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Aliases for FTSJ3 Gene

Aliases for FTSJ3 Gene

  • FtsJ RNA Methyltransferase Homolog 3 2 3 5
  • 2-O-Ribose RNA Methyltransferase SPB1 Homolog 3 4
  • Putative RRNA Methyltransferase 3 3 4
  • Protein FtsJ Homolog 3 3 4
  • SPB1 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • RRNA (Uridine-2-O-)-Methyltransferase 3 3
  • SPB1 RNA Methyltransferase Homolog 3
  • Pre-RRNA Processing Protein FTSJ3 3
  • FtsJ Homolog 3 (E. Coli) 2
  • FtsJ Homolog 3 3
  • EC 2.1.1.- 4
  • EPCS3 3
  • SPB1 3

External Ids for FTSJ3 Gene

Previous GeneCards Identifiers for FTSJ3 Gene

  • GC17M061547
  • GC17M064323
  • GC17M062237
  • GC17M062370
  • GC17M059250
  • GC17M061896
  • GC17M057264

Summaries for FTSJ3 Gene

Entrez Gene Summary for FTSJ3 Gene

  • Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FTSJ3 Gene

FTSJ3 (FtsJ RNA Methyltransferase Homolog 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA methyltransferase activity.

UniProtKB/Swiss-Prot for FTSJ3 Gene

  • Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Gene Wiki entry for FTSJ3 Gene

Additional gene information for FTSJ3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTSJ3 Gene

Genomics for FTSJ3 Gene

GeneHancer (GH) Regulatory Elements for FTSJ3 Gene

Promoters and enhancers for FTSJ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I063825 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 628.8 +3.0 2951 3.6 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 FTSJ3 PSMC5 CEP95 DDX42 POLG2 SMARCD2 CSH2 DDX5 ENSG00000281311 ENSG00000265982
GH17I063837 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 118.4 -11.0 -10959 7.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SMARCD2 GC17P063839 FTSJ3 CEP95 POLG2 DDX42 ENSG00000265982 PLEKHM1P1 DDX5 DCAF7
GH17I063829 Enhancer 0.5 dbSUPER 614.9 +0.5 527 0.7 HDGF GATA3 PKNOX1 POLR2A FTSJ3 CSH2 PSMC5
GH17I064500 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 96.7 -674.8 -674760 7.7 CLOCK FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX5 CEP95 POLG2 FTSJ3 DDX42 PLEKHM1P1 ENSG00000265982 SMARCD2 SLC16A6P1 ENSG00000281311
GH17I063740 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 100 +88.1 88053 3.5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 STRADA FTSJ3 DDX5 SMARCD2 POLG2 CEP95 DDX42 ENSG00000281311 CSH2 EEF1DP7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FTSJ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FTSJ3 gene promoter:

Genomic Locations for FTSJ3 Gene

Genomic Locations for FTSJ3 Gene
chr17:63,819,433-63,830,012
(GRCh38/hg38)
Size:
10,580 bases
Orientation:
Minus strand
chr17:61,896,793-61,907,372
(GRCh37/hg19)

Genomic View for FTSJ3 Gene

Genes around FTSJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTSJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTSJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTSJ3 Gene

Proteins for FTSJ3 Gene

  • Protein details for FTSJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY81-SPB1_HUMAN
    Recommended name:
    pre-rRNA processing protein FTSJ3
    Protein Accession:
    Q8IY81
    Secondary Accessions:
    • B2RCA5
    • D3DU22
    • Q8N3A3
    • Q8WXX1
    • Q9BWM4
    • Q9NXT6

    Protein attributes for FTSJ3 Gene

    Size:
    847 amino acids
    Molecular mass:
    96558 Da
    Quaternary structure:
    • Interacts with NIP7.
    SequenceCaution:
    • Sequence=BAA90924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FTSJ3 Gene

Post-translational modifications for FTSJ3 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at posLast=214214, posLast=218218, and posLast=710710
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FTSJ3 Gene

Domains & Families for FTSJ3 Gene

Gene Families for FTSJ3 Gene

Suggested Antigen Peptide Sequences for FTSJ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY81

UniProtKB/Swiss-Prot:

SPB1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
genes like me logo Genes that share domains with FTSJ3: view

Function for FTSJ3 Gene

Molecular function for FTSJ3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2-O-methylnucleoside.
UniProtKB/Swiss-Prot Function:
Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Enzyme Numbers (IUBMB) for FTSJ3 Gene

Phenotypes From GWAS Catalog for FTSJ3 Gene

Gene Ontology (GO) - Molecular Function for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 21903422
GO:0008168 methyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
GO:0008650 rRNA (uridine-2-O-)-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with FTSJ3: view
genes like me logo Genes that share phenotypes with FTSJ3: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FTSJ3 Gene

Localization for FTSJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTSJ3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FTSJ3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with FTSJ3: view

Pathways & Interactions for FTSJ3 Gene

SuperPathways for FTSJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0001510 RNA methylation IEA --
GO:0006364 rRNA processing IEA --
GO:0031167 rRNA methylation IBA,IEA --
genes like me logo Genes that share ontologies with FTSJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FTSJ3 Gene

Drugs & Compounds for FTSJ3 Gene

(1) Drugs for FTSJ3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for FTSJ3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with FTSJ3: view

Transcripts for FTSJ3 Gene

mRNA/cDNA for FTSJ3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTSJ3 Gene

FtsJ homolog 3 (E. coli):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FTSJ3 Gene

GeneLoc Exon Structure for
FTSJ3
ECgene alternative splicing isoforms for
FTSJ3

Expression for FTSJ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTSJ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FTSJ3 Gene

This gene is overexpressed in Lung (16.4), Peripheral blood mononuclear cells (12.1), and Adrenal (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FTSJ3 Gene



Protein tissue co-expression partners for FTSJ3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FTSJ3 Gene:

FTSJ3

SOURCE GeneReport for Unigene cluster for FTSJ3 Gene:

Hs.463785

Evidence on tissue expression from TISSUES for FTSJ3 Gene

  • Liver(4.3)
  • Intestine(4.2)
  • Skin(4.2)
  • Nervous system(3.9)
  • Lung(2.5)
  • Blood(2)
genes like me logo Genes that share expression patterns with FTSJ3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTSJ3 Gene

Orthologs for FTSJ3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FTSJ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJ3 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia FTSJ3 33 34
  • 87.36 (n)
dog
(Canis familiaris)
Mammalia FTSJ3 33 34
  • 86.52 (n)
mouse
(Mus musculus)
Mammalia Ftsj3 33 16 34
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Ftsj3 33
  • 84.41 (n)
oppossum
(Monodelphis domestica)
Mammalia FTSJ3 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ3 33 34
  • 69.53 (n)
lizard
(Anolis carolinensis)
Reptilia FTSJ3 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj3 33
  • 70.98 (n)
Str.15904 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3413 33
zebrafish
(Danio rerio)
Actinopterygii ftsj 33 34
  • 63.82 (n)
wufa11d10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.481 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003002 33
  • 52.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8939 35 33 34
  • 51.96 (n)
worm
(Caenorhabditis elegans)
Secernentea H06I04.3a 35
  • 55 (a)
H06I04.3b 35
  • 55 (a)
H06I04.3 34
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB1 34
  • 36 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.20336 33
corn
(Zea mays)
Liliopsida Zm.14347 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9297 34
  • 47 (a)
OneToOne
Species where no ortholog for FTSJ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FTSJ3 Gene

ENSEMBL:
Gene Tree for FTSJ3 (if available)
TreeFam:
Gene Tree for FTSJ3 (if available)

Paralogs for FTSJ3 Gene

(2) SIMAP similar genes for FTSJ3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FTSJ3: view

No data available for Paralogs for FTSJ3 Gene

Variants for FTSJ3 Gene

Sequence variations from dbSNP and Humsavar for FTSJ3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000576455 -- 63,828,367(-) T/C upstream_transcript_variant
rs1000628655 -- 63,827,929(-) C/A/T upstream_transcript_variant
rs1000685753 -- 63,823,182(-) G/A intron_variant
rs1000752852 -- 63,823,343(-) C/G intron_variant
rs1000853832 -- 63,819,374(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FTSJ3 Gene

Variant ID Type Subtype PubMed ID
nsv510720 CNV deletion 20534489
nsv517272 CNV gain+loss 19592680
nsv833510 CNV loss 17160897

Variation tolerance for FTSJ3 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FTSJ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTSJ3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTSJ3 Gene

Disorders for FTSJ3 Gene

Additional Disease Information for FTSJ3

No disorders were found for FTSJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTSJ3 Gene

Publications for FTSJ3 Gene

  1. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello LG … Zanchin NI (PloS one 2011) 3 4 58
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FTSJ3 Gene

Sources for FTSJ3 Gene

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