Aliases for FTCDNL1 Gene

Aliases for FTCDNL1 Gene

  • Formiminotransferase Cyclodeaminase N-Terminal Like 2 3 5
  • Formiminotransferase N-Terminal Subdomain-Containing Protein 3 4
  • Formiminotransferase-Cyclodeaminase N-Terminal-Like Protein 3 4
  • FONG 3 4
  • Formiminotransferase N-Terminal Sub-Domain Containing Gene 2
  • Formiminotransferase N-Terminal Sub-Domain Containing 3

External Ids for FTCDNL1 Gene

Previous GeneCards Identifiers for FTCDNL1 Gene

  • GC02M200628

Summaries for FTCDNL1 Gene

GeneCards Summary for FTCDNL1 Gene

FTCDNL1 (Formiminotransferase Cyclodeaminase N-Terminal Like) is a Protein Coding gene. Diseases associated with FTCDNL1 include Osteoporosis. Gene Ontology (GO) annotations related to this gene include transferase activity and folic acid binding. An important paralog of this gene is FTCD.

Additional gene information for FTCDNL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FTCDNL1 Gene

Genomics for FTCDNL1 Gene

GeneHancer (GH) Regulatory Elements for FTCDNL1 Gene

Promoters and enhancers for FTCDNL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J199850 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 172 1.6 EP300 CTCF NRF1 TCF12 MYC POLR2G USF1 PHF8 ZFX ZIC2 FTCDNL1 lnc-FTCDNL1-1 ENSG00000232732 lnc-C2orf69-1
GH02J199737 Enhancer 0.9 ENCODE 29.1 +112.3 112286 2.3 EP300 CTCF ZSCAN5C TCF12 NCOR1 FOXA1 KDM6A TCF7 TRIM28 REST FTCDNL1 SATB2 piR-61514-100 piR-50515 lnc-FTCDNL1-1 LINC01877
GH02J199756 Enhancer 0.4 Ensembl ENCODE 60.5 +94.1 94148 2 STAT1 FTCDNL1 piR-50515 piR-61514-100 lnc-FTCDNL1-1
GH02J199743 Enhancer 0.5 Ensembl 34.6 +107.3 107272 2.6 NANOG TCF12 ZNF398 SMARCA4 TRIM28 HLF L3MBTL2 ZNF596 ZNF548 SCRT2 FTCDNL1 piR-61514-100 piR-50515 lnc-FTCDNL1-1 LINC01877
GH02J199778 Enhancer 0.5 Ensembl 27.8 +72.0 71972 1.2 ATF2 CREB1 JUND PKNOX1 ATF7 JUN FTCDNL1 MF281428-011 piR-50515 lnc-FTCDNL1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FTCDNL1

Genomic Locations for FTCDNL1 Gene

Genomic Locations for FTCDNL1 Gene
chr2:199,760,536-199,851,173
(GRCh38/hg38)
Size:
90,638 bases
Orientation:
Minus strand
chr2:200,625,259-200,715,896
(GRCh37/hg19)
Size:
90,638 bases
Orientation:
Minus strand

Genomic View for FTCDNL1 Gene

Genes around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTCDNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTCDNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTCDNL1 Gene

Proteins for FTCDNL1 Gene

  • Protein details for FTCDNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RQL4-FONG_HUMAN
    Recommended name:
    Formiminotransferase N-terminal subdomain-containing protein
    Protein Accession:
    E5RQL4

    Protein attributes for FTCDNL1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTCDNL1 Gene

Post-translational modifications for FTCDNL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FTCDNL1 Gene

Domains & Families for FTCDNL1 Gene

Gene Families for FTCDNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FTCDNL1 Gene

Suggested Antigen Peptide Sequences for FTCDNL1 Gene

GenScript: Design optimal peptide antigens:
  • HCG1653746, isoform CRA_d (E5RQL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

E5RQL4

UniProtKB/Swiss-Prot:

FONG_HUMAN :
  • Belongs to the formiminotransferase family.
Family:
  • Belongs to the formiminotransferase family.
genes like me logo Genes that share domains with FTCDNL1: view

Function for FTCDNL1 Gene

Phenotypes From GWAS Catalog for FTCDNL1 Gene

Gene Ontology (GO) - Molecular Function for FTCDNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FTCDNL1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTCDNL1 Gene

Localization for FTCDNL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FTCDNL1 gene
Compartment Confidence
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FTCDNL1 Gene

Pathways & Interactions for FTCDNL1 Gene

PathCards logo

SuperPathways for FTCDNL1 Gene

No Data Available

Interacting Proteins for FTCDNL1 Gene

;

Gene Ontology (GO) - Biological Process for FTCDNL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FTCDNL1 Gene

Drugs & Compounds for FTCDNL1 Gene

No Compound Related Data Available

Transcripts for FTCDNL1 Gene

mRNA/cDNA for FTCDNL1 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FTCDNL1 Gene

No ASD Table

Relevant External Links for FTCDNL1 Gene

GeneLoc Exon Structure for
FTCDNL1

Expression for FTCDNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FTCDNL1 Gene

mRNA differential expression in normal tissues according to GTEx for FTCDNL1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FTCDNL1

mRNA Expression by UniProt/SwissProt for FTCDNL1 Gene:

E5RQL4-FONG_HUMAN
Tissue specificity: Widely expressed with highest levels in liver and skeletal muscle, and moderate levels in kidney, bone and pancreas.
genes like me logo Genes that share expression patterns with FTCDNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTCDNL1 Gene

Orthologs for FTCDNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTCDNL1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 33 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FTCDNL1 31
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 6 (a)
OneToMany
chicken
(Gallus gallus)
Aves FTCD 31
  • 6 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FTCDNL1 31
  • 23 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FTCDNL1 31
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 6 (a)
OneToMany
Species where no ortholog for FTCDNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTCDNL1 Gene

ENSEMBL:
Gene Tree for FTCDNL1 (if available)
TreeFam:
Gene Tree for FTCDNL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FTCDNL1: view image

Paralogs for FTCDNL1 Gene

Paralogs for FTCDNL1 Gene

genes like me logo Genes that share paralogs with FTCDNL1: view

Variants for FTCDNL1 Gene

Additional dbSNP identifiers (rs#s) for FTCDNL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FTCDNL1 Gene

Variant ID Type Subtype PubMed ID
esv3593949 CNV loss 21293372

Variation tolerance for FTCDNL1 Gene

Gene Damage Index Score: 1.75; 33.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FTCDNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTCDNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FTCDNL1 Gene

Disorders for FTCDNL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FTCDNL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FTCDNL1

genes like me logo Genes that share disorders with FTCDNL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FTCDNL1 Gene

Publications for FTCDNL1 Gene

  1. Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. (PMID: 21573128) Kou I … Ikegawa S (PloS one 2011) 2 3 4 54
  2. Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis. (PMID: 26492493) Lu HF … Chang WC (PloS one 2015) 3 54
  3. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 54
  4. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low SK … Nakamura Y (Cancer science 2013) 3 54
  5. Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases. (PMID: 23303384) Zhou H … Ito H (Journal of human genetics 2013) 3 54

Products for FTCDNL1 Gene

Sources for FTCDNL1 Gene