FSBP Gene (Protein Coding)

Fibrinogen Silencer Binding Protein

GC08M094378
GIFtS:
29
See more...

Aliases for FSBP Gene

Aliases for FSBP Gene

  • Fibrinogen Silencer Binding Protein 2 3 5
  • Fibrinogen Silencer-Binding Protein 3 4
  • FSBP 5

External Ids for FSBP Gene

Previous GeneCards Identifiers for FSBP Gene

  • GC08U990078
  • GC08M095231
  • GC08M095112
  • GC08M095341
  • GC08M095400
  • GC08M095513

Summaries for FSBP Gene

GeneCards Summary for FSBP Gene

FSBP (Fibrinogen Silencer Binding Protein) is a Protein Coding gene. Diseases associated with FSBP include 3-Methylglutaconic Aciduria, Type Vii. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot Summary for FSBP Gene

  • Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Additional gene information for FSBP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FSBP Gene

Genomics for FSBP Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FSBP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J094434 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.4 422 6.7 REST IKZF1 MTA2 PKNOX1 MTA1 IKZF2 CTCF POLR2A SP1 DPF2 RAD54B FSBP VIRMA ENSG00000253704 lnc-VIRMA-4 GEM
GH08J094467 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 606 -31.6 -31649 2.4 ZNF592 MAFK JUND ZBTB33 FSBP piR-57461-260 VIRMA RAD54B RF00017-7180
GH08J094432 Promoter 0.4 EPDnew 600.7 +4.5 4546 0.1 ATF2 FSBP RAD54B lnc-VIRMA-4 GEM
GH08J095167 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -731.3 -731348 6.2 GATAD2A ATF7 ZNF629 REST TFE3 IKZF1 RXRB IRF2 SP1 HDAC1 C8orf37 VIRMA FSBP ENSG00000253878 TP53INP1 INTS8 ENSG00000272509 PLEKHF2 HSALNG0067077 HSALNG0067082
GH08J094446 Enhancer 0.9 Ensembl ENCODE 6.6 -10.7 -10749 2.2 ZNF512 IKZF1 JUND FOXA1 ZSCAN4 REST DPF2 HDAC1 SP1 RUNX3 FSBP ENSG00000253704 piR-57461-260 RAD54B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FSBP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FSBP

Genomic Locations for FSBP Gene

Genomic Locations for FSBP Gene
chr8:94,378,377-94,436,952
(GRCh38/hg38)
Size:
58,576 bases
Orientation:
Minus strand
chr8:95,390,605-95,449,180
(GRCh37/hg19)
Size:
58,576 bases
Orientation:
Minus strand

Genomic View for FSBP Gene

Genes around FSBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FSBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FSBP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FSBP Gene

Proteins for FSBP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FSBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95073-FSBP_HUMAN
    Recommended name:
    Fibrinogen silencer-binding protein
    Protein Accession:
    O95073
    Secondary Accessions:
    • Q8N4S5

    Protein attributes for FSBP Gene

    Size:
    299 amino acids
    Molecular mass:
    34768 Da
    Quaternary structure:
    • Interacts with APBA1 (via PDZ 1 and 2 domains).
    Miscellaneous:
    • Intragenic, in the second intron of RAB54B gene.

    Alternative splice isoforms for FSBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FSBP Gene

Protein Expression for FSBP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FSBP Gene

  • Ubiquitination at Lys15
  • Modification sites at PhosphoSitePlus

Other Protein References for FSBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FSBP Gene

Domains & Families for FSBP Gene

Gene Families for FSBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FSBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FSBP Gene

GenScript: Design optimal peptide antigens:
  • Fibrinogen silencer-binding protein (FSBP_HUMAN)
genes like me logo Genes that share domains with FSBP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FSBP Gene

Function for FSBP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FSBP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.

Phenotypes From GWAS Catalog for FSBP Gene

Gene Ontology (GO) - Molecular Function for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20531236
GO:0042802 identical protein binding IPI 19060904
genes like me logo Genes that share ontologies with FSBP: view

Animal Model Products

CRISPR Products

miRNA for FSBP Gene

miRTarBase miRNAs that target FSBP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSBP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSBP Gene

Localization for FSBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FSBP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FSBP gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FSBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20531236
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FSBP: view

Pathways & Interactions for FSBP Gene

PathCards logo

SuperPathways for FSBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FSBP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FSBP Gene

Drugs & Compounds for FSBP Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FSBP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FSBP Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FSBP

Alternative Splicing Database (ASD) splice patterns (SP) for FSBP Gene

No ASD Table

Relevant External Links for FSBP Gene

GeneLoc Exon Structure for
FSBP

Expression for FSBP Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FSBP Gene

mRNA expression in normal human tissues for FSBP Gene
mRNA expression by GTEx for FSBP GenemRNA expression by BioGPS for FSBP Gene

Protein differential expression in normal tissues from HIPED for FSBP Gene

This gene is overexpressed in CD8 Tcells (41.9) and Retina (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSBP Gene



Protein tissue co-expression partners for FSBP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FSBP

SOURCE GeneReport for Unigene cluster for FSBP Gene:

Hs.30561

mRNA Expression by UniProt/SwissProt for FSBP Gene:

O95073-FSBP_HUMAN
Tissue specificity: Expressed in multiple tissues including brain.
genes like me logo Genes that share expression patterns with FSBP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSBP Gene

Orthologs for FSBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for FSBP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FSBP 30
  • 99.67 (n)
Dog
(Canis familiaris)
 Mammalia FSBP 30
  • 96.32 (n)
Cow
(Bos Taurus)
 Mammalia FSBP 30 31
  • 94.98 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fsbp 30 17 31
  • 89.07 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC102550523 30
  • 88.26 (n)
Oppossum
(Monodelphis domestica)
 Mammalia FSBP 31
  • 84 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FSBP 30 31
  • 77.14 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FSBP 31
  • 77 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fsbp 30
  • 63.97 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC101884826 30
  • 59.67 (n)
Species where no ortholog for FSBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FSBP Gene

ENSEMBL:
Gene Tree for FSBP (if available)
TreeFam:
Gene Tree for FSBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FSBP: view image

Paralogs for FSBP Gene

No data available for Paralogs for FSBP Gene

Variants for FSBP Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FSBP Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs3136422 - p.Arg226Lys

Additional dbSNP identifiers (rs#s) for FSBP Gene

Structural Variations from Database of Genomic Variants (DGV) for FSBP Gene

Variant ID Type Subtype PubMed ID
nsv1031480 CNV gain 25217958
nsv611749 CNV loss 21841781
nsv6313 CNV insertion 18451855

Variation tolerance for FSBP Gene

Gene Damage Index Score: 1.06; 21.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FSBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FSBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSBP Gene

Disorders for FSBP Gene

MalaCards: The human disease database

(1) MalaCards diseases for FSBP Gene - From: DISEASES

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type vii
  • mgca7
- elite association - COSMIC cancer census association via MalaCards
Search FSBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FSBP

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FSBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FSBP Gene

Publications for FSBP Gene

  1. An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PMID: 20531236) Lau KF … Miller CC (Neuroreport 2010) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. (PMID: 30631154) Hu Q … Yang L (Cell research 2019) 3
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3

ExternalLinks

View latest publications for FSBP gene in Mastermind

Products for FSBP Gene

Sources for FSBP Gene