Aliases for FRS3 Gene
External Ids for FRS3 Gene
Previous GeneCards Identifiers for FRS3 Gene
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
GeneCards Summary for FRS3 Gene
FRS3 (Fibroblast Growth Factor Receptor Substrate 3) is a Protein Coding gene. Diseases associated with FRS3 include Multiple Endocrine Neoplasia, Type Iv and Kallmann Syndrome. Among its related pathways are RET signaling and NGF Pathway. Gene Ontology (GO) annotations related to this gene include insulin receptor binding and fibroblast growth factor receptor binding. An important paralog of this gene is FRS2.
UniProtKB/Swiss-Prot Summary for FRS3 Gene
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.