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Aliases for FSD1L Gene
Aliases for FSD1L Gene
External Ids for FSD1L Gene
- HGNC: 13753
- Entrez Gene: 83856
- Ensembl: ENSG00000106701
- OMIM: 609829
- UniProtKB: Q9BXM9
Previous HGNC Symbols for FSD1L Gene
- CSDUFD1
- CCDC10
- FSD1NL
- FSD1CL
Previous GeneCards Identifiers for FSD1L Gene
- GC09P105343
- GC09P107250
- GC09P108210
- GC09P077813
Summaries for FSD1L Gene
GeneCards Summary for FSD1L Gene
FSD1L (Fibronectin Type III And SPRY Domain Containing 1 Like) is a Protein Coding gene. Diseases associated with FSD1L include Pancreatic Adenosquamous Carcinoma. An important paralog of this gene is FSD1.
Additional gene information for FSD1L Gene
- HGNC(13753)
- Entrez Gene(83856)
- Ensembl(ENSG00000106701)
- OMIM(609829)
- UniProtKB(Q9BXM9)
- Open Targets Platform(ENSG00000106701)
- Search for FSD1L at DataMed
- Search for FSD1L at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FSD1L Gene
Genomics for FSD1L Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FSD1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FSD1L on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FSD1L
- Top Transcription factor binding sites by QIAGEN in the FSD1L gene promoter:
-
- FOXI1
- FOXJ2 (long isoform)
- HFH-3
- Nkx2-5
- Pax-5
Genomic Locations for FSD1L Gene
Genomic Locations for FSD1L Gene
- chr9:105,442,183-105,552,433
- (GRCh38/hg38)
- Size:
- 110,251 bases
- Orientation:
- Plus strand
- chr9:108,210,077-108,314,714
- (GRCh37/hg19)
- Size:
- 104,638 bases
- Orientation:
- Plus strand
Genomic View for FSD1L Gene
Genes around FSD1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.2 by HGNC
- 9q31.2 by Entrez Gene
- 9q31.2 by Ensembl
FSD1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSD1L Gene
Proteins for FSD1L Gene
-
Protein details for FSD1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BXM9-FSD1L_HUMAN
- Recommended name:
- FSD1-like protein
- Protein Accession:
- Q9BXM9
- A2A338
- A6NKH7
- B7Z5S6
- B7Z5W3
- Q5T879
- Q5T880
Protein attributes for FSD1L Gene
- Size:
- 530 amino acids
- Molecular mass:
- 59578 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- [Isoform 3]: Due to intron retention.
Protein Expression for FSD1L Gene
Post-translational modifications for FSD1L Gene
Other Protein References for FSD1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FSD1L
- Invitrogen Antibodies for FSD1L (AFLGC-FSD1L)
- antibodies-online: Show 4 available FSD1L Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for FSD1L
- Search Origene for MassSpec and Protein Over-expression Lysates for FSD1L
- Origene Custom Protein Services for FSD1L
-
Signalway Proteins for FSD1L
No data available for DME Specific Peptides for FSD1L Gene
Domains & Families for FSD1L Gene
Gene Families for FSD1L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for FSD1L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FSD1L Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57313, highly similar to Homo sapiens fibronectin type III and SPRY domain containing 1-like, transcript variant 1, mRNA (B7Z3W5_HUMAN)
- FSD1 N-terminal-like protein (FSD1L_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FSD1L Gene
Function for FSD1L Gene
Phenotypes From GWAS Catalog for FSD1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for FSD1L Gene
- MGI mutant phenotypes for FSD1L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FSD1L:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased vaccinia virus (VACV) infection
- Increased G1 DNA content
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Strongly decreased CFP-tsO45G cell surface transport
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- G0/1 arrest
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FSD1L - Select products 50% OFF >
- * FSD1L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FSD1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSD1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSD1L
miRNA for FSD1L Gene
- miRTarBase miRNAs that target FSD1L
-
- mmu-miR-410-3p (MIRT583425)
- mmu-miR-344d-3p (MIRT583426)
- mmu-miR-344e-3p (MIRT583427)
- mmu-miR-590-3p (MIRT583428)
- mmu-miR-129-5p (MIRT589997)
- mmu-miR-1896 (MIRT589998)
- mmu-miR-3113-5p (MIRT589999)
- mmu-miR-3085-3p (MIRT590000)
- mmu-miR-3064-5p (MIRT590001)
- mmu-miR-3087-3p (MIRT590002)
- mmu-miR-3470b (MIRT590003)
- mmu-miR-3964 (MIRT604982)
- mmu-miR-511-3p (MIRT604983)
- mmu-miR-466a-5p (MIRT604984)
- mmu-miR-1198-5p (MIRT604985)
- mmu-miR-466p-5p (MIRT604986)
- mmu-miR-1187 (MIRT604987)
- mmu-miR-466e-5p (MIRT604988)
- mmu-miR-466l-5p (MIRT604989)
- mmu-miR-466d-5p (MIRT604990)
- mmu-miR-466i-5p (MIRT604991)
- mmu-miR-466k (MIRT604992)
- mmu-miR-3961 (MIRT606419)
- mmu-miR-344f-3p (MIRT606420)
- mmu-miR-681 (MIRT606421)
- hsa-miR-4786-3p (MIRT658055)
- hsa-miR-501-5p (MIRT658056)
- hsa-miR-500a-5p (MIRT658057)
- hsa-miR-4668-3p (MIRT658058)
- hsa-miR-1305 (MIRT658059)
- hsa-miR-380-3p (MIRT658060)
- hsa-miR-411-3p (MIRT658061)
- hsa-miR-379-3p (MIRT658062)
- hsa-miR-4495 (MIRT658063)
- hsa-miR-181c-5p (MIRT727641)
- hsa-miR-181d-5p (MIRT727642)
- hsa-miR-181b-5p (MIRT727643)
- hsa-miR-181a-5p (MIRT727644)
- hsa-miR-130a-5p (MIRT762493)
- hsa-miR-136-5p (MIRT762596)
- hsa-miR-23a-3p (MIRT764010)
- hsa-miR-23b-3p (MIRT764028)
- hsa-miR-23c (MIRT764046)
- hsa-miR-3145-5p (MIRT764997)
- hsa-miR-508-5p (MIRT773146)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSD1L
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Clone Products
- Applied Biological Materials (abm): Clones for FSD1L - Select products 50% OFF >
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-
- MG225941
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- MR225941L3
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- RC221846
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- MR225941L3V
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- RC221846L3V
- RC221846L4V
- RC227045L3V
- RC227045L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FSD1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSD1L
Cell Line Products
-
Horizon Cell Lines for FSD1L
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSD1L Gene
Localization for FSD1L Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Actin filaments (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FSD1L Gene
Pathways & Interactions for FSD1L Gene
Interacting Proteins for FSD1L Gene
GPS-Prot Interaction Network for FSD1L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for FSD1L Gene
Transcripts for FSD1L Gene
mRNA/cDNA for FSD1L Gene
- 6 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374707 7062 nts (view in UCSC)
- ENST00000374710 7664 nts (view in UCSC)
- ENST00000394926 1947 nts (view in UCSC)
- ENST00000469022 1836 nts (view in UCSC)
- ENST00000480279 566 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FSD1L - Select products 50% OFF >
- * FSD1L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FSD1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSD1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSD1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSD1L
- Browse OriGene Inhibitory RNA Products For FSD1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSD1L
Clone Products
- Applied Biological Materials (abm): Clones for FSD1L - Select products 50% OFF >
- * FSD1L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG225941
- MG225942
- MR225941
- MR225941L3
- MR225941L4
- MR225942
- MR225942L3
- MR225942L4
- RC213672
- RC213672L3
- RC213672L4
- RC221846
- RC221846L3
- RC221846L4
- RC227045
- RC227045L3
- RC227045L4
- RC238569
- RC238627
- RG213672
- RG221846
- RG227045
- MR225941L3V
- MR225941L4V
- MR225942L3V
- MR225942L4V
- RC213672L3V
- RC213672L4V
- RC221846L3V
- RC221846L4V
- RC227045L3V
- RC227045L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FSD1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSD1L
Relevant External Links for FSD1L Gene
- GeneLoc Exon Structure for
- FSD1L
Expression for FSD1L Gene
This gene is overexpressed in Fetal Brain (22.0), Spinal cord (12.8), Testis (12.1), and Brain (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FSD1L Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FSD1L
SOURCE GeneReport for Unigene cluster for FSD1L Gene:
Hs.136901Evidence on tissue expression from TISSUES for FSD1L Gene
- Nervous system(3)
Primer Products
-
OriGene qPCR primer pairs for FSD1L
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSD1L Gene
Orthologs for FSD1L Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FSD1L 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FSD1L 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FSD1L 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FSD1L 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fsd1l 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FSD1L 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fsd1l 30 |
|
||
| Chicken (Gallus gallus) |
Aves | FSD1L 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FSD1L 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fsd1l 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fsd1l 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Trim9 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | trim-9 31 |
|
OneToMany |
- Species where no ortholog for FSD1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FSD1L Gene
- ENSEMBL:
- Gene Tree for FSD1L (if available)
- TreeFam:
- Gene Tree for FSD1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FSD1L: view image
Paralogs for FSD1L Gene
Variants for FSD1L Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3891705 | CNV | loss | 25118596 |
| nsv1037750 | CNV | gain | 25217958 |
| nsv1053973 | CNV | loss | 25217958 |
| nsv1110046 | CNV | deletion | 24896259 |
| nsv416298 | CNV | deletion | 16902084 |
| nsv615115 | CNV | loss | 21841781 |
| nsv982334 | CNV | duplication | 23825009 |
Gene Damage Index Score:
2.67;
45.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSD1L Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FSD1L Gene
Disorders for FSD1L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pancreatic adenosquamous carcinoma |
|
|
Search FSD1L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FSD1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FSD1L Gene
Publications for FSD1L Gene
- Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31. (PMID: 11267680) Carim-Todd L … Sumoy L (Biochimica et biophysica acta 2001) 2 3 4
- Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry JR … Murabito JM (Nature genetics 2009) 3 41
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
- Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3
- RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization. (PMID: 29435596) Tanghe G … Declercq W (Cellular and molecular life sciences : CMLS 2018) 3
ExternalLinks
Products for FSD1L Gene
- Custom Antibody Services
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- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For FSD1L
- OriGene qPCR primer pairs for FSD1L
- OriGene CRISPR knockouts for FSD1L
- MG225941
- MG225942
- MR225941
- MR225941L3
- MR225941L4
- MR225942
- MR225942L3
- MR225942L4
- RC213672
- RC213672L3
- RC213672L4
- RC221846
- RC221846L3
- RC221846L4
- RC227045
- RC227045L3
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- RC238569
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- RG213672
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- MR225941L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse Antibodies
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- Invitrogen Antibodies for FSD1L (AFLGC-FSD1L)
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- VectorBuilder Stable cell line generation for FSD1L
- antibodies-online: Show 4 available FSD1L Antibodies ranked by validation data
- antibodies-online: Search results for available FSD1L related products ranked by validation data
- antibodies-online: Search results for available FSD1L related products ranked by validation data
- Horizon Cell Lines for FSD1L
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSD1L
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for FSD1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSD1L
- Signalway Proteins for FSD1L
Sources for FSD1L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
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