Aliases for FUCA2 Gene
External Ids for FUCA2 Gene
Previous GeneCards Identifiers for FUCA2 Gene
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
GeneCards Summary for FUCA2 Gene
FUCA2 (Alpha-L-Fucosidase 2) is a Protein Coding gene. Diseases associated with FUCA2 include Fucosidosis and Laryngotracheitis. Among its related pathways are Lysosome and Innate Immune System. Gene Ontology (GO) annotations related to this gene include fucose binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA1.
UniProtKB/Swiss-Prot Summary for FUCA2 Gene
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.