This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015] See more...

Aliases for FTX Gene

Subcategory (RNA class) for FTX Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for FTX Gene

  • FTX Transcript, XIST Regulator 2 3 5
  • FTX Transcript, XIST Regulator (Non-Protein Coding) 2 3
  • Mir-374a-545 Cluster Host Gene (Non-Protein Coding) 2 3
  • Five Prime To XIST 2 3
  • FTX 2 170
  • Non-Protein Coding RNA 182 2
  • HSALNG0138614 169
  • NONHSAG054789 94
  • HSALNG0138622 169
  • HSALNG0138610 169
  • NONHSAG054785 94
  • NCRNA00182 3
  • LINC00182 3
  • MIR374AHG 3

External Ids for FTX Gene

Previous HGNC Symbols for FTX Gene

  • NCRNA00182
  • MIR374AHG

Previous GeneCards Identifiers for FTX Gene

  • GC0XU990359
  • GC0XM073248
  • GC0XM073183
  • GC0XM073963

Summaries for FTX Gene

Entrez Gene Summary for FTX Gene

  • This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]

GeneCards Summary for FTX Gene

FTX (FTX Transcript, XIST Regulator) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FTX include Glioma and Renal Cell Carcinoma, Nonpapillary.

Rfam classification for FTX Gene

  • FTX transcript, XIST regulator conserved region 4
  • FTX transcript, XIST regulator conserved region 3
  • FTX transcript, XIST regulator conserved region 2
  • FTX transcript, XIST regulator conserved region 1
  • FTX transcript, XIST regulator conserved region 5
  • Metazoan signal recognition particle RNA
  • microRNA mir-374

Additional gene information for FTX Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for FTX Gene

Genomics for FTX Gene

GeneHancer (GH) Regulatory Elements for FTX Gene

Promoters and enhancers for FTX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FTX on UCSC Golden Path with GeneCards custom track

Genomic Locations for FTX Gene

Genomic Locations for FTX Gene
chrX:73,940,435-74,293,574
(GRCh38/hg38)
Size:
353,140 bases
Orientation:
Minus strand
chrX:73,183,790-73,513,409
(GRCh37/hg19)
Size:
329,620 bases
Orientation:
Minus strand

Genomic View for FTX Gene

Genes around FTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTX Gene

Proteins for FTX Gene

No data available for DME Specific Peptides for FTX Gene

Domains & Families for FTX Gene

Gene Families for FTX Gene

genes like me logo Genes that share domains with FTX: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FTX Gene

Function for FTX Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTX Gene

Localization for FTX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FTX gene
Compartment Confidence
plasma membrane 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FTX Gene

Pathways & Interactions for FTX Gene

PathCards logo

SuperPathways for FTX Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with FTX: view

No data available for Pathways by source and SIGNOR curated interactions for FTX Gene

Drugs & Compounds for FTX Gene

No Compound Related Data Available

Transcripts for FTX Gene

mRNA/cDNA for FTX Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(72) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(70) RNACentral transcripts :
(16) LncBook transcripts :
(2) NONCODE transcripts :
(56) LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTX Gene

No ASD Table

Relevant External Links for FTX Gene

GeneLoc Exon Structure for
FTX
ECgene alternative splicing isoforms for
FTX

Expression for FTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTX Gene

NURSA nuclear receptor signaling pathways regulating expression of FTX Gene:

FTX

SOURCE GeneReport for Unigene cluster for FTX Gene:

Hs.349570
genes like me logo Genes that share expression patterns with FTX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTX Gene

Orthologs for FTX Gene

Evolution for FTX Gene

ENSEMBL:
Gene Tree for FTX (if available)
TreeFam:
Gene Tree for FTX (if available)

No data available for Orthologs for FTX Gene

Paralogs for FTX Gene

No data available for Paralogs for FTX Gene

Variants for FTX Gene

Sequence variations from dbSNP and Humsavar for FTX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002777 -- 74,219,524(-) C/T intron_variant
rs1000033517 -- 74,218,756(-) A/G intron_variant
rs1000052061 -- 74,226,897(-) T/C intron_variant
rs1000057337 -- 74,091,321(-) C/T intron_variant
rs1000063390 -- 74,142,763(-) T/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FTX Gene

Variant ID Type Subtype PubMed ID
esv2740225 CNV deletion 23290073
esv2740226 CNV deletion 23290073
esv2740227 CNV deletion 23290073

Additional Variant Information for FTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTX

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FTX Gene

Disorders for FTX Gene

MalaCards: The human disease database

(4) MalaCards diseases for FTX Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FTX in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FTX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FTX Gene

Publications for FTX Gene

  1. Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. (PMID: 21118898) Chureau C … Rougeulle C (Human molecular genetics 2011) 2 3 56
  2. [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3 56
  3. Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. (PMID: 12045143) Chureau C … Duret L (Genome research 2002) 2 3 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression. (PMID: 29925853) Yang Y … Wu T (Gene therapy 2018) 3 56

Products for FTX Gene

Sources for FTX Gene