Aliases for FURIN Gene
- FUR 3 4
- Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein) 2
- Furin (Paired Basic Amino Acid Cleaving Enzyme) 2
- Proprotein Convertase Subtilisin/Kexin Type 3 3
- Furin, Membrane Associated Receptor Protein 3
- Dibasic Processing Enzyme 3
- Dibasic-Processing Enzyme 4
- FES Upstream Region 3
- EC 3.4.21 50
- FURIN 5
External Ids for FURIN Gene
Previous HGNC Symbols for FURIN Gene
Previous GeneCards Identifiers for FURIN Gene
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
GeneCards Summary for FURIN Gene
FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Avian Influenza and Cerebral Amyloid Angiopathy, Itm2b-Related, 1. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PCSK4.
UniProtKB/Swiss-Prot Summary for FURIN Gene
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278).
(Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins.
(Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin.
(Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP.
(Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells.