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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein un... See more...
Aliases for FURIN Gene
Aliases for FURIN Gene
- Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein) 2
- Furin (Paired Basic Amino Acid Cleaving Enzyme) 2
- Proprotein Convertase Subtilisin/Kexin Type 3 3
- Furin, Membrane Associated Receptor Protein 3
- Dibasic Processing Enzyme 3
- Dibasic-Processing Enzyme 4
- FES Upstream Region 3
- EC 3.4.21 51
- FURIN 5
External Ids for FURIN Gene
- HGNC: 8568
- Entrez Gene: 5045
- Ensembl: ENSG00000140564
- OMIM: 136950
- UniProtKB: P09958
Previous HGNC Symbols for FURIN Gene
- PCSK3
- FUR
- PACE
Previous GeneCards Identifiers for FURIN Gene
- GC15P084851
- GC15P088999
- GC15P089141
- GC15P089212
- GC15P091411
- GC15P067523
Summaries for FURIN Gene
-
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2020]
GeneCards Summary for FURIN Gene
FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Avian Influenza and Cerebral Amyloid Angiopathy, Itm2b-Related, 1. Among its related pathways are Lipoprotein metabolism and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PCSK4.
UniProtKB/Swiss-Prot Summary for FURIN Gene
-
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999).
-
(Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins.
-
(Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.
-
(Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP.
Additional gene information for FURIN Gene
- HGNC(8568)
- Entrez Gene(5045)
- Ensembl(ENSG00000140564)
- OMIM(136950)
- UniProtKB(P09958)
- Open Targets Platform(ENSG00000140564)
- Monarch Initiative
- Search for FURIN at DataMed
- Search for FURIN at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FURIN Gene
Genomics for FURIN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FURIN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FURIN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FURIN
- Top Transcription factor binding sites by QIAGEN in the FURIN gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- GATA-1
- TBP
- YY1
Genomic Locations for FURIN Gene
Genomic Locations for FURIN Gene
- chr15:90,868,588-90,883,458
- (GRCh38/hg38)
- Size:
- 14,871 bases
- Orientation:
- Plus strand
- chr15:91,411,822-91,426,688
- (GRCh37/hg19)
- Size:
- 14,867 bases
- Orientation:
- Plus strand
Genomic View for FURIN Gene
Genes around FURIN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.1 by HGNC
- 15q26.1 by Entrez Gene
- 15q26.1 by Ensembl
FURIN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FURIN Gene
Proteins for FURIN Gene
-
Protein details for FURIN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09958-FURIN_HUMAN
- Recommended name:
- Furin
- Protein Accession:
- P09958
- Q14336
- Q6LBS3
- Q9UCZ5
Protein attributes for FURIN Gene
- Size:
- 794 amino acids
- Molecular mass:
- 86678 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters (PubMed:11331585).
Protein Expression for FURIN Gene
Selected DME Specific Peptides for FURIN Gene
- P09958:
-
- HGTRCAGEVAA
- GSIFVWA
- LTWRDMQHL
- FMTTHSWDEDP
- TLSISSAT
- HGTRCAGE
- PCHASCATCQGPA
- HTGTSASAP
- GGVRMLDG
- TDCLSCPSHASLDPVEQTCSRQSQSSRES
- IYSASWGPEDDG
- QGRGGLGSI
- NNYGTLT
- STLATTYSSG
- VTDAVEARSL
- RPHDYSADGFNDW
- YGYGLLDAG
- CDGYTNSI
- HPDLAGNYDP
- DGYTNSI
- DPDPQPRYT
- GIVVSILDDGIEKNHPDL
- EPKDIGK
- WASGNGG
- AAGIIAL
- CGVGVAY
Post-translational modifications for FURIN Gene
- The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
- Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.
-
Glycosylation at Asn387, Asn440, and Asn553
- NX_P09958 (NX_P09958-1)
-
Ubiquitination at Lys748
- NX_P09958 (NX_P09958-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FURIN Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FURIN
- Novus Biologicals Antibodies for FURIN
-
Abcam antibodies for FURIN
- Invitrogen Antibodies for FURIN (AFLGC-FURIN)
- antibodies-online: Show 28 available FURIN Antibodies ranked by validation data
- Compare Top FURIN Antibodies
-
Recommended
- 81 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Biorbyt antibodies for FURIN
-
Santa Cruz Biotechnology (SCBT) Antibodies for FURIN
- Sino Biological Antibodies for FURIN
Protein Products
-
OriGene Purified Proteins for FURIN
- Search Origene for MassSpec and Protein Over-expression Lysates for FURIN
- Origene Custom Protein Services for FURIN
- Novus Biologicals lysates for FURIN
- ProSpec Recombinant Proteins for FURIN
-
Signalway Proteins for FURIN
-
Abcam proteins for FURIN
Assay Products
- G Biosciences Immunotag™ Human FUR (Furin) ELISA
- RayBiotech Human Furin ELISA
-
Custom Assay ServicesOriGene ELISA Kits for FURIN
- Novus Biologicals ELISA Kits for FURIN
-
Boster Bio ELISA Kits for FURIN
-
Signalway ELISA kits for FURIN
Domains & Families for FURIN Gene
Gene Families for FURIN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for FURIN Gene
- InterPro:
- Blocks:
-
- Subtilisin serine protease family (S8) signature
- Furin-like repeat
- Proprotein convertase, P domain
- ProtoNet:
Suggested Antigen Peptide Sequences for FURIN Gene
- GenScript: Design optimal peptide antigens:
-
- Paired basic amino acid residue-cleaving enzyme (FURIN_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P09958UniProtKB/Swiss-Prot:
FURIN_HUMAN :- Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
- Belongs to the peptidase S8 family. Furin subfamily.
- Domain:
-
- Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
- Family:
-
- Belongs to the peptidase S8 family. Furin subfamily.
Function for FURIN Gene
Molecular function for FURIN Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.; EC=3.4.21.75; Evidence={ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222, ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280, ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548, ECO:0000269|PubMed:7737999, ECO:0000269|PubMed:9130696};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 6.0. {ECO:0000269|PubMed:9130696};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by the not secondly cleaved propeptide (PubMed:9130696, PubMed:11799113). Inhibited by m-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)-benzamidine (m-guanidinomethyl-Phac-RVR-Amb) and 4-guanidinomethyl-phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148) (PubMed:24666235, PubMed:25974265).
Enzyme Numbers (IUBMB) for FURIN Gene
Phenotypes From GWAS Catalog for FURIN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 14744861 |
| GO:0004175 | endopeptidase activity | TAS | -- |
| GO:0004252 | serine-type endopeptidase activity | TAS | -- |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IDA | 10567353 |
| GO:0005515 | protein binding | IPI | 20608975 |
Phenotypes for FURIN Gene
- MGI mutant phenotypes for FURIN:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- mortality/aging
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- limbs/digits/tail phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for FURIN:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased IL-8 secretion
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased Sindbis virus (SINV) infection
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance (Z-score > 2)
- Increased viability with SS1P at EC90
- Increased viability after borna disease (rVSVΔG*/BDVG) virus infection
- Synthetic lethal with gemcitabine
Animal Models for FURIN Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FURIN - Select products 50% OFF >
- * FURIN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FURIN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FURIN
-
Santa Cruz Biotechnology (SCBT) CRISPR for FURIN
miRNA for FURIN Gene
- miRTarBase miRNAs that target FURIN
-
- hsa-miR-24-3p (MIRT005919)
- mmu-miR-19b-3p (MIRT012486)
- mmu-miR-149-5p (MIRT014558)
- mmu-miR-9-5p (MIRT015391)
- hsa-miR-103a-3p (MIRT027060)
- hsa-miR-16-5p (MIRT031785)
- hsa-miR-615-3p (MIRT039979)
- hsa-miR-484 (MIRT042240)
- hsa-miR-6778-5p (MIRT476678)
- hsa-miR-1233-5p (MIRT476679)
- hsa-miR-6766-5p (MIRT476680)
- hsa-miR-6756-5p (MIRT476681)
- hsa-miR-6508-3p (MIRT476682)
- hsa-miR-6739-5p (MIRT476683)
- hsa-miR-6733-5p (MIRT476684)
- hsa-miR-3153 (MIRT476685)
- hsa-miR-4505 (MIRT476686)
- hsa-miR-5787 (MIRT476687)
- hsa-miR-6089 (MIRT476688)
- hsa-miR-4286 (MIRT476689)
- hsa-miR-6783-5p (MIRT476690)
- hsa-miR-6856-5p (MIRT476691)
- hsa-miR-6758-5p (MIRT476692)
- hsa-miR-140-3p (MIRT476693)
- hsa-miR-6838-5p (MIRT476694)
- hsa-miR-497-5p (MIRT476695)
- hsa-miR-424-5p (MIRT476696)
- hsa-miR-195-5p (MIRT476697)
- hsa-miR-15a-5p (MIRT476698)
- hsa-miR-15b-5p (MIRT476699)
- hsa-miR-107 (MIRT476700)
- hsa-miR-1273h-5p (MIRT736863)
- hsa-miR-148a-3p (MIRT737667)
- hsa-miR-148b-3p (MIRT737680)
- hsa-miR-149-3p (MIRT737728)
- hsa-miR-152-3p (MIRT737869)
- hsa-miR-302c-3p (MIRT739648)
- hsa-miR-30b-3p (MIRT739753)
- hsa-miR-328-5p (MIRT741288)
- hsa-miR-3689a-3p (MIRT742255)
- hsa-miR-3689b-3p (MIRT742325)
- hsa-miR-3689c (MIRT742395)
- hsa-miR-4253 (MIRT743354)
- hsa-miR-4640-5p (MIRT746326)
- hsa-miR-4697-3p (MIRT747219)
- hsa-miR-4726-5p (MIRT747755)
- hsa-miR-4728-5p (MIRT747824)
- hsa-miR-4738-5p (MIRT748023)
- hsa-miR-520f-3p (MIRT750242)
- hsa-miR-6076 (MIRT751689)
- hsa-miR-6779-5p (MIRT755494)
- hsa-miR-6780a-5p (MIRT755570)
- hsa-miR-6785-5p (MIRT755819)
- hsa-miR-6797-3p (MIRT756168)
- hsa-miR-6799-5p (MIRT756299)
- hsa-miR-6862-5p (MIRT757890)
- hsa-miR-6883-5p (MIRT758404)
- hsa-miR-6885-5p (MIRT758538)
- hsa-miR-7106-5p (MIRT758851)
- hsa-miR-1285-3p (MIRT790082)
- hsa-miR-3187-5p (MIRT790257)
- hsa-miR-331-3p (MIRT790286)
- hsa-miR-4292 (MIRT790412)
- hsa-miR-4779 (MIRT790635)
- hsa-miR-5189-5p (MIRT790706)
- hsa-miR-612 (MIRT790823)
- hsa-miR-6721-5p (MIRT790886)
- hsa-miR-6731-5p (MIRT790899)
- hsa-miR-6791-5p (MIRT790963)
- hsa-miR-6805-5p (MIRT790977)
- hsa-miR-6860 (MIRT791047)
- hsa-miR-8085 (MIRT791140)
- hsa-miR-939-3p (MIRT791165)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FURIN
- Browse OriGene Inhibitory RNA Products For FURIN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FURIN
Clone Products
- Applied Biological Materials (abm): Clones for FURIN - Select products 50% OFF >
- * FURIN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FURIN
- Addgene plasmids for FURIN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FURIN
Cell Line Products
-
Horizon Cell Lines for FURIN
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FURIN Gene
Localization for FURIN Gene
Subcellular locations from UniProtKB/Swiss-Prot for FURIN Gene
- Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Cell membrane. Single-pass type I membrane protein. Secreted. Endosome membrane. Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface (PubMed:9412467, PubMed:11799113). Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (PubMed:11799113). {ECO:0000269 PubMed:11799113, ECO:0000269 PubMed:9412467}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 4 |
| endosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | NOT extracellular space | IDA | 10567353 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IGI | 17938254 |
Pathways & Interactions for FURIN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.65
|
.45
|
| 2 | Lipoprotein metabolism | ||
| 3 | Degradation of the extracellular matrix | ||
| 4 | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||
| 5 | Notch Signaling Pathway (WikiPathways) | ||
Pathways by source for FURIN Gene
4 Sino Biological pathways for FURIN Gene
4 BioSystems pathways for FURIN Gene
38 Reactome pathways for FURIN Gene
2 GeneGo (Thomson Reuters) pathways for FURIN Gene
- CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
- Development Notch Signaling Pathway
1 R&D Systems pathway for FURIN Gene
1 GeneTex pathway for FURIN Gene
Interacting Proteins for FURIN Gene
Selected Interacting proteins:
P09958-FURIN_HUMAN
ENSP00000483552
for FURIN Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FURIN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001825 | blastocyst formation | IEA | -- |
| GO:0006465 | signal peptide processing | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | TAS | -- |
| GO:0009966 | regulation of signal transduction | IEA | -- |
Drugs & Compounds for FURIN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pirfenidone | Approved, Investigational | Pharma | Target | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 86 | |
| Capric acid | Experimental | Pharma | Target | 0 | ||
| Calcium | Nutra | 6556 | ||||
| PHENYLACETYL-ARG-VAL-ARG-4-AMIDINOBENZYLAMIDE | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for FURIN Gene
mRNA/cDNA for FURIN Gene
- 7 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000268171 4247 nts (view in UCSC)
- ENST00000558794 844 nts (view in UCSC)
- ENST00000559353 587 nts (view in UCSC)
- ENST00000560018 421 nts (view in UCSC)
- ENST00000560824 580 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FURIN - Select products 50% OFF >
- * FURIN CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FURIN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FURIN
-
Santa Cruz Biotechnology (SCBT) CRISPR for FURIN
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FURIN
- Browse OriGene Inhibitory RNA Products For FURIN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FURIN
Clone Products
- Applied Biological Materials (abm): Clones for FURIN - Select products 50% OFF >
- * FURIN as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FURIN
- Addgene plasmids for FURIN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FURIN
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for FURIN Gene
- GeneLoc Exon Structure for
- FURIN
Expression for FURIN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Hypoblast (Extraembryonic Tissues)
-
Epidermis (Integumentary System)
- Corneocytes Stratified Epidermis
-
Epithelial Cells
- Corneocytes Stratified Epidermis
-
Heart (Cardiovascular System)
- Cushion Mesenchymal Cells Endocardium
- Primitive Streak (Early Embryonic Tissues)
- Bone (Muscoskeletal System)
- Extraembryonic Tissues (Extraembryonic Tissues)
- Uncategorized
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for FURIN Gene
This gene is overexpressed in Liver (x7.4) and Whole Blood (x5.2).
This gene is overexpressed in Bone marrow mesenchymal stem cell (37.9), Salivary gland (12.3), Skin (8.6), and Placenta (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FURIN Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FURIN
SOURCE GeneReport for Unigene cluster for FURIN Gene:
Hs.513153mRNA Expression by UniProt/SwissProt for FURIN Gene:
P09958-FURIN_HUMAN
Tissue specificity:
Seems to be expressed ubiquitously.
Evidence on tissue expression from TISSUES for FURIN Gene
- Liver(4.8)
- Blood(4.6)
- Lung(4.6)
- Nervous system(3.5)
- Kidney(3.4)
- Pancreas(3.3)
- Muscle(3.2)
- Heart(3.1)
- Intestine(3.1)
- Skin(3.1)
- Spleen(2.9)
- Bone marrow(2.9)
- Lymph node(2.7)
- Thyroid gland(2.6)
- Stomach(2.6)
- Adrenal gland(2.4)
- Eye(2.3)
Primer Products
-
OriGene qPCR primer pairs for FURIN
-
OriGene qPCR primer pairs and template standards for FURIN
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FURIN Gene
Orthologs for FURIN Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FURIN 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FURIN 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FURIN 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Furin 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Furin 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FURIN 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FURIN 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FURIN 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FURIN 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | furin 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397747 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | furina 30 31 |
|
OneToMany | |
| furinb 31 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001330 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | kpc-1 30 |
|
- Species where no ortholog for FURIN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FURIN Gene
- ENSEMBL:
- Gene Tree for FURIN (if available)
- TreeFam:
- Gene Tree for FURIN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FURIN: view image
Paralogs for FURIN Gene
Variants for FURIN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FURIN Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16944971 | - | p.Ala43Val | |||
| VAR_055343 | - | p.Trp547Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4706n54 | CNV | gain+loss | 21841781 |
| dgv4707n54 | CNV | gain | 21841781 |
| dgv4708n54 | CNV | gain+loss | 21841781 |
| dgv4709n54 | CNV | gain | 21841781 |
| dgv4710n54 | CNV | gain+loss | 21841781 |
| dgv4711n54 | CNV | loss | 21841781 |
| esv22296 | CNV | loss | 19812545 |
| nsv1144744 | CNV | deletion | 24896259 |
| nsv515661 | CNV | loss | 19592680 |
| nsv570398 | CNV | loss | 21841781 |
| nsv570405 | CNV | gain | 21841781 |
| nsv570426 | CNV | gain | 21841781 |
| nsv570428 | CNV | loss | 21841781 |
| nsv570430 | CNV | loss | 21841781 |
| nsv570431 | CNV | gain | 21841781 |
| nsv570432 | CNV | gain+loss | 21841781 |
| nsv570434 | CNV | loss | 21841781 |
| nsv570436 | CNV | loss | 21841781 |
| nsv833089 | CNV | loss | 17160897 |
| nsv952028 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.07;
50.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FURIN Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FURIN Gene
Disorders for FURIN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| avian influenza |
|
|
| cerebral amyloid angiopathy, itm2b-related, 1 |
|
|
| anthrax disease |
|
|
| diphtheria |
|
|
| borna disease |
|
|
Search FURIN in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FURIN
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FURIN Gene
Publications for FURIN Gene
- The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. (PMID: 11799113) Anderson ED … Thomas G (The Journal of biological chemistry 2002) 3 4 23
- PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. (PMID: 11331585) Crump CM … Thomas G (The EMBO journal 2001) 3 4 23
- Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage. (PMID: 9130696) Anderson ED … Thomas G (The EMBO journal 1997) 3 4 23
- Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. (PMID: 8846780) Jones BG … Thomas G (The EMBO journal 1995) 3 4 23
- Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. (PMID: 1629222) Leduc R … Thomas G (The Journal of biological chemistry 1992) 3 4 23
ExternalLinks
Products for FURIN Gene
- View all 15 R&D Systems FURIN (Furin) Products
- View all R&D Systems FURIN (Furin) Proteins and Enzymes
- View all 12 R&D Systems FURIN (Furin) Primary Antibodies
- View all R&D Systems FURIN (Furin) ELISAs
- View all R&D Systems FURIN (Furin) Luminex Assays
- Learn more about R&D Systems custom FURIN antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for FURIN
- Custom Assay ServicesOriGene ELISA Kits for FURIN
- OriGene Purified Proteins for FURIN
- Search Origene for MassSpec and Protein Over-expression Lysates for FURIN
- Origene Custom Protein Services for FURIN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FURIN
- Browse OriGene Inhibitory RNA Products For FURIN
- OriGene qPCR primer pairs for FURIN
- OriGene qPCR primer pairs and template standards for FURIN
- OriGene CRISPR knockouts for FURIN
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FURIN
- Sino Biological Human cDNA Clone for FURIN
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for FURIN
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FURIN
- Novus Biologicals lysates for FURIN
- Novus Biologicals ELISA Kits for FURIN
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- Abcam proteins for FURIN
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- VectorBuilder Custom and pre-made DNA vectors for FURIN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FURIN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FURIN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FURIN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FURIN
- Addgene plasmids for FURIN
- antibodies-online: Show 28 available FURIN Antibodies ranked by validation data
- Compare Top FURIN Antibodies
- Recommended
- 81 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 22 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 33 available FURIN Elisa Kits ranked by validation data
- Compare Top FURIN Elisa Kits
- antibodies-online: Show 26 available FURIN Proteins ranked by validation data
- Compare Top FURIN Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FURIN
- Search Santa Cruz Biotechnology (SCBT) for FURIN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FURIN
- Horizon Cell Lines for FURIN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FURIN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FURIN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FURIN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FURIN
- Biorbyt antibodies for FURIN
Sources for FURIN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
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- (132) dbSUPER
- (133) TISSUES
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- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB