Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008] See more...

Aliases for FTSJ3 Gene

Aliases for FTSJ3 Gene

  • FtsJ RNA 2'-O-Methyltransferase 3 2 3 5
  • Pre-RRNA 2'-O-Ribose RNA Methyltransferase FTSJ3 3 4
  • FtsJ RNA Methyltransferase Homolog 3 2 3
  • Putative RRNA Methyltransferase 3 3 4
  • Protein FtsJ Homolog 3 3 4
  • SPB1 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • 2'-O-Ribose RNA Methyltransferase SPB1 Homolog 3
  • RRNA (Uridine-2'-O-)-Methyltransferase 3 3
  • SPB1 RNA Methyltransferase Homolog 3
  • Pre-RRNA Processing Protein FTSJ3 3
  • FtsJ Homolog 3 (E. Coli) 2
  • FtsJ Homolog 3 3
  • EC 2.1.1.- 4
  • EPCS3 3
  • SPB1 3

External Ids for FTSJ3 Gene

Previous GeneCards Identifiers for FTSJ3 Gene

  • GC17M061547
  • GC17M064323
  • GC17M062237
  • GC17M062370
  • GC17M059250
  • GC17M061896
  • GC17M057264

Summaries for FTSJ3 Gene

Entrez Gene Summary for FTSJ3 Gene

  • Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FTSJ3 Gene

FTSJ3 (FtsJ RNA 2'-O-Methyltransferase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA methyltransferase activity. An important paralog of this gene is FTSJ1.

UniProtKB/Swiss-Prot Summary for FTSJ3 Gene

  • RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
  • (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973).

Gene Wiki entry for FTSJ3 Gene

Additional gene information for FTSJ3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FTSJ3 Gene

Genomics for FTSJ3 Gene

GeneHancer (GH) Regulatory Elements for FTSJ3 Gene

Promoters and enhancers for FTSJ3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FTSJ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FTSJ3 gene promoter:
  • AML1a
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • POU2F1
  • Sp1

Genomic Locations for FTSJ3 Gene

Genomic Locations for FTSJ3 Gene
chr17:63,819,433-63,830,012
(GRCh38/hg38)
Size:
10,580 bases
Orientation:
Minus strand
chr17:61,896,793-61,907,372
(GRCh37/hg19)
Size:
10,580 bases
Orientation:
Minus strand

Genomic View for FTSJ3 Gene

Genes around FTSJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTSJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTSJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTSJ3 Gene

Proteins for FTSJ3 Gene

  • Protein details for FTSJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY81-SPB1_HUMAN
    Recommended name:
    pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
    Protein Accession:
    Q8IY81
    Secondary Accessions:
    • B2RCA5
    • D3DU22
    • Q8N3A3
    • Q8WXX1
    • Q9BWM4
    • Q9NXT6

    Protein attributes for FTSJ3 Gene

    Size:
    847 amino acids
    Molecular mass:
    96558 Da
    Quaternary structure:
    • Interacts with NIP7.
    • (Microbial infection) Interacts with TARBP2/TRBP in case of infection by HIV-1; leading to recruitment to HIV-1 TAR RNA (PubMed:30626973). The complex formed with TARBP2/TRBP is independent of DICER (PubMed:30626973).
    SequenceCaution:
    • Sequence=BAA90924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FTSJ3 Gene

Post-translational modifications for FTSJ3 Gene

No data available for DME Specific Peptides for FTSJ3 Gene

Domains & Families for FTSJ3 Gene

Suggested Antigen Peptide Sequences for FTSJ3 Gene

GenScript: Design optimal peptide antigens:
  • rRNA (uridine-2'-O-)-methyltransferase 3 (RRMJ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IY81

UniProtKB/Swiss-Prot:

SPB1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
genes like me logo Genes that share domains with FTSJ3: view

Function for FTSJ3 Gene

Molecular function for FTSJ3 Gene

UniProtKB/Swiss-Prot Function:
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:48628, Rhea:RHEA-COMP:12164, Rhea:RHEA-COMP:12165, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:58956, Rhea:RHEA-COMP:15261, Rhea:RHEA-COMP:15262, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90675, ChEBI:CHEBI:90676; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58957; Evidence=. ;.

Enzyme Numbers (IUBMB) for FTSJ3 Gene

Phenotypes From GWAS Catalog for FTSJ3 Gene

Gene Ontology (GO) - Molecular Function for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21903422
GO:0008168 methyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with FTSJ3: view
genes like me logo Genes that share phenotypes with FTSJ3: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FTSJ3 Gene

Localization for FTSJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTSJ3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FTSJ3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA,IBA --
GO:0030687 preribosome, large subunit precursor IBA 21873635
GO:0030688 preribosome, small subunit precursor IEA --
genes like me logo Genes that share ontologies with FTSJ3: view

Pathways & Interactions for FTSJ3 Gene

PathCards logo

SuperPathways for FTSJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2'-O-methylation IEA --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0001510 RNA methylation IDA,IEA 30626973
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with FTSJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FTSJ3 Gene

Drugs & Compounds for FTSJ3 Gene

(1) Drugs for FTSJ3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for FTSJ3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with FTSJ3: view

Transcripts for FTSJ3 Gene

mRNA/cDNA for FTSJ3 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FTSJ3 Gene

GeneLoc Exon Structure for
FTSJ3
ECgene alternative splicing isoforms for
FTSJ3

Expression for FTSJ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTSJ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FTSJ3 Gene

This gene is overexpressed in Lung (16.4), Peripheral blood mononuclear cells (12.1), and Adrenal (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FTSJ3 Gene



Protein tissue co-expression partners for FTSJ3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FTSJ3 Gene:

FTSJ3

SOURCE GeneReport for Unigene cluster for FTSJ3 Gene:

Hs.463785

Evidence on tissue expression from TISSUES for FTSJ3 Gene

  • Liver(4.3)
  • Intestine(4.2)
  • Skin(4.2)
  • Nervous system(3.9)
  • Lung(2.5)
  • Blood(2)
genes like me logo Genes that share expression patterns with FTSJ3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTSJ3 Gene

Orthologs for FTSJ3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FTSJ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJ3 33 32
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FTSJ3 33 32
  • 87.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FTSJ3 33 32
  • 86.52 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ftsj3 17 33 32
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Ftsj3 32
  • 84.41 (n)
oppossum
(Monodelphis domestica)
Mammalia FTSJ3 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ3 33 32
  • 69.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FTSJ3 33
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj3 32
  • 70.98 (n)
Str.15904 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.3413 32
zebrafish
(Danio rerio)
Actinopterygii ftsj 33 32
  • 63.82 (n)
OneToOne
wufa11d10 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.481 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003002 32
  • 52.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8939 33 34 32
  • 51.96 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H06I04.3a 34
  • 55 (a)
H06I04.3b 34
  • 55 (a)
H06I04.3 33
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB1 33
  • 36 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.14347 32
rice
(Oryza sativa)
Liliopsida Os.20336 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9297 33
  • 47 (a)
OneToOne
Species where no ortholog for FTSJ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FTSJ3 Gene

ENSEMBL:
Gene Tree for FTSJ3 (if available)
TreeFam:
Gene Tree for FTSJ3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FTSJ3: view image

Paralogs for FTSJ3 Gene

Paralogs for FTSJ3 Gene

(2) SIMAP similar genes for FTSJ3 Gene using alignment to 8 proteins:

  • SPB1_HUMAN
  • J3KRY4_HUMAN
  • J3KS36_HUMAN
  • J3KS74_HUMAN
  • J3QKT6_HUMAN
  • J3QR05_HUMAN
  • J3QRS5_HUMAN
  • J3QSE2_HUMAN
genes like me logo Genes that share paralogs with FTSJ3: view

Variants for FTSJ3 Gene

Sequence variations from dbSNP and Humsavar for FTSJ3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000576455 -- 63,828,367(-) T/C upstream_transcript_variant
rs1000628655 -- 63,827,929(-) C/A/T upstream_transcript_variant
rs1000685753 -- 63,823,182(-) G/A intron_variant
rs1000752852 -- 63,823,343(-) C/G intron_variant
rs1000853832 -- 63,819,374(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FTSJ3 Gene

Variant ID Type Subtype PubMed ID
nsv510720 CNV deletion 20534489
nsv517272 CNV gain+loss 19592680
nsv833510 CNV loss 17160897

Variation tolerance for FTSJ3 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FTSJ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTSJ3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTSJ3 Gene

Disorders for FTSJ3 Gene

Additional Disease Information for FTSJ3

No disorders were found for FTSJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTSJ3 Gene

Publications for FTSJ3 Gene

  1. FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing. (PMID: 30626973) Ringeard M … Bennasser Y (Nature 2019) 2 3 4 56
  2. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello LG … Zanchin NI (PloS one 2011) 3 4 56
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for FTSJ3 Gene

Sources for FTSJ3 Gene