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FTX Gene(RNA Gene)

FTX Transcript, XIST Regulator

GCID:
GC0XM073946
GIFtS:
17
Genes Participants
UDN Logo

Aliases for FTX Gene

Subcategory (RNA class) for FTX Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for FTX Gene

  • FTX Transcript, XIST Regulator 2 3
  • FTX Transcript, XIST Regulator (Non-Protein Coding) 2 3 5
  • Mir-374a-545 Cluster Host Gene (Non-Protein Coding) 2 3
  • Five Prime To XIST 2 3
  • Non-Protein Coding RNA 182 2
  • NCRNA00182 3
  • LINC00182 3
  • MIR374AHG 3

External Ids for FTX Gene

Previous HGNC Symbols for FTX Gene

  • NCRNA00182
  • MIR374AHG

Previous GeneCards Identifiers for FTX Gene

  • GC0XU990359
  • GC0XM073248
  • GC0XM073183
  • GC0XM073963

Summaries for FTX Gene

Entrez Gene Summary for FTX Gene

  • This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]

GeneCards Summary for FTX Gene

FTX (FTX Transcript, XIST Regulator) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with FTX include Renal Cell Carcinoma, Nonpapillary and Glioma.

Additional gene information for FTX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTX Gene

Genomics for FTX Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FTX Gene

Promoters and enhancers for FTX Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ074289 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 650.7 +1.9 1874 4.6 HDGF PKNOX1 SMAD1 ARNT SIN3A YY1 POLR2B SP3 REST KAT8 ENSG00000277922 FTX RAB11FIP1P1 RN7SL648P JPX ENSG00000271533 RLIM GC0XM074299 MIR374A
GH0XJ073943 Promoter/Enhancer 1.7 Ensembl ENCODE 73.4 +349.0 348961 2.4 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 JPX ENSG00000276784 ENSG00000274430 FTX RAB11FIP1P1 DDX3P1 ENSG00000271199 ENSG00000271533 CHIC1 ENSG00000228906
GH0XJ073849 Promoter/Enhancer 1.6 Ensembl ENCODE 53.1 +442.6 442556 3.6 PKNOX1 SMAD1 ARNT FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 GC0XM073852 XIST ENSG00000278039 RAB11FIP1P1 JPX FTX DDX3P1 RN7SL648P TOMM20P4 ENSG00000271199
GH0XJ074342 Enhancer 1.1 Ensembl ENCODE 13.2 -50.1 -50056 1.9 FEZF1 ZNF2 ETS1 ZNF766 ZNF143 KLF7 FOS RUNX3 KLF13 DEK ENSG00000226515 FTX ZCCHC13 ENSG00000271533 LOC727681
GH0XJ074381 Enhancer 0.9 Ensembl ENCODE 15.1 -88.8 -88801 1.3 CTCF PKNOX1 ZBTB6 ZSCAN4 KLF14 RAD21 SMC3 ZNF143 PRDM10 ZNF654 FTX SLC16A2 ENSG00000228906 DDX3P1 RPS6P26 RN7SL790P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FTX on UCSC Golden Path with GeneCards custom track

Genomic Locations for FTX Gene

Genomic Locations for FTX Gene
chrX:73,946,555-74,293,574
(GRCh38/hg38)
Size:
347,020 bases
Orientation:
Minus strand
chrX:73,183,790-73,513,409
(GRCh37/hg19)
Size:
329,620 bases
Orientation:
Minus strand

Genomic View for FTX Gene

Genes around FTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTX Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FTX Gene

Proteins for FTX Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for FTX Gene

No Post-translational modifications

No data available for DME Specific Peptides for FTX Gene

Domains & Families for FTX Gene

Gene Families for FTX Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FTX: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FTX Gene

Function for FTX Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTX Gene

Localization for FTX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FTX Gene

Pathways & Interactions for FTX Gene

SuperPathways for FTX Gene

PathCards logo More details on SuperPathways for FTX
No Data Available

Interacting Proteins for FTX Gene

Gene Ontology (GO) - Biological Process for FTX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FTX Gene

Drugs & Compounds for FTX Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FTX Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FTX Gene

(4) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(18) RNA Central transcripts :

Unigene Clusters for FTX Gene

FTX transcript, XIST regulator (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTX Gene

No ASD Table

Relevant External Links for FTX Gene

GeneLoc Exon Structure for
FTX
ECgene alternative splicing isoforms for
FTX

Expression for FTX Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTX Gene

mRNA expression in normal human tissues for FTX Gene
mRNA expression by GTEx for FTX Gene

NURSA nuclear receptor signaling pathways regulating expression of FTX Gene:

FTX

SOURCE GeneReport for Unigene cluster for FTX Gene:

Hs.349570
genes like me logo Genes that share expression patterns with FTX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTX Gene

Orthologs for FTX Gene

Evolution for FTX Gene

ENSEMBL:
Gene Tree for FTX (if available)
TreeFam:
Gene Tree for FTX (if available)

No data available for Orthologs for FTX Gene

Paralogs for FTX Gene

No data available for Paralogs for FTX Gene

Variants for FTX Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for FTX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002777 -- 74,219,524(-) C/T intron_variant
rs1000033517 -- 74,218,756(-) A/G intron_variant
rs1000052061 -- 74,226,897(-) T/C intron_variant
rs1000057337 -- 74,091,321(-) C/T intron_variant
rs1000063390 -- 74,142,763(-) T/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FTX Gene

Variant ID Type Subtype PubMed ID
esv2740225 CNV deletion 23290073
esv2740226 CNV deletion 23290073
esv2740227 CNV deletion 23290073

Additional Variant Information for FTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FTX Gene

Disorders for FTX Gene

MalaCards: The human disease database

(4) MalaCards diseases for FTX Gene - From: LncRNADisease and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search FTX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FTX

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FTX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FTX Gene

Publications for FTX Gene

  1. Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. (PMID: 21118898) Chureau C … Rougeulle C (Human molecular genetics 2011) 2 3 58
  2. [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3 58
  3. Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. (PMID: 12045143) Chureau C … Duret L (Genome research 2002) 2 3 58
  4. Long noncoding RNA FTX regulates cardiomyocyte apoptosis by targeting miR-29b-1-5p and Bcl2l2. (PMID: 29117536) Long B … Zhang SY (Biochemical and biophysical research communications 2018) 3 58
  5. Knockdown of Long Noncoding RNA FTX Inhibits Proliferation, Migration, and Invasion in Renal Cell Carcinoma Cells. (PMID: 27983937) He X … Li Y (Oncology research 2017) 3 58

Products for FTX Gene

Sources for FTX Gene

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