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Aliases for FUCA2 Gene

Aliases for FUCA2 Gene

  • Alpha-L-Fucosidase 2 2 3 4 5
  • Alpha-L-Fucoside Fucohydrolase 2 3 4
  • Fucosidase, Alpha-L- 2, Plasma 2 3
  • Plasma Fucosidase 2 3
  • A-L-Fucosidase 2 2 3
  • Plasma Alpha-L-Fucosidase 3
  • I+/--L-Fucosidase 2 3
  • α-L-Fucosidase 2 2
  • EC 4
  • DJ20N2.5 3

External Ids for FUCA2 Gene

Previous GeneCards Identifiers for FUCA2 Gene

  • GC06U990037
  • GC06M143797
  • GC06M143796
  • GC06M143857
  • GC06M141380

Summaries for FUCA2 Gene

Entrez Gene Summary for FUCA2 Gene

  • This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

GeneCards Summary for FUCA2 Gene

FUCA2 (Alpha-L-Fucosidase 2) is a Protein Coding gene. Among its related pathways are Other glycan degradation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include fucose binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA1.

UniProtKB/Swiss-Prot for FUCA2 Gene

  • Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Wiki entry for FUCA2 Gene

Additional gene information for FUCA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUCA2 Gene

Genomics for FUCA2 Gene

GeneHancer (GH) Regulatory Elements for FUCA2 Gene

Promoters and enhancers for FUCA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J143510 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.1 +0.6 606 2.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZFP41 MEF2D FUCA2 LOC105378035 LTV1 VDAC1P8 ADAT2 ENSG00000270890 PLAGL1 GC06M143473
GH06J143513 Enhancer 0.7 ENCODE 650.7 -1.7 -1656 0.2 ELF3 CTCF RB1 ARID4B ZIC2 IRF4 RAD21 CTBP1 PATZ1 ZNF143 LOC105378035 FUCA2 PHACTR2 PHACTR2-AS1 ADAT2 GC06M143473
GH06J143566 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.5 -55.3 -55254 0.7 STAT5A BMI1 BATF IRF4 CHAMP1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 PHACTR2 FUCA2 LTV1 ZC2HC1B PHACTR2-AS1 GC06M143473
GH06J142940 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.7 +567.4 567404 8.3 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 GLIS1 HIVEP2 ADAT2 VDAC1P8 LTV1 TUBB8P2 ENSG00000270890 ENSG00000233138 AIG1 FUCA2 ENSG00000232618
GH06J144304 Enhancer 0.2 ENCODE 4.8 -792.9 -792935 0.8 GC06P144306 ENSG00000225311 STX11 FUCA2 UTRN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUCA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUCA2 gene promoter:
  • Brachyury
  • AML1a
  • FOXL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Arnt
  • HNF-1A
  • HNF-1

Genomic Locations for FUCA2 Gene

Genomic Locations for FUCA2 Gene
17,073 bases
Minus strand
17,073 bases
Minus strand

Genomic View for FUCA2 Gene

Genes around FUCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUCA2 Gene

Proteins for FUCA2 Gene

  • Protein details for FUCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasma alpha-L-fucosidase
    Protein Accession:
    Secondary Accessions:
    • E9PEB6
    • Q7Z6V1
    • Q7Z6Y2
    • Q8NBK4

    Protein attributes for FUCA2 Gene

    467 amino acids
    Molecular mass:
    54067 Da
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for FUCA2 Gene


neXtProt entry for FUCA2 Gene

Post-translational modifications for FUCA2 Gene

  • Glycosylation at Asn377, Asn239, and isoforms=171
  • Ubiquitination at Lys85
  • Modification sites at PhosphoSitePlus

Other Protein References for FUCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FUCA2 Gene

Domains & Families for FUCA2 Gene

Gene Families for FUCA2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FUCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 29 family.
  • Belongs to the glycosyl hydrolase 29 family.
genes like me logo Genes that share domains with FUCA2: view

Function for FUCA2 Gene

Molecular function for FUCA2 Gene

UniProtKB/Swiss-Prot Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
UniProtKB/Swiss-Prot CatalyticActivity:
An alpha-L-fucoside + H(2)O = L-fucose + an alcohol.
GENATLAS Biochemistry:
fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides (glycoprotein isoform catabolism)

Enzyme Numbers (IUBMB) for FUCA2 Gene

Gene Ontology (GO) - Molecular Function for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004560 alpha-L-fucosidase activity IDA 19666478
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with FUCA2: view
genes like me logo Genes that share phenotypes with FUCA2: view

Animal Models for FUCA2 Gene

MGI Knock Outs for FUCA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for FUCA2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FUCA2 Gene

Localization for FUCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUCA2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUCA2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
lysosome 5
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 19666478
GO:0005764 lysosome IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with FUCA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FUCA2 Gene

Pathways & Interactions for FUCA2 Gene

genes like me logo Genes that share pathways with FUCA2: view

Pathways by source for FUCA2 Gene

3 Reactome pathways for FUCA2 Gene
1 KEGG pathway for FUCA2 Gene

Gene Ontology (GO) - Biological Process for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006004 fucose metabolic process IDA 19666478
GO:0008152 metabolic process IEA --
GO:0009617 response to bacterium IMP 19666478
GO:0016139 glycoside catabolic process IDA 19666478
genes like me logo Genes that share ontologies with FUCA2: view

No data available for SIGNOR curated interactions for FUCA2 Gene

Drugs & Compounds for FUCA2 Gene

(4) Drugs for FUCA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved, Investigational Pharma 0
Propyl alcohol Approved, Experimental Pharma 0
Water Approved Pharma 0
1-Butanol Experimental Pharma 0

(4) Additional Compounds for FUCA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Caproic alcohol
  • Hexanol
  • N-Hexyl alcohol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
  • 1-Hydroxymethylpropane
  • 2-Methyl-1-propanol
  • 2-Methylpropanol
  • I-butanol
  • I-butyl alcohol
  • 6-Deoxy-L-mannose
  • L-(+)-Rhamnose
  • L-Mannomethylose
  • L-Rha
  • L-Rhamnose
genes like me logo Genes that share compounds with FUCA2: view

Transcripts for FUCA2 Gene

mRNA/cDNA for FUCA2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(343) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUCA2 Gene

Fucosidase, alpha-L- 2, plasma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - - - -
SP4: - -
SP5: - - - -

Relevant External Links for FUCA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUCA2 Gene

This gene is overexpressed in Serum (43.1) and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUCA2 Gene:


SOURCE GeneReport for Unigene cluster for FUCA2 Gene:


Evidence on tissue expression from TISSUES for FUCA2 Gene

  • Nervous system(4.7)
  • Liver(4.5)
genes like me logo Genes that share expression patterns with FUCA2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUCA2 Gene

Orthologs for FUCA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUCA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUCA2 34 33
  • 99.85 (n)
(Canis familiaris)
Mammalia FUCA2 34 33
  • 88.01 (n)
(Bos Taurus)
Mammalia FUCA2 34 33
  • 87.99 (n)
(Mus musculus)
Mammalia Fuca2 16 34 33
  • 82.99 (n)
(Rattus norvegicus)
Mammalia Fuca2 33
  • 82.76 (n)
(Ornithorhynchus anatinus)
Mammalia FUCA2 34
  • 82 (a)
(Monodelphis domestica)
Mammalia FUCA2 34
  • 70 (a)
(Gallus gallus)
Aves FUCA2 34 33
  • 75.04 (n)
(Anolis carolinensis)
Reptilia FUCA2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fuca2 33
  • 68.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68702 33
(Danio rerio)
Actinopterygii fuca2 34 33
  • 63.05 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9330 33
fruit fly
(Drosophila melanogaster)
Insecta Fuca 34 33
  • 59.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007285 33
  • 56.91 (n)
(Caenorhabditis elegans)
Secernentea W03G11.3 34 33
  • 58.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1844 34
  • 57 (a)
CSA.1698 34
  • 53 (a)
-- 34
  • 53 (a)
-- 34
  • 47 (a)
-- 34
  • 44 (a)
Cin.3711 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3711 33
Species where no ortholog for FUCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUCA2 Gene

Gene Tree for FUCA2 (if available)
Gene Tree for FUCA2 (if available)
Evolutionary constrained regions (ECRs) for FUCA2: view image

Paralogs for FUCA2 Gene

Paralogs for FUCA2 Gene

(1) SIMAP similar genes for FUCA2 Gene using alignment to 3 proteins:

  • Q7Z6V1_HUMAN
  • Q7Z6V2_HUMAN
genes like me logo Genes that share paralogs with FUCA2: view

Variants for FUCA2 Gene

Sequence variations from dbSNP and Humsavar for FUCA2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000234278 -- 143,495,092(-) G/A 3_prime_UTR_variant
rs1000303499 -- 143,502,424(-) G/T coding_sequence_variant, missense_variant
rs1000433619 -- 143,508,272(-) A/G intron_variant
rs1000582360 -- 143,497,957(-) G/A intron_variant
rs1000605440 -- 143,501,260(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUCA2 Gene

Variant ID Type Subtype PubMed ID
esv2759475 CNV gain 17122850
nsv965776 CNV duplication 23825009

Variation tolerance for FUCA2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.56; 94.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUCA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUCA2 Gene

Disorders for FUCA2 Gene

Additional Disease Information for FUCA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FUCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUCA2 Gene

Publications for FUCA2 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  2. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PMID: 19666478) Liu TW … Lin CH (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for FUCA2 Gene

Sources for FUCA2 Gene

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