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This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression... See more...
Aliases for FUS Gene
Aliases for FUS Gene
External Ids for FUS Gene
- HGNC: 4010
- Entrez Gene: 2521
- Ensembl: ENSG00000089280
- OMIM: 137070
- UniProtKB: P35637
Previous HGNC Symbols for FUS Gene
- ALS6
Previous GeneCards Identifiers for FUS Gene
- GC16P030273
- GC16P031688
- GC16P031188
- GC16P031227
- GC16P031098
- GC16P031191
- GC16P028753
- GC16P031295
- GC16P031313
- GC16P031333
- GC16P031418
- GC16P031181
- GC16P031184
- GC16P031229
- GC16P031234
- GC16P031265
- GC16P031279
Summaries for FUS Gene
-
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
GeneCards Summary for FUS Gene
FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include Tremor, Hereditary Essential, 4 and Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is EWSR1.
UniProtKB/Swiss-Prot Summary for FUS Gene
-
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
Additional gene information for FUS Gene
- HGNC(4010)
- Entrez Gene(2521)
- Ensembl(ENSG00000089280)
- OMIM(137070)
- UniProtKB(P35637)
- Open Targets Platform(ENSG00000089280)
- Monarch Initiative
- Search for FUS at DataMed
- Search for FUS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUS Gene
Genomics for FUS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FUS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FUS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUS
- Top Transcription factor binding sites by QIAGEN in the FUS gene promoter:
-
- FOXO1
- FOXO1a
- NRSF form 1
- NRSF form 2
- STAT5A
Genomic Locations for FUS Gene
Genomic Locations for FUS Gene
- chr16:31,180,110-31,194,871
- (GRCh38/hg38)
- Size:
- 14,762 bases
- Orientation:
- Plus strand
- chr16:31,191,431-31,206,192
- (GRCh37/hg19)
- Size:
- 14,762 bases
- Orientation:
- Plus strand
Genomic View for FUS Gene
Genes around FUS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
FUS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FUS Gene
Proteins for FUS Gene
-
Protein details for FUS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35637-FUS_HUMAN
- Recommended name:
- RNA-binding protein FUS
- Protein Accession:
- P35637
- Q9H4A8
Protein attributes for FUS Gene
- Size:
- 526 amino acids
- Molecular mass:
- 53426 Da
- Quaternary structure:
-
- Self-oligomerizes (via N-terminal region) (PubMed:25453086). Oligomerization is essential for chromatin binding (PubMed:25453086). Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1 (PubMed:9660765). Interacts through its C-terminus with SFRS13A (PubMed:9774382). Interacts with OTUB1 and SARNP. Interacts with LRSAM1 (PubMed:27615052). Interacts with SAFB1 in a DNA-dependent manner; this interaction tethers FUS to chromatin (PubMed:27731383). Interacts with MATR3 (PubMed:27731383). Interacts with SNRNP70 and POLR2A; these interactions couple RNA transcription and splicing (PubMed:26124092). Interacts (through its RNA-binding domain) with RALY (through its RNA-binding domain); both are components of the same RNPs (PubMed:30354839).
Three dimensional structures from OCA and Proteopedia for FUS Gene
Protein Expression for FUS Gene
Post-translational modifications for FUS Gene
- Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
- Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.
-
Ubiquitination at Lys316 and Lys365
- NX_P35637 (NX_P35637-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FUS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences FUS / TLS Antibody
- G Biosciences Immunotag™ FUS Antibody
- GeneTex Anti-FUS antibody [C1C3] and Anti-FUS antibody [JJ09-31]
- NSJ Bioreagents FUS Antibody
-
Custom Antibody ServicesOriGene Antibodies for FUS
- Novus Biologicals Antibodies for FUS
-
Abcam antibodies for FUS
- Invitrogen Antibodies for FUS (AFLGC-FUS)
-
Biorbyt antibodies for FUS
-
Santa Cruz Biotechnology (SCBT) Antibodies for FUS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FUS
- Origene Custom Protein Services for FUS
- antibodies-online: Show 2 available Fusion (FUS) Proteins ranked by validation data
- Compare Top Fusion (FUS) Proteins
-
Quality Products:
-
Abcam proteins for FUS
Assay Products
- antibodies-online: Show 3 available Fusion (FUS) Elisa Kits ranked by validation data
- Compare Top Fusion (FUS) Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FUS Gene
Domains & Families for FUS Gene
Gene Families for FUS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FUS Gene
- InterPro:
- Blocks:
-
- Zn-finger, Ran-binding
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for FUS Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58049, highly similar to RNA-binding protein FUS (B4DR70_HUMAN)
- Translocated in liposarcoma protein (FUS_HUMAN)
- Fusion, derived from t(12 (Q6IBQ5_HUMAN)
- Fusion (Involved in t(12 (Q8TBR3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P35637- Family:
-
- Belongs to the RRM TET family.
Function for FUS Gene
Molecular function for FUS Gene
- UniProtKB/Swiss-Prot Function:
- DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
- GENATLAS Biochemistry:
- RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged in myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)
Phenotypes From GWAS Catalog for FUS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 25453086 |
| GO:0003712 | transcription coregulator activity | IBA | 21873635 |
| GO:0003713 | transcription coactivator activity | IDA | 21909421 |
Phenotypes for FUS Gene
- GenomeRNAi human phenotypes for FUS:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Increased cell number in G2M, increased nuclei size in G2M
- shRNA abundance <= 25%
- Increased Nanog expression
- Increased NF-kappaB reporter expression
- Decreased influenza A virus infection
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FUS - Select products 50% OFF >
- * FUS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FUS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUS
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUS
miRNA for FUS Gene
- miRTarBase miRNAs that target FUS
-
- hsa-miR-197-3p (MIRT004196)
- mmu-miR-7b-5p (MIRT009237)
- hsa-miR-664a-3p (MIRT035826)
- hsa-miR-1296-5p (MIRT036115)
- hsa-miR-615-3p (MIRT040469)
- hsa-miR-331-3p (MIRT043384)
- hsa-miR-125b-5p (MIRT046086)
- hsa-miR-221-3p (MIRT046900)
- hsa-miR-181b-5p (MIRT047277)
- hsa-miR-10a-5p (MIRT047505)
- hsa-miR-1260b (MIRT052707)
- mmu-miR-466o-3p (MIRT578784)
- mmu-miR-466m-3p (MIRT578785)
- mmu-miR-466f-3p (MIRT578786)
- mmu-miR-466i-3p (MIRT578787)
- mmu-miR-362-3p (MIRT578788)
- mmu-miR-329-3p (MIRT578789)
- hsa-miR-661 (MIRT623870)
- hsa-miR-6860 (MIRT623871)
- hsa-miR-612 (MIRT623872)
- hsa-miR-5189-5p (MIRT623873)
- hsa-miR-3187-5p (MIRT623874)
- hsa-miR-1285-3p (MIRT623875)
- hsa-miR-939-3p (MIRT623876)
- hsa-miR-6849-3p (MIRT623877)
- hsa-miR-4482-5p (MIRT623878)
- hsa-miR-3130-5p (MIRT623879)
- hsa-miR-1273e (MIRT650107)
- hsa-miR-6514-3p (MIRT650108)
- hsa-miR-6811-3p (MIRT650109)
- hsa-miR-214-5p (MIRT650110)
- hsa-miR-7703 (MIRT672478)
- hsa-miR-6720-5p (MIRT672479)
- hsa-miR-6512-3p (MIRT672480)
- hsa-miR-1255b-5p (MIRT672481)
- hsa-miR-1255a (MIRT672482)
- hsa-miR-6744-5p (MIRT672483)
- hsa-miR-3116 (MIRT672484)
- hsa-miR-1254 (MIRT672485)
- hsa-miR-4252 (MIRT672486)
- hsa-miR-4537 (MIRT672487)
- hsa-miR-4793-3p (MIRT672488)
- hsa-miR-766-3p (MIRT672489)
- hsa-miR-508-5p (MIRT672490)
- hsa-miR-1255b-2-3p (MIRT761655)
- hsa-miR-1273g-3p (MIRT761935)
- hsa-miR-340-3p (MIRT765714)
- hsa-miR-4293 (MIRT768424)
- hsa-miR-4432 (MIRT768966)
- hsa-miR-4434 (MIRT769091)
- hsa-miR-4516 (MIRT769924)
- hsa-miR-451b (MIRT769948)
- hsa-miR-4522 (MIRT769978)
- hsa-miR-4531 (MIRT770068)
- hsa-miR-455-3p (MIRT770321)
- hsa-miR-4684-5p (MIRT770994)
- hsa-miR-4696 (MIRT771256)
- hsa-miR-4786-5p (MIRT772293)
- hsa-miR-4802-3p (MIRT772549)
- hsa-miR-5703 (MIRT775218)
- hsa-miR-6499-3p (MIRT776258)
- hsa-miR-6510-3p (MIRT776734)
- hsa-miR-6516-5p (MIRT777119)
- hsa-miR-6771-3p (MIRT778619)
- hsa-miR-6807-5p (MIRT779573)
- hsa-miR-6827-3p (MIRT779912)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FUS
- Browse OriGene Inhibitory RNA Products For FUS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUS
Clone Products
- Applied Biological Materials (abm): Clones for FUS - Select products 50% OFF >
- * FUS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208306
- MR208306
- MR208306L3
- MR208306L4
- RC201808
- RC201808L1
- RC201808L2
- RC201808L3
- RC201808L4
- RC230222
- RC230222L3
- RC230222L4
- RC230232
- RC230232L3
- RC230232L4
- RG201808
- RG230222
- RG230232
- RR211011
- RR211011L3
- RR211011L4
- MR208306L3V
- MR208306L4V
- RC201808L1V
- RC201808L2V
- RC201808L3V
- RC201808L4V
- RC230222L3V
- RC230222L4V
- RC230232L3V
- RC230232L4V
- RR211011L3V
- RR211011L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FUS
- Addgene plasmids for FUS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FUS
Cell Line Products
-
Horizon Cell Lines for FUS
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FUS Gene
Localization for FUS Gene
Subcellular locations from UniProtKB/Swiss-Prot for FUS Gene
- Nucleus. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. {ECO:0000269 PubMed:25453086}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 16365397 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005844 | polysome | IEA | -- |
| GO:0030425 | dendrite | IEA | -- |
Pathways & Interactions for FUS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Translational Control | ||
| 4 | Transcriptional misregulation in cancer | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for FUS Gene
1 BioSystems pathway for FUS Gene
4 Reactome pathways for FUS Gene
1 KEGG pathway for FUS Gene
2 Cell Signaling Technology pathways for FUS Gene
Interacting Proteins for FUS Gene
Selected Interacting proteins:
P35637-FUS_HUMAN
ENSP00000254108
for FUS Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FUS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA,IDA | 26124092 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 25453086 |
| GO:0008380 | RNA splicing | IDA | 26124092 |
| GO:0010467 | gene expression | IEA | -- |
Transcripts for FUS Gene
mRNA/cDNA for FUS Gene
- 4 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000254108 1824 nts (view in UCSC)
- ENST00000380244 1818 nts (view in UCSC)
- ENST00000474990 827 nts (view in UCSC)
- ENST00000483853 778 nts (view in UCSC)
- ENST00000487045 952 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FUS - Select products 50% OFF >
- * FUS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FUS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FUS
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FUS
- Browse OriGene Inhibitory RNA Products For FUS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUS
Clone Products
- Applied Biological Materials (abm): Clones for FUS - Select products 50% OFF >
- * FUS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208306
- MR208306
- MR208306L3
- MR208306L4
- RC201808
- RC201808L1
- RC201808L2
- RC201808L3
- RC201808L4
- RC230222
- RC230222L3
- RC230222L4
- RC230232
- RC230232L3
- RC230232L4
- RG201808
- RG230222
- RG230232
- RR211011
- RR211011L3
- RR211011L4
- MR208306L3V
- MR208306L4V
- RC201808L1V
- RC201808L2V
- RC201808L3V
- RC201808L4V
- RC230222L3V
- RC230222L4V
- RC230232L3V
- RC230232L4V
- RR211011L3V
- RR211011L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FUS
- Addgene plasmids for FUS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FUS
Relevant External Links for FUS Gene
- GeneLoc Exon Structure for
- FUS
Expression for FUS Gene
This gene is overexpressed in Lymph node (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUS Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUS
SOURCE GeneReport for Unigene cluster for FUS Gene:
Hs.46894mRNA Expression by UniProt/SwissProt for FUS Gene:
P35637-FUS_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for FUS Gene
- Nervous system(4.9)
- Lung(4.8)
- Liver(4.8)
- Intestine(4.2)
- Skin(4.2)
- Kidney(4.1)
- Muscle(4)
- Heart(3.9)
- Eye(3.8)
- Bone marrow(3.7)
- Lymph node(3.7)
- Thyroid gland(3.6)
- Spleen(3.6)
- Stomach(3.6)
- Adrenal gland(3.6)
- Pancreas(3.4)
- Blood(3.4)
- Gall bladder(3.1)
- Bone(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FUS Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- epiglottis
- face
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- salivary gland
- skull
- tongue
- vocal cord
Thorax:
- bronchus
- clavicle
- esophagus
- heart
- lung
- scapula
- trachea
Abdomen:
- biliary tract
- liver
- stomach
Limb:
- arm
- digit
- finger
- foot
- forearm
- hand
- humerus
- lower limb
- shin
- shoulder
- thigh
- toe
- upper limb
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for FUS
-
OriGene qPCR primer pairs and template standards for FUS
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FUS Gene
Orthologs for FUS Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FUS 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fus 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FUS 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FUS 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FUS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FUS 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FUS 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | fus-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fus 31 |
|
OneToOne | |
| zgc56390 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | caz 31 |
|
ManyToMany | |
| CG14718 31 |
|
ManyToMany |
- Species where no ortholog for FUS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FUS Gene
- ENSEMBL:
- Gene Tree for FUS (if available)
- TreeFam:
- Gene Tree for FUS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FUS: view image
Paralogs for FUS Gene
Variants for FUS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUS Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 647759 | Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 | 31,185,103(+) | G/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 649131 | Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 | 31,185,081(+) | T/TGGCGGC | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION | |
| 650787 | Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 | 31,191,412(+) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 653781 | Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 | 31,190,309(+) | CAGT/C | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION | |
| 654997 | Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 | 31,185,099(+) | C/CGGTGGTGGT | NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION |
Residual Variation Intolerance Score:
13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FUS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUS Gene
Disorders for FUS Gene
(82) MalaCards diseases for FUS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tremor, hereditary essential, 4 |
|
|
| amyotrophic lateral sclerosis 6 with or without frontotemporal dementia |
|
|
| juvenile amyotrophic lateral sclerosis |
|
|
| amyotrophic lateral sclerosis type 6 |
|
|
| myxoid liposarcoma |
|
Search FUS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FUS_HUMAN- Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. {ECO:0000269 PubMed:7503811}.
- Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. {ECO:0000269 PubMed:8187069}.
- Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. {ECO:0000269 PubMed:11063792}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. {ECO:0000269 PubMed:11063792}.
- Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:19251627, ECO:0000269 PubMed:19251628, ECO:0000269 PubMed:19861302, ECO:0000269 PubMed:20124201, ECO:0000269 PubMed:27604643}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:22863194}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for FUS Gene
myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation
Additional Disease Information for FUS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
Publications for FUS Gene
- Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PMID: 7503811) Rabbitts TH … Nathan P (Nature genetics 1993) 2 3 4 23
- Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PMID: 19251627) Kwiatkowski TJ … Brown RH (Science (New York, N.Y.) 2009) 2 3 4
- Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PMID: 19251628) Vance C … Shaw CE (Science (New York, N.Y.) 2009) 2 3 4
- Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. (PMID: 10442642) Bertrand P … Lopez BS (Oncogene 1999) 3 4 23
- The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. (PMID: 30354839) Gasperini L … Macchi P (Molecular biology of the cell 2018) 3 4
ExternalLinks
Products for FUS Gene
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- MG208306
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- antibodies-online: Show 657 available Fusion (FUS) Antibodies ranked by validation data
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- Biorbyt antibodies for FUS
Sources for FUS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
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- (82) BioGPS
- (83) Illumina
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