Aliases for FRS2 Gene
External Ids for FRS2 Gene
Previous GeneCards Identifiers for FRS2 Gene
GeneCards Summary for FRS2 Gene
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include Rete Testis Adenoma and Well-Differentiated Liposarcoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and RET signaling. Gene Ontology (GO) annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.
UniProtKB/Swiss-Prot Summary for FRS2 Gene
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.