This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008] See more...

Aliases for FSTL1 Gene

Aliases for FSTL1 Gene

  • Follistatin Like 1 2 3 5
  • FRP 2 3 4
  • Follistatin-Related Protein 1 3 4
  • Follistatin-Like Protein 1 3 4
  • OCC-1 2 3
  • Tsc36 2 3
  • FSL1 2 3
  • OCC1 2 3
  • Follistatin-Like 1 2
  • MIR198 3
  • FSTL1 5

External Ids for FSTL1 Gene

Previous GeneCards Identifiers for FSTL1 Gene

  • GC03M116747
  • GC03M119753
  • GC03M121394
  • GC03M121434
  • GC03M121595
  • GC03M120111

Summaries for FSTL1 Gene

Entrez Gene Summary for FSTL1 Gene

  • This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSTL1 Gene

FSTL1 (Follistatin Like 1) is a Protein Coding gene. Diseases associated with FSTL1 include Rheumatoid Arthritis and Arthritis. Among its related pathways are Signaling by GPCR and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is FSTL4.

UniProtKB/Swiss-Prot Summary for FSTL1 Gene

  • Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes.

Gene Wiki entry for FSTL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FSTL1 Gene

Genomics for FSTL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FSTL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FSTL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FSTL1

Top Transcription factor binding sites by QIAGEN in the FSTL1 gene promoter:
  • AP-1
  • ARP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for FSTL1 Gene

Latest Assembly
chr3:120,392,293-120,450,993
(GRCh38/hg38)
Size:
58,701 bases
Orientation:
Minus strand

Previous Assembly
chr3:120,111,140-120,169,839
(GRCh37/hg19 by Entrez Gene)
Size:
58,700 bases
Orientation:
Minus strand

chr3:120,111,140-120,170,100
(GRCh37/hg19 by Ensembl)
Size:
58,961 bases
Orientation:
Minus strand

Genomic View for FSTL1 Gene

Genes around FSTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSTL1 Gene

Proteins for FSTL1 Gene

  • Protein details for FSTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12841-FSTL1_HUMAN
    Recommended name:
    Follistatin-related protein 1
    Protein Accession:
    Q12841
    Secondary Accessions:
    • A8K523
    • B4DTT5
    • D3DN90
    • Q549Z0

    Protein attributes for FSTL1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34986 Da
    Quaternary structure:
    • Interacts with SCN10A (By similarity). Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20860622, PubMed:20054002).

    Alternative splice isoforms for FSTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSTL1 Gene

Post-translational modifications for FSTL1 Gene

  • Glycosylation at Asn144, Asn175, and Asn180
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FSTL1_HUMAN (1252)

Other Protein References for FSTL1 Gene

No data available for DME Specific Peptides for FSTL1 Gene

Domains & Families for FSTL1 Gene

Gene Families for FSTL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FSTL1 Gene

InterPro:
Blocks:
  • Protease inhibitor, Kazal-type
  • von Willebrand factor, type C
  • Follistatin-like, N-terminal
  • Kazal-type serine protease inhibitor signature

Suggested Antigen Peptide Sequences for FSTL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50214, highly similar to Follistatin-related protein 1 (B4DTT5_HUMAN)
  • cDNA FLJ52277, highly similar to Follistatin-related protein 1 (B4DTZ8_HUMAN)
  • Follistatin-like protein 1 (FSTL1_HUMAN)
genes like me logo Genes that share domains with FSTL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FSTL1 Gene

Function for FSTL1 Gene

Molecular function for FSTL1 Gene

UniProtKB/Swiss-Prot Function:
Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes.

Phenotypes From GWAS Catalog for FSTL1 Gene

Gene Ontology (GO) - Molecular Function for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA,IPI 19060904
GO:0008201 heparin binding TAS,IEA --
genes like me logo Genes that share ontologies with FSTL1: view
genes like me logo Genes that share phenotypes with FSTL1: view

Animal Models for FSTL1 Gene

MGI Knock Outs for FSTL1:

Animal Models for research

  • Taconic Biosciences Mouse Models for FSTL1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSTL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSTL1 Gene

Localization for FSTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSTL1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 3
plasma membrane 2
cytoskeleton 2
nucleus 2
endosome 2
golgi apparatus 2
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,HDA 16502470
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with FSTL1: view

Pathways & Interactions for FSTL1 Gene

PathCards logo

SuperPathways for FSTL1 Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 Signaling by BMP
genes like me logo Genes that share pathways with FSTL1: view

Pathways by source for FSTL1 Gene

2 Reactome pathways for FSTL1 Gene
2 GeneTex pathways for FSTL1 Gene

Gene Ontology (GO) - Biological Process for FSTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IBA 21873635
GO:0030154 cell differentiation IBA 21873635
GO:0030509 BMP signaling pathway TAS --
GO:0030510 regulation of BMP signaling pathway IBA 21873635
GO:0043066 negative regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with FSTL1: view

No data available for SIGNOR curated interactions for FSTL1 Gene

Drugs & Compounds for FSTL1 Gene

(6) Drugs for FSTL1 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma 928
Anticholesteremic Agents Pharma 2282
Antimetabolites Pharma 12727
Hydroxymethylglutaryl-CoA Reductase Inhibitors Pharma 2369
Hypolipidemic Agents Pharma 3074
genes like me logo Genes that share compounds with FSTL1: view

Transcripts for FSTL1 Gene

mRNA/cDNA for FSTL1 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSTL1

Alternative Splicing Database (ASD) splice patterns (SP) for FSTL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5:
SP6: - - -
SP7:
SP8: - - - -
SP9:

Relevant External Links for FSTL1 Gene

GeneLoc Exon Structure for
FSTL1

Expression for FSTL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FSTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FSTL1 Gene

This gene is overexpressed in Amniocyte (46.7) and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FSTL1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FSTL1

SOURCE GeneReport for Unigene cluster for FSTL1 Gene:

Hs.269512

mRNA Expression by UniProt/SwissProt for FSTL1 Gene:

Q12841-FSTL1_HUMAN
Tissue specificity: Overexpressed in synovial tissues from rheumatoid arthritis.

Evidence on tissue expression from TISSUES for FSTL1 Gene

  • Nervous system(5)
  • Kidney(4.8)
  • Bone marrow(4.4)
  • Skin(4.3)
  • Heart(4.2)
  • Muscle(3.8)
  • Bone(3.7)
  • Lung(3.7)
  • Eye(3.3)
  • Spleen(3)
  • Thyroid gland(2.9)
  • Intestine(2.8)
  • Pancreas(2.8)
  • Liver(2.7)
  • Lymph node(2.6)
  • Blood(2.4)
  • Gall bladder(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with FSTL1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSTL1 Gene

Orthologs for FSTL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSTL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-198 30
  • 100 (a)
OneToOne
FSTL1 29
  • 99.46 (n)
Cow
(Bos Taurus)
Mammalia FSTL1 29 30
  • 93.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FSTL1 29 30
  • 92.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fstl1 29 16 30
  • 88.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fstl1 29
  • 88.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia FSTL1 30
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FSTL1 30
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FSTL1 29 30
  • 82.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FSTL1 30
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fstl1 29
  • 74.23 (n)
Str.10997 29
African clawed frog
(Xenopus laevis)
Amphibia xFRP 29
Zebrafish
(Danio rerio)
Actinopterygii fstl1b 29 30
  • 72.09 (n)
OneToMany
fstl1a 30
  • 65 (a)
OneToMany
FSTL1 (3 of 3) 30
  • 5 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 7 (a)
OneToMany
Species where no ortholog for FSTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FSTL1 Gene

ENSEMBL:
Gene Tree for FSTL1 (if available)
TreeFam:
Gene Tree for FSTL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FSTL1: view image
Alliance of Genome Resources:
Additional Orthologs for FSTL1

Paralogs for FSTL1 Gene

Paralogs for FSTL1 Gene

(6) SIMAP similar genes for FSTL1 Gene using alignment to 4 proteins:

  • FSTL1_HUMAN
  • B4DTT5_HUMAN
  • C9J5G4_HUMAN
  • H7C4W4_HUMAN
genes like me logo Genes that share paralogs with FSTL1: view

Variants for FSTL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FSTL1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs139355917 Benign: not provided 120,402,809(-) G/A
NM_007085.5(FSTL1):c.804C>T (p.Asp268=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FSTL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FSTL1 Gene

Variant ID Type Subtype PubMed ID
dgv8523n54 CNV loss 21841781
esv25295 CNV loss 19812545
esv2669703 CNV deletion 23128226
esv3597573 CNV loss 21293372
nsv1131720 CNV deletion 24896259
nsv3969 CNV insertion 18451855
nsv436396 CNV deletion 17901297
nsv591394 CNV loss 21841781
nsv829698 CNV gain 17160897

Variation tolerance for FSTL1 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSTL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSTL1
Leiden Open Variation Database (LOVD)
FSTL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSTL1 Gene

Disorders for FSTL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FSTL1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
arthritis
  • inflammatory disorder of joint
coronary aneurysm
  • aneurysm of coronary vessels
heart aneurysm
  • cardiac aneurysm
- elite association - COSMIC cancer census association via MalaCards
Search FSTL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FSTL1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FSTL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSTL1 Gene

Publications for FSTL1 Gene

  1. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. (PMID: 15638044) Ehara Y … Tokunaga K (Clinical and experimental rheumatology 2004) 3 4 22 40
  2. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. (PMID: 9786430) Tanaka M … Nakao K (International immunology 1998) 2 3 4 22
  3. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. (PMID: 7957230) Zwijsen A … Slegers H (European journal of biochemistry 1994) 2 3 4 22
  4. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 40
  5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 40

Products for FSTL1 Gene

Sources for FSTL1 Gene