Aliases for FSBP Gene
External Ids for FSBP Gene
- HGNC: 43653
- Entrez Gene: 100861412
- Ensembl: ENSG00000265817
- OMIM: 616306
- UniProtKB: O95073
Previous GeneCards Identifiers for FSBP Gene
- GC08U990078
- GC08M095231
- GC08M095112
- GC08M095341
- GC08M095400
- GC08M095513
Summaries for FSBP Gene
GeneCards Summary for FSBP Gene
FSBP (Fibrinogen Silencer Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is RAD54B.
UniProtKB/Swiss-Prot for FSBP Gene
-
Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FSBP Gene
Genomics for FSBP Gene
GeneHancer (GH) Regulatory Elements for FSBP Gene
Promoters and enhancers for FSBP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08I094434 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | 0.0 | -17 | 5.8 | PKNOX1 SIN3A YY1 TCF12 POLR2B REST ATF4 GMEB1 SMARCA4 PBX2 | RAD54B FSBP GC08P094436 VIRMA ENSG00000253704 GC08M094432 | |
| GH08I094439 | Enhancer | 1.1 | Ensembl ENCODE | 6.5 | -4.0 | -3997 | 2.1 | PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 TCF12 ZNF207 ZNF143 ATF7 | GC08M094432 RAD54B FSBP GC08P094456 | |
| GH08I094467 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 6 | -31.2 | -31234 | 1.5 | JUND ZBTB33 ZNF592 | RAD54B VIRMA FSBP GC08P094456 | |
| GH08I093900 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 5.9 | +533.1 | 533084 | 6.7 | PKNOX1 JUN EP300 MAFF JUND FOXK2 POLR2A TARDBP IKZF1 NBN | LOC105375646 PDP1 LINC00535 FAM92A FSBP GC08M093861 | |
| GH08I094058 | Enhancer | 1 | Ensembl ENCODE | 5 | +377.3 | 377333 | 1.7 | ATF1 PKNOX1 NEUROD1 SIN3A ZBTB7B RFX5 FOS ATF7 RCOR1 CEBPB | ENSG00000253585 FSBP GC08M094039 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FSBP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FSBP Gene
Genomic Locations for FSBP Gene
- chr8:94,372,170-94,436,952
- (GRCh38/hg38)
- Size:
- 64,783 bases
- Orientation:
- Minus strand
- chr8:95,390,605-95,449,180
- (GRCh37/hg19)
Genomic View for FSBP Gene
Genes around FSBP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q22.1 by Ensembl
- 8q22.1 by Entrez Gene
- 8q22.1 by HGNC
FSBP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FSBP Gene
Proteins for FSBP Gene
-
Protein details for FSBP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95073-FSBP_HUMAN
- Recommended name:
- Fibrinogen silencer-binding protein
- Protein Accession:
- O95073
- Q8N4S5
Protein attributes for FSBP Gene
- Size:
- 299 amino acids
- Molecular mass:
- 34768 Da
- Quaternary structure:
-
- Interacts with APBA1 (via PDZ 1 and 2 domains).
- Miscellaneous:
-
- Intragenic, in the second intron of RAB54B gene.
Protein Expression for FSBP Gene
Post-translational modifications for FSBP Gene
Other Protein References for FSBP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FSBP
- Invitrogen Antibodies for FSBP
- antibodies-online: Search results for available FSBP related products ranked by validation data
- Search GeneTex for Antibodies for FSBP
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FSBP
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- Novus Biologicals proteins for FSBP
- ProSpec Recombinant Proteins for FSBP
- antibodies-online: Search results for 3 available FSBP Proteins ranked by validation data
- Compare Top FSBP Proteins
-
Quality Products:
- Search GeneTex for Proteins for FSBP
Assay Products
- antibodies-online: Search results for available FSBP related products ranked by validation data
No data available for DME Specific Peptides for FSBP Gene
Domains & Families for FSBP Gene
Gene Families for FSBP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FSBP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FSBP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FSBP Gene
Function for FSBP Gene
Molecular function for FSBP Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.
Phenotypes From GWAS Catalog for FSBP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20531236 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 19060904 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSBP
-
- Search ViGene Biosciences for FSBP
CRISPR Products
-
OriGene CRISPR knockouts for FSBP
- genomics-online: gRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- Applied Biological Materials CRISPR for FSBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSBP
- GenScript: Design CRISPR guide RNA sequences for FSBP
miRNA for FSBP Gene
- miRTarBase miRNAs that target FSBP
miRNA Products
- Search ViGene Biosciences for FSBP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for FSBP
- Browse OriGene Inhibitory RNA Products For FSBP
- genomics-online: shRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- Search ViGene Biosciences for FSBP
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FSBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FSBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FSBP Gene
Localization for FSBP Gene
Subcellular locations from UniProtKB/Swiss-Prot for FSBP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 20531236 |
Pathways & Interactions for FSBP Gene
No Data Available
Interacting Proteins for FSBP Gene
Selected Interacting proteins:
ENSP00000420405
O95073-FSBP_HUMAN
for FSBP Gene via
STRING
UniProtKB
IID
| Symbol | External ID(s) | Details |
|---|---|---|
| PLCG2 | ||
| SH2D2A | ||
| ANKRD36BP1 | ||
| ATPAF2 | ||
| CDC23 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FSBP Gene
Transcripts for FSBP Gene
mRNA/cDNA for FSBP Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FSBP Gene
- Fibrinogen silencer binding protein:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FSBP
- genomics-online: gRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- Applied Biological Materials CRISPR for FSBP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FSBP
- GenScript: Design CRISPR guide RNA sequences for FSBP
miRNA Products
- Search ViGene Biosciences for FSBP
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for FSBP
- Browse OriGene Inhibitory RNA Products For FSBP
- genomics-online: shRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- Search ViGene Biosciences for FSBP
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FSBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSBP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for FSBP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FSBP Gene
This gene is overexpressed in CD8 Tcells (41.9) and Retina (27.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FSBP Gene
NURSA nuclear receptor signaling pathways regulating expression of FSBP Gene:
FSBPSOURCE GeneReport for Unigene cluster for FSBP Gene:
Hs.30561mRNA Expression by UniProt/SwissProt for FSBP Gene:
O95073-FSBP_HUMAN
Tissue specificity:
Expressed in multiple tissues including brain.
Primer Products
-
OriGene qPCR primer pairs for FSBP
- genomics-online: primer clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FSBP Gene
Orthologs for FSBP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FSBP 33 |
|
||
| dog (Canis familiaris) |
Mammalia | FSBP 33 |
|
||
| cow (Bos Taurus) |
Mammalia | FSBP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fsbp 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102550523 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FSBP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FSBP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FSBP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fsbp 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101884826 33 |
|
- Species where no ortholog for FSBP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FSBP Gene
Variants for FSBP Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000210868 | -- | 94,430,080(-) | G/A | 3_prime_UTR_variant | |
| rs1000381786 | -- | 94,432,931(-) | A/G | intron_variant | |
| rs1000773869 | -- | 94,438,943(-) | T/A | upstream_transcript_variant | |
| rs1001115919 | -- | 94,431,504(-) | G/A | 3_prime_UTR_variant | |
| rs1001218143 | -- | 94,429,323(-) | T/C | 3_prime_UTR_variant |
Gene Damage Index Score:
1.06;
21.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FSBP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FSBP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FSBP Gene
Disorders for FSBP Gene
Additional Disease Information for FSBP
No disorders were found for FSBP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FSBP Gene
Publications for FSBP Gene
- An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. (PMID: 20531236) Lau KF … Miller CC (Neuroreport 2010) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
Products for FSBP Gene
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- OriGene qPCR primer pairs for FSBP
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- ProSpec Recombinant Proteins for FSBP
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for FSBP
- VectorBuilder custom plasmid, inducible vectors for FSBP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FSBP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available FSBP related products ranked by validation data
- antibodies-online: Search results for available FSBP related products ranked by validation data
- antibodies-online: Search results for 3 available FSBP Proteins ranked by validation data
- Compare Top FSBP Proteins
- Quality Products:
- Search GeneTex for Antibodies for FSBP
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- Horizon Cell Lines for FSBP
- genomics-online: cdna clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- orf clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- genomics-online: gRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- genomics-online: primer clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
- genomics-online: shRNA clones - Search results for 19 available FSBP gene related products
- Overview of 19 available FSBP gene related products
Sources for FSBP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems