This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression... See more...

Aliases for FUS Gene

Aliases for FUS Gene

  • FUS RNA Binding Protein 2 3 5
  • TLS 2 3 4
  • Heterogeneous Nuclear Ribonucleoprotein P2 2 3
  • Translocated In Liposarcoma Protein 3 4
  • 75 KDa DNA-Pairing Protein 3 4
  • RNA-Binding Protein FUS 3 4
  • Fused In Sarcoma 2 3
  • Oncogene FUS 3 4
  • Oncogene TLS 3 4
  • HNRNPP2 2 3
  • FUS1 2 3
  • Fusion (Involved In T(12;16) In Malignant Liposarcoma) 2
  • Fusion, Derived From T(12;16) Malignant Liposarcoma 2
  • Fusion Gene In Myxoid Liposarcoma 3
  • Amyotrophic Lateral Sclerosis 6 2
  • Translocated In Liposarcoma 2
  • Fus-Like Protein 3
  • HnRNP-P2 2
  • POMP75 3
  • POMp75 4
  • ALS6 3
  • ETM4 3
  • FUS 5

External Ids for FUS Gene

Previous HGNC Symbols for FUS Gene

  • ALS6

Previous GeneCards Identifiers for FUS Gene

  • GC16P030273
  • GC16P031688
  • GC16P031188
  • GC16P031227
  • GC16P031098
  • GC16P031191
  • GC16P028753
  • GC16P031295
  • GC16P031313
  • GC16P031333
  • GC16P031418
  • GC16P031181
  • GC16P031184
  • GC16P031229
  • GC16P031234
  • GC16P031265
  • GC16P031279

Summaries for FUS Gene

Entrez Gene Summary for FUS Gene

  • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

GeneCards Summary for FUS Gene

FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include Tremor, Hereditary Essential, 4 and Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is EWSR1.

UniProtKB/Swiss-Prot Summary for FUS Gene

  • DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).

Gene Wiki entry for FUS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUS Gene

Genomics for FUS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FUS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUS

Top Transcription factor binding sites by QIAGEN in the FUS gene promoter:
  • FOXO1
  • FOXO1a
  • NRSF form 1
  • NRSF form 2
  • STAT5A

Genomic Locations for FUS Gene

Genomic Locations for FUS Gene
chr16:31,180,110-31,194,871
(GRCh38/hg38)
Size:
14,762 bases
Orientation:
Plus strand
chr16:31,191,431-31,206,192
(GRCh37/hg19)
Size:
14,762 bases
Orientation:
Plus strand

Genomic View for FUS Gene

Genes around FUS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUS Gene

Proteins for FUS Gene

  • Protein details for FUS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35637-FUS_HUMAN
    Recommended name:
    RNA-binding protein FUS
    Protein Accession:
    P35637
    Secondary Accessions:
    • Q9H4A8

    Protein attributes for FUS Gene

    Size:
    526 amino acids
    Molecular mass:
    53426 Da
    Quaternary structure:
    • Self-oligomerizes (via N-terminal region) (PubMed:25453086). Oligomerization is essential for chromatin binding (PubMed:25453086). Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1 (PubMed:9660765). Interacts through its C-terminus with SFRS13A (PubMed:9774382). Interacts with OTUB1 and SARNP. Interacts with LRSAM1 (PubMed:27615052). Interacts with SAFB1 in a DNA-dependent manner; this interaction tethers FUS to chromatin (PubMed:27731383). Interacts with MATR3 (PubMed:27731383). Interacts with SNRNP70 and POLR2A; these interactions couple RNA transcription and splicing (PubMed:26124092). Interacts (through its RNA-binding domain) with RALY (through its RNA-binding domain); both are components of the same RNPs (PubMed:30354839).

    Three dimensional structures from OCA and Proteopedia for FUS Gene

    Alternative splice isoforms for FUS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUS Gene

Post-translational modifications for FUS Gene

  • Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
  • Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region.
  • Ubiquitination at Lys316 and Lys365
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FUS Gene

Domains & Families for FUS Gene

Gene Families for FUS Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FUS Gene

InterPro:
Blocks:
  • Zn-finger, Ran-binding
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for FUS Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58049, highly similar to RNA-binding protein FUS (B4DR70_HUMAN)
  • Translocated in liposarcoma protein (FUS_HUMAN)
  • Fusion, derived from t(12 (Q6IBQ5_HUMAN)
  • Fusion (Involved in t(12 (Q8TBR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35637

UniProtKB/Swiss-Prot:

FUS_HUMAN :
  • Belongs to the RRM TET family.
Family:
  • Belongs to the RRM TET family.
genes like me logo Genes that share domains with FUS: view

Function for FUS Gene

Molecular function for FUS Gene

UniProtKB/Swiss-Prot Function:
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
GENATLAS Biochemistry:
RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged in myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)

Phenotypes From GWAS Catalog for FUS Gene

Gene Ontology (GO) - Molecular Function for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 25453086
GO:0003712 transcription coregulator activity IBA 21873635
GO:0003713 transcription coactivator activity IDA 21909421
genes like me logo Genes that share ontologies with FUS: view
genes like me logo Genes that share phenotypes with FUS: view

Human Phenotype Ontology for FUS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for FUS Gene

miRTarBase miRNAs that target FUS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FUS Gene

Localization for FUS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUS Gene

Nucleus. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. {ECO:0000269 PubMed:25453086}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUS gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 16365397
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with FUS: view

Pathways & Interactions for FUS Gene

genes like me logo Genes that share pathways with FUS: view

Pathways by source for FUS Gene

1 KEGG pathway for FUS Gene
2 Cell Signaling Technology pathways for FUS Gene

SIGNOR curated interactions for FUS Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 26124092
GO:0006357 regulation of transcription by RNA polymerase II IDA 25453086
GO:0008380 RNA splicing IDA 26124092
GO:0010467 gene expression IEA --
genes like me logo Genes that share ontologies with FUS: view

Drugs & Compounds for FUS Gene

(2) Drugs for FUS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FUS: view

Transcripts for FUS Gene

mRNA/cDNA for FUS Gene

4 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUS

Alternative Splicing Database (ASD) splice patterns (SP) for FUS Gene

No ASD Table

Relevant External Links for FUS Gene

GeneLoc Exon Structure for
FUS

Expression for FUS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUS Gene

Protein differential expression in normal tissues from HIPED for FUS Gene

This gene is overexpressed in Lymph node (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUS Gene



Protein tissue co-expression partners for FUS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUS

SOURCE GeneReport for Unigene cluster for FUS Gene:

Hs.46894

mRNA Expression by UniProt/SwissProt for FUS Gene:

P35637-FUS_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FUS Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.8)
  • Intestine(4.2)
  • Skin(4.2)
  • Kidney(4.1)
  • Muscle(4)
  • Heart(3.9)
  • Eye(3.8)
  • Bone marrow(3.7)
  • Lymph node(3.7)
  • Thyroid gland(3.6)
  • Spleen(3.6)
  • Stomach(3.6)
  • Adrenal gland(3.6)
  • Pancreas(3.4)
  • Blood(3.4)
  • Gall bladder(3.1)
  • Bone(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FUS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • salivary gland
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with FUS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FUS Gene

Orthologs for FUS Gene

This gene was present in the common ancestor of animals.

Orthologs for FUS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FUS 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fus 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FUS 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FUS 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FUS 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FUS 31
  • 91 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FUS 31
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fus-prov 30
Zebrafish
(Danio rerio)
Actinopterygii fus 31
  • 65 (a)
OneToOne
zgc56390 30
Fruit Fly
(Drosophila melanogaster)
Insecta caz 31
  • 42 (a)
ManyToMany
CG14718 31
  • 25 (a)
ManyToMany
Species where no ortholog for FUS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FUS Gene

ENSEMBL:
Gene Tree for FUS (if available)
TreeFam:
Gene Tree for FUS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUS: view image

Paralogs for FUS Gene

Paralogs for FUS Gene

(3) SIMAP similar genes for FUS Gene using alignment to 5 proteins:

  • FUS_HUMAN
  • H3BNZ4_HUMAN
  • H3BPE7_HUMAN
  • Q6IBQ5_HUMAN
  • Q8TBR3_HUMAN
genes like me logo Genes that share paralogs with FUS: view

Variants for FUS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUS Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
647759 Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 31,185,103(+) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
649131 Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 31,185,081(+) T/TGGCGGC NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION
650787 Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 31,191,412(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
653781 Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 31,190,309(+) CAGT/C NON_CODING_TRANSCRIPT_VARIANT,INFRAME_DELETION
654997 Uncertain Significance: Amyotrophic lateral sclerosis type 6; Tremor, hereditary essential, 4 31,185,099(+) C/CGGTGGTGGT NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION

Additional dbSNP identifiers (rs#s) for FUS Gene

Structural Variations from Database of Genomic Variants (DGV) for FUS Gene

Variant ID Type Subtype PubMed ID
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781

Variation tolerance for FUS Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUS Gene

Human Gene Mutation Database (HGMD)
FUS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUS Gene

Disorders for FUS Gene

MalaCards: The human disease database

(82) MalaCards diseases for FUS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FUS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FUS_HUMAN
  • Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. {ECO:0000269 PubMed:7503811}.
  • Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. {ECO:0000269 PubMed:8187069}.
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. {ECO:0000269 PubMed:11063792}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. {ECO:0000269 PubMed:11063792}.
  • Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:19251627, ECO:0000269 PubMed:19251628, ECO:0000269 PubMed:19861302, ECO:0000269 PubMed:20124201, ECO:0000269 PubMed:27604643}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:22863194}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FUS Gene

myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

Additional Disease Information for FUS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FUS: view

Publications for FUS Gene

  1. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PMID: 7503811) Rabbitts TH … Nathan P (Nature genetics 1993) 2 3 4 23
  2. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PMID: 19251627) Kwiatkowski TJ … Brown RH (Science (New York, N.Y.) 2009) 2 3 4
  3. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PMID: 19251628) Vance C … Shaw CE (Science (New York, N.Y.) 2009) 2 3 4
  4. Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. (PMID: 10442642) Bertrand P … Lopez BS (Oncogene 1999) 3 4 23
  5. The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. (PMID: 30354839) Gasperini L … Macchi P (Molecular biology of the cell 2018) 3 4

Products for FUS Gene

Sources for FUS Gene