Aliases for FUBP3 Gene

Aliases for FUBP3 Gene

  • Far Upstream Element Binding Protein 3 2 3 5
  • Far Upstream Element (FUSE) Binding Protein 3 2 3
  • Far Upstream Element-Binding Protein 3 3 4
  • FUSE-Binding Protein 3 3 4
  • FBP3 3 4
  • FUBP3 5

External Ids for FUBP3 Gene

Previous HGNC Symbols for FUBP3 Gene

  • FBP3

Previous GeneCards Identifiers for FUBP3 Gene

  • GC09P124470
  • GC09P125001
  • GC09P126809
  • GC09P128746
  • GC09P128730
  • GC09U900642
  • GC09P132444
  • GC09P133454
  • GC09P102941

Summaries for FUBP3 Gene

GeneCards Summary for FUBP3 Gene

FUBP3 (Far Upstream Element Binding Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1.

UniProtKB/Swiss-Prot Summary for FUBP3 Gene

  • May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FUBP3 Gene

Genomics for FUBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FUBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FUBP3

Top Transcription factor binding sites by QIAGEN in the FUBP3 gene promoter:
  • AML1a
  • AREB6
  • Cart-1
  • Egr-1
  • MIF-1
  • NF-1
  • NF-1/L
  • Olf-1
  • p300

Genomic Locations for FUBP3 Gene

Latest Assembly
chr9:130,578,965-130,638,352
(GRCh38/hg38)
Size:
59,388 bases
Orientation:
Plus strand

Previous Assembly
chr9:133,454,964-133,513,739
(GRCh37/hg19 by Entrez Gene)
Size:
58,776 bases
Orientation:
Plus strand

chr9:133,454,352-133,513,739
(GRCh37/hg19 by Ensembl)
Size:
59,388 bases
Orientation:
Plus strand

Genomic View for FUBP3 Gene

Genes around FUBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP3 Gene

Proteins for FUBP3 Gene

  • Protein details for FUBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I24-FUBP3_HUMAN
    Recommended name:
    Far upstream element-binding protein 3
    Protein Accession:
    Q96I24
    Secondary Accessions:
    • A3KFK8
    • A3KFL0
    • Q92946
    • Q9BVB6

    Protein attributes for FUBP3 Gene

    Size:
    572 amino acids
    Molecular mass:
    61640 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50893.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH01325.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for FUBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUBP3 Gene

Post-translational modifications for FUBP3 Gene

  • Ubiquitination at Lys15, Lys87, Lys57, and Lys378
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FUBP3 Gene

Domains & Families for FUBP3 Gene

Gene Families for FUBP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUBP3 Gene

InterPro:
Blocks:
  • KH, type 1

Suggested Antigen Peptide Sequences for FUBP3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58115, highly similar to Far upstream element-binding protein 3 (A3KFK8_HUMAN)
  • Far upstream element-binding protein 3 (FUBP3_HUMAN)
genes like me logo Genes that share domains with FUBP3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FUBP3 Gene

Function for FUBP3 Gene

Molecular function for FUBP3 Gene

UniProtKB/Swiss-Prot Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Phenotypes From GWAS Catalog for FUBP3 Gene

Gene Ontology (GO) - Molecular Function for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IDA 8940189
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IBA 21873635
genes like me logo Genes that share ontologies with FUBP3: view
genes like me logo Genes that share phenotypes with FUBP3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUBP3 Gene

Localization for FUBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUBP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,NAS 8940189
GO:0005737 cytoplasm IBA,IDA 19087307
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with FUBP3: view

Pathways & Interactions for FUBP3 Gene

PathCards logo

SuperPathways for FUBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA 8940189
GO:0010468 regulation of gene expression IBA 21873635
GO:0010628 positive regulation of gene expression IDA 19087307
GO:0045893 positive regulation of transcription, DNA-templated IDA 8940189
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 8940183
genes like me logo Genes that share ontologies with FUBP3: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP3 Gene

Drugs & Compounds for FUBP3 Gene

No Compound Related Data Available

Transcripts for FUBP3 Gene

mRNA/cDNA for FUBP3 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FUBP3

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for FUBP3 Gene

GeneLoc Exon Structure for
FUBP3

Expression for FUBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUBP3 Gene

This gene is overexpressed in Breast (43.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUBP3 Gene



Protein tissue co-expression partners for FUBP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FUBP3

SOURCE GeneReport for Unigene cluster for FUBP3 Gene:

Hs.98751

mRNA Expression by UniProt/SwissProt for FUBP3 Gene:

Q96I24-FUBP3_HUMAN
Tissue specificity: Detected in a number of cell lines.

Evidence on tissue expression from TISSUES for FUBP3 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Kidney(2.1)
  • Skin(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with FUBP3: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUBP3 Gene

Orthologs for FUBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FUBP3 29 30
  • 99.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FUBP3 29 30
  • 90.5 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FUBP3 30
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fubp3 29
  • 89.16 (n)
Mouse
(Mus musculus)
Mammalia Fubp3 29 16 30
  • 88.83 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FUBP3 30
  • 85 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FUBP3 29 30
  • 83.8 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FUBP3 29 30
  • 84.26 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fubp3 29
  • 78.41 (n)
Zebrafish
(Danio rerio)
Actinopterygii fubp3 29 30
  • 71.01 (n)
OneToMany
CABZ01073334.1 30
  • 71 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Psi 29 30
  • 48.12 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea CELE_C12D8.1 29
  • 47.92 (n)
C12D8.1a 31
  • 36 (a)
C12D8.1b 31
  • 36 (a)
C36E6.1a 31
  • 34 (a)
C36E6.1b 31
  • 34 (a)
C12D8.1 30
  • 26 (a)
ManyToMany
ZK418.9 30 31
  • 25 (a)
ManyToMany
C36E6.1 30
  • 24 (a)
ManyToMany
M01A10.1 30 31
  • 23 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 34 (a)
ManyToMany
-- 30
  • 32 (a)
ManyToMany
-- 30
  • 21 (a)
ManyToMany
Species where no ortholog for FUBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FUBP3 Gene

ENSEMBL:
Gene Tree for FUBP3 (if available)
TreeFam:
Gene Tree for FUBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FUBP3: view image
Alliance of Genome Resources:
Additional Orthologs for FUBP3

Paralogs for FUBP3 Gene

(4) SIMAP similar genes for FUBP3 Gene using alignment to 1 proteins:

  • FUBP3_HUMAN
genes like me logo Genes that share paralogs with FUBP3: view

Variants for FUBP3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FUBP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FUBP3 Gene

Variant ID Type Subtype PubMed ID
dgv7718n100 CNV gain 25217958
dgv7719n100 CNV gain 25217958
dgv7720n100 CNV gain 25217958
esv1002669 CNV gain 20482838
nsv1041989 CNV gain 25217958
nsv1054840 CNV gain 25217958
nsv825121 CNV gain 20364138
nsv825122 CNV gain 20364138
nsv831734 CNV gain 17160897
nsv831735 CNV loss 17160897

Variation tolerance for FUBP3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUBP3
Leiden Open Variation Database (LOVD)
FUBP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FUBP3 Gene

Disorders for FUBP3 Gene

Additional Disease Information for FUBP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FUBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUBP3 Gene

Publications for FUBP3 Gene

  1. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PMID: 8940189) Davis-Smyth T … Levens D (The Journal of biological chemistry 1996) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 40
  4. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (PMID: 19087307) Weber A … Kristiansen G (BMC cancer 2008) 3 22
  5. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G … Hirschhorn JN (Nature genetics 2008) 3 40

Products for FUBP3 Gene

Sources for FUBP3 Gene