Aliases for FTL Gene
External Ids for FTL Gene
Previous GeneCards Identifiers for FTL Gene
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
GeneCards Summary for FTL Gene
FTL (Ferritin Light Chain) is a Protein Coding gene. Diseases associated with FTL include Hyperferritinemia With Or Without Cataract and Neurodegeneration With Brain Iron Accumulation 3. Among its related pathways are Clathrin derived vesicle budding and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and ferric iron binding. An important paralog of this gene is FTH1.
UniProtKB/Swiss-Prot Summary for FTL Gene
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).