa-miR-887-5p (MIRT690879)
- hsa-miR-3913-5p (MIRT690880)
- hsa-miR-3122 (MIRT690881)
- hsa-miR-450a-1-3p (MIRT690882)
- hsa-miR-6780a-5p (MIRT690883)
- hsa-miR-6779-5p (MIRT690884)
- hsa-miR-3689c (MIRT690885)
- hsa-miR-3689b-3p (MIRT690886)
- hsa-miR-3689a-3p (MIRT690887)
- hsa-miR-30b-3p (MIRT690888)
- hsa-miR-1273h-5p (MIRT690889)
- hsa-miR-6788-5p (MIRT690890)
- hsa-miR-30c-2-3p (MIRT690891)
- hsa-miR-30c-1-3p (MIRT690892)
- hsa-miR-7977 (MIRT690893)
- hsa-miR-5693 (MIRT690894)
- hsa-miR-383-3p (MIRT690895)
- hsa-miR-3591-3p (MIRT690896)
- hsa-miR-21-3p (MIRT690897)
miRNA Products
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- MG219943
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- RC219898
- RC219898L1
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- RR210375
- RR210375L3
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- RC219898L3V
- RC219898L4V
- RR210375L3V
- RR210375L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FUT2
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Cell Line Products
-
Horizon Cell Lines for FUT2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT2 Gene
Localization for FUT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FUT2 Gene
- Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | TAS | 11698403 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0032580 | Golgi cisterna membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 19199708 |
Pathways & Interactions for FUT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Globo Sphingolipid Metabolism | ||
| 2 | Glycosphingolipid biosynthesis - lacto and neolacto series | ||
| 3 | Metabolism | ||
Pathways by source for FUT2 Gene
1 BioSystems pathway for FUT2 Gene
UniProtKB/Swiss-Prot Q10981-FUT2_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for FUT2 Gene
GPS-Prot Interaction Network for FUT2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001936 | regulation of endothelial cell proliferation | ISS | -- |
| GO:0005975 | carbohydrate metabolic process | TAS | 7876235 |
| GO:0006486 | protein glycosylation | IBA,TAS | 11698403 |
| GO:0006664 | glycolipid metabolic process | ISS | -- |
| GO:0030155 | regulation of cell adhesion | ISS | -- |
Drugs & Compounds for FUT2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GDP-L-fucose |
|
15839-70-0 |
|
Transcripts for FUT2 Gene
mRNA/cDNA for FUT2 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000391876 1593 nts (view in UCSC)
- ENST00000425340 3116 nts (view in UCSC)
- ENST00000522283 312 nts (view in UCSC)
- ENST00000522966 1449 nts (view in UCSC)
CRISPR Products
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for FUT2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG219943
- MR219943
- MR219943L3
- MR219943L4
- MR229401
- RC215830
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- MR219943L3V
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- RR210375L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FUT2
- Addgene plasmids for FUT2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FUT2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: |
Relevant External Links for FUT2 Gene
- GeneLoc Exon Structure for
- FUT2
Expression for FUT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Epithelial Cells (Uncategorized)
- Liver (Hepatobiliary System)
-
Colon (Gastrointestinal Tract)
-
Epidermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for FUT2 Gene
This gene is overexpressed in Minor Salivary Gland (x17.9), Esophagus - Mucosa (x6.8), and Colon - Transverse (x5.6).
This gene is overexpressed in Kidney (33.5), Stomach (23.0), and Oral epithelium (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUT2
SOURCE GeneReport for Unigene cluster for FUT2 Gene:
Hs.579928mRNA Expression by UniProt/SwissProt for FUT2 Gene:
Q10981-FUT2_HUMAN
Tissue specificity:
Small intestine, colon and lung.
Evidence on tissue expression from TISSUES for FUT2 Gene
- Skin(2.8)
- Intestine(2.8)
- Stomach(2.7)
- Blood(2.7)
- Lung(2.5)
- Nervous system(2.5)
- Saliva(2.4)
- Heart(2.3)
- Muscle(2.3)
- Pancreas(2.3)
- Kidney(2.2)
- Spleen(2.1)
- Liver(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for FUT2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT2 Gene
Orthologs for FUT2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FUT2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC484398 30 |
|
||
| FUT2 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | FUT2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fut2 30 17 31 |
|
OneToMany | |
| Sec1 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Fut2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FUT2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FUT2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100497569 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | fut1 30 |
|
- Species where no ortholog for FUT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for FUT2 Gene
- ENSEMBL:
- Gene Tree for FUT2 (if available)
- TreeFam:
- Gene Tree for FUT2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FUT2: view image
Paralogs for FUT2 Gene
(4) SIMAP similar genes for FUT2 Gene using alignment to 8 proteins:
- FUT2_HUMAN
- A8K2L2_HUMAN
- B3W6G7_HUMAN
- B5B9L6_HUMAN
- E7EW73_HUMAN
- L8EC57_HUMAN
- Q5XLR8_HUMAN
- Q7KZZ1_HUMAN
Pseudogenes.org Pseudogenes for FUT2 Gene
Variants for FUT2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for FUT2 Gene
- FUT2_HUMAN-Q10981
- Three alleles have been identified in the Japanese population: Se1, Se2, and Sej.
- FUT2_HUMAN-Q10981
- Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency.
- FUT2_HUMAN-Q10981
- Genetic variation in FUT2 results in the non-secretor phenotype which gives rise to non-functional FUT2, resulting in a lack of the H type-1 oligosaccharide ligand in secretions, and this prevents Norwalk virus binding contributing to resistance to Norwalk virus infection.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUT2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714890 | Benign: not provided | 48,703,364(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 715544 | Benign: not provided | 48,703,838(+) | G/A | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT | |
| 724072 | Likely Benign: not provided | 48,703,400(+) | C/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 729703 | Benign: not provided | 48,703,766(+) | AC/A | FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| rs1047781 | Benign: SECRETOR/NONSECRETOR POLYMORPHISM, JAPANESE TYPE. - | 48,703,374(+) | A/Tp.Ile140Phe | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2664951 | CNV | deletion | 23128226 |
| esv2676755 | CNV | deletion | 23128226 |
| esv2718682 | CNV | deletion | 23290073 |
| esv2762045 | CNV | loss | 21179565 |
| esv3583453 | CNV | loss | 25503493 |
| esv3583454 | CNV | loss | 25503493 |
| esv3644596 | CNV | loss | 21293372 |
| esv3644597 | CNV | loss | 21293372 |
| esv3644598 | CNV | loss | 21293372 |
| esv3644599 | CNV | loss | 21293372 |
| esv3893230 | CNV | loss | 25118596 |
| nsv442468 | CNV | loss | 18776908 |
| nsv458719 | CNV | loss | 19166990 |
| nsv516677 | CNV | loss | 19592680 |
| nsv579904 | CNV | loss | 21841781 |
| nsv579905 | CNV | loss | 21841781 |
| nsv579906 | CNV | loss | 21841781 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
21.88;
99.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FUT2 Gene
- Blood Group Antigen Gene Mutation Database (BGMUT)
- Blood Group System
- Human Gene Mutation Database (HGMD)
- FUT2
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FUT2
SNP Genotyping and Copy Number Assay Products
Disorders for FUT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vitamin b12 plasma level quantitative trait locus 1 |
|
|
| bombay phenotype |
|
|
| gastroenteritis |
|
|
| pernicious anemia |
|
|
| intrinsic factor deficiency |
|
|
Search FUT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FUT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FUT2 Gene
Publications for FUT2 Gene
- Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies. (PMID: 19757028) Silva LM … David L (Glycoconjugate journal 2010) 3 23 41
- Common variants of FUT2 are associated with plasma vitamin B12 levels. (PMID: 18776911) Hazra A … Hunter DJ (Nature genetics 2008) 3 4 41
- Genetic variation of FUT2 in Ovambos, Turks, and Mongolians. (PMID: 18422843) Soejima M … Koda Y (Transfusion 2008) 3 23 41
- Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. (PMID: 17537929) Kindberg E … Svensson L (Journal of clinical microbiology 2007) 3 23 41
- A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection. (PMID: 16514298) Kindberg E … Svensson L (AIDS (London, England) 2006) 3 23 41
ExternalLinks
Products for FUT2 Gene
- Custom Antibody ServicesOriGene Antibodies for FUT2
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- Custom Assay Services
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- MG219943
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- RC215830
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 9 available FUT2 Antibodies ranked by validation data
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- antibodies-online: Show 9 available FUT2 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for FUT2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUT2
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- Boster Bio Antibodies for FUT2
- Browse Boster Bio ELISA Kits
Sources for FUT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (90) CYP
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- (95) GeneTex
- (96) Taconic Biosciences
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- (98) ProteomicsDB
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- (101) ClinicalTrials
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- (104) diseasecard
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- (152) DiseaseEnhancer
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