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This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs,... See more...
Aliases for FSCN1 Gene
Aliases for FSCN1 Gene
External Ids for FSCN1 Gene
- HGNC: 11148
- Entrez Gene: 6624
- Ensembl: ENSG00000075618
- OMIM: 602689
- UniProtKB: Q16658
Previous HGNC Symbols for FSCN1 Gene
- SNL
Previous GeneCards Identifiers for FSCN1 Gene
- GC07P005276
- GC07P005376
- GC07P005405
- GC07P005598
- GC07P005544
- GC07P005632
Summaries for FSCN1 Gene
-
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
GeneCards Summary for FSCN1 Gene
FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Juvenile Xanthogranuloma and Inverted Papilloma. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is FSCN2.
UniProtKB/Swiss-Prot Summary for FSCN1 Gene
-
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Additional gene information for FSCN1 Gene
- HGNC(11148)
- Entrez Gene(6624)
- Ensembl(ENSG00000075618)
- OMIM(602689)
- UniProtKB(Q16658)
- Open Targets Platform(ENSG00000075618)
- Search for FSCN1 at DataMed
- Search for FSCN1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FSCN1 Gene
Genomics for FSCN1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FSCN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FSCN1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FSCN1
- Top Transcription factor binding sites by QIAGEN in the FSCN1 gene promoter:
-
- CREB
- deltaCREB
- p53
Genomic Locations for FSCN1 Gene
Genomic Locations for FSCN1 Gene
- chr7:5,592,816-5,606,655
- (GRCh38/hg38)
- Size:
- 13,840 bases
- Orientation:
- Plus strand
- chr7:5,632,439-5,646,286
- (GRCh37/hg19)
- Size:
- 13,848 bases
- Orientation:
- Plus strand
Genomic View for FSCN1 Gene
Genes around FSCN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.1 by HGNC
- 7p22.1 by Entrez Gene
- 7p22.1 by Ensembl
FSCN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSCN1 Gene
Proteins for FSCN1 Gene
-
Protein details for FSCN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16658-FSCN1_HUMAN
- Recommended name:
- Fascin
- Protein Accession:
- Q16658
- A6NI89
- B2RE97
- Q96IC5
- Q96IH1
- Q9BRF1
Protein attributes for FSCN1 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 54530 Da
- Quaternary structure:
-
- Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (By similarity). Interacts with NGFR (By similarity). Associates with CTNNB1 (By similarity). Interacts with PLXNB3 (PubMed:21706053).
- SequenceCaution:
-
- Sequence=AAH07539.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for FSCN1 Gene
Post-translational modifications for FSCN1 Gene
- Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FSCN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Fascin (7H1) monoclonal antibody and Immunotag™ FSCN1 Antibody
- NSJ Bioreagents Fascin Antibody (Mouse Monoclonal)
- Novus Biologicals Antibodies for FSCN1
-
Abcam antibodies for FSCN1
- Invitrogen Antibodies for FSCN1 (AFLGC-FSCN1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FSCN1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FSCN1
- Origene Custom Protein Services for FSCN1
- ProSpec Recombinant Proteins for FSCN1
-
Abcam proteins for FSCN1
Assay Products
- G Biosciences Immunotag™ Human FSCN1 (Fascin) ELISA and Immunotag™ Fascin ELISA Kit
- Novus Biologicals ELISA Kits for FSCN1
-
Signalway ELISA kits for FSCN1
No data available for DME Specific Peptides for FSCN1 Gene
Domains & Families for FSCN1 Gene
Gene Families for FSCN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FSCN1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FSCN1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ38511 fis, clone HCHON2000417, highly similar to FASCIN (B3KTM9_HUMAN)
- p55 (FSCN1_HUMAN)
- FSCN1 protein (Q96IH1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16658UniProtKB/Swiss-Prot:
FSCN1_HUMAN :- Composed of four fascin beta-trefoil domains.
- Belongs to the fascin family.
- Domain:
-
- Composed of four fascin beta-trefoil domains.
- Family:
-
- Belongs to the fascin family.
Function for FSCN1 Gene
Molecular function for FSCN1 Gene
- UniProtKB/Swiss-Prot Function:
- Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Phenotypes From GWAS Catalog for FSCN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003779 | actin binding | IEA,IDA | 8999969 |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0008144 | drug binding | IDA | 20393565 |
| GO:0030674 | protein binding, bridging | IEA | -- |
Phenotypes for FSCN1 Gene
- MGI mutant phenotypes for FSCN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FSCN1:
Animal Models for FSCN1 Gene
- MGI Knock Outs for FSCN1:
-
- Fscn1 Fscn1<tm1.1(KOMP)Vlcg>
Animal Model Products
-
Taconic Biosciences Mouse Models for FSCN1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FSCN1 - Select products 50% OFF >
- * FSCN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FSCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
miRNA for FSCN1 Gene
- miRTarBase miRNAs that target FSCN1
-
- hsa-miR-133a-3p (MIRT003542)
- hsa-miR-145-5p (MIRT003543)
- hsa-miR-143-3p (MIRT005771)
- hsa-miR-133b (MIRT006554)
- hsa-miR-30a-5p (MIRT028511)
- hsa-miR-221-3p (MIRT046860)
- hsa-miR-17-3p (MIRT050745)
- bta-miR-145 (MIRT053913)
- hsa-miR-6801-5p (MIRT476701)
- hsa-miR-7162-3p (MIRT476702)
- hsa-miR-4649-3p (MIRT476703)
- hsa-miR-6501-3p (MIRT476704)
- hsa-miR-583 (MIRT476705)
- hsa-miR-24-3p (MIRT476706)
- hsa-miR-6792-5p (MIRT493811)
- hsa-miR-4283 (MIRT493812)
- hsa-miR-760 (MIRT493813)
- hsa-miR-5008-5p (MIRT493814)
- hsa-miR-3663-3p (MIRT493815)
- hsa-miR-1247-3p (MIRT493816)
- hsa-miR-7113-5p (MIRT493817)
- hsa-miR-761 (MIRT493818)
- hsa-miR-3619-5p (MIRT493819)
- hsa-miR-214-3p (MIRT493820)
- hsa-miR-4705 (MIRT493821)
- hsa-miR-6813-5p (MIRT493822)
- hsa-miR-6085 (MIRT493823)
- hsa-miR-29c-3p (MIRT493824)
- hsa-miR-29b-3p (MIRT493825)
- hsa-miR-29a-3p (MIRT493826)
- hsa-miR-6816-5p (MIRT569091)
- hsa-miR-3196 (MIRT569092)
- hsa-miR-3180-3p (MIRT569093)
- hsa-miR-3180 (MIRT569094)
- hsa-miR-6787-5p (MIRT569095)
- hsa-miR-6721-5p (MIRT569096)
- hsa-miR-663a (MIRT569097)
- hsa-miR-1908-5p (MIRT569098)
- hsa-miR-4763-3p (MIRT569099)
- hsa-miR-1207-5p (MIRT569100)
- hsa-miR-4749-5p (MIRT569101)
- hsa-miR-4706 (MIRT569102)
- hsa-miR-6722-3p (MIRT569103)
- hsa-miR-1909-3p (MIRT569104)
- hsa-miR-6802-3p (MIRT721836)
- hsa-miR-4284 (MIRT721837)
- hsa-miR-6862-3p (MIRT721838)
- hsa-miR-6784-3p (MIRT721839)
- hsa-miR-4707-5p (MIRT721840)
- hsa-miR-6764-5p (MIRT721841)
- hsa-miR-1915-3p (MIRT721842)
- hsa-miR-6837-5p (MIRT721843)
- hsa-miR-4685-5p (MIRT721844)
- hsa-miR-5088-5p (MIRT721845)
- hsa-miR-133a-5p (MIRT731721)
- hsa-miR-326 (MIRT733126)
- hsa-miR-429 (MIRT733149)
- hsa-miR-200b-3p (MIRT735429)
- hsa-miR-184 (MIRT738190)
- hsa-miR-185-3p (MIRT738206)
- hsa-miR-2115-5p (MIRT738965)
- hsa-miR-299-3p (MIRT739546)
- hsa-miR-3180-5p (MIRT740798)
- hsa-miR-3652 (MIRT741889)
- hsa-miR-3919 (MIRT742948)
- hsa-miR-4265 (MIRT743501)
- hsa-miR-4296 (MIRT743796)
- hsa-miR-4322 (MIRT744034)
- hsa-miR-4417 (MIRT744142)
- hsa-miR-4430 (MIRT744327)
- hsa-miR-4446-3p (MIRT744613)
- hsa-miR-4489 (MIRT745255)
- hsa-miR-4492 (MIRT745284)
- hsa-miR-4498 (MIRT745365)
- hsa-miR-4505 (MIRT745524)
- hsa-miR-4533 (MIRT746010)
- hsa-miR-4656 (MIRT746653)
- hsa-miR-4673 (MIRT746856)
- hsa-miR-4681 (MIRT746925)
- hsa-miR-4722-5p (MIRT747593)
- hsa-miR-4731-5p (MIRT747933)
- hsa-miR-4736 (MIRT747996)
- hsa-miR-4747-5p (MIRT748240)
- hsa-miR-4770 (MIRT748670)
- hsa-miR-4804-5p (MIRT749025)
- hsa-miR-5001-5p (MIRT749358)
- hsa-miR-501-3p (MIRT749526)
- hsa-miR-502-3p (MIRT749532)
- hsa-miR-5196-5p (MIRT750024)
- hsa-miR-520a-5p (MIRT750191)
- hsa-miR-525-5p (MIRT750298)
- hsa-miR-539-5p (MIRT750346)
- hsa-miR-5787 (MIRT751473)
- hsa-miR-6088 (MIRT751936)
- hsa-miR-6746-3p (MIRT754485)
- hsa-miR-6805-5p (MIRT756476)
- hsa-miR-6846-5p (MIRT757435)
- hsa-miR-6848-5p (MIRT757509)
- hsa-miR-7150 (MIRT759161)
- hsa-miR-762 (MIRT759500)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSCN1
- Browse OriGene Inhibitory RNA Products For FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
Clone Products
- Applied Biological Materials (abm): Clones for FSCN1 - Select products 50% OFF >
- * FSCN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FSCN1
- Addgene plasmids for FSCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSCN1
Cell Line Products
-
Horizon Cell Lines for FSCN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSCN1 Gene
Localization for FSCN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FSCN1 Gene
- Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, filopodium. Cell projection, invadopodium. Cell projection, microvillus. Cell junction. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250 UniProtKB:Q61553, ECO:0000269 PubMed:21706053}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IDA | 3525578 |
| GO:0001726 | ruffle | IBA,IDA | 3525578 |
| GO:0002102 | podosome | IDA | 20137952 |
| GO:0005737 | cytoplasm | IBA,IDA | 9571235 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FSCN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | Cytoskeletal Signaling | ||
| 3 | Wnt / Hedgehog / Notch | ||
| 4 | MicroRNAs in cancer | ||
| 5 | MAPK Erk Pathway | ||
Pathways by source for FSCN1 Gene
1 Sino Biological pathway for FSCN1 Gene
4 Reactome pathways for FSCN1 Gene
1 KEGG pathway for FSCN1 Gene
1 GeneGo (Thomson Reuters) pathway for FSCN1 Gene
- Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
2 Cell Signaling Technology pathways for FSCN1 Gene
Interacting Proteins for FSCN1 Gene
Selected Interacting proteins:
Q16658-FSCN1_HUMAN
ENSP00000371798
for FSCN1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FSCN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0007043 | cell-cell junction assembly | IDA | 9571235 |
| GO:0007163 | establishment or maintenance of cell polarity | IBA | 21873635 |
| GO:0010592 | positive regulation of lamellipodium assembly | IDA | 9571235 |
| GO:0016477 | cell migration | IEA,IMP | 20393565 |
Transcripts for FSCN1 Gene
mRNA/cDNA for FSCN1 Gene
- 1 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000382361 2784 nts (view in UCSC)
- ENST00000405801 550 nts (view in UCSC)
- ENST00000444748 580 nts (view in UCSC)
- ENST00000447103 713 nts (view in UCSC)
- ENST00000473330 2215 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FSCN1 - Select products 50% OFF >
- * FSCN1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FSCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSCN1
- Browse OriGene Inhibitory RNA Products For FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
Clone Products
- Applied Biological Materials (abm): Clones for FSCN1 - Select products 50% OFF >
- * FSCN1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FSCN1
- Addgene plasmids for FSCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSCN1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for FSCN1 Gene
- GeneLoc Exon Structure for
- FSCN1
Expression for FSCN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Lung (Respiratory System)
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Limb (Muscoskeletal System)
- Progress Zone Cells Limb Bud
- Limb Bud
- Neural Tube (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Bone (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Cartilage (Muscoskeletal System)
- Progress Zone Cells Limb Bud
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Eye (Sensory Organs)
- Endoderm (Gastrulation Derivatives)
This gene is overexpressed in Testis (10.8), Fetal Brain (7.6), and Lymph node (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FSCN1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FSCN1
SOURCE GeneReport for Unigene cluster for FSCN1 Gene:
Hs.118400mRNA Expression by UniProt/SwissProt for FSCN1 Gene:
Q16658-FSCN1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for FSCN1 Gene
- Nervous system(5)
- Eye(4.8)
- Lung(4.8)
- Muscle(4.7)
- Liver(4.6)
- Skin(4)
- Kidney(4)
- Pancreas(3.3)
- Heart(3.1)
- Intestine(2.8)
- Lymph node(2.7)
- Spleen(2.7)
- Blood(2.6)
- Bone(2.3)
- Adrenal gland(2.2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for FSCN1
-
OriGene qPCR primer pairs and template standards for FSCN1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSCN1 Gene
Orthologs for FSCN1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fscn1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fscn1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FSCN1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FSCN1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FSCN1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FSCN1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fscn1 30 |
|
||
| MGC75811 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397934 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fscn1a 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | sn 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for FSCN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FSCN1 Gene
- ENSEMBL:
- Gene Tree for FSCN1 (if available)
- TreeFam:
- Gene Tree for FSCN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FSCN1: view image
Paralogs for FSCN1 Gene
Variants for FSCN1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3482n106 | OTHER | inversion | 24896259 |
| esv2665366 | CNV | deletion | 23128226 |
| nsv1153033 | CNV | deletion | 26484159 |
| nsv436904 | CNV | insertion | 17901297 |
| nsv819922 | CNV | gain | 19587683 |
| nsv830890 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSCN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FSCN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FSCN1 Gene
Disorders for FSCN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| juvenile xanthogranuloma |
|
|
| inverted papilloma |
|
|
| rosai-dorfman disease |
|
|
| langerhans cell histiocytosis |
|
|
| bile duct cancer |
|
|
Search FSCN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FSCN1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FSCN1 Gene
Publications for FSCN1 Gene
- cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PMID: 8068206) Duh FM … Lerman MI (DNA and cell biology 1994) 2 3 4 23
- The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. (PMID: 20137952) Li A … Machesky LM (Current biology : CB 2010) 3 4 23
- Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PMID: 10783262) Tubb BE … Bryan J (Genomics 2000) 2 3 23
- Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. (PMID: 9571235) Yamashiro S … Matsumura F (Molecular biology of the cell 1998) 3 4 23
- Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. (PMID: 8999969) Ono S … Matsumura F (The Journal of biological chemistry 1997) 3 4 23
ExternalLinks
Products for FSCN1 Gene
- Custom Antibody ServicesOriGene Antibodies for FSCN1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FSCN1
- Origene Custom Protein Services for FSCN1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FSCN1
- Browse OriGene Inhibitory RNA Products For FSCN1
- OriGene qPCR primer pairs for FSCN1
- OriGene qPCR primer pairs and template standards for FSCN1
- OriGene CRISPR knockouts for FSCN1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FSCN1
- Sino Biological Human cDNA Clone for FSCN1
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for FSCN1
- Novus Biologicals proteins and lysates for FSCN1
- Novus Biologicals ELISA Kits for FSCN1
- Browse Antibodies
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- ProSpec Recombinant Proteins for FSCN1
- Taconic Biosciences Mouse Models for FSCN1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FSCN1 (AFLGC-FSCN1)
- VectorBuilder Custom and pre-made DNA vectors for FSCN1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FSCN1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FSCN1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FSCN1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FSCN1
- Addgene plasmids for FSCN1
- antibodies-online: Show 55 available FSCN1 Antibodies ranked by validation data
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- antibodies-online: Show 37 available FSCN1 Elisa Kits ranked by validation data
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- antibodies-online: Show 16 available FSCN1 Proteins ranked by validation data
- Compare Top FSCN1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FSCN1
- Search Santa Cruz Biotechnology (SCBT) for FSCN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
- Horizon Cell Lines for FSCN1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSCN1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
Sources for FSCN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
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- (118) HPO
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB