Aliases for FUNDC2 Gene

Aliases for FUNDC2 Gene

  • FUN14 Domain Containing 2 2 3 5
  • HCBP6 2 3 4
  • Cervical Cancer Proto-Oncogene 3 Protein 3 4
  • Hepatitis C Virus Core-Binding Protein 6 3 4
  • FUN14 Domain-Containing Protein 2 3 4
  • HCC-3 3 4
  • DC44 2 3
  • Cervical Cancer Oncogene 3 3
  • PD03104 3
  • FUNDC2 5
  • HCC3 3

External Ids for FUNDC2 Gene

Previous GeneCards Identifiers for FUNDC2 Gene

  • GC0XP153818
  • GC0XP153908
  • GC0XP154254
  • GC0XP142800

Summaries for FUNDC2 Gene

GeneCards Summary for FUNDC2 Gene

FUNDC2 (FUN14 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is FUNDC1.

Gene Wiki entry for FUNDC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUNDC2 Gene

Genomics for FUNDC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FUNDC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ155025 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 600.7 +1.7 1677 3.7 ARHGAP35 CREB1 PRDM10 REST ZNF629 IKZF1 ZNF692 POLR2A BACH1 JUND F8 FUNDC2 lnc-F8-1 lnc-F8-2 F8A1 WASH6P PLXNA3 GAB3 IKBKG F8A2
GH0XJ155026 Enhancer 0.5 Ensembl 600.7 -1.1 -1079 0.2 IKZF1 MTA2 HMBOX1 ZFP91 DPF2 VEZF1 SMARCE1 FUNDC2 F8 lnc-F8-1 lnc-F8-2 HSALNG0140892 F8A1
GH0XJ155022 Promoter 1.2 EPDnew Ensembl 0.4 -5.8 -5779 6 ATF7 IKZF1 ZNF24 EP300 UBTF HMBOX1 NCOR1 CEBPG TAL1 ATF4 F8 F8A1 TMLHE FUNDC2 lnc-F8-1 lnc-F8-2 HSALNG0140892
GH0XJ155009 Enhancer 0.8 Ensembl ENCODE 0.4 -15.9 -15860 1.8 REST SP1 SOX6 YY1 GABPA JUND NR2F2 TAL1 HNF4A RXRA F8A1 lnc-F8-1 lnc-F8-2 F8 FUNDC2 HSALNG0140892
GH0XJ155007 Enhancer 0.7 Ensembl ENCODE 0.4 -18.5 -18479 3 IKZF1 PKNOX1 ZNF24 NFIC ZNF592 DPF2 RARA MEIS2 HNF4A NR4A1 FAM3A HSALNG0140892 lnc-F8-1 F8 FUNDC2 lnc-F8-2 F8A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUNDC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUNDC2

Top Transcription factor binding sites by QIAGEN in the FUNDC2 gene promoter:
  • ATF-2
  • c-Ets-1
  • C/EBPalpha
  • C/EBPbeta
  • CRE-BP1
  • Elk-1
  • NCX
  • NF-1
  • Nkx2-5
  • Roaz

Genomic Locations for FUNDC2 Gene

Genomic Locations for FUNDC2 Gene
chrX:155,025,980-155,060,304
(GRCh38/hg38)
Size:
34,325 bases
Orientation:
Plus strand
chrX:154,254,255-154,288,578
(GRCh37/hg19)
Size:
34,324 bases
Orientation:
Plus strand

Genomic View for FUNDC2 Gene

Genes around FUNDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUNDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUNDC2 Gene

Proteins for FUNDC2 Gene

  • Protein details for FUNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWH2-FUND2_HUMAN
    Recommended name:
    FUN14 domain-containing protein 2
    Protein Accession:
    Q9BWH2
    Secondary Accessions:
    • B2R7W5
    • D3DWY5
    • Q8NHX8
    • Q9H2I6

    Protein attributes for FUNDC2 Gene

    Size:
    189 amino acids
    Molecular mass:
    20676 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44731.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for FUNDC2 Gene

Post-translational modifications for FUNDC2 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for FUNDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FUNDC2 Gene

Domains & Families for FUNDC2 Gene

Gene Families for FUNDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUNDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FUNDC2 Gene

GenScript: Design optimal peptide antigens:
  • Hepatitis C virus core-binding protein 6 (FUND2_HUMAN)
  • FUN14 domain containing 2 (Q5HYP8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BWH2

UniProtKB/Swiss-Prot:

FUND2_HUMAN :
  • Belongs to the FUN14 family.
Family:
  • Belongs to the FUN14 family.
genes like me logo Genes that share domains with FUNDC2: view

Function for FUNDC2 Gene

Phenotypes From GWAS Catalog for FUNDC2 Gene

genes like me logo Genes that share phenotypes with FUNDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUNDC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUNDC2 Gene

Localization for FUNDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUNDC2 gene
Compartment Confidence
mitochondrion 5
nucleus 4
extracellular 1
endoplasmic reticulum 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IBA 21873635
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FUNDC2 Gene

Pathways & Interactions for FUNDC2 Gene

PathCards logo

SuperPathways for FUNDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 autophagy of mitochondrion IBA 21873635
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Pathways by source and SIGNOR curated interactions for FUNDC2 Gene

Drugs & Compounds for FUNDC2 Gene

No Compound Related Data Available

Transcripts for FUNDC2 Gene

mRNA/cDNA for FUNDC2 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUNDC2

Alternative Splicing Database (ASD) splice patterns (SP) for FUNDC2 Gene

No ASD Table

Relevant External Links for FUNDC2 Gene

GeneLoc Exon Structure for
FUNDC2

Expression for FUNDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUNDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for FUNDC2 Gene

This gene is overexpressed in Nasal epithelium (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUNDC2 Gene



Protein tissue co-expression partners for FUNDC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUNDC2

SOURCE GeneReport for Unigene cluster for FUNDC2 Gene:

Hs.356050

Evidence on tissue expression from TISSUES for FUNDC2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Muscle(4.4)
  • Eye(4.3)
  • Blood(4.3)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with FUNDC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUNDC2 Gene

Orthologs for FUNDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FUNDC2 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FUNDC2 30 31
  • 90.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fundc2 30 17 31
  • 88.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FUNDC2 30 31
  • 88.45 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FUNDC2 31
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC365778 30
  • 82.67 (n)
Oppossum
(Monodelphis domestica)
Mammalia FUNDC2 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FUNDC2 30 31
  • 71.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FUNDC2 31
  • 64 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fundc2 31
  • 63 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7326 31
  • 37 (a)
OneToMany
Species where no ortholog for FUNDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FUNDC2 Gene

ENSEMBL:
Gene Tree for FUNDC2 (if available)
TreeFam:
Gene Tree for FUNDC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUNDC2: view image

Paralogs for FUNDC2 Gene

Paralogs for FUNDC2 Gene

(1) SIMAP similar genes for FUNDC2 Gene using alignment to 3 proteins:

  • FUND2_HUMAN
  • H7C0K8_HUMAN
  • L0R6G9_HUMAN

Pseudogenes.org Pseudogenes for FUNDC2 Gene

genes like me logo Genes that share paralogs with FUNDC2: view

Variants for FUNDC2 Gene

Additional dbSNP identifiers (rs#s) for FUNDC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FUNDC2 Gene

Variant ID Type Subtype PubMed ID
esv29972 CNV gain 17803354
esv33784 CNV gain+loss 17666407
esv3559508 CNV deletion 23714750
esv3577569 CNV gain 25503493
nsv1141093 CNV deletion 24896259
nsv1151194 CNV insertion 26484159
nsv477388 CNV novel sequence insertion 20440878

Variation tolerance for FUNDC2 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUNDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUNDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUNDC2 Gene

Disorders for FUNDC2 Gene

No disorders were found for FUNDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUNDC2 Gene

Publications for FUNDC2 Gene

  1. Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. (PMID: 29786068) Ma Q … Chen Q (Cell death and differentiation 2019) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. [Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein]. (PMID: 12665903) Li K … Chen J (Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3

Products for FUNDC2 Gene

Sources for FUNDC2 Gene