Aliases for FSTL3 Gene
External Ids for FSTL3 Gene
Previous GeneCards Identifiers for FSTL3 Gene
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FSTL3 Gene
FSTL3 (Follistatin Like 3) is a Protein Coding gene. Diseases associated with FSTL3 include Leukemia, Chronic Lymphocytic. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include fibronectin binding and activin binding. An important paralog of this gene is FST.
UniProtKB/Swiss-Prot for FSTL3 Gene
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.