The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene.... See more...

Aliases for FUT2 Gene

Aliases for FUT2 Gene

  • Fucosyltransferase 2 2 3 4 5
  • GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3 4
  • Secretor Blood Group Alpha-2-Fucosyltransferase 2 3 4
  • Secretor Factor 2 3 4
  • SEC2 2 3 4
  • Fucosyltransferase 2 (Secretor Status Included) 2 3
  • Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3
  • Alpha (1,2) Fucosyltransferase 2 3
  • Alpha(1,2)FT 2 3 4
  • Alpha(1,2)FT2 2 3
  • EC 2.4.1.69 4 51
  • Se2 2 3
  • Sej 2 3
  • Type 1 Galactoside Alpha-(1,2)-Fucosyltransferase FUT2 4
  • Type 2 Galactoside Alpha-(1,2)-Fucosyltransferase FUT2 4
  • Galactoside Alpha-(1,2)-Fucosyltransferase 2 4
  • Galactoside 2-L-Fucosyltransferase 3
  • EC 2.4.1.344 4
  • B12QTL1 3
  • FUT2 5
  • SE2 4
  • SE 3
  • Se 4

External Ids for FUT2 Gene

Previous HGNC Symbols for FUT2 Gene

  • SE

Previous GeneCards Identifiers for FUT2 Gene

  • GC19P049896
  • GC19P049551
  • GC19P053859
  • GC19P053875
  • GC19P053869
  • GC19P049199
  • GC19P045578

Summaries for FUT2 Gene

Entrez Gene Summary for FUT2 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT2 Gene

FUT2 (Fucosyltransferase 2) is a Protein Coding gene. Diseases associated with FUT2 include Vitamin B12 Plasma Level Quantitative Trait Locus 1 and Bombay Phenotype. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT1.

UniProtKB/Swiss-Prot Summary for FUT2 Gene

  • Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).

Gene Wiki entry for FUT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT2 Gene

Genomics for FUT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FUT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUT2

Top Transcription factor binding sites by QIAGEN in the FUT2 gene promoter:
  • AhR
  • ATF6
  • E47
  • Elk-1
  • LCR-F1
  • p53
  • SRY
  • Tal-1

Genomic Locations for FUT2 Gene

Genomic Locations for FUT2 Gene
chr19:48,695,971-48,705,951
(GRCh38/hg38)
Size:
9,981 bases
Orientation:
Plus strand
chr19:49,199,228-49,209,207
(GRCh37/hg19)
Size:
9,980 bases
Orientation:
Plus strand

Genomic View for FUT2 Gene

Genes around FUT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT2 Gene

Proteins for FUT2 Gene

  • Protein details for FUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10981-FUT2_HUMAN
    Recommended name:
    Galactoside alpha-(1,2)-fucosyltransferase 2
    Protein Accession:
    Q10981
    Secondary Accessions:
    • Q0VAG5
    • Q14338
    • Q5D0G2

    Protein attributes for FUT2 Gene

    Size:
    343 amino acids
    Molecular mass:
    39017 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA11638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.

neXtProt entry for FUT2 Gene

Selected DME Specific Peptides for FUT2 Gene

Q10981:
  • TGYPCSWTFYHHLR
  • GMWTINA
  • FVVTSNGM
  • EFTLHDH
  • VGVHVRRGDY
  • AHFILFVFTVSTIFH
  • NYHLNDWMEE
  • MNGRPAFIP
  • TIYLANYTLPDSPFLK
  • WAAYLTGGDT
  • YRHIPGEYVR
  • QCNHTIMTIGTFG
  • GRLGNQMGEYATL
  • FRITLPVL
  • LAPIFRI
  • KDFALLTQCNHT
  • AAFLPEW
  • QQRLAKIQAMWELP
  • GDVVFAG
  • VWKGVVADR
  • GTFGIWAAYL
  • QIPVLASTSKALGPSQLRG
  • WCRENID

Post-translational modifications for FUT2 Gene

  • Glycosylation at Asn188, Asn282, and Asn308
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT2 Gene

Antibody Products

  • Abcam antibodies for FUT2
  • Boster Bio Antibodies for FUT2
  • Santa Cruz Biotechnology (SCBT) Antibodies for FUT2

Domains & Families for FUT2 Gene

Gene Families for FUT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Enzymes
  • Predicted membrane proteins

Protein Domains for FUT2 Gene

InterPro:
Blocks:
  • Glycosyl transferase, family 11
ProtoNet:

Suggested Antigen Peptide Sequences for FUT2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75308, highly similar to Human alpha(1,2)fucosyltransferase (FUT2) gene (A8K2L2_HUMAN)
  • Fucosyltransferase (B3W6G7_HUMAN)
  • Fucosyltransferase (B5B9L6_HUMAN)
  • Secretor factor (FUT2_HUMAN)
  • Alpha 1,2 fucosyltransferase (Q5XLR8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q10981

UniProtKB/Swiss-Prot:

FUT2_HUMAN :
  • Belongs to the glycosyltransferase 11 family.
Family:
  • Belongs to the glycosyltransferase 11 family.
genes like me logo Genes that share domains with FUT2: view

Function for FUT2 Gene

Molecular function for FUT2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50664, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133506, ChEBI:CHEBI:133509; EC=2.4.1.69; Evidence={ECO:0000269|PubMed:7876235};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:133510; EC=2.4.1.344; Evidence={ECO:0000269|PubMed:7876235};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+); Xref=Rhea:RHEA:48800, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90376, ChEBI:CHEBI:90803; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48304, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM1a + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+); Xref=Rhea:RHEA:48320, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:88069, ChEBI:CHEBI:90262; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+); Xref=Rhea:RHEA:48792, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90800, ChEBI:CHEBI:90802; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+); Xref=Rhea:RHEA:32175, ChEBI:CHEBI:15378, ChEBI:CHEBI:17292, ChEBI:CHEBI:28743, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; EC=2.4.1.69; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GD1b + GDP-beta-L-fucose = ganglioside Fuc-GD1b + GDP + H(+); Xref=Rhea:RHEA:48324, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82939, ChEBI:CHEBI:90265; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = gangliosideFuc-GM1 (d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:42040, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:77709, ChEBI:CHEBI:78607; Evidence={ECO:0000250|UniProtKB:Q10984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+); Xref=Rhea:RHEA:42044, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:62571, ChEBI:CHEBI:62649; Evidence={ECO:0000250|UniProtKB:Q10984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+); Xref=Rhea:RHEA:62616, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:90811, ChEBI:CHEBI:142612; Evidence={ECO:0000250|UniProtKB:Q9JL27};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+); Xref=Rhea:RHEA:62964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:84728, ChEBI:CHEBI:546807; Evidence={ECO:0000250|UniProtKB:Q28113};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11.5 mM for phenyl-beta-D-galactoside {ECO:0000269|PubMed:7876235}; KM=3.6 mM for lacto-N-biose {ECO:0000269|PubMed:7876235}; KM=3.8 mM for N-acetyllactosamine {ECO:0000269|PubMed:7876235}; KM=197 uM for GDP-fucose {ECO:0000269|PubMed:7876235};
GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,2),2,type I (secretor status)

Enzyme Numbers (IUBMB) for FUT2 Gene

Phenotypes From GWAS Catalog for FUT2 Gene

Gene Ontology (GO) - Molecular Function for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity IBA,TAS 11698403
GO:0008417 fucosyltransferase activity TAS 7876235
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0031127 alpha-(1,2)-fucosyltransferase activity ISS --
genes like me logo Genes that share ontologies with FUT2: view
genes like me logo Genes that share phenotypes with FUT2: view

Animal Models for FUT2 Gene

MGI Knock Outs for FUT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT2 Gene

Localization for FUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT2 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with FUT2: view

Pathways & Interactions for FUT2 Gene

genes like me logo Genes that share pathways with FUT2: view

UniProtKB/Swiss-Prot Q10981-FUT2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT2 Gene

SIGNOR curated interactions for FUT2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001936 regulation of endothelial cell proliferation ISS --
GO:0005975 carbohydrate metabolic process TAS 7876235
GO:0006486 protein glycosylation IBA,TAS 11698403
GO:0006664 glycolipid metabolic process ISS --
GO:0030155 regulation of cell adhesion ISS --
genes like me logo Genes that share ontologies with FUT2: view

Drugs & Compounds for FUT2 Gene

(3) Drugs for FUT2 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 3266
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for FUT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT2: view

Transcripts for FUT2 Gene

mRNA/cDNA for FUT2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT2

Alternative Splicing Database (ASD) splice patterns (SP) for FUT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for FUT2 Gene

GeneLoc Exon Structure for
FUT2

Expression for FUT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT2 Gene

This gene is overexpressed in Minor Salivary Gland (x17.9), Esophagus - Mucosa (x6.8), and Colon - Transverse (x5.6).

Protein differential expression in normal tissues from HIPED for FUT2 Gene

This gene is overexpressed in Kidney (33.5), Stomach (23.0), and Oral epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUT2

SOURCE GeneReport for Unigene cluster for FUT2 Gene:

Hs.579928

mRNA Expression by UniProt/SwissProt for FUT2 Gene:

Q10981-FUT2_HUMAN
Tissue specificity: Small intestine, colon and lung.

Evidence on tissue expression from TISSUES for FUT2 Gene

  • Skin(2.8)
  • Intestine(2.8)
  • Stomach(2.7)
  • Blood(2.7)
  • Lung(2.5)
  • Nervous system(2.5)
  • Saliva(2.4)
  • Heart(2.3)
  • Muscle(2.3)
  • Pancreas(2.3)
  • Kidney(2.2)
  • Spleen(2.1)
  • Liver(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with FUT2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT2 Gene

Orthologs for FUT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FUT2 30 31
  • 99.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC484398 30
  • 87.51 (n)
FUT2 31
  • 60 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FUT2 30 31
  • 85.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fut2 30 17 31
  • 78.91 (n)
OneToMany
Sec1 31
  • 61 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Fut2 30
  • 77.45 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FUT2 31
  • 63 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FUT2 31
  • 59 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 60 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100497569 30
  • 61.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia fut1 30
Species where no ortholog for FUT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FUT2 Gene

ENSEMBL:
Gene Tree for FUT2 (if available)
TreeFam:
Gene Tree for FUT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUT2: view image

Paralogs for FUT2 Gene

Paralogs for FUT2 Gene

(4) SIMAP similar genes for FUT2 Gene using alignment to 8 proteins:

  • FUT2_HUMAN
  • A8K2L2_HUMAN
  • B3W6G7_HUMAN
  • B5B9L6_HUMAN
  • E7EW73_HUMAN
  • L8EC57_HUMAN
  • Q5XLR8_HUMAN
  • Q7KZZ1_HUMAN

Pseudogenes.org Pseudogenes for FUT2 Gene

genes like me logo Genes that share paralogs with FUT2: view

Variants for FUT2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT2 Gene

FUT2_HUMAN-Q10981
Three alleles have been identified in the Japanese population: Se1, Se2, and Sej.
FUT2_HUMAN-Q10981
Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency.
FUT2_HUMAN-Q10981
Genetic variation in FUT2 results in the non-secretor phenotype which gives rise to non-functional FUT2, resulting in a lack of the H type-1 oligosaccharide ligand in secretions, and this prevents Norwalk virus binding contributing to resistance to Norwalk virus infection.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUT2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
714890 Benign: not provided 48,703,364(+) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
715544 Benign: not provided 48,703,838(+) G/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT
724072 Likely Benign: not provided 48,703,400(+) C/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
729703 Benign: not provided 48,703,766(+) AC/A FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1047781 Benign: SECRETOR/NONSECRETOR POLYMORPHISM, JAPANESE TYPE. - 48,703,374(+) A/Tp.Ile140Phe MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for FUT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FUT2 Gene

Variant ID Type Subtype PubMed ID
esv2664951 CNV deletion 23128226
esv2676755 CNV deletion 23128226
esv2718682 CNV deletion 23290073
esv2762045 CNV loss 21179565
esv3583453 CNV loss 25503493
esv3583454 CNV loss 25503493
esv3644596 CNV loss 21293372
esv3644597 CNV loss 21293372
esv3644598 CNV loss 21293372
esv3644599 CNV loss 21293372
esv3893230 CNV loss 25118596
nsv442468 CNV loss 18776908
nsv458719 CNV loss 19166990
nsv516677 CNV loss 19592680
nsv579904 CNV loss 21841781
nsv579905 CNV loss 21841781
nsv579906 CNV loss 21841781
nsv9739 CNV gain+loss 18304495

Variation tolerance for FUT2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.88; 99.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT2 Gene

Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
Human Gene Mutation Database (HGMD)
FUT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT2

SNP Genotyping and Copy Number Assay Products

Disorders for FUT2 Gene

MalaCards: The human disease database

(17) MalaCards diseases for FUT2 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
vitamin b12 plasma level quantitative trait locus 1
  • b12qtl1
bombay phenotype
  • bombay phenotype, digenic
gastroenteritis
  • cholera morbus
pernicious anemia
  • addison's anaemia
intrinsic factor deficiency
  • ifd
- elite association - COSMIC cancer census association via MalaCards
Search FUT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FUT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT2 Gene

Publications for FUT2 Gene

  1. Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies. (PMID: 19757028) Silva LM … David L (Glycoconjugate journal 2010) 3 23 41
  2. Common variants of FUT2 are associated with plasma vitamin B12 levels. (PMID: 18776911) Hazra A … Hunter DJ (Nature genetics 2008) 3 4 41
  3. Genetic variation of FUT2 in Ovambos, Turks, and Mongolians. (PMID: 18422843) Soejima M … Koda Y (Transfusion 2008) 3 23 41
  4. Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark. (PMID: 17537929) Kindberg E … Svensson L (Journal of clinical microbiology 2007) 3 23 41
  5. A nonsense mutation (428G-->A) in the fucosyltransferase FUT2 gene affects the progression of HIV-1 infection. (PMID: 16514298) Kindberg E … Svensson L (AIDS (London, England) 2006) 3 23 41

Products for FUT2 Gene

Sources for FUT2 Gene