Aliases for FSHR Gene
External Ids for FSHR Gene
Previous HGNC Symbols for FSHR Gene
Previous GeneCards Identifiers for FSHR Gene
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for FSHR Gene
FSHR (Follicle Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with FSHR include Ovarian Hyperstimulation Syndrome and Ovarian Dysgenesis 1. Among its related pathways are Signaling by GPCR and Transcription_CREM signaling in testis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled peptide receptor activity. An important paralog of this gene is LHCGR.
UniProtKB/Swiss-Prot Summary for FSHR Gene
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).