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This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016] See more...
Aliases for FUT1 Gene
Aliases for FUT1 Gene
- Fucosyltransferase 1 (H Blood Group) 2 3 5
- GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 1 3 4
- Type 1 Galactoside Alpha-(1,2)-Fucosyltransferase FUT1 3 4
- Type 2 Galactoside Alpha-(1,2)-Fucosyltransferase FUT1 3 4
- Galactoside Alpha-(1,2)-Fucosyltransferase 1 3 4
- Galactoside 2-Alpha-L-Fucosyltransferase 2 3
- Blood Group H Alpha 2-Fucosyltransferase 3 4
- Alpha(1,2)FT 1 3 4
- EC 2.4.1.69 4 51
- HSC 3 4
- H 3 4
- Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay Phenotype Included) 2
- Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase) 2
- Truncated Alpha(1,2)Fucosyltransferase 3
- Nonfunctional Fucosyltransferase 1 3
- Alpha(1,2) Fucosyltransferase 1 3
- Truncated Fucosyltransferase 1 3
- H Glycosyltransferase 3
- H Glycosytransferase 3
- Fucosyltransferase 1 4
- Truncated FUT1 3
- EC 2.4.1.344 4
- FUT1 5
- HH 3
External Ids for FUT1 Gene
- HGNC: 4012
- Entrez Gene: 2523
- Ensembl: ENSG00000174951
- OMIM: 211100
- UniProtKB: P19526
Previous HGNC Symbols for FUT1 Gene
- H
- HSC
Previous GeneCards Identifiers for FUT1 Gene
- GC19M049964
- GC19M049619
- GC19M053927
- GC19M053943
- GC19M049251
- GC19M045630
Summaries for FUT1 Gene
-
This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]
GeneCards Summary for FUT1 Gene
FUT1 (Fucosyltransferase 1 (H Blood Group)) is a Protein Coding gene. Diseases associated with FUT1 include Bombay Phenotype and Orange Allergy. Among its related pathways are Immune response Lectin induced complement pathway and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT2.
UniProtKB/Swiss-Prot Summary for FUT1 Gene
-
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
Additional gene information for FUT1 Gene
- HGNC(4012)
- Entrez Gene(2523)
- Ensembl(ENSG00000174951)
- OMIM(211100)
- UniProtKB(P19526)
- Open Targets Platform(ENSG00000174951)
- Monarch Initiative
- Search for FUT1 at DataMed
- Search for FUT1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUT1 Gene
Genomics for FUT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FUT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FUT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUT1
- Top Transcription factor binding sites by QIAGEN in the FUT1 gene promoter:
-
- ATF
- MyoD
- p300
- PPAR-gamma1
- PPAR-gamma2
- STAT3
Genomic Locations for FUT1 Gene
Genomic Locations for FUT1 Gene
- chr19:48,748,011-48,755,390
- (GRCh38/hg38)
- Size:
- 7,380 bases
- Orientation:
- Minus strand
- chr19:49,251,268-49,258,647
- (GRCh37/hg19)
- Size:
- 7,380 bases
- Orientation:
- Minus strand
Genomic View for FUT1 Gene
Genes around FUT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
FUT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FUT1 Gene
Proteins for FUT1 Gene
-
Protein details for FUT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19526-FUT1_HUMAN
- Recommended name:
- Galactoside alpha-(1,2)-fucosyltransferase 1
- Protein Accession:
- P19526
- O14505
- O14506
- O14507
Protein attributes for FUT1 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 41251 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
Selected DME Specific Peptides for FUT1 Gene
- P19526:
-
- FVVTSNGM
- LAPVFRI
- EFTLHDH
- PVFVVTS
- LHDWMSE
- VGVHVRRGDY
- LCLAFLLVC
- CPQHPASLSGTWT
- FAGDGQEA
- LVTPPVAIFCLPG
- GGDTVYLAN
- QCNHTIMTIGTFG
- FRITLPVL
- KDFALLTQCNHT
- AAFLPEW
- MTIGTFGFWAAYL
- GRFGNQMGQYATLLALAQLNGRRAFI
- GFPCSWTFFHH
- LCPDRRLVT
Post-translational modifications for FUT1 Gene
Other Protein References for FUT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents FUT1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FUT1
- Novus Biologicals Antibodies for FUT1
-
Abcam antibodies for FUT1
- Invitrogen Antibodies for FUT1 (AFLGC-FUT1)
-
Biorbyt antibodies for FUT1
-
Boster Bio Antibodies for FUT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FUT1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FUT1
- Origene Custom Protein Services for FUT1
-
Abcam proteins for FUT1
Domains & Families for FUT1 Gene
Gene Families for FUT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Blood group antigen proteins
- Enzymes
- Predicted membrane proteins
Protein Domains for FUT1 Gene
- InterPro:
- Blocks:
-
- Glycosyl transferase, family 11
- ProtoNet:
Suggested Antigen Peptide Sequences for FUT1 Gene
- GenScript: Design optimal peptide antigens:
-
- Truncated alpha-2 fucosyltransferase 1 (A7XM28_HUMAN)
- Truncated alpha-2 fucosyltransferase 1 (A7XM32_HUMAN)
- Alpha-2 fucosyltransferase 1 (A7XM36_HUMAN)
- Fucosyltransferase (B3GVB9_HUMAN)
- Alpha(1,2)fucosyltransferase (C0L7J0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P19526- Family:
-
- Belongs to the glycosyltransferase 11 family.
Function for FUT1 Gene
Molecular function for FUT1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:50668, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:133507, ChEBI:CHEBI:133510; EC=2.4.1.344; Evidence={ECO:0000269|PubMed:2118655};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GA1 + GDP-beta-L-fucose = ganglioside Fuc-GA1 + GDP + H(+); Xref=Rhea:RHEA:48320, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:88069, ChEBI:CHEBI:90262; Evidence={ECO:0000250|UniProtKB:O09160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+); Xref=Rhea:RHEA:32175, ChEBI:CHEBI:15378, ChEBI:CHEBI:17292, ChEBI:CHEBI:28743, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; EC=2.4.1.69; Evidence={ECO:0000250|UniProtKB:O09160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+); Xref=Rhea:RHEA:48304, ChEBI:CHEBI:15378, ChEBI:CHEBI:17006, ChEBI:CHEBI:28691, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189; Evidence={ECO:0000250|UniProtKB:O09160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ganglioside GM1a + GDP-beta-L-fucose = ganglioside Fuc-GM1 + GDP + H(+); Xref=Rhea:RHEA:48292, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:82639, ChEBI:CHEBI:90189; Evidence={ECO:0000250|UniProtKB:F6Q1T7};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+); Xref=Rhea:RHEA:62964, ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189, ChEBI:CHEBI:84728, ChEBI:CHEBI:546807; Evidence={ECO:0000250|UniProtKB:F6Q1T7};.
- UniProtKB/Swiss-Prot Induction:
- Increased by TNF.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.4 mM for phenyl beta-D-galactoside {ECO:0000269|PubMed:2118655};
- GENATLAS Biochemistry:
- fucosyltransferase,alpha-(1,2),1 (synthesis of H blood antigen),regulating the expression of ABO antigenes in erythrocyte membranes and related antigens in several tissues
Enzyme Numbers (IUBMB) for FUT1 Gene
Phenotypes From GWAS Catalog for FUT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity | IBA,TAS | 11698403 |
| GO:0008417 | fucosyltransferase activity | TAS | 2118655 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0031127 | alpha-(1,2)-fucosyltransferase activity | ISS | -- |
Phenotypes for FUT1 Gene
- MGI mutant phenotypes for FUT1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FUT1:
Animal Model Products
-
Taconic Biosciences Mouse Models for FUT1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FUT1 - Select products 50% OFF >
- * FUT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FUT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUT1
miRNA for FUT1 Gene
- miRTarBase miRNAs that target FUT1
-
- hsa-miR-132-3p (MIRT021792)
- hsa-miR-5692a (MIRT530506)
- hsa-miR-196a-3p (MIRT542182)
- hsa-miR-661 (MIRT542183)
- hsa-miR-4725-5p (MIRT542184)
- hsa-miR-6860 (MIRT542185)
- hsa-miR-612 (MIRT542186)
- hsa-miR-5189-5p (MIRT542187)
- hsa-miR-3187-5p (MIRT542188)
- hsa-miR-1285-3p (MIRT542189)
- hsa-miR-5699-3p (MIRT542190)
- hsa-miR-4421 (MIRT542191)
- hsa-miR-939-3p (MIRT542192)
- hsa-miR-339-5p (MIRT542193)
- hsa-miR-10b-5p (MIRT542194)
- hsa-miR-10a-5p (MIRT542195)
- hsa-miR-6720-5p (MIRT631794)
- hsa-miR-6512-3p (MIRT631795)
- hsa-miR-766-3p (MIRT631796)
- hsa-miR-6849-3p (MIRT631797)
- hsa-miR-508-5p (MIRT631798)
- hsa-miR-7703 (MIRT664103)
- hsa-miR-6735-3p (MIRT664104)
- hsa-miR-4252 (MIRT664105)
- hsa-miR-3922-3p (MIRT664106)
- hsa-miR-3176 (MIRT664107)
- hsa-miR-3190-5p (MIRT664108)
- hsa-miR-4793-3p (MIRT664109)
- hsa-miR-1292-3p (MIRT664110)
- hsa-miR-1273g-3p (MIRT664111)
- hsa-miR-514a-5p (MIRT664112)
- hsa-miR-587 (MIRT718755)
- hsa-miR-5087 (MIRT718756)
- hsa-miR-8068 (MIRT718757)
- hsa-miR-8069 (MIRT718758)
- hsa-miR-1273f (MIRT718759)
- hsa-miR-122-3p (MIRT735414)
- hsa-miR-1288-5p (MIRT762254)
- hsa-miR-4459 (MIRT769269)
- hsa-miR-4648 (MIRT770607)
- hsa-miR-4654 (MIRT770758)
- hsa-miR-4683 (MIRT770947)
- hsa-miR-4769-5p (MIRT772186)
- hsa-miR-541-3p (MIRT773946)
- hsa-miR-6089 (MIRT775737)
- hsa-miR-6134 (MIRT775937)
- hsa-miR-654-5p (MIRT777291)
- hsa-miR-6721-5p (MIRT777824)
- hsa-miR-6888-5p (MIRT781093)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FUT1
- Browse OriGene Inhibitory RNA Products For FUT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT1
Clone Products
- Applied Biological Materials (abm): Clones for FUT1 - Select products 50% OFF >
- * FUT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FUT1
- Addgene plasmids for FUT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FUT1
Cell Line Products
-
Horizon Cell Lines for FUT1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT1 Gene
Localization for FUT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FUT1 Gene
- Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250 UniProtKB:O09160}.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 4 |
| extracellular | 3 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | TAS | 11698403 |
| GO:0005887 | integral component of plasma membrane | TAS | 2118655 |
| GO:0016020 | membrane | TAS | 2118655 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0032580 | Golgi cisterna membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FUT1 Gene
Pathways & Interactions for FUT1 Gene
Pathways by source for FUT1 Gene
1 Sino Biological pathway for FUT1 Gene
2 BioSystems pathways for FUT1 Gene
UniProtKB/Swiss-Prot P19526-FUT1_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for FUT1 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| B3GNT4 | ||
| CEBPA | ||
| CSGALNACT2 | ||
| FUT4 | ||
| FUT5 |
GPS-Prot Interaction Network for FUT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001936 | regulation of endothelial cell proliferation | ISS | -- |
| GO:0001954 | positive regulation of cell-matrix adhesion | IMP | 18205178 |
| GO:0005975 | carbohydrate metabolic process | TAS | 2118655 |
| GO:0006486 | protein glycosylation | IBA,TAS | 11698403 |
| GO:0010595 | positive regulation of endothelial cell migration | IMP | 18205178 |
No data available for SIGNOR curated interactions for FUT1 Gene
Drugs & Compounds for FUT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine diphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GDP-L-fucose |
|
15839-70-0 |
|
Transcripts for FUT1 Gene
mRNA/cDNA for FUT1 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310160 4246 nts (view in UCSC)
- ENST00000597220 649 nts (view in UCSC)
- ENST00000599826 681 nts (view in UCSC)
- ENST00000601931 847 nts (view in UCSC)
- ENST00000601988 815 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FUT1 - Select products 50% OFF >
- * FUT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for FUT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FUT1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUT1
Clone Products
- Applied Biological Materials (abm): Clones for FUT1 - Select products 50% OFF >
- * FUT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FUT1
- Addgene plasmids for FUT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FUT1
Relevant External Links for FUT1 Gene
- GeneLoc Exon Structure for
- FUT1
Expression for FUT1 Gene
mRNA differential expression in normal tissues according to GTEx for FUT1 Gene
This gene is overexpressed in Pancreas (x9.8) and Stomach (x5.6).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUT1
SOURCE GeneReport for Unigene cluster for FUT1 Gene:
Hs.69747Evidence on tissue expression from TISSUES for FUT1 Gene
- Nervous system(4.8)
- Intestine(2.5)
- Blood(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT1 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- lymphatic
Regions:
Thorax:
- thymus
Abdomen:
- liver
- spleen
General:
- blood
- bone marrow
- coagulation system
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for FUT1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FUT1 Gene
Orthologs for FUT1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FUT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FUT1 30 |
|
||
| -- 31 |
|
ManyToMany | |||
| Cow (Bos Taurus) |
Mammalia | FUT1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fut1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fut1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FUT1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FUT1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fut1 30 |
|
- Species where no ortholog for FUT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for FUT1 Gene
- ENSEMBL:
- Gene Tree for FUT1 (if available)
- TreeFam:
- Gene Tree for FUT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FUT1: view image
Paralogs for FUT1 Gene
(4) SIMAP similar genes for FUT1 Gene using alignment to 18 proteins:
- FUT1_HUMAN
- A7XM28_HUMAN
- A7XM32_HUMAN
- A7XM36_HUMAN
- B3GVB9_HUMAN
- C0L7J0_HUMAN
- C7F6W7_HUMAN
- E3UTT6_HUMAN
- F1D990_HUMAN
- F5BH05_HUMAN
- I7C6Y9_HUMAN
- J9XSG7_HUMAN
- Q4JGW8_HUMAN
- Q6IZA2_HUMAN
- Q8IVN2_HUMAN
- Q8WXB6_HUMAN
- T1WH77_HUMAN
- U5NK91_HUMAN
Variants for FUT1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for FUT1 Gene
- FUT1_HUMAN-P19526
- Genetic variations in FUT1 define the H blood group and are responsible for the Bombay and para-Bombay phenotypes [MIM:616754]. Erythrocytes from individuals with the Bombay and para-Bombay blood group phenotypes are deficient in H antigens.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUT1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 733897 | Benign: not provided | 48,751,225(-) | G/C | SYNONYMOUS_VARIANT | |
| rs104894686 | Affects: Bombay phenotype | 48,750,334(-) | G/C | NONSENSE | |
| rs104894687 | Pathogenic: Para-Bombay phenotype. - | 48,750,791(-) | A/Tp.Leu164His | MISSENSE_VARIANT | |
| rs104894688 | Pathogenic: Para-Bombay phenotype | 48,750,456(-) | G/A | NONSENSE | |
| rs150074056 | Pathogenic: Para-Bombay phenotype | 48,750,933(-) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.24;
70.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FUT1 Gene
- Blood Group Antigen Gene Mutation Database (BGMUT)
- Blood Group System
- Human Gene Mutation Database (HGMD)
- FUT1
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FUT1
SNP Genotyping and Copy Number Assay Products
Disorders for FUT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bombay phenotype |
|
|
| orange allergy |
|
|
| lipodystrophy, congenital generalized, type 2 |
|
|
| niemann-pick disease, type c1 |
|
|
Search FUT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FUT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FUT1 Gene
Publications for FUT1 Gene
- Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis. (PMID: 18205178) Moehler TM … Schwartz-Albiez R (Journal of cellular physiology 2008) 3 4 23
- [Study on the frequency of alpha-1,2-fucosyltransferase gene h4 allele (C35T) in Chinese population]. (PMID: 16331565) Xu XG … Yan LX (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2005) 3 23 41
- Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. (PMID: 9299444) Koda Y … Kimura H (Biochemical and biophysical research communications 1997) 3 4 23
- Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles. (PMID: 9122901) Wagner FF … Flegel WA (Transfusion 1997) 3 4 23
- Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria. (PMID: 19572973) Matzhold EM … Lanzer G (Transfusion 2009) 3 23
ExternalLinks
Products for FUT1 Gene
- Custom Antibody ServicesOriGene Antibodies for FUT1
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- Addgene plasmids for FUT1
- antibodies-online: Show 11 available FUT1 Antibodies ranked by validation data
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- antibodies-online: Show 18 available FUT1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for FUT1
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- Horizon Cell Lines for FUT1
- Browse GeneCopoeia Cell Lines
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- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for FUT1
Sources for FUT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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