Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FSHB Gene

Aliases for FSHB Gene

  • Follicle Stimulating Hormone Subunit Beta 2 3
  • Follicle Stimulating Hormone, Beta Polypeptide 2 3
  • Follicle Stimulating Hormone Beta Subunit 3 5
  • Follitropin, Beta Chain 2 3
  • FSH-Beta 3 4
  • FSH-B 3 4
  • Follicle-Stimulating Hormone Beta Subunit 4
  • Follitropin Subunit Beta 3
  • Follitropin Beta Chain 4
  • HH24 3

External Ids for FSHB Gene

Previous GeneCards Identifiers for FSHB Gene

  • GC11P031850
  • GC11P031028
  • GC11P030292
  • GC11P030217
  • GC11P029945

Summaries for FSHB Gene

Entrez Gene Summary for FSHB Gene

  • The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FSHB Gene

FSHB (Follicle Stimulating Hormone Subunit Beta) is a Protein Coding gene. Diseases associated with FSHB include Hypogonadotropic Hypogonadism 24 Without Anosmia and Hypogonadism. Among its related pathways are Ovarian steroidogenesis and Transcription_CREM signaling in testis. Gene Ontology (GO) annotations related to this gene include hormone activity and follicle-stimulating hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for FSHB Gene

  • Stimulates development of follicle and spermatogenesis in the reproductive organs.

Gene Wiki entry for FSHB Gene

Additional gene information for FSHB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSHB Gene

Genomics for FSHB Gene

GeneHancer (GH) Regulatory Elements for FSHB Gene

Promoters and enhancers for FSHB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J030230 Promoter 0.5 EPDnew 650.7 +0.3 309 0.1 FSHB LOC105376607
GH11J030206 Enhancer 0.6 ENCODE 11.6 -24.0 -24034 0.9 CBFB EBF1 MEF2B ELF1 DPF2 ATF2 TARDBP IKZF1 EED MLLT1 FSHB ARL14EP PIR58414 PIR56798 LOC105376607
GH11J030196 Enhancer 0.5 ENCODE 11.7 -33.9 -33899 0.2 CTCF XRCC5 ZNF654 SMC3 ZNF143 TRIM22 RAD21 PIR58414 FSHB GC11P030179 GC11P030178 LOC105376607
GH11J030486 Enhancer 1.4 FANTOM5 Ensembl ENCODE 3.2 +257.7 257688 2.8 PKNOX1 FOXA2 SIN3A FEZF1 YY1 SLC30A9 ZNF213 RXRA KAT8 NFIL3 MPPED2 ARL14EP FSHB ENSG00000255480 GC11P030582
GH11J030197 Enhancer 0.3 ENCODE 11.7 -32.6 -32576 1 SETDB1 PIR58414 FSHB GC11P030179 GC11P030178 LOC105376607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FSHB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FSHB gene promoter:
  • deltaCREB
  • CREB
  • Nkx2-5
  • FOXJ2 (long isoform)
  • FOXJ2
  • Sox5
  • SRY
  • MEF-2A

Genomic Locations for FSHB Gene

Genomic Locations for FSHB Gene
4,590 bases
Plus strand
4,262 bases
Plus strand

Genomic View for FSHB Gene

Genes around FSHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSHB Gene

Proteins for FSHB Gene

  • Protein details for FSHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Follitropin subunit beta
    Protein Accession:
    Secondary Accessions:
    • A2TF08
    • A5JVV3
    • Q14D61

    Protein attributes for FSHB Gene

    129 amino acids
    Molecular mass:
    14700 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for FSHB Gene

neXtProt entry for FSHB Gene

Post-translational modifications for FSHB Gene

  • Glycosylation at isoforms=42 and isoforms=25
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FSHB_HUMAN (165)

Other Protein References for FSHB Gene

Antibody Products

No data available for DME Specific Peptides for FSHB Gene

Domains & Families for FSHB Gene

Gene Families for FSHB Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FSHB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with FSHB: view

Function for FSHB Gene

Molecular function for FSHB Gene

UniProtKB/Swiss-Prot Function:
Stimulates development of follicle and spermatogenesis in the reproductive organs.
GENATLAS Biochemistry:
follicle stimulating hormone,beta polypeptide

Phenotypes From GWAS Catalog for FSHB Gene

Gene Ontology (GO) - Molecular Function for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 8220432
GO:0005515 protein binding IPI 11222739
GO:0016913 follicle-stimulating hormone activity IMP 11514332
genes like me logo Genes that share ontologies with FSHB: view
genes like me logo Genes that share phenotypes with FSHB: view

Human Phenotype Ontology for FSHB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FSHB Gene

MGI Knock Outs for FSHB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSHB

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FSHB Gene

Localization for FSHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSHB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSHB gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 14602737
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with FSHB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FSHB Gene

Pathways & Interactions for FSHB Gene

genes like me logo Genes that share pathways with FSHB: view

Gene Ontology (GO) - Biological Process for FSHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006701 progesterone biosynthetic process TAS 14557487
GO:0007165 signal transduction TAS 8220432
GO:0007179 transforming growth factor beta receptor signaling pathway IEP 14557487
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007267 cell-cell signaling IBA --
genes like me logo Genes that share ontologies with FSHB: view

No data available for SIGNOR curated interactions for FSHB Gene

Drugs & Compounds for FSHB Gene

(13) Drugs for FSHB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for FSHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FSHB: view

Transcripts for FSHB Gene

mRNA/cDNA for FSHB Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FSHB Gene

Follicle stimulating hormone, beta polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSHB

Alternative Splicing Database (ASD) splice patterns (SP) for FSHB Gene

No ASD Table

Relevant External Links for FSHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FSHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSHB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FSHB Gene

This gene is overexpressed in Pituitary (x52.5).

NURSA nuclear receptor signaling pathways regulating expression of FSHB Gene:


SOURCE GeneReport for Unigene cluster for FSHB Gene:


Evidence on tissue expression from TISSUES for FSHB Gene

  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FSHB Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • endocrine
  • reproductive
  • skeleton
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • ovary
  • pelvis
  • testicle
  • uterus
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with FSHB: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FSHB Gene

Orthologs for FSHB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSHB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FSHB 34 33
  • 98.45 (n)
(Bos Taurus)
Mammalia FSHB 34 33
  • 86.05 (n)
-- 34
  • 85 (a)
(Mus musculus)
Mammalia Fshb 16 34 33
  • 85.01 (n)
(Rattus norvegicus)
Mammalia Fshb 33
  • 83.98 (n)
(Canis familiaris)
Mammalia FSHB 34 33
  • 79.59 (n)
(Ornithorhynchus anatinus)
Mammalia FSHB 34
  • 70 (a)
(Monodelphis domestica)
Mammalia FSHB 34
  • 69 (a)
(Gallus gallus)
Aves FSHB 34 33
  • 72.22 (n)
(Anolis carolinensis)
Reptilia FSHB 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fshb 33
  • 63.82 (n)
(Danio rerio)
Actinopterygii fshb 34 33
  • 55.43 (n)
Species where no ortholog for FSHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSHB Gene

Gene Tree for FSHB (if available)
Gene Tree for FSHB (if available)
Evolutionary constrained regions (ECRs) for FSHB: view image

Paralogs for FSHB Gene

Paralogs for FSHB Gene

(9) SIMAP similar genes for FSHB Gene using alignment to 3 proteins:

  • Q1W658_HUMAN
  • Q27RP3_HUMAN Pseudogenes for FSHB Gene

genes like me logo Genes that share paralogs with FSHB: view

Variants for FSHB Gene

Sequence variations from dbSNP and Humsavar for FSHB Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs10835638 association, isolated follicle-stimulating hormone deficiency 30,230,805(+) G/A/T upstream_transcript_variant
rs121909666 pathogenic, Follicle-stimulating hormone deficiency, isolated 30,233,692(+) C/A/T coding_sequence_variant, stop_gained, synonymous_variant
rs143137782 uncertain-significance, isolated follicle-stimulating hormone deficiency 30,234,698(+) T/C 3_prime_UTR_variant
rs148454792 uncertain-significance, isolated follicle-stimulating hormone deficiency 30,233,737(+) C/A coding_sequence_variant, missense_variant
rs374623109 likely-pathogenic, Follicle-stimulating hormone deficiency, isolated 30,233,753(+) C/T coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for FSHB Gene

Variant ID Type Subtype PubMed ID
nsv437712 CNV loss 16327808
nsv553946 CNV loss 21841781

Variation tolerance for FSHB Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSHB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSHB Gene

Disorders for FSHB Gene

MalaCards: The human disease database

(12) MalaCards diseases for FSHB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 24 without anosmia
  • hh24
hypogonadotropic hypogonadism
  • congenital idiopathic hypogonadotropic hypogonadism
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards
Search FSHB in MalaCards View complete list of genes associated with diseases


  • Hypogonadotropic hypogonadism 24 without anosmia (HH24) [MIM:229070]: A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH24 is characterized by primary amenorrhea in women, oligo or azoospermia with low to normal testosterone levels in men, and infertility. {ECO:0000269 PubMed:8220432, ECO:0000269 PubMed:9271483, ECO:0000269 PubMed:9280841}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FSHB Gene

delayed puberty,primary amenorrhea,infertility (FSH deficiency,isolated),hypogonadism in man

Additional Disease Information for FSHB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FSHB: view

Publications for FSHB Gene

  1. Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. (PMID: 19897680) Grigorova M … Laan M (The Journal of clinical endocrinology and metabolism 2010) 3 22 44 58
  2. Association of AccI polymorphism in the follicle-stimulating hormone beta gene with polycystic ovary syndrome. (PMID: 11119757) Tong Y … Ng SC (Fertility and sterility 2000) 3 22 44 58
  3. A reevaluation of the amino acid sequence of human follitropin beta-subunit. (PMID: 3151250) Shome B … Ward DN (Journal of protein chemistry 1988) 2 3 4 58
  4. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. (PMID: 2885163) Watkins PC … Shows TB (DNA (Mary Ann Liebert, Inc.) 1987) 2 3 4 58
  5. FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. (PMID: 20233786) Corpuz PS … Coss D (Molecular endocrinology (Baltimore, Md.) 2010) 3 22 58

Products for FSHB Gene

Sources for FSHB Gene

Loading form....