Aliases for FRZB Gene
External Ids for FRZB Gene
Previous GeneCards Identifiers for FRZB Gene
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
GeneCards Summary for FRZB Gene
FRZB (Frizzled Related Protein) is a Protein Coding gene. Diseases associated with FRZB include Osteoarthritis and Holzgreve Syndrome. Among its related pathways are Hepatitis C and Hepatocellular Carcinoma and Adipogenesis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Wnt-protein binding. An important paralog of this gene is SFRP4.
UniProtKB/Swiss-Prot Summary for FRZB Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.