Aliases for FSHB Gene
External Ids for FSHB Gene
Previous GeneCards Identifiers for FSHB Gene
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for FSHB Gene
FSHB (Follicle Stimulating Hormone Subunit Beta) is a Protein Coding gene. Diseases associated with FSHB include Hypogonadotropic Hypogonadism 24 Without Anosmia and Hypogonadism. Among its related pathways are Signaling by GPCR and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to this gene include hormone activity and follicle-stimulating hormone activity. An important paralog of this gene is TSHB.
UniProtKB/Swiss-Prot Summary for FSHB Gene
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).