Aliases for FSHB Gene
External Ids for FSHB Gene
Previous GeneCards Identifiers for FSHB Gene
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for FSHB Gene
FSHB (Follicle Stimulating Hormone Subunit Beta) is a Protein Coding gene. Diseases associated with FSHB include Hypogonadotropic Hypogonadism 24 Without Anosmia and Hypogonadism. Among its related pathways are Signaling by GPCR and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include hormone activity and follicle-stimulating hormone activity. An important paralog of this gene is TSHB.
UniProtKB/Swiss-Prot Summary for FSHB Gene
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).