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This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Juvenile Xanthogranuloma and Inverted Papilloma. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is FSCN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003779 | actin binding | IEA,IDA | 8999969 |
GO:0005515 | protein binding | IPI | 15161933 |
GO:0008144 | drug binding | IDA | 20393565 |
GO:0030674 | protein binding, bridging | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | 3525578 |
GO:0001726 | ruffle | IBA,IDA | 3525578 |
GO:0002102 | podosome | IDA | 20137952 |
GO:0005737 | cytoplasm | IBA,IDA | 9571235 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytokine Signaling in Immune system | ||
2 | Cytoskeletal Signaling | ||
3 | Wnt / Hedgehog / Notch | ||
4 | MicroRNAs in cancer | ||
5 | MAPK Erk Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007015 | actin filament organization | IEA | -- |
GO:0007043 | cell-cell junction assembly | IDA | 9571235 |
GO:0007163 | establishment or maintenance of cell polarity | IBA | 21873635 |
GO:0010592 | positive regulation of lamellipodium assembly | IDA | 9571235 |
GO:0016477 | cell migration | IEA,IMP | 20393565 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FSCN1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fscn1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fscn1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FSCN1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FSCN1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FSCN1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FSCN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fscn1 30 |
|
||
MGC75811 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397934 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fscn1a 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | sn 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3482n106 | OTHER | inversion | 24896259 |
esv2665366 | CNV | deletion | 23128226 |
nsv1153033 | CNV | deletion | 26484159 |
nsv436904 | CNV | insertion | 17901297 |
nsv819922 | CNV | gain | 19587683 |
nsv830890 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
juvenile xanthogranuloma |
|
|
inverted papilloma |
|
|
rosai-dorfman disease |
|
|
langerhans cell histiocytosis |
|
|
bile duct cancer |
|
|