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Aliases for FSD2 Gene

Aliases for FSD2 Gene

  • Fibronectin Type III And SPRY Domain Containing 2 2 3 5
  • SPRY Domain-Containing Protein 1 3 4
  • SPRY Domain Containing 1 2 3
  • SPRYD1 3 4
  • Fibronectin Type III And SPRY Domain-Containing Protein 2 3

External Ids for FSD2 Gene

Previous HGNC Symbols for FSD2 Gene

  • SPRYD1

Previous GeneCards Identifiers for FSD2 Gene

  • GC15M081222
  • GC15M083424

Summaries for FSD2 Gene

Entrez Gene Summary for FSD2 Gene

  • This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FSD2 Gene

FSD2 (Fibronectin Type III And SPRY Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is CMYA5.

Additional gene information for FSD2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSD2 Gene

Genomics for FSD2 Gene

GeneHancer (GH) Regulatory Elements for FSD2 Gene

Promoters and enhancers for FSD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I082803 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -2.4 -2401 9.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 WHAMM FSD2 AP3B2 FAM103A1 SCARNA15 EFL1 GOLGA6L9 C15orf40 GC15M082841
GH15I082950 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 9.8 -145.9 -145939 2.6 NFIB FEZF1 ZNF335 GLIS2 ZSCAN5C RUNX3 EGR2 ZNF398 ZEB2 NFIL3 HOMER2 FAM103A1 AP3B2 C15orf40 FSD2 GC15M082960 PIR42152 LOC105370928
GH15I082749 Promoter/Enhancer 1.6 Ensembl ENCODE 10.7 +55.4 55375 3.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SNHG21 AP3B2 FSD2 HOMER2 C15orf40 HDGFL3 GOLGA6L10 GC15M082753 ENSG00000259442 GC15P082732
GH15I082848 Enhancer 1.2 Ensembl ENCODE 10.6 -43.9 -43856 2.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FAM103A1 C15orf40 WHAMM HOMER2 FSD2 EFL1 GOLGA6L9 GC15M082841 GC15P082870
GH15I082852 Enhancer 0.7 Ensembl ENCODE 10.5 -47.1 -47085 1.4 NFIC ZNF316 NFIB SCRT2 MAFG MAFK EMSY FAM103A1 C15orf40 HOMER2 FSD2 WHAMM GC15M082841 GC15P082870
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FSD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FSD2 gene promoter:

Genomic Locations for FSD2 Gene

Genomic Locations for FSD2 Gene
chr15:82,755,362-82,806,211
(GRCh38/hg38)
Size:
50,850 bases
Orientation:
Minus strand
chr15:83,424,114-83,474,822
(GRCh37/hg19)

Genomic View for FSD2 Gene

Genes around FSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FSD2 Gene

Proteins for FSD2 Gene

  • Protein details for FSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L4K1-FSD2_HUMAN
    Recommended name:
    Fibronectin type III and SPRY domain-containing protein 2
    Protein Accession:
    A1L4K1
    Secondary Accessions:
    • B3KVG1
    • B7ZM02

    Protein attributes for FSD2 Gene

    Size:
    749 amino acids
    Molecular mass:
    85385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FSD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSD2 Gene

Post-translational modifications for FSD2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FSD2 Gene

Domains & Families for FSD2 Gene

Gene Families for FSD2 Gene

Suggested Antigen Peptide Sequences for FSD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FSD2: view

No data available for UniProtKB/Swiss-Prot for FSD2 Gene

Function for FSD2 Gene

Phenotypes From GWAS Catalog for FSD2 Gene

Gene Ontology (GO) - Molecular Function for FSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FSD2: view

Phenotypes for FSD2 Gene

GenomeRNAi human phenotypes for FSD2:
genes like me logo Genes that share phenotypes with FSD2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD2 Gene

Localization for FSD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSD2 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FSD2 Gene

Pathways & Interactions for FSD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FSD2 Gene

Drugs & Compounds for FSD2 Gene

No Compound Related Data Available

Transcripts for FSD2 Gene

Unigene Clusters for FSD2 Gene

Fibronectin type III and SPRY domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FSD2 Gene

No ASD Table

Relevant External Links for FSD2 Gene

GeneLoc Exon Structure for
FSD2
ECgene alternative splicing isoforms for
FSD2

Expression for FSD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FSD2 Gene

mRNA differential expression in normal tissues according to GTEx for FSD2 Gene

This gene is overexpressed in Muscle - Skeletal (x9.6), Heart - Left Ventricle (x9.4), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for FSD2 Gene

This gene is overexpressed in Breast (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FSD2 Gene



Protein tissue co-expression partners for FSD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FSD2 Gene:

FSD2

SOURCE GeneReport for Unigene cluster for FSD2 Gene:

Hs.719372

Evidence on tissue expression from TISSUES for FSD2 Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with FSD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSD2 Gene

Orthologs for FSD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FSD2 33 34
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia FSD2 33 34
  • 87.02 (n)
rat
(Rattus norvegicus)
Mammalia Fsd2 33
  • 83.49 (n)
mouse
(Mus musculus)
Mammalia Fsd2 33 16 34
  • 83.38 (n)
dog
(Canis familiaris)
Mammalia FSD2 33 34
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia FSD2 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FSD2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FSD2 33 34
  • 64.11 (n)
lizard
(Anolis carolinensis)
Reptilia FSD2 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fsd2 33
  • 59.02 (n)
zebrafish
(Danio rerio)
Actinopterygii FSD2 34
  • 44 (a)
OneToOne
Species where no ortholog for FSD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FSD2 Gene

ENSEMBL:
Gene Tree for FSD2 (if available)
TreeFam:
Gene Tree for FSD2 (if available)

Paralogs for FSD2 Gene

Paralogs for FSD2 Gene

(1) SIMAP similar genes for FSD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FSD2: view

Variants for FSD2 Gene

Sequence variations from dbSNP and Humsavar for FSD2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000078693 -- 82,808,340(-) A/G upstream_transcript_variant
rs1000100041 -- 82,771,924(-) C/T intron_variant
rs1000153013 -- 82,765,032(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000217024 -- 82,778,456(-) A/G intron_variant
rs1000220462 -- 82,774,418(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FSD2 Gene

Variant ID Type Subtype PubMed ID
nsv817702 CNV loss 17921354
nsv471687 CNV gain 15918152
nsv469557 CNV loss 16826518
nsv1120052 OTHER inversion 24896259
esv3581791 CNV loss 25503493
esv34318 CNV loss 17911159
esv2674021 CNV deletion 23128226
dgv2637n100 CNV gain 25217958

Variation tolerance for FSD2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSD2 Gene

Disorders for FSD2 Gene

Additional Disease Information for FSD2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSD2 Gene

Publications for FSD2 Gene

  1. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PMID: 20966410) Dong C … Sacco RL (Stroke 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for FSD2 Gene

Sources for FSD2 Gene

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