Aliases for FSCN1 Gene
External Ids for FSCN1 Gene
Previous HGNC Symbols for FSCN1 Gene
Previous GeneCards Identifiers for FSCN1 Gene
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
GeneCards Summary for FSCN1 Gene
FSCN1 (Fascin Actin-Bundling Protein 1) is a Protein Coding gene. Diseases associated with FSCN1 include Juvenile Xanthogranuloma and Hodgkin's Lymphoma, Lymphocytic-Histiocytic Predominance. Among its related pathways are Cytoskeletal Signaling and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is FSCN2.
UniProtKB/Swiss-Prot for FSCN1 Gene
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.