Free for academic non-profit institutions. Other users need a Commercial license
This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015] See more...
Aliases for FTX Gene
Subcategory (RNA class) for FTX Gene
lncRNA
Quality Score for this RNA gene is
15
Aliases for FTX Gene
External Ids for FTX Gene
- HGNC: 37190
- Entrez Gene: 100302692
- Ensembl: ENSG00000230590
- OMIM: 300936
Previous HGNC Symbols for FTX Gene
- NCRNA00182
- MIR374AHG
Previous GeneCards Identifiers for FTX Gene
- GC0XU990359
- GC0XM073248
- GC0XM073183
- GC0XM073963
Summaries for FTX Gene
-
This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]
GeneCards Summary for FTX Gene
FTX (FTX Transcript, XIST Regulator) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FTX include Glioma and Renal Cell Carcinoma, Nonpapillary.
Rfam classification for FTX Gene
-
FTX transcript, XIST regulator conserved region 4
-
FTX transcript, XIST regulator conserved region 3
-
FTX transcript, XIST regulator conserved region 2
-
FTX transcript, XIST regulator conserved region 1
-
FTX transcript, XIST regulator conserved region 5
-
Metazoan signal recognition particle RNA
-
microRNA mir-374
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for FTX Gene
Genomics for FTX Gene
GeneHancer (GH) Regulatory Elements for FTX Gene
Promoters and enhancers for FTX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FTX on UCSC Golden Path with GeneCards custom track
Genomic Locations for FTX Gene
Genomic Locations for FTX Gene
- chrX:73,940,435-74,293,574
- (GRCh38/hg38)
- Size:
- 353,140 bases
- Orientation:
- Minus strand
- chrX:73,183,790-73,513,409
- (GRCh37/hg19)
- Size:
- 329,620 bases
- Orientation:
- Minus strand
Genomic View for FTX Gene
Genes around FTX on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq13.2 by HGNC
- Xq13.2 by Entrez Gene
- Xq13.2 by Ensembl
FTX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FTX Gene
Proteins for FTX Gene
Post-translational modifications for FTX Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FTX
- Origene Custom Protein Services for FTX
No data available for DME Specific Peptides for FTX Gene
Domains & Families for FTX Gene
Gene Families for FTX Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FTX Gene
Function for FTX Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for FTX
- Applied Biological Materials (abm): CRISPR Clones for FTX - Select products 50% OFF >
- * FTX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FTX CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for FTX - Select products 50% OFF >
- * FTX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FTX tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTX Gene
Localization for FTX Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FTX Gene
Pathways & Interactions for FTX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010628 | positive regulation of gene expression | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FTX Gene
Transcripts for FTX Gene
mRNA/cDNA for FTX Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (72) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000651392 4008 bps
- ENST00000638437 12267 bps (ENST00000638437.1)
- ENST00000603672 1077 bps (ENST00000603672.5)
- ENST00000430772 919 bps (ENST00000430772.5)
- ENST00000602776 827 bps (ENST00000602776.5)
- (70) RNACentral transcripts :
- (16) LncBook transcripts :
- (2) NONCODE transcripts :
- (56) LNCipedia transcripts :
CRISPR Products
- Browse CRISPR knockouts for FTX
- Applied Biological Materials (abm): CRISPR Clones for FTX - Select products 50% OFF >
- * FTX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FTX CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for FTX - Select products 50% OFF >
- * FTX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FTX tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for FTX Gene
NURSA nuclear receptor signaling pathways regulating expression of FTX Gene:
FTXSOURCE GeneReport for Unigene cluster for FTX Gene:
Hs.349570Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTX Gene
Orthologs for FTX Gene
No data available for Orthologs for FTX Gene
Paralogs for FTX Gene
No data available for Paralogs for FTX Gene
Variants for FTX Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002777 | -- | 74,219,524(-) | C/T | intron_variant | |
| rs1000033517 | -- | 74,218,756(-) | A/G | intron_variant | |
| rs1000052061 | -- | 74,226,897(-) | T/C | intron_variant | |
| rs1000057337 | -- | 74,091,321(-) | C/T | intron_variant | |
| rs1000063390 | -- | 74,142,763(-) | T/A/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740225 | CNV | deletion | 23290073 |
| esv2740226 | CNV | deletion | 23290073 |
| esv2740227 | CNV | deletion | 23290073 |
Additional Variant Information for FTX Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FTX
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FTX Gene
Disorders for FTX Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glioma |
|
|
| renal cell carcinoma, nonpapillary |
|
|
| hepatocellular carcinoma |
|
|
| colorectal cancer |
|
Search FTX in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FTX
No data available for UniProtKB/Swiss-Prot and Genatlas for FTX Gene
Publications for FTX Gene
- Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. (PMID: 21118898) Chureau C … Rougeulle C (Human molecular genetics 2011) 2 3 56
- [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3 56
- Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. (PMID: 12045143) Chureau C … Duret L (Genome research 2002) 2 3 56
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
- LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression. (PMID: 29925853) Yang Y … Wu T (Gene therapy 2018) 3 56
ExternalLinks
Products for FTX Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FTX
- Origene Custom Protein Services for FTX
- Browse OriGene Inhibitory RNA Products For FTX
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for FTX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FTX
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for FTX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for FTX
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FTX
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for FTX
Sources for FTX Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource