Aliases for FTSJ3 Gene
- FtsJ RNA 2'-O-Methyltransferase 3 2 3 5
- Pre-RRNA 2'-O-Ribose RNA Methyltransferase FTSJ3 3 4
- FtsJ RNA Methyltransferase Homolog 3 2 3
- Putative RRNA Methyltransferase 3 3 4
- Protein FtsJ Homolog 3 3 4
- SPB1 RNA Methyltransferase Homolog (S. Cerevisiae) 2
- 2'-O-Ribose RNA Methyltransferase SPB1 Homolog 3
External Ids for FTSJ3 Gene
Previous GeneCards Identifiers for FTSJ3 Gene
Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FTSJ3 Gene
FTSJ3 (FtsJ RNA 2'-O-Methyltransferase 3) is a Protein Coding gene. Diseases associated with FTSJ3 include Tinea Manuum and Robinow Syndrome, Autosomal Dominant 1. Gene Ontology (GO) annotations related to this gene include rRNA methyltransferase activity. An important paralog of this gene is FTSJ1.
UniProtKB/Swiss-Prot Summary for FTSJ3 Gene
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973).