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Aliases for FSTL3 Gene

Aliases for FSTL3 Gene

  • Follistatin Like 3 2 3 5
  • Follistatin-Like 3 (Secreted Glycoprotein) 2 3
  • Follistatin-Related Gene Protein 3 4
  • Follistatin-Like Protein 3 3 4
  • FLRG 3 4
  • Follistatin-Related Protein 3 3
  • Follistatin-Related Protein 2
  • FSRP 3

External Ids for FSTL3 Gene

Previous GeneCards Identifiers for FSTL3 Gene

  • GC19P000728
  • GC19P000616
  • GC19P000627
  • GC19P000446

Summaries for FSTL3 Gene

Entrez Gene Summary for FSTL3 Gene

  • Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSTL3 Gene

FSTL3 (Follistatin Like 3) is a Protein Coding gene. Diseases associated with FSTL3 include Leukemia, Chronic Lymphocytic. Among its related pathways are Signaling by NODAL and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include fibronectin binding and activin binding. An important paralog of this gene is FST.

UniProtKB/Swiss-Prot for FSTL3 Gene

  • Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Gene Wiki entry for FSTL3 Gene

Additional gene information for FSTL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSTL3 Gene

Genomics for FSTL3 Gene

GeneHancer (GH) Regulatory Elements for FSTL3 Gene

Promoters and enhancers for FSTL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000674 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.1 +2.4 2387 7.7 HDGF PKNOX1 SMAD1 ARNT SIN3A ZBTB7B POLR2B E2F8 ZNF207 ZNF143 FSTL3 TCF3 HCN2 PALM RPS2P52
GH19J001097 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 +429.7 429701 17 MLX DMAP1 IRF4 YY1 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 GPX4 GC19P001106 GC19P001105 CIRBP TMEM259 LOC100288123 DAZAP1 TCF3 PTBP1 GRIN3B
GH19J000543 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 9.9 -132.1 -132118 2.2 HDAC1 PKNOX1 ATF1 KLF17 YBX1 NFXL1 ZNF2 ZNF366 SCRT2 KLF7 GZMM PTBP1 DAZAP1 ENSG00000267317 TMEM259 CNN2 SBNO2 CDC34 MIER2 FSTL3
GH19J000479 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.8 -196.1 -196080 0.8 HDGF PKNOX1 ATF1 ARNT ZNF133 ARID4B SIN3A YBX1 ZNF2 TCF12 DAZAP1 TMEM259 PTBP1 ENSG00000267317 MIER2 CNN2 MED16 GRIN3B SBNO2 RPS15
GH19J000747 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 +75.6 75550 9.4 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZBTB7B BRCA1 ZNF143 FOS SP5 MISP PRTN3 ELANE CFD FSTL3 PLPP2 TPGS1 GC19P000749 GC19P000763 PALM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FSTL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FSTL3 gene promoter:
  • MyoD
  • Lmo2
  • c-Myc
  • Max1

Genomic Locations for FSTL3 Gene

Genomic Locations for FSTL3 Gene
chr19:676,365-683,399
(GRCh38/hg38)
Size:
7,035 bases
Orientation:
Plus strand
chr19:676,389-683,392
(GRCh37/hg19)
Size:
7,004 bases
Orientation:
Plus strand

Genomic View for FSTL3 Gene

Genes around FSTL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL3 Gene

Proteins for FSTL3 Gene

  • Protein details for FSTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95633-FSTL3_HUMAN
    Recommended name:
    Follistatin-related protein 3
    Protein Accession:
    O95633
    Secondary Accessions:
    • A8K7E3

    Protein attributes for FSTL3 Gene

    Size:
    263 amino acids
    Molecular mass:
    27663 Da
    Quaternary structure:
    • Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.

    Three dimensional structures from OCA and Proteopedia for FSTL3 Gene

    Alternative splice isoforms for FSTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL3 Gene

Post-translational modifications for FSTL3 Gene

  • Glycosylation at Asn215 and isoforms=273
  • Modification sites at PhosphoSitePlus

Other Protein References for FSTL3 Gene

Antibody Products

  • R&D Systems Antibodies for FSTL3 (Follistatin-related Gene Protein/FLRG)
  • Abcam antibodies for FSTL3
  • Boster Bio Antibodies for FSTL3

No data available for DME Specific Peptides for FSTL3 Gene

Domains & Families for FSTL3 Gene

Gene Families for FSTL3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FSTL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSTL3: view

No data available for UniProtKB/Swiss-Prot for FSTL3 Gene

Function for FSTL3 Gene

Molecular function for FSTL3 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
GENATLAS Biochemistry:
follistatin-like 3,secreted glycoprotein,expressed in a wide range of adult tissues,not detected in hematopoietic cells except in patients with a B cell chronic leukemia and a translocation t(11;19)(q13;p13)

Phenotypes From GWAS Catalog for FSTL3 Gene

Gene Ontology (GO) - Molecular Function for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 16336961
GO:0005515 protein binding IEA,IPI 15574124
GO:0048185 activin binding IPI 12697670
genes like me logo Genes that share ontologies with FSTL3: view
genes like me logo Genes that share phenotypes with FSTL3: view

Animal Models for FSTL3 Gene

MGI Knock Outs for FSTL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FSTL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL3 Gene

Localization for FSTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL3 Gene

Isoform 1: Secreted.
Isoform 2: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. {ECO:0000269 PubMed:16150905}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSTL3 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16150905
GO:0005634 nucleus IDA,IEA 16150905
GO:0005654 nucleoplasm IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with FSTL3: view

Pathways & Interactions for FSTL3 Gene

genes like me logo Genes that share pathways with FSTL3: view

Pathways by source for FSTL3 Gene

1 GeneGo (Thomson Reuters) pathway for FSTL3 Gene

SIGNOR curated interactions for FSTL3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for FSTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001822 kidney development IEA --
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FSTL3: view

Drugs & Compounds for FSTL3 Gene

(2) Drugs for FSTL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FSTL3: view

Transcripts for FSTL3 Gene

mRNA/cDNA for FSTL3 Gene

Unigene Clusters for FSTL3 Gene

Follistatin-like 3 (secreted glycoprotein):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:

Relevant External Links for FSTL3 Gene

GeneLoc Exon Structure for
FSTL3
ECgene alternative splicing isoforms for
FSTL3

Expression for FSTL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FSTL3 Gene

This gene is overexpressed in Amniocyte (49.0) and Cerebrospinal fluid (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSTL3 Gene



Protein tissue co-expression partners for FSTL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FSTL3 Gene:

FSTL3

SOURCE GeneReport for Unigene cluster for FSTL3 Gene:

Hs.529038

mRNA Expression by UniProt/SwissProt for FSTL3 Gene:

O95633-FSTL3_HUMAN
Tissue specificity: Expressed in a wide range of tissues.

Evidence on tissue expression from TISSUES for FSTL3 Gene

  • Muscle(2.5)
  • Nervous system(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with FSTL3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSTL3 Gene

Orthologs for FSTL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FSTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSTL3 34 33
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FSTL3 34 33
  • 91.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FSTL3 34 33
  • 88.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fstl3 33
  • 83.4 (n)
mouse
(Mus musculus)
Mammalia Fstl3 16 34 33
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia FSTL3 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSTL3 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSTL3 34 33
  • 69.8 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fstl3 33
  • 61.36 (n)
zebrafish
(Danio rerio)
Actinopterygii fstl3 34 33
  • 60.94 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fs 34
  • 12 (a)
OneToMany
Species where no ortholog for FSTL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSTL3 Gene

ENSEMBL:
Gene Tree for FSTL3 (if available)
TreeFam:
Gene Tree for FSTL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FSTL3: view image

Paralogs for FSTL3 Gene

Paralogs for FSTL3 Gene

(5) SIMAP similar genes for FSTL3 Gene using alignment to 3 proteins:

  • FSTL3_HUMAN
  • K7EM71_HUMAN
  • K7ES54_HUMAN
genes like me logo Genes that share paralogs with FSTL3: view

Variants for FSTL3 Gene

Sequence variations from dbSNP and Humsavar for FSTL3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000126542 -- 683,617(+) G/A downstream_transcript_variant
rs1000539551 -- 683,892(+) A/G downstream_transcript_variant
rs1001307917 -- 683,846(+) A/C downstream_transcript_variant
rs1001339503 -- 679,504(+) C/T intron_variant
rs1001340161 -- 678,995(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FSTL3 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv2717766 CNV deletion 23290073
nsv1071485 CNV deletion 25765185
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv577978 CNV gain 21841781
nsv578163 CNV loss 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for FSTL3 Gene

Gene Damage Index Score: 0.54; 11.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSTL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSTL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL3 Gene

Disorders for FSTL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FSTL3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search FSTL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FSTL3_HUMAN
  • Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. {ECO:0000269 PubMed:9671416}.

Genatlas disease for FSTL3 Gene

B cell chronic leukemia with a translocation t(11;19)(p13;q13) juxtaposing CCND1 and FSTL3 with an expression of the FSTL3 in hematopoietic cells

Additional Disease Information for FSTL3

genes like me logo Genes that share disorders with FSTL3: view

Publications for FSTL3 Gene

  1. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. (PMID: 9671416) Hayette S … Rimokh R (Oncogene 1998) 2 3 4 22 58
  2. The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. (PMID: 18768470) Stamler R … Thompson TB (The Journal of biological chemistry 2008) 3 4 22 58
  3. AF10-dependent transcription is enhanced by its interaction with FLRG. (PMID: 17868029) Forissier S … Rimokh R (Biology of the cell 2007) 3 4 22 58
  4. A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin. (PMID: 16336961) Maguer-Satta V … Rimokh R (Experimental cell research 2006) 3 4 22 58
  5. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. (PMID: 16150905) Saito S … Schneyer A (Endocrinology 2005) 3 4 22 58

Products for FSTL3 Gene

  • Boster Bio Antibodies for FSTL3
  • Boster Bio ELISA Kits for FSTL3

Sources for FSTL3 Gene

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