Aliases for FSCN1 Gene
Aliases for FSCN1 Gene
External Ids for FSCN1 Gene
- HGNC: 11148
- Entrez Gene: 6624
- Ensembl: ENSG00000075618
- OMIM: 602689
- UniProtKB: Q16658
Previous HGNC Symbols for FSCN1 Gene
- SNL
Previous GeneCards Identifiers for FSCN1 Gene
- GC07P005276
- GC07P005376
- GC07P005405
- GC07P005598
- GC07P005544
Summaries for FSCN1 Gene
-
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
GeneCards Summary for FSCN1 Gene
FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Juvenile Xanthogranuloma and Hodgkin's Lymphoma, Lymphocytic-Histiocytic Predominance. Among its related pathways are Cytoskeletal Signaling and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is FSCN2.
UniProtKB/Swiss-Prot for FSCN1 Gene
-
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSCN1 Gene
Genomics for FSCN1 Gene
GeneHancer (GH) Regulatory Elements for FSCN1 Gene
Promoters and enhancers for FSCN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FSCN1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FSCN1 gene promoter:
-
- deltaCREB
- CREB
- p53
Regulatory Element Products
Genomic Locations for FSCN1 Gene
Genomic Locations for FSCN1 Gene
- chr7:5,592,805-5,606,656
- (GRCh38/hg38)
- Size:
- 13,852 bases
- Orientation:
- Plus strand
- chr7:5,632,439-5,646,286
- (GRCh37/hg19)
- Size:
- 13,848 bases
- Orientation:
- Plus strand
Genomic View for FSCN1 Gene
Genes around FSCN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.1 by Entrez Gene
- 7p22.1 by HGNC
- 7p22.1 by Ensembl
FSCN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSCN1 Gene
Proteins for FSCN1 Gene
-
Protein details for FSCN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16658-FSCN1_HUMAN
- Recommended name:
- Fascin
- Protein Accession:
- Q16658
- A6NI89
- B2RE97
- Q96IC5
- Q96IH1
- Q9BRF1
Protein attributes for FSCN1 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 54530 Da
- Quaternary structure:
-
- Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development. Associates with beta-catenin (By similarity). Interacts with PLXNB3 (PubMed:21706053).
- SequenceCaution:
-
- Sequence=AAH07539.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FSCN1 Gene
Post-translational modifications for FSCN1 Gene
- Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FSCN1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FSCN1 (Fascin)
-
Custom Antibody ServicesOriGene Antibodies for FSCN1
- Novus Biologicals Antibodies for FSCN1
-
Abcam antibodies for FSCN1
- Invitrogen Antibodies for FSCN1
- GeneTex FSCN1 Antibody for FSCN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FSCN1
Protein Products
-
OriGene Purified Proteins for FSCN1
- Search Origene for MassSpec and Protein Over-expression Lysates for FSCN1
- Origene Custom Protein Services for FSCN1
- ProSpec Recombinant Proteins for FSCN1
- Search GeneTex for Proteins for FSCN1
-
Abcam proteins for FSCN1
No data available for DME Specific Peptides for FSCN1 Gene
Domains & Families for FSCN1 Gene
Gene Families for FSCN1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FSCN1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FSCN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16658UniProtKB/Swiss-Prot:
FSCN1_HUMAN :- Composed of four beta-trefoil domains.
- Belongs to the fascin family.
- Domain:
-
- Composed of four beta-trefoil domains.
- Family:
-
- Belongs to the fascin family.
Function for FSCN1 Gene
Molecular function for FSCN1 Gene
- UniProtKB/Swiss-Prot Function:
- Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Phenotypes From GWAS Catalog for FSCN1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0003779 | actin binding | IDA,IEA | 8999969 |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0008144 | drug binding | IDA,IEA | 20393565 |
| GO:0030674 | protein binding, bridging | IEA | -- |
Phenotypes for FSCN1 Gene
- MGI mutant phenotypes for FSCN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FSCN1:
Animal Models for FSCN1 Gene
- MGI Knock Outs for FSCN1:
-
- Fscn1 Fscn1<tm1.1(KOMP)Vlcg>
Animal Model Products
-
Taconic Biosciences Mouse Models for FSCN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSCN1
-
CRISPR Products
-
OriGene CRISPR knockouts for FSCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
- genomics-online: gRNA clones - Search results for available FSCN1 gene related products
- Applied Biological Materials CRISPR for FSCN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
- GenScript: Design CRISPR guide RNA sequences for FSCN1
miRNA for FSCN1 Gene
- miRTarBase miRNAs that target FSCN1
-
- hsa-mir-133a-3p (MIRT003542)
- hsa-mir-145-5p (MIRT003543)
- hsa-mir-143-3p (MIRT005771)
- hsa-mir-133b (MIRT006554)
- hsa-mir-30a-5p (MIRT028511)
- hsa-mir-221-3p (MIRT046860)
- hsa-mir-17-3p (MIRT050745)
- bta-mir-145 (MIRT053913)
- hsa-mir-6801-5p (MIRT476701)
- hsa-mir-7162-3p (MIRT476702)
- hsa-mir-4649-3p (MIRT476703)
- hsa-mir-6501-3p (MIRT476704)
- hsa-mir-583 (MIRT476705)
- hsa-mir-24-3p (MIRT476706)
- hsa-mir-6792-5p (MIRT493811)
- hsa-mir-4283 (MIRT493812)
- hsa-mir-760 (MIRT493813)
- hsa-mir-5008-5p (MIRT493814)
- hsa-mir-3663-3p (MIRT493815)
- hsa-mir-1247-3p (MIRT493816)
- hsa-mir-7113-5p (MIRT493817)
- hsa-mir-761 (MIRT493818)
- hsa-mir-3619-5p (MIRT493819)
- hsa-mir-214-3p (MIRT493820)
- hsa-mir-4705 (MIRT493821)
- hsa-mir-6813-5p (MIRT493822)
- hsa-mir-6085 (MIRT493823)
- hsa-mir-29c-3p (MIRT493824)
- hsa-mir-29b-3p (MIRT493825)
- hsa-mir-29a-3p (MIRT493826)
- hsa-mir-6816-5p (MIRT569091)
- hsa-mir-3196 (MIRT569092)
- hsa-mir-3180-3p (MIRT569093)
- hsa-mir-3180 (MIRT569094)
- hsa-mir-6787-5p (MIRT569095)
- hsa-mir-6721-5p (MIRT569096)
- hsa-mir-663a (MIRT569097)
- hsa-mir-1908-5p (MIRT569098)
- hsa-mir-4763-3p (MIRT569099)
- hsa-mir-1207-5p (MIRT569100)
- hsa-mir-4749-5p (MIRT569101)
- hsa-mir-4706 (MIRT569102)
- hsa-mir-6722-3p (MIRT569103)
- hsa-mir-1909-3p (MIRT569104)
- hsa-mir-6802-3p (MIRT721836)
- hsa-mir-4284 (MIRT721837)
- hsa-mir-6862-3p (MIRT721838)
- hsa-mir-6784-3p (MIRT721839)
- hsa-mir-4707-5p (MIRT721840)
- hsa-mir-6764-5p (MIRT721841)
- hsa-mir-1915-3p (MIRT721842)
- hsa-mir-6837-5p (MIRT721843)
- hsa-mir-4685-5p (MIRT721844)
- hsa-mir-5088-5p (MIRT721845)
- hsa-mir-133a-5p (MIRT731721)
- hsa-mir-326 (MIRT733126)
- hsa-mir-429 (MIRT733149)
- hsa-mir-200b-3p (MIRT735429)
- hsa-mir-184 (MIRT738190)
- hsa-mir-185-3p (MIRT738206)
- hsa-mir-2115-5p (MIRT738965)
- hsa-mir-299-3p (MIRT739546)
- hsa-mir-3180-5p (MIRT740798)
- hsa-mir-3652 (MIRT741889)
- hsa-mir-3919 (MIRT742948)
- hsa-mir-4265 (MIRT743501)
- hsa-mir-4296 (MIRT743796)
- hsa-mir-4322 (MIRT744034)
- hsa-mir-4417 (MIRT744142)
- hsa-mir-4430 (MIRT744327)
- hsa-mir-4446-3p (MIRT744613)
- hsa-mir-4489 (MIRT745255)
- hsa-mir-4492 (MIRT745284)
- hsa-mir-4498 (MIRT745365)
- hsa-mir-4505 (MIRT745524)
- hsa-mir-4533 (MIRT746010)
- hsa-mir-4656 (MIRT746653)
- hsa-mir-4673 (MIRT746856)
- hsa-mir-4681 (MIRT746925)
- hsa-mir-4722-5p (MIRT747593)
- hsa-mir-4731-5p (MIRT747933)
- hsa-mir-4736 (MIRT747996)
- hsa-mir-4747-5p (MIRT748240)
- hsa-mir-4770 (MIRT748670)
- hsa-mir-4804-5p (MIRT749025)
- hsa-mir-5001-5p (MIRT749358)
- hsa-mir-501-3p (MIRT749526)
- hsa-mir-502-3p (MIRT749532)
- hsa-mir-5196-5p (MIRT750024)
- hsa-mir-520a-5p (MIRT750191)
- hsa-mir-525-5p (MIRT750298)
- hsa-mir-539-5p (MIRT750346)
- hsa-mir-5787 (MIRT751473)
- hsa-mir-6088 (MIRT751936)
- hsa-mir-6746-3p (MIRT754485)
- hsa-mir-6805-5p (MIRT756476)
- hsa-mir-6846-5p (MIRT757435)
- hsa-mir-6848-5p (MIRT757509)
- hsa-mir-7150 (MIRT759161)
- hsa-mir-762 (MIRT759500)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FSCN1
- Browse OriGene Inhibitory RNA Products For FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
- genomics-online: shRNA clones - Search results for available FSCN1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FSCN1
- VectorBuilder custom plasmid, inducible vectors for FSCN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSCN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FSCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSCN1
- genomics-online: cdna clones - Search results for available FSCN1 gene related products
- orf clones - Search results for available FSCN1 gene related products
- Applied Biological Materials Clones for FSCN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FSCN1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FSCN1 Gene
Localization for FSCN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FSCN1 Gene
- Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cell projection, microvillus. Cell junction. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol (PubMed:21706053). Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250 UniProtKB:Q61553, ECO:0000269 PubMed:21706053}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 2 |
| mitochondrion | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001725 | stress fiber | IDA | 3525578 |
| GO:0001726 | ruffle | IDA | 3525578 |
| GO:0002102 | podosome | IDA | 20137952 |
| GO:0005737 | cytoplasm | IEA,IDA | 9571235 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FSCN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytokine Signaling in Immune system | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Cytoskeletal Signaling | ||
| 4 | Wnt / Hedgehog / Notch | ||
| 5 | MAPK-Erk Pathway | ||
Pathways by source for FSCN1 Gene
1 Sino Biological pathway for FSCN1 Gene
4 Reactome pathways for FSCN1 Gene
1 KEGG pathway for FSCN1 Gene
1 GeneGo (Thomson Reuters) pathway for FSCN1 Gene
2 Cell Signaling Technology pathways for FSCN1 Gene
Interacting Proteins for FSCN1 Gene
Selected Interacting proteins:
Q16658-FSCN1_HUMAN
ENSP00000371798
for FSCN1 Gene via
UniProtKB
STRING
IID
MINT
GPS-Prot Interaction Network for FSCN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0007043 | cell-cell junction assembly | IDA | 9571235 |
| GO:0007163 | establishment or maintenance of cell polarity | IBA | -- |
| GO:0008283 | cell proliferation | TAS | 8068206 |
| GO:0009653 | anatomical structure morphogenesis | IBA | -- |
No data available for SIGNOR curated interactions for FSCN1 Gene
Transcripts for FSCN1 Gene
mRNA/cDNA for FSCN1 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (825) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000382361 2777 bps (uc003sou.4)
- ENST00000444748 580 bps (uc064beu.1)
- ENST00000447103 713 bps (uc064bev.1)
- ENST00000405801 550 bps (uc064bew.1)
- ENST00000473330 2215 bps (uc064bex.1)
Unigene Clusters for FSCN1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FSCN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
- genomics-online: gRNA clones - Search results for available FSCN1 gene related products
- Applied Biological Materials CRISPR for FSCN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
- GenScript: Design CRISPR guide RNA sequences for FSCN1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FSCN1
- Browse OriGene Inhibitory RNA Products For FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
- genomics-online: shRNA clones - Search results for available FSCN1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FSCN1
- VectorBuilder custom plasmid, inducible vectors for FSCN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSCN1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FSCN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FSCN1
- genomics-online: cdna clones - Search results for available FSCN1 gene related products
- orf clones - Search results for available FSCN1 gene related products
- Applied Biological Materials Clones for FSCN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||
| SP7: |
Expression for FSCN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Lung (Respiratory System)
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Trachea
- Basal Cells Respiratory Bronchioles
-
Limb (Muscoskeletal System)
- Progress Zone Cells Limb Bud
- Limb Bud
- Neural Tube (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Bone (Muscoskeletal System)
- Progress Zone Cells Limb Bud
-
Cartilage (Muscoskeletal System)
- Progress Zone Cells Limb Bud
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Eye (Sensory Organs)
- Endoderm (Gastrulation Derivatives)
This gene is overexpressed in Testis (10.8), Fetal Brain (7.6), and Lymph node (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FSCN1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FSCN1 Gene:
FSCN1SOURCE GeneReport for Unigene cluster for FSCN1 Gene:
Hs.118400mRNA Expression by UniProt/SwissProt for FSCN1 Gene:
Q16658-FSCN1_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for FSCN1 Gene
- Nervous system(5)
- Lung(4.8)
- Eye(4.7)
- Muscle(4.6)
- Liver(4.5)
- Skin(3.8)
- Kidney(3.7)
- Pancreas(3.1)
- Lymph node(2.9)
- Spleen(2.9)
- Heart(2.5)
- Intestine(2.3)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FSCN1
-
OriGene qPCR primer pairs for FSCN1
- genomics-online: primer clones - Search results for available FSCN1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSCN1 Gene
Orthologs for FSCN1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FSCN1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FSCN1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FSCN1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fscn1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fscn1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FSCN1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FSCN1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FSCN1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FSCN1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fscn1 33 |
|
||
| MGC75811 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397934 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fscn1a 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | sn 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for FSCN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FSCN1 Gene
- ENSEMBL:
- Gene Tree for FSCN1 (if available)
- TreeFam:
- Gene Tree for FSCN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FSCN1: view image
Paralogs for FSCN1 Gene
Variants for FSCN1 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030171 | -- | 5,591,485(+) | G/T | upstream_transcript_variant | |
| rs1000420210 | -- | 5,596,098(+) | G/A | intron_variant | |
| rs1000716134 | -- | 5,604,394(+) | C/T | intron_variant | |
| rs1001404577 | -- | 5,606,568(+) | G/C | 3_prime_UTR_variant | |
| rs1001440092 | -- | 5,592,706(+) | G/C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3482n106 | OTHER | inversion | 24896259 |
| esv2665366 | CNV | deletion | 23128226 |
| nsv1153033 | CNV | deletion | 26484159 |
| nsv436904 | CNV | insertion | 17901297 |
| nsv819922 | CNV | gain | 19587683 |
| nsv830890 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSCN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FSCN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSCN1 Gene
Disorders for FSCN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| juvenile xanthogranuloma |
|
|
| hodgkin's lymphoma, lymphocytic-histiocytic predominance |
|
|
| rosai-dorfman disease |
|
|
| papilloma |
|
|
| alk+ histiocytosis |
|
|
Search FSCN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FSCN1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FSCN1 Gene
Publications for FSCN1 Gene
- cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. (PMID: 8068206) Duh FM … Lerman MI (DNA and cell biology 1994) 2 3 4 22 58
- The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. (PMID: 20137952) Li A … Machesky LM (Current biology : CB 2010) 3 4 22 58
- Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. (PMID: 10783262) Tubb BE … Bryan J (Genomics 2000) 2 3 22 58
- Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. (PMID: 9571235) Yamashiro S … Matsumura F (Molecular biology of the cell 1998) 3 4 22 58
- Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. (PMID: 8999969) Ono S … Matsumura F (The Journal of biological chemistry 1997) 3 4 22 58
Products for FSCN1 Gene
- R&D Systems Antibodies for FSCN1 (Fascin)
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- Custom Antibody ServicesOriGene Antibodies for FSCN1
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals
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- ProSpec Recombinant Proteins for FSCN1
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- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FSCN1
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSCN1
- VectorBuilder custom plasmid, inducible vectors for FSCN1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSCN1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FSCN1
- antibodies-online: Search results for 215 available FSCN1 Antibodies ranked by validation data
- Compare Top FSCN1 Antibodies
- antibodies-online: Search results for 28 available FSCN1 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 18 available FSCN1 Proteins ranked by validation data
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- GeneTex FSCN1 Antibody for FSCN1
- Search GeneTex for Proteins for FSCN1
- Santa Cruz Biotechnology (SCBT) Antibodies for FSCN1
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- Santa Cruz Biotechnology (SCBT) CRISPR for FSCN1
- Horizon Cell Lines for FSCN1
- genomics-online: cdna clones - Search results for available FSCN1 gene related products
- orf clones - Search results for available FSCN1 gene related products
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- genomics-online: primer clones - Search results for available FSCN1 gene related products
- genomics-online: shRNA clones - Search results for available FSCN1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FSCN1
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- GeneCopoeia miRNA 3'UTR Target clone products for FSCN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSCN1
Sources for FSCN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
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- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
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- (169) Biorbyt