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This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015] See more...
Aliases for FTX Gene
Subcategory (RNA class) for FTX Gene
lncRNA
Number of RNA Genes sources:
3 / 17
Aliases for FTX Gene
External Ids for FTX Gene
- HGNC: 37190
- Entrez Gene: 100302692
- Ensembl: ENSG00000230590
- OMIM: 300936
Previous HGNC Symbols for FTX Gene
- NCRNA00182
- MIR374AHG
Previous GeneCards Identifiers for FTX Gene
- GC0XU990359
- GC0XM073248
- GC0XM073183
- GC0XM073963
Summaries for FTX Gene
-
This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]
GeneCards Summary for FTX Gene
FTX (FTX Transcript, XIST Regulator) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FTX include Glioma and Renal Cell Carcinoma, Nonpapillary.
Rfam classification for FTX Gene
-
FTX transcript, XIST regulator conserved region 4
-
FTX transcript, XIST regulator conserved region 3
-
FTX transcript, XIST regulator conserved region 2
-
FTX transcript, XIST regulator conserved region 1
-
FTX transcript, XIST regulator conserved region 5
-
Metazoan signal recognition particle RNA
-
microRNA mir-374
Additional gene information for FTX Gene
- HGNC(37190)
- Entrez Gene(100302692)
- Ensembl(ENSG00000230590)
- OMIM(300936)
- Open Targets Platform(ENSG00000230590)
- Search for FTX at DataMed
- Search for FTX at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for FTX Gene
Genomics for FTX Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FTX Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FTX on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for FTX Gene
Genomic Locations for FTX Gene
- chrX:73,940,435-74,293,574
- (GRCh38/hg38)
- Size:
- 353,140 bases
- Orientation:
- Minus strand
- chrX:73,183,790-73,513,409
- (GRCh37/hg19)
- Size:
- 329,620 bases
- Orientation:
- Minus strand
Genomic View for FTX Gene
Genes around FTX on UCSC Golden Path with GeneCards custom track
FTX in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- Xq13.2 by HGNC
- Xq13.2 by Entrez Gene
- Xq13.2 by Ensembl
FTX Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FTX Gene
Proteins for FTX Gene
Post-translational modifications for FTX Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FTX
- Origene Custom Protein Services for FTX
No data available for DME Specific Peptides for FTX Gene
Domains & Families for FTX Gene
Gene Families for FTX Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FTX Gene
Function for FTX Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FTX - Select products 50% OFF >
- * FTX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FTX
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for FTX - Select products 50% OFF >
- * FTX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTX Gene
Localization for FTX Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FTX Gene
Pathways & Interactions for FTX Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010628 | positive regulation of gene expression | IEA | -- |
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for FTX Gene
Transcripts for FTX Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for FTX Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000043C800_9606 | lncRNA | 2356 | 3 |
HGNC: 37190, RefSeq: NR_028379, LNCipedia: FTX:2, |
| URS0000A7A257_9606 | lncRNA | 1367 | 3 |
Ensembl: ENST00000638985 (view in UCSC) , LncBook: HSALNT0283725, LNCipedia: FTX:51, |
| URS00005595C6_9606 | lncRNA | 905 | 3 |
Ensembl: ENST00000603952 (view in UCSC) , LNCipedia: FTX:58, NONCODE: NONHSAT137585.2, |
| URS00001F4683_9606 | lncRNA | 574 | 3 |
Ensembl: ENST00000602576 (view in UCSC) , LncBook: HSALNT0283753, LNCipedia: FTX:10, |
| URS0000A9D490_9606 | lncRNA | 12267 | 2 |
Ensembl: ENST00000638437 (view in UCSC) , LNCipedia: FTX:54, |
FTX in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for FTX Gene
- 3 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FTX - Select products 50% OFF >
- * FTX CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FTX
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for FTX - Select products 50% OFF >
- * FTX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
Relevant External Links for FTX Gene
- GeneLoc Exon Structure for
- FTX
Expression for FTX Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FTX
SOURCE GeneReport for Unigene cluster for FTX Gene:
Hs.349570Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTX Gene
Orthologs for FTX Gene
No data available for Orthologs for FTX Gene
Paralogs for FTX Gene
No data available for Paralogs for FTX Gene
Variants for FTX Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740225 | CNV | deletion | 23290073 |
| esv2740226 | CNV | deletion | 23290073 |
| esv2740227 | CNV | deletion | 23290073 |
Additional Variant Information for FTX Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FTX
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for FTX Gene
Disorders for FTX Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glioma |
|
|
| renal cell carcinoma, nonpapillary |
|
|
| hepatocellular carcinoma |
|
|
| colorectal cancer |
|
|
| retinitis pigmentosa |
|
|
Search FTX in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FTX
No data available for UniProtKB/Swiss-Prot and Genatlas for FTX Gene
Publications for FTX Gene
- Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. (PMID: 21118898) Chureau C … Rougeulle C (Human molecular genetics 2011) 2 3
- [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3
- Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. (PMID: 12045143) Chureau C … Duret L (Genome research 2002) 2 3
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
- lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma. (PMID: 29845188) Li X … Qin C (International journal of oncology 2018) 3
ExternalLinks
Products for FTX Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FTX
- Origene Custom Protein Services for FTX
- Browse OriGene Inhibitory RNA Products For FTX
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for FTX
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FTX
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for FTX
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for FTX
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FTX
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for FTX
Sources for FTX Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB