Aliases for FRZB Gene
External Ids for FRZB Gene
Previous GeneCards Identifiers for FRZB Gene
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
GeneCards Summary for FRZB Gene
FRZB (Frizzled Related Protein) is a Protein Coding gene. Diseases associated with FRZB include Osteoarthritis and Holzgreve Syndrome. Among its related pathways are Endochondral Ossification and WNT Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is SFRP4.
UniProtKB/Swiss-Prot Summary for FRZB Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.