Aliases for FSCN1 Gene
External Ids for FSCN1 Gene
Previous HGNC Symbols for FSCN1 Gene
Previous GeneCards Identifiers for FSCN1 Gene
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
GeneCards Summary for FSCN1 Gene
FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Juvenile Xanthogranuloma and Inverted Papilloma. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is FSCN2.
UniProtKB/Swiss-Prot Summary for FSCN1 Gene
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).