Aliases for FSIP2 Gene
Aliases for FSIP2 Gene
External Ids for FSIP2 Gene
- HGNC: 21675
- Entrez Gene: 401024
- Ensembl: ENSG00000188738
- OMIM: 615796
- UniProtKB: Q5CZC0
Previous GeneCards Identifiers for FSIP2 Gene
- GC02P186813
- GC02P186435
- GC02P186318
- GC02U901571
- GC02P186603
- GC02P178463
Summaries for FSIP2 Gene
-
This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]
GeneCards Summary for FSIP2 Gene
FSIP2 (Fibrous Sheath Interacting Protein 2) is a Protein Coding gene.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSIP2 Gene
Genomics for FSIP2 Gene
GeneHancer (GH) Regulatory Elements for FSIP2 Gene
Promoters and enhancers for FSIP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J185738 | Promoter/Enhancer | 1.3 | Ensembl ENCODE | 650.7 | +0.3 | 273 | 1 | RB1 MZF1 SIN3A ZNF2 ZNF48 RAD21 GLIS2 CBX5 ZNF143 BCLAF1 | LOC101927196 FSIP2 RPL21P32 | |
| GH02J185290 | Enhancer | 0.5 | ENCODE | 10.5 | -448.1 | -448140 | 0.8 | CTCF ZFP69B FOXA2 FOXA3 SIN3A FOXA1 | FSIP2 LOC101927196 LOC105373782 ELF2P4 | |
| GH02J185643 | Enhancer | 1 | ENCODE dbSUPER | 4.2 | -94.0 | -94006 | 2.5 | ELF3 SOX13 IRF2 TFAP4 FOXA2 SAP130 CEBPG ZNF384 BATF ZNF644 | FSIP2-AS1 LOC101927196 FSIP2 GC02P185663 ELF2P4 | |
| GH02J185635 | Enhancer | 0.5 | dbSUPER | 4.5 | -100.3 | -100335 | 6.2 | ZNF316 MAFF MAFG EMSY MAFK | LOC101927196 ENSG00000212581 FSIP2-AS1 FSIP2 GC02P185663 ELF2P4 | |
| GH02J185623 | Enhancer | 0.2 | dbSUPER | 11 | -113.8 | -113834 | 3.5 | LOC101927196 ENSG00000212581 FSIP2 GC02P185663 ELF2P4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FSIP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FSIP2 Gene
Genomic Locations for FSIP2 Gene
- chr2:185,738,628-185,833,290
- (GRCh38/hg38)
- Size:
- 94,663 bases
- Orientation:
- Plus strand
- chr2:186,603,355-186,698,017
- (GRCh37/hg19)
- Size:
- 94,663 bases
- Orientation:
- Plus strand
Genomic View for FSIP2 Gene
Genes around FSIP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q32.1 by Entrez Gene
- 2q32.1 by HGNC
- 2q32.1 by Ensembl
FSIP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSIP2 Gene
Proteins for FSIP2 Gene
-
Protein details for FSIP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5CZC0-FSIP2_HUMAN
- Recommended name:
- Fibrous sheath-interacting protein 2
- Protein Accession:
- Q5CZC0
- Q53TL3
- Q53TN5
- Q5HYH2
- Q6ZTZ5
- Q6ZU14
- Q6ZU21
Protein attributes for FSIP2 Gene
- Size:
- 6907 amino acids
- Molecular mass:
- 780607 Da
- Quaternary structure:
-
- May interact with AKAP4.
- SequenceCaution:
-
- Sequence=AAY14863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AK126051; Type=Frameshift; Positions=6474; Evidence={ECO:0000305}; Sequence=CAI46017.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAI46017.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
Protein Expression for FSIP2 Gene
Post-translational modifications for FSIP2 Gene
Other Protein References for FSIP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FSIP2
- Invitrogen Antibodies for FSIP2
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-
Boster Bio Antibodies for FSIP2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FSIP2
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- Search GeneTex for Proteins for FSIP2
Assay Products
No data available for DME Specific Peptides for FSIP2 Gene
Domains & Families for FSIP2 Gene
Gene Families for FSIP2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FSIP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FSIP2 Gene
Function for FSIP2 Gene
Phenotypes for FSIP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
- Browse CRISPR knockouts for FSIP2
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- genomics-online: gRNA clones - Search results for 12 available FSIP2 gene related products
- Overview of 12 available FSIP2 gene related products
- Applied Biological Materials CRISPR for FSIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSIP2
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miRNA for FSIP2 Gene
- miRTarBase miRNAs that target FSIP2
-
- hsa-mir-4646-3p (MIRT525508)
- hsa-mir-6516-5p (MIRT525509)
- hsa-mir-4433b-5p (MIRT525510)
- hsa-mir-3678-3p (MIRT525511)
- hsa-mir-1273h-3p (MIRT525512)
- hsa-mir-6124 (MIRT525513)
- hsa-mir-4771 (MIRT525514)
- hsa-mir-3166 (MIRT525515)
- hsa-mir-339-5p (MIRT525516)
- hsa-mir-4275 (MIRT525517)
- hsa-mir-4272 (MIRT525518)
- hsa-mir-4496 (MIRT525519)
- hsa-mir-6859-5p (MIRT525520)
- hsa-mir-3916 (MIRT525521)
- hsa-mir-3125 (MIRT525522)
- hsa-mir-583 (MIRT525523)
- hsa-mir-6818-3p (MIRT525524)
- hsa-mir-6787-3p (MIRT525525)
- hsa-mir-8067 (MIRT525526)
- hsa-mir-6508-5p (MIRT525527)
- hsa-mir-5685 (MIRT525528)
- hsa-mir-4690-3p (MIRT525529)
- hsa-mir-8063 (MIRT525530)
- hsa-mir-6771-3p (MIRT525531)
- hsa-mir-548as-3p (MIRT525532)
- hsa-mir-7158-5p (MIRT525533)
- hsa-mir-3679-5p (MIRT525534)
- hsa-mir-1185-5p (MIRT525535)
- hsa-mir-767-3p (MIRT525536)
- hsa-mir-651-3p (MIRT525537)
- hsa-mir-7-2-3p (MIRT525538)
- hsa-mir-7-1-3p (MIRT525539)
- hsa-mir-7702 (MIRT634858)
- hsa-mir-502-5p (MIRT634859)
- hsa-mir-4694-5p (MIRT634860)
- hsa-mir-3140-3p (MIRT634861)
- hsa-mir-4641 (MIRT634862)
- hsa-mir-1915-5p (MIRT634863)
- hsa-mir-6841-3p (MIRT634864)
- hsa-mir-8060 (MIRT634865)
- hsa-mir-6809-3p (MIRT636823)
- hsa-mir-4753-3p (MIRT636824)
- hsa-mir-7977 (MIRT636825)
- hsa-mir-466 (MIRT636826)
- hsa-mir-4672 (MIRT636827)
- hsa-mir-3941 (MIRT636828)
- hsa-mir-3124-3p (MIRT636829)
- hsa-mir-130b-5p (MIRT636830)
- hsa-mir-586 (MIRT636831)
- hsa-mir-208b-5p (MIRT636832)
- hsa-mir-208a-5p (MIRT636833)
- hsa-mir-4643 (MIRT636834)
- hsa-mir-4789-3p (MIRT636836)
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 12 available FSIP2 gene related products
- Overview of 12 available FSIP2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FSIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSIP2
- Applied Biological Materials Clones for FSIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FSIP2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSIP2 Gene
Localization for FSIP2 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Microtubules (2)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FSIP2 Gene
Pathways & Interactions for FSIP2 Gene
No Data Available
Interacting Proteins for FSIP2 Gene
No data available for Pathways by source and SIGNOR curated interactions for FSIP2 Gene
Transcripts for FSIP2 Gene
mRNA/cDNA for FSIP2 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000424728 20788 bps (uc061qle.1)
- ENST00000465275 348 bps (uc061qlf.1)
- ENST00000469367 858 bps (uc061qlg.1)
- ENST00000429412 2726 bps (uc061qlh.1)
- ENST00000415915 3869 bps (uc061qlk.1)
Unigene Clusters for FSIP2 Gene
CRISPR Products
- Browse CRISPR knockouts for FSIP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSIP2
- genomics-online: gRNA clones - Search results for 12 available FSIP2 gene related products
- Overview of 12 available FSIP2 gene related products
- Applied Biological Materials CRISPR for FSIP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSIP2
- GenScript: Design CRISPR guide RNA sequences for FSIP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSIP2
- Browse OriGene Inhibitory RNA Products For FSIP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSIP2
- genomics-online: shRNA clones - Search results for 12 available FSIP2 gene related products
- Overview of 12 available FSIP2 gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FSIP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSIP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSIP2
- Applied Biological Materials Clones for FSIP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FSIP2 Gene
mRNA differential expression in normal tissues according to GTEx for FSIP2 Gene
This gene is overexpressed in Testis (x17.2) and Colon - Transverse (x9.8).
This gene is overexpressed in Breast (18.9), Plasma (9.8), and Liver (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSIP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FSIP2 Gene:
FSIP2SOURCE GeneReport for Unigene cluster for FSIP2 Gene:
Hs.98025Primer Products
-
OriGene qPCR primer pairs for FSIP2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSIP2 Gene
Orthologs for FSIP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FSIP2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FSIP2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FSIP2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fsip2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fsip2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FSIP2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | FSIP2 34 |
|
OneToOne |
- Species where no ortholog for FSIP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for FSIP2 Gene
- ENSEMBL:
- Gene Tree for FSIP2 (if available)
- TreeFam:
- Gene Tree for FSIP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FSIP2: view image
Paralogs for FSIP2 Gene
Pseudogenes.org Pseudogenes for FSIP2 Gene
No data available for Paralogs for FSIP2 Gene
Variants for FSIP2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs796052180 | likely-benign, Long QT syndrome | 185,791,079(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000018227 | -- | 185,797,432(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs1000200184 | -- | 185,761,960(+) | G/C | intron_variant | |
| rs1000278024 | -- | 185,757,031(+) | T/G | intron_variant | |
| rs1000308018 | -- | 185,832,404(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4114n100 | CNV | gain | 25217958 |
| dgv4128n100 | CNV | loss | 25217958 |
| dgv7226n54 | CNV | loss | 21841781 |
| esv2721236 | CNV | deletion | 23290073 |
| esv3575317 | CNV | gain | 25503493 |
| esv3584232 | CNV | loss | 25503493 |
| esv3593653 | CNV | gain | 21293372 |
| nsv584020 | CNV | loss | 21841781 |
Gene Damage Index Score:
15.57;
97.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSIP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FSIP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSIP2 Gene
Disorders for FSIP2 Gene
Additional Disease Information for FSIP2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FSIP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSIP2 Gene
Publications for FSIP2 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
- Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours. (PMID: 25609015) Litchfield K … Turnbull C (Nature communications 2015) 3 58
- Joubert Syndrome in French Canadians and Identification of Mutations in CEP104. (PMID: 26477546) Srour M … Michaud JL (American journal of human genetics 2015) 4 58
- Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. (PMID: 22072270) Wang KS … Zeng M (Journal of neural transmission (Vienna, Austria : 1996) 2012) 3 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
Products for FSIP2 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSIP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available FSIP2 related products ranked by validation data
- antibodies-online: Search results for available FSIP2 related products ranked by validation data
- antibodies-online: Search results for available FSIP2 related products ranked by validation data
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- Overview of 12 available FSIP2 gene related products
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- Overview of 12 available FSIP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSIP2
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- Boster Bio Antibodies for FSIP2
- Browse Boster Bio ELISA Kits
Sources for FSIP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
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