Aliases for FUT10 Gene

Aliases for FUT10 Gene

  • Fucosyltransferase 10 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 10 3 4
  • Alpha-(1,3)-Fucosyltransferase 10 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase X 3 4
  • Fuc-TX 3 4
  • FucT-X 3 4
  • Fucosyltransferase 10 (Alpha (1,3) Fucosyltransferase) 2
  • Alpha 1,3-Fucosyl Transferase 3
  • EC 2.4.1.- 4
  • EC 2.4.1 52
  • FUCTX 3

External Ids for FUT10 Gene

Previous GeneCards Identifiers for FUT10 Gene

  • GC00U991275
  • GC08M033679
  • GC08M033084
  • GC08M033286
  • GC08M033347
  • GC08M031760
  • GC08M033228
  • GC08M033370

Summaries for FUT10 Gene

GeneCards Summary for FUT10 Gene

FUT10 (Fucosyltransferase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT11.

UniProtKB/Swiss-Prot Summary for FUT10 Gene

Additional gene information for FUT10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT10 Gene

Genomics for FUT10 Gene

GeneHancer (GH) Regulatory Elements for FUT10 Gene

Promoters and enhancers for FUT10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUT10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUT10

Top Transcription factor binding sites by QIAGEN in the FUT10 gene promoter:
  • c-Ets-1
  • Elk-1
  • FOXF2
  • FOXO4
  • HFH-1
  • LCR-F1
  • MEF-2
  • MEF-2A
  • Nkx6-1
  • YY1

Genomic Locations for FUT10 Gene

Genomic Locations for FUT10 Gene
chr8:33,308,611-33,473,478
(GRCh38/hg38)
Size:
164,868 bases
Orientation:
Minus strand
chr8:33,228,342-33,330,940
(GRCh37/hg19)
Size:
102,599 bases
Orientation:
Minus strand

Genomic View for FUT10 Gene

Genes around FUT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT10 Gene

Proteins for FUT10 Gene

  • Protein details for FUT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F1-FUT10_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 10
    Protein Accession:
    Q6P4F1
    Secondary Accessions:
    • A8KAC8
    • Q70GG3
    • Q8IVI6
    • Q8IVI7
    • Q8IVJ3
    • Q8TE43
    • Q9BSR3

    Protein attributes for FUT10 Gene

    Size:
    479 amino acids
    Molecular mass:
    56094 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD24023.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT10 Gene

neXtProt entry for FUT10 Gene

Selected DME Specific Peptides for FUT10 Gene

Q6P4F1:
  • GRLGQCG
  • QDNYIDAFECM
  • VDSYGECL
  • FSHPRELA
  • WWSPLTGE
  • FHEESPKNNYKLFH
  • DYITEKFWR
  • ALRWLVDRNQNFS
  • TATFSRHS
  • SFEQSKKEA
  • LFYGTDF
  • WRPLKLGVVPVYYG
  • LFNYTATF

Post-translational modifications for FUT10 Gene

  • Glycosylation at Asn110 and Asn168
  • Modification sites at PhosphoSitePlus

Domains & Families for FUT10 Gene

Gene Families for FUT10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUT10 Gene

Blocks:
  • Glycosyl transferase, family 10
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FUT10 Gene

GenScript: Design optimal peptide antigens:
  • Galactoside 3-L-fucosyltransferase 10 (FUT10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P4F1

UniProtKB/Swiss-Prot:

FUT10_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT10: view

Function for FUT10 Gene

Molecular function for FUT10 Gene

UniProtKB/Swiss-Prot Function:
Probable fucosyltransferase.

Enzyme Numbers (IUBMB) for FUT10 Gene

Phenotypes From GWAS Catalog for FUT10 Gene

Gene Ontology (GO) - Molecular Function for FUT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity IEA,TAS 11698403
genes like me logo Genes that share ontologies with FUT10: view
genes like me logo Genes that share phenotypes with FUT10: view

Animal Model Products

CRISPR Products

miRNA for FUT10 Gene

miRTarBase miRNAs that target FUT10

Clone Products

  • Addgene plasmids for FUT10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT10 Gene

Localization for FUT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT10 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT10 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
endoplasmic reticulum 4
extracellular 2
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT10: view

Pathways & Interactions for FUT10 Gene

PathCards logo

SuperPathways for FUT10 Gene

No Data Available

UniProtKB/Swiss-Prot Q6P4F1-FUT10_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT10 Gene

;

Gene Ontology (GO) - Biological Process for FUT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 11698403
GO:0006486 protein glycosylation TAS 11698403
GO:0006605 protein targeting NAS 11698403
GO:0007399 nervous system development NAS 11698403
GO:0009566 fertilization NAS 11698403
genes like me logo Genes that share ontologies with FUT10: view

No data available for Pathways by source and SIGNOR curated interactions for FUT10 Gene

Drugs & Compounds for FUT10 Gene

No Compound Related Data Available

Transcripts for FUT10 Gene

mRNA/cDNA for FUT10 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for FUT10

Alternative Splicing Database (ASD) splice patterns (SP) for FUT10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: - - - -
SP10:

Relevant External Links for FUT10 Gene

GeneLoc Exon Structure for
FUT10

Expression for FUT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUT10 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT10 Gene



Protein tissue co-expression partners for FUT10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUT10

SOURCE GeneReport for Unigene cluster for FUT10 Gene:

Hs.458713

Evidence on tissue expression from TISSUES for FUT10 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FUT10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT10 Gene

Orthologs for FUT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FUT10 31 30
  • 88.28 (n)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUT10 31
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUT10 31 30
  • 84.89 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut10 30
  • 83.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FUT10 31
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut10 17 31 30
  • 81.49 (n)
oppossum
(Monodelphis domestica)
Mammalia FUT10 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT10 31 30
  • 69.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUT10 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut10 30
  • 65.46 (n)
zebrafish
(Danio rerio)
Actinopterygii fut10 31 30
  • 61.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta FucTB 31 32 30
  • 50.27 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
-- 31
  • 22 (a)
ManyToMany
CSA.7058 31
  • 22 (a)
ManyToMany
CSA.7837 31
  • 21 (a)
ManyToMany
CSA.4386 31
  • 21 (a)
ManyToMany
CSA.4383 31
  • 21 (a)
ManyToMany
CSA.7839 31
  • 21 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
ONA8 31
  • 20 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
CSA.4388 31
  • 20 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
CSA.4382 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
CSA.4384 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
-- 31
  • 18 (a)
ManyToMany
-- 31
  • 15 (a)
ManyToMany
CSA.4387 31
  • 14 (a)
ManyToMany
Species where no ortholog for FUT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT10 Gene

ENSEMBL:
Gene Tree for FUT10 (if available)
TreeFam:
Gene Tree for FUT10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUT10: view image

Paralogs for FUT10 Gene

Paralogs for FUT10 Gene

(1) SIMAP similar genes for FUT10 Gene using alignment to 1 proteins:

  • FUT10_HUMAN
genes like me logo Genes that share paralogs with FUT10: view

Variants for FUT10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUT10 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs16880853 - p.Tyr268His
rs16880994 - p.Leu59Phe
rs17855838 - p.Leu368Val
rs17855839 - p.Arg371Pro

Additional dbSNP identifiers (rs#s) for FUT10 Gene

Structural Variations from Database of Genomic Variants (DGV) for FUT10 Gene

Variant ID Type Subtype PubMed ID
esv2657939 CNV deletion 23128226
esv3576539 CNV gain 25503493
esv3616832 CNV loss 21293372
esv3616833 CNV loss 21293372
esv3616835 CNV loss 21293372
nsv1019414 CNV loss 25217958
nsv465634 CNV loss 19166990
nsv478872 CNV novel sequence insertion 20440878
nsv610929 CNV loss 21841781

Variation tolerance for FUT10 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.98; 93.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT10 Gene

Disorders for FUT10 Gene

Additional Disease Information for FUT10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FUT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT10 Gene

Publications for FUT10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PMID: 11698403) Roos C … Renkonen R (The Journal of biological chemistry 2002) 3 4 54
  4. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. (PMID: 12370785) Baboval T … Smith FI (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for FUT10 Gene

Sources for FUT10 Gene